| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S D Hor. Overcoming obstacles to effective treatment: use of clinical practice improvement methodology. The Journal of clinical psychiatry. vol 58 Suppl 1. 1997-03-19. PMID:9054904. |
among the findings were the following: (1) the majority of patients receiving psychiatric drugs do not have a specific psychiatric diagnosis; (2) a significant proportion of patients with a specific diagnosis of major depression do not receive antidepressant medication; (3) cost-containment strategies appeared to markedly limit psychiatric referral and frequency of visits and use of serotonin selective reuptake inhibitor treatment; and (4) severity of the primary illness in the study population was markedly increased in patients with a psychiatric diagnosis. |
1997-03-19 |
2023-08-12 |
Not clear |
| E Davids, K P Lesc. [The 5-HT1A receptor: a new effective principle in psychopharmacologic therapy?]. Fortschritte der Neurologie-Psychiatrie. vol 64. issue 11. 1997-03-18. PMID:9064274. |
preliminary results suggest that beta-adrenoceptor blockers may be useful as adjunctive medication in the treatment of depression by augmenting the antidepressant efficacy of selective serotonin reuptake inhibitors. |
1997-03-18 |
2023-08-12 |
Not clear |
| D D Walczak, J T Apter, J A Halikas, R L Borison, J S Carman, G L Post, R Patrick, J B Cohn, L A Cunningham, B Rittberg, S H Preskorn, J S Kang, C S Wilco. The oral dose-effect relationship for fluvoxamine: a fixed-dose comparison against placebo in depressed outpatients. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists. vol 8. issue 3. 1997-03-14. PMID:8899132. |
a 13-item subscore of the standard 21-item hamilton depression scale was used to minimize the possible contribution of known side effects from serotonin reuptake inhibitors to the overall ham-d score. |
1997-03-14 |
2023-08-12 |
Not clear |
| A Cappiello, R T Malison, C J McDougle, S J Vegso, D S Charney, G R Heninger, L H Pric. Seasonal variation in neuroendocrine and mood responses to i.v. L-tryptophan in depressed patients and healthy subjects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 5. 1997-03-14. PMID:8914120. |
these data support previous evidence that 5-ht function is abnormal in depression and further suggest a seasonal variability of such abnormalities that is absent in healthy subjects. |
1997-03-14 |
2023-08-12 |
human |
| A Neumeister, N Praschak-Rieder, B Besselmann, M L Rao, J Glück, S Kaspe. Effects of tryptophan depletion on drug-free patients with seasonal affective disorder during a stable response to bright light therapy. Archives of general psychiatry. vol 54. issue 2. 1997-03-13. PMID:9040281. |
light therapy-induced remission from depression may be associated with changes in brain serotonin function. |
1997-03-13 |
2023-08-12 |
Not clear |
| A González-Pinto, J J López Ibor, J Sáiz, M Gutiérrez, J L Figuerido, M J García Godo. [The clomipramine test and subtypes of depression]. Actas luso-espanolas de neurologia, psiquiatria y ciencias afines. vol 24. issue 6. 1997-03-12. PMID:9054201. |
in this study, the neuroendocrine responses to acute intravenous administration of the serotonin (5-ht) reuptake inhibitor clomipramine were assessed in patients with major depression with melancholia (dmm) and matched subjects with major depression (dm) (without melancholia) and dysthimic disorder (td). |
1997-03-12 |
2023-08-12 |
human |
| M Patris, J M Bouchard, T Bougerol, J F Charbonnier, J F Chevalier, G Clerc, C Cyran, P Van Amerongen, O Lemming, H E Høpfner Peterse. Citalopram versus fluoxetine: a double-blind, controlled, multicentre, phase III trial in patients with unipolar major depression treated in general practice. International clinical psychopharmacology. vol 11. issue 2. 1997-03-11. PMID:8803650. |
two selective serotonin reuptake inhibitors (ssris), citalopram and fluoxetine, both at a daily dose of 20 mg, were compared in patients with unipolar major depression treated in general practice. |
1997-03-11 |
2023-08-12 |
Not clear |
| Z Y Sun, S Schache. Development of short-term heterosynaptic facilitation at aplysia sensorimotor synapses in vitro is accompanied by changes in the functional expression of presynaptic serotonin receptors. Journal of neurophysiology. vol 76. issue 4. 1997-03-11. PMID:8899600. |
the sensorimotor synapse of aplysia expresses various shortlasting changes in synaptic efficacy including homosynaptic depression (hsd) and heterosynaptic facilitation by serotonin (5-ht) either at nondepressed sensory neuron (sn) synaptic connections or at sn synaptic connections first depressed by hsd. |
1997-03-11 |
2023-08-12 |
aplysia |
| R J Wurtman, J J Wurtma. Brain Serotonin, Carbohydrate-craving, obesity and depression. Advances in experimental medicine and biology. vol 398. 1997-03-06. PMID:9045545. |
brain serotonin, carbohydrate-craving, obesity and depression. |
1997-03-06 |
2023-08-12 |
Not clear |
| Y Wang, C H Jeng, J C Lin, J Y Wan. Serotonin modulates ethanol-induced depression in cerebellar Purkinje neurons. Alcoholism, clinical and experimental research. vol 20. issue 7. 1997-03-03. PMID:8904976. |
serotonin modulates ethanol-induced depression in cerebellar purkinje neurons. |
1997-03-03 |
2023-08-12 |
rat |
