| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A J Cleare, A McGregor, V O'Kean. Neuroendocrine evidence for an association between hypothyroidism, reduced central 5-HT activity and depression. Clinical endocrinology. vol 43. issue 6. 1996-10-15. PMID:8736274. |
we tested the hypothesis that central 5-ht activity is reduced in hypothyroidism, and that this subsequently lowers the threshold for developing depression. |
1996-10-15 |
2023-08-12 |
Not clear |
| J F Deaki. Does selectivity matter? International clinical psychopharmacology. vol 11 Suppl 1. 1996-10-09. PMID:8732439. |
it is now clear that selective serotonin reuptake inhibitors (ssris) are more effective than noradrenaline reuptake inhibitors (naris) in the treatment of obsessional compulsive disorder, and obsessional features in depression predict a responsivity to ssris. |
1996-10-09 |
2023-08-12 |
human |
| H M Hochberg, D Kanter, V P House. Electrocardiographic findings during extended clinical trials of fluvoxamine in depression: one years experience. Pharmacopsychiatry. vol 28. issue 6. 1996-10-09. PMID:8773292. |
fluvoxamine, a selective serotonin reuptake inhibitor (ssri), is used to treat depression. |
1996-10-09 |
2023-08-12 |
Not clear |
| C Moret, M Brile. Effects of acute and repeated administration of citalopram on extracellular levels of serotonin in rat brain. European journal of pharmacology. vol 295. issue 2-3. 1996-09-26. PMID:8720583. |
this finding suggests that a 5-ht autoreceptor antagonist or a combination of such a drug with a 5-ht uptake inhibitor would produce a greater increase of extracellular levels of 5-ht in hyposerotonergic states such as depression. |
1996-09-26 |
2023-08-12 |
rat |
| D J Goldstei. Effects of third trimester fluoxetine exposure on the newborn. Journal of clinical psychopharmacology. vol 15. issue 6. 1996-09-26. PMID:8748430. |
prospectively identified fluoxetine-exposed pregnancies were evaluated to determine whether fluoxetine, a serotonin reuptake inhibitor commonly used for the treatment of depression and obsessive-compulsive disorder, might be associated with neonatal complications after maternal fluoxetine exposure during the third trimester through delivery. |
1996-09-26 |
2023-08-12 |
Not clear |
| A J Cleare, R M Murray, V O'Kean. Reduced prolactin and cortisol responses to d-fenfluramine in depressed compared to healthy matched control subjects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 14. issue 5. 1996-09-12. PMID:8703303. |
d-fenfluramine, a specific 5-ht releasing agent without the catecholamine effects of d,l-fenfluramine, was used as a neuroendocrine challenge in 19 subjects with major depression and 19 healthy controls. |
1996-09-12 |
2023-08-12 |
human |
| N Sonino, G A Fav. Serotonin, Cushing's disease, and depression. Psychotherapy and psychosomatics. vol 65. issue 2. 1996-09-06. PMID:8711083. |
serotonin, cushing's disease, and depression. |
1996-09-06 |
2023-08-12 |
Not clear |
| B E Leonar. Serotonin receptors and their function in sleep, anxiety disorders and depression. Psychotherapy and psychosomatics. vol 65. issue 2. 1996-09-06. PMID:8711084. |
serotonin receptors and their function in sleep, anxiety disorders and depression. |
1996-09-06 |
2023-08-12 |
rat |
| R J Wurtman, J J Wurtma. Brain serotonin, carbohydrate-craving, obesity and depression. Obesity research. vol 3 Suppl 4. 1996-09-05. PMID:8697046. |
brain serotonin, carbohydrate-craving, obesity and depression. |
1996-09-05 |
2023-08-12 |
Not clear |
| P A Newhous. Use of serotonin selective reuptake inhibitors in geriatric depression. The Journal of clinical psychiatry. vol 57 Suppl 5. 1996-07-19. PMID:8647788. |
use of serotonin selective reuptake inhibitors in geriatric depression. |
1996-07-19 |
2023-08-12 |
Not clear |
| P A Newhous. Use of serotonin selective reuptake inhibitors in geriatric depression. The Journal of clinical psychiatry. vol 57 Suppl 5. 1996-07-19. PMID:8647788. |
the advent of the serotonin selective reuptake inhibitors (ssris) represents a significant advance in the treatment of depression. |
1996-07-19 |
2023-08-12 |
Not clear |
| R Kuze. Management of depression. Current trends in primary care. Postgraduate medicine. vol 99. issue 5. 1996-07-19. PMID:8650085. |
