| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A J Cleare, J Bearn, T Allain, A McGregor, S Wessely, R M Murray, V O'Kean. Contrasting neuroendocrine responses in depression and chronic fatigue syndrome. Journal of affective disorders. vol 34. issue 4. 1996-02-20. PMID:8550954. |
hypothalamic-pituitary-adrenal (hpa) axis and central 5-ht function were compared in chronic fatigue syndrome (cfs), depression and healthy states. |
1996-02-20 |
2023-08-12 |
Not clear |
| A J Cleare, J Bearn, T Allain, A McGregor, S Wessely, R M Murray, V O'Kean. Contrasting neuroendocrine responses in depression and chronic fatigue syndrome. Journal of affective disorders. vol 34. issue 4. 1996-02-20. PMID:8550954. |
these data confirm that depression is associated with hypercotisolaemia and reduced central 5-ht neurotransmission and suggest that cfs may be associated with hypocortisolaemia and increased 5-ht function. |
1996-02-20 |
2023-08-12 |
Not clear |
| Y Gustafson, I Nilsson, M Mattsson, M Aström, G Buch. Epidemiology and treatment of post-stroke depression. Drugs & aging. vol 7. issue 4. 1996-02-07. PMID:8535057. |
the study evaluated a selective serotonin reuptake inhibitor (citalopram) and concluded that the drug was well tolerated and effective for the treatment of post-stroke depression. |
1996-02-07 |
2023-08-12 |
Not clear |
| S L Kelich, P L Meade, D E Seyle. Developmental toxicity of amesergide administered by gavage to CD rats and New Zealand white rabbits. Fundamental and applied toxicology : official journal of the Society of Toxicology. vol 27. issue 2. 1996-02-01. PMID:8529820. |
amesergide is a selective serotonin 5-htic/2 receptor antagonist being developed for the treatment of depression. |
1996-02-01 |
2023-08-12 |
rat |
| J E Cabral-Filho, E M Trindade-Filho, R C Guede. Effect of d-fenfluramine on cortical spreading depression in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 28. issue 3. 1996-01-24. PMID:8520530. |
we investigated the effect of a single ip injection of d-fenfluramine (d-fen; 5-10 mg/kg), a serotonin reuptake blocker, on cortical spreading depression (sd) in 17 male wistar rats (300-360 g body weight). |
1996-01-24 |
2023-08-12 |
rat |
| M B Keller, W Harrison, J A Fawcett, A Gelenberg, R M Hirschfeld, D Klein, J H Kocsis, J P McCullough, A J Rush, A Schatzber. Treatment of chronic depression with sertraline or imipramine: preliminary blinded response rates and high rates of undertreatment in the community. Psychopharmacology bulletin. vol 31. issue 2. 1996-01-04. PMID:7491369. |
in this article, we report a preliminary analysis of the first 12-week phase of a multicenter clinical trial that will eventually include approximately 635 patients in acute, continuation, crossover, and maintenance studies of sertraline, a selective serotonin reuptake inhibitor (ssri), and imipramine, a tricyclic antidepressant, for the treatment of chronic depression. |
1996-01-04 |
2023-08-12 |
Not clear |
| S Hyni. [5-hydroxytryptamine (serotonin) receptors--nomenclature and classification of types and subtypes]. Ceskoslovenska fysiologie. vol 44. issue 3. 1995-12-26. PMID:7586016. |
5-ht plays an important role in depression; to cure this disease, drugs which increase levels of this neurotransmitter are used. |
1995-12-26 |
2023-08-12 |
Not clear |
| P J McGrath, F M Quitkin, D F Klei. Bromocriptine treatment of relapses seen during selective serotonin re-uptake inhibitor treatment of depression. Journal of clinical psychopharmacology. vol 15. issue 4. 1995-12-19. PMID:7593717. |
bromocriptine treatment of relapses seen during selective serotonin re-uptake inhibitor treatment of depression. |
1995-12-19 |
2023-08-12 |
Not clear |
| E A Ottevange. Fluvoxamine and clomipramine in depressed hospitalised patients: results from a randomised, double-blind study. L'Encephale. vol 21. issue 4. 1995-12-18. PMID:7588171. |
the efficacy of the selective serotonin reuptake inhibitors (ssris) and the tricyclic antidepressants is well established, although data on the efficacy of ssris in severe depression is limited. |
1995-12-18 |
2023-08-12 |
Not clear |
| D J Haleem, A Yasmeen, M A Haleem, A Zafa. 24h withdrawal following repeated administration of caffeine attenuates brain serotonin but not tryptophan in rat brain: implications for caffeine-induced depression. Life sciences. vol 57. issue 19. 1995-12-15. PMID:7475912. |
24h withdrawal following repeated administration of caffeine attenuates brain serotonin but not tryptophan in rat brain: implications for caffeine-induced depression. |
1995-12-15 |
2023-08-12 |
rat |