| Y Wang, C H Jeng, J C Lin, J Y Wan. Serotonin modulates ethanol-induced depression in cerebellar Purkinje neurons. Alcoholism, clinical and experimental research. vol 20. issue 7. 1997-03-03. PMID:8904976. |
5-ht also potentiated depressions induced by gamma-aminobutyric acid; however, this modulatory response was quantitatively smaller than 5-ht-induced potentiation of ethanol depression. |
1997-03-03 |
2023-08-12 |
rat |
| A A Piergies, J Sweet, M Johnson, B F Roth-Schechter, S Allar. The effect of co-administration of zolpidem with fluoxetine: pharmacokinetics and pharmacodynamics. International journal of clinical pharmacology and therapeutics. vol 34. issue 4. 1997-02-27. PMID:8861737. |
since early treatment of depression with selective serotonin reuptake inhibitor (ssri) can be associated with insomnia, daytime antidepressive therapy with ssri is often combined with nighttime administration of a hypnotic. |
1997-02-27 |
2023-08-12 |
human |
| T A Slotkin, E C McCook, J C Ritchie, F J Seidle. Do glucocorticoids contribute to the abnormalities in serotonin transporter expression and function seen in depression? An animal model. Biological psychiatry. vol 40. issue 7. 1997-02-21. PMID:8886290. |
do glucocorticoids contribute to the abnormalities in serotonin transporter expression and function seen in depression? |
1997-02-21 |
2023-08-12 |
rat |
| T A Slotkin, E C McCook, J C Ritchie, F J Seidle. Do glucocorticoids contribute to the abnormalities in serotonin transporter expression and function seen in depression? An animal model. Biological psychiatry. vol 40. issue 7. 1997-02-21. PMID:8886290. |
thus, elevated glucocorticoids are not responsible for reduced platelet serotonin transporter expression in depression, nor for resistance to imipramine's effect in platelets in elderly depression; however, reduced synaptosomal [3h]serotonin uptake indicates that glucocorticoids can affect transport efficiency, even when the number of transporter molecules is unaltered. |
1997-02-21 |
2023-08-12 |
rat |
| b' V S Kosti\\xc4\\x87, D Leci\\xc4\\x87, M Doder, J Marinkovi\\xc4\\x87, S Filipovi\\xc4\\x8. Prolactin and cortisol responses to fenfluramine in Parkinson\'s disease. Biological psychiatry. vol 40. issue 8. 1997-02-21. PMID:8894070.' |
to evaluate central serotonergic function in parkinson's disease in relation to depression, we examined prolactin and cortisol responses to a single-dose challenge with fenfluramine (60 mg orally), a serotonin releasing/uptake-inhibiting agent, in the course of 5 hours in 11 patients with parkinson's disease associated with major depression (sads-rdc), 22 nondepressed parkinsonians, and 20 age- and gender-matched healthy controls. |
1997-02-21 |
2023-08-12 |
Not clear |
| R Sandy. Suicidal behavior is attenuated in patients with multiple sclerosis by treatment with electromagnetic fields. The International journal of neuroscience. vol 87. issue 1-2. 1997-02-21. PMID:8913816. |
these findings demonstrate that in ms pulsed applications of picotesla level emfs improve mental depression and may reduce the risk of suicide by a mechanism involving the augmentation of 5-ht neurotransmission and resynchronization of circadian melatonin secretion. |
1997-02-21 |
2023-08-12 |
Not clear |
| J A Lopez-Garcia, A E Kin. Pre- and post-synaptic actions of 5-hydroxytryptamine in the rat lumbar dorsal horn in vitro: implications for somatosensory transmission. The European journal of neuroscience. vol 8. issue 10. 1997-02-19. PMID:8921310. |
5-ht produced a depression of spontaneous dorsal root potentials and a slow primary afferent depolarization (pad): the pad versus 5-ht concentration-response curve was bell shaped (maximum at 5 microm; 250 +/- 41.5 microv). |
1997-02-19 |
2023-08-12 |
rat |
| J A Lopez-Garcia, A E Kin. Pre- and post-synaptic actions of 5-hydroxytryptamine in the rat lumbar dorsal horn in vitro: implications for somatosensory transmission. The European journal of neuroscience. vol 8. issue 10. 1997-02-19. PMID:8921310. |
these data suggest that whilst depression of synaptic transmission is the predominant effect of 5-ht in the deep dorsal horn, this is not easily related to pad or cellular actions of 5-ht on dorsal horn neurons. |
1997-02-19 |
2023-08-12 |
rat |
| V A Randall, S J MacLennan, G R Martin, V G Wilso. The effect of forskolin on 5-HT1-like and angiotensin II-induced vasoconstriction and cyclic AMP content of the rabbit isolated femoral artery. British journal of pharmacology. vol 118. issue 3. 1997-02-14. PMID:8762087. |
the directly-acting adenylyl cyclase activator, forskolin (1 microm), abolished responses to angiotensin ii and caused a rightward shift and concomitant depression of the 5-ht concentration-effect (e/[a]) curve. |
1997-02-14 |
2023-08-12 |
rabbit |
| S Kojima, Y Shim. Investigation into the 5-hydroxytryptamine-induced atropine-resistant neurogenic contraction of guinea-pig proximal colon. British journal of pharmacology. vol 117. issue 8. 1997-02-13. PMID:8732267. |
the 5-ht4 receptor antagonist, dau 6285 (3 microm) shifted the concentration-response curves to both 5-ht and 5-meot to the right without significant depression of the maximum, but the 5-ht1/5-ht2 receptor antagonist, metitepine (0.1 microm) and the 5-ht3 receptor antagonist, ondansetron (0.3 microm) had no effect on the control curves to 5-ht and 5-meot. |
1997-02-13 |
2023-08-12 |
Not clear |