selective serotonin reuptake inhibitors are well tolerated and are considered by many to be the agents of choice in primary care treatment of depression because of their favorable adverse-effect profile. |
1996-07-19 |
2023-08-12 |
Not clear |
| G M Goodwi. How do antidepressants affect serotonin receptors? The role of serotonin receptors in the therapeutic and side effect profile of the SSRIs. The Journal of clinical psychiatry. vol 57 Suppl 4. 1996-07-09. PMID:8636065. |
the serotonin selective reuptake inhibitors (ssris) have proved to be an important development in the treatment of depression because of both their greater practical ease of use and their selective primary action on a single binding site. |
1996-07-09 |
2023-08-12 |
Not clear |
| T G Dina. Serotonin and the regulation of hypothalamic-pituitary-adrenal axis function. Life sciences. vol 58. issue 20. 1996-07-05. PMID:8637392. |
these findings have major implications for the interpretation of neuroendocrine studies of 5ht conducted in psychiatric conditions, such as depression. |
1996-07-05 |
2023-08-12 |
Not clear |
| C K Cohn, D S Robinson, D L Roberts, U E Schwiderski, K O'Brien, J R Ien. Responders to antidepressant drug treatment: a study comparing nefazodone, imipramine, and placebo in patients with major depression. The Journal of clinical psychiatry. vol 57 Suppl 2. 1996-06-25. PMID:8626358. |
nefazodone hydrochloride, an antidepressant that acts as a 5-ht2 antagonist and serotonin (5-ht) and norepinephrine uptake inhibitor, was evaluated in a double-blind, imipramine- and placebo-controlled study involving 128 patients with major depression. |
1996-06-25 |
2023-08-12 |
Not clear |
| A D Ogilvie, S Battersby, V J Bubb, G Fink, A J Harmar, G M Goodwim, C A Smit. Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet (London, England). vol 347. issue 9003. 1996-05-09. PMID:8602004. |
polymorphism in serotonin transporter gene associated with susceptibility to major depression. |
1996-05-09 |
2023-08-12 |
Not clear |
| A V Ravindran, J Griffiths, Z Merali, H Anisma. Lymphocyte subsets associated with major depression and dysthymia: modification by antidepressant treatment. Psychosomatic medicine. vol 57. issue 6. 1996-05-01. PMID:8600482. |
after treatment with a specific serotonin reuptake inhibitor, the symptoms of depression were alleviated in both the major depressive and dysthymic patients. |
1996-05-01 |
2023-08-12 |
human |
| M el Mansari, C Bouchard, P Blie. Alteration of serotonin release in the guinea pig orbito-frontal cortex by selective serotonin reuptake inhibitors. Relevance to treatment of obsessive-compulsive disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 13. issue 2. 1996-04-25. PMID:8597523. |
since the delay of the maximal therapeutic effect of selective 5-ht reuptake inhibitors (ssri) is longer in ocd than in major depression and the terminal 5-ht autoreceptor is not desensitized in the guinea pig frontal cortex after 3 weeks of ssri administration, the effects of the ssri paroxetine (10 mg/kg/day) and fluoxetine (5 mg/kg/day) on 5-ht release and on the sensitivity of the terminal 5-ht autoreceptor were investigated in the guinea pig frontal cortex, the orbito-frontal cortex, and the head of caudate nucleus following a washout period after 3 and 8 weeks of treatment. |
1996-04-25 |
2023-08-12 |
Not clear |
| M el Mansari, C Bouchard, P Blie. Alteration of serotonin release in the guinea pig orbito-frontal cortex by selective serotonin reuptake inhibitors. Relevance to treatment of obsessive-compulsive disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 13. issue 2. 1996-04-25. PMID:8597523. |
this could be attributable to a smaller degree of 5-ht reuptake inhibition achieved with fluoxetine, in keeping with the notion that higher doses of ssri are generally required to improve ocd than depression. |
1996-04-25 |
2023-08-12 |
Not clear |
| T D Brewerto. Toward a unified theory of serotonin dysregulation in eating and related disorders. Psychoneuroendocrinology. vol 20. issue 6. 1996-03-21. PMID:8584599. |
these include feeding disturbances, depression and suicide, impulsivity and violence, anxiety and harm avoidance, obsessive-compulsive features, seasonal variation of symptoms, as well as disturbances in neuroendocrine and vascular tissues, as well as other neurochemical systems linked to 5-ht, such as temperature. |
1996-03-21 |
2023-08-12 |
human |