| D J Haleem, A Yasmeen, M A Haleem, A Zafa. 24h withdrawal following repeated administration of caffeine attenuates brain serotonin but not tryptophan in rat brain: implications for caffeine-induced depression. Life sciences. vol 57. issue 19. 1995-12-15. PMID:7475912. |
in view of a possible role of 5-ht in caffeine-induced depression the effects of repeated administration of high doses of caffeine on brain 5-ht metabolism are investigated in rats. |
1995-12-15 |
2023-08-12 |
rat |
| D J Haleem, A Yasmeen, M A Haleem, A Zafa. 24h withdrawal following repeated administration of caffeine attenuates brain serotonin but not tryptophan in rat brain: implications for caffeine-induced depression. Life sciences. vol 57. issue 19. 1995-12-15. PMID:7475912. |
the findings are discussed as repeated caffeine administration producing adaptive changes in the serotonergic neurons to decrease the conversion of tryptophan to 5-ht and this may precipitate depression particularly in conditions of caffeine withdrawal. |
1995-12-15 |
2023-08-12 |
rat |
| V M Storozhuk, V V Sachenko, J A Kruchenk. Dependence of sensorimotor cortex neuron activity on noradrenergic and serotoninergic transmission in unspecific thalamic nuclei. Neuroscience. vol 68. issue 2. 1995-12-12. PMID:7477943. |
background and evoked impulse activity greatly increased by application of 5-hydroxytryptamine after preliminary lisergamide-induced depression of the impulse activity. |
1995-12-12 |
2023-08-12 |
Not clear |
| M J Villa. [New concepts relating to histochemistry of the serotonergic neural systems of the raphe nucleus]. Acta psiquiatrica y psicologica de America latina. vol 40. issue 4. 1995-12-07. PMID:7484182. |
all these results have expanded our knowledge on the raphe nuclei and suggest that many other substances, apart from serotonin, could be involved in the regulation of processes such as sleep, anxiety and depression. |
1995-12-07 |
2023-08-12 |
Not clear |
| L Staner, M Kerkhofs, D Detroux, S Leyman, P Linkowski, J Mendlewic. Acute, subchronic and withdrawal sleep EEG changes during treatment with paroxetine and amitriptyline: a double-blind randomized trial in major depression. Sleep. vol 18. issue 6. 1995-11-30. PMID:7481419. |
paroxetine (30 mg), a selective serotonin (5-ht) reuptake inhibitor, was compared in a double-blind trial to amitriptyline (150 mg) in a sample of 40 inpatients aged 18-65 years who fulfilled research diagnostic criteria for major depression. |
1995-11-30 |
2023-08-12 |
Not clear |
| M I Wilde, R Whittingto. Paroxetine. A pharmacoeconomic evaluation of its use in depression. PharmacoEconomics. vol 8. issue 1. 1995-11-29. PMID:10155603. |
there has been intense debate about whether the use of paroxetine or other selective serotonin reuptake inhibitors (ssris) as alternatives to tricyclic antidepressants for first-line treatment of depression can be justified, considering their higher acquisition costs. |
1995-11-29 |
2023-08-12 |
Not clear |
| J D Bentkover, J P Feighne. Cost analysis of paroxetine versus imipramine in major depression. PharmacoEconomics. vol 8. issue 3. 1995-11-29. PMID:10155618. |
a simulation decision analytical model was used to compare the annual direct medical costs of treating patients with major depression using the selective serotonin reuptake inhibitor (ssri) paroxetine or the tricyclic antidepressant (tca) imipramine. |
1995-11-29 |
2023-08-12 |
Not clear |
| b' R Krul\\xc3\\xadk, P Bures, Z Fisar, K Fuksov\\xc3\\xa1, J Sikora, D Beitlov\\xc3\\xa. [Ca(2+)-channel blockers and binding of tricyclic antidepressive agents]. Ceskoslovenska psychiatrie. vol 91. issue 3. 1995-11-20. PMID:7553947.' |
mechanism of ca(2+)-channel blockers action in the treatment of depression may be connected rather with changes in signal transduction through serotonin and catecholamine receptor systems than with direct interaction of drugs with binding sites for tricyclic antidepressants. |
1995-11-20 |
2023-08-12 |
human |
| F Fernández-de-Miguel, P Drapea. Synapse formation and function: insights from identified leech neurons in culture. Journal of neurobiology. vol 27. issue 3. 1995-10-17. PMID:7673895. |
the release of 5-ht is quantal, calcium-dependent, and shows activity-dependent facilitation and depression. |
1995-10-17 |
2023-08-12 |
Not clear |
| M B Keller, D L Hank. Anxiety symptom relief in depression treatment outcomes. The Journal of clinical psychiatry. vol 56 Suppl 6. 1995-09-28. PMID:7649969. |
in studies comparing benzodiazepines, monoamine oxidase inhibitors (maois), serotonin selective reuptake inhibitors (ssris), and tricyclic antidepressants (tcas) in the treatment of concurrent anxiety and depression, all have some measure of success depending on the degree of depression and the type of anxiety disorder. |
1995-09-28 |
2023-08-12 |
Not clear |