| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Biver, D Wikler, F Lotstra, P Damhaut, S Goldman, J Mendlewic. Serotonin 5-HT2 receptor imaging in major depression: focal changes in orbito-insular cortex. The British journal of psychiatry : the journal of mental science. vol 171. 1998-02-23. PMID:9463603. |
serotonin 5-ht2 receptor imaging in major depression: focal changes in orbito-insular cortex. |
1998-02-23 |
2023-08-12 |
Not clear |
| F Biver, D Wikler, F Lotstra, P Damhaut, S Goldman, J Mendlewic. Serotonin 5-HT2 receptor imaging in major depression: focal changes in orbito-insular cortex. The British journal of psychiatry : the journal of mental science. vol 171. 1998-02-23. PMID:9463603. |
we studied type-2 serotonin (5-ht2) receptors in the brain of patients with major depression. |
1998-02-23 |
2023-08-12 |
Not clear |
| M R Briejer, C Mathis, J A Schuurke. 5-HT receptor types in the rat ileum longitudinal muscle: focus on 5-HT2 receptors mediating contraction. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 9. issue 4. 1998-02-04. PMID:9430791. |
using (if possible) 5-ht2a receptor-selective concentrations, ketanserin, ritanserin, metergoline, spiperone, mianserin, methiothepin, mesulergine, methysergide and cisapride all inhibited the contractions to 5-ht, causing a depression of the curve to 5-ht (i.e. |
1998-02-04 |
2023-08-12 |
rat |
| A L Weiner, F F Tilden, C A McKa. Serotonin syndrome: case report and review of the literature. Connecticut medicine. vol 61. issue 11. 1998-01-30. PMID:9419960. |
she was already being treated for depression with paroxetine (paxil), a selective serotonin reuptake inhibitor. |
1998-01-30 |
2023-08-12 |
Not clear |
| O Bodlun. [Anxiety and depression as a hidden problem in primary health care. Only one case in four identified]. Lakartidningen. vol 94. issue 49. 1998-01-29. PMID:9445933. |
one third of the patients with a clinical diagnosis of anxiety and 47 per cent of those with diagnosed depression were offered appropriate treatment, usually medication with a selective serotonin re-uptake inhibitor (ssri) and consultation with a medical social worker. |
1998-01-29 |
2023-08-12 |
Not clear |
| P A Broderic. Alprazolam, diazepam, yohimbine, clonidine: in vivo CA1 hippocampal norepinephrine and serotonin release profiles under chloral hydrate anesthesia. Progress in neuro-psychopharmacology & biological psychiatry. vol 21. issue 7. 1998-01-28. PMID:9421826. |
indeed, 5-ht is a component of the dorsal ascending noradrenergic bundle and both neurotransmitters, ne and 5-ht, have been implicated in clinical depression. |
1998-01-28 |
2023-08-12 |
rat |
| C R Grünschlag, H L Haas, D R Steven. 5-HT inhibits lateral entorhinal cortical neurons of the rat in vitro by activation of potassium channel-coupled 5-HT1A receptors. Brain research. vol 770. issue 1-2. 1998-01-21. PMID:9372196. |
intracellular application of qx-314, a blocker of potassium conductance, significantly reduced depression of synaptic potentials by 5-ht agonists. |
1998-01-21 |
2023-08-12 |
rat |
| H H Hansen, C Sánchez, E Meie. Neonatal administration of the selective serotonin reuptake inhibitor Lu 10-134-C increases forced swimming-induced immobility in adult rats: a putative animal model of depression? The Journal of pharmacology and experimental therapeutics. vol 283. issue 3. 1998-01-15. PMID:9400008. |
neonatal administration of the selective serotonin reuptake inhibitor lu 10-134-c increases forced swimming-induced immobility in adult rats: a putative animal model of depression? |
1998-01-15 |
2023-08-12 |
human |
| J D Favre, C Guelfi-Sozzi, B Delalleau, H Lô. Tianeptine and alcohol dependence. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 7 Suppl 3. 1998-01-15. PMID:9405962. |
several arguments are in favour of the use of antidepressant drugs in alcohol-dependent patients, especially those acting on the serotoninergic system: (1) neurochemical data indicate the interaction between alcohol and 5-ht metabolism, (2) pharmacological studies show an improvement in the behaviour of alcoholized animals treated with antidepressants, (3) depression is a frequent disease in alcoholic patients. |
1998-01-15 |
2023-08-12 |
Not clear |
| H O Kalkma. Hypersensitivity to meta-chlorophenylpiperazine (mCPP) in migraine and drug withdrawal. International journal of clinical pharmacology research. vol 17. issue 2-3. 1998-01-07. PMID:9403358. |
rats exposed to chronic mild stress (which is also a key factor in the precipitation of human depression) were hypersensitive to mcpp, whilst chronic treatment with antidepressant serotonin re-uptake inhibitors suppressed the responsiveness to mcpp. |
1998-01-07 |
2023-08-12 |
human |
| R B Lydiard, S M Stahl, M Hertzman, W M Harriso. A double-blind, placebo-controlled study comparing the effects of sertraline versus amitriptyline in the treatment of major depression. The Journal of clinical psychiatry. vol 58. issue 11. 1998-01-06. PMID:9413414. |
this study was designed to compare the efficacy, safety, tolerability profiles, and effects on quality of life of the serotonin selective reuptake inhibitor antidepressant sertraline versus the nonselective tricyclic antidepressant amitriptyline and placebo in patients with major depression. |
1998-01-06 |
2023-08-12 |
Not clear |
| P E Stokes, A Holt. Fluoxetine tenth anniversary update: the progress continues. Clinical therapeutics. vol 19. issue 5. 1997-12-30. PMID:9385500. |
rapid discontinuation or missed doses of short-half-life selective serotonin reuptake inhibitors, tcas, and heterocyclic antidepressants are associated with withdrawal symptoms of a somatic and psychological nature, which cannot only be disruptive, but can also be suggestive of relapse or recurrence of depression. |
1997-12-30 |
2023-08-12 |
Not clear |
| L A Piazza, J C Markowitz, J H Kocsis, A C Leon, L Portera, N L Miller, D Adle. Sexual functioning in chronically depressed patients treated with SSRI antidepressants: a pilot study. The American journal of psychiatry. vol 154. issue 12. 1997-12-22. PMID:9396959. |
this prospective study assessed changes in depression and sexual functioning in chronically depressed men and women during treatment with selective serotonin reuptake inhibitors (ssris). |
1997-12-22 |
2023-08-12 |
Not clear |
| A Zangen, D H Overstreet, G Yadi. High serotonin and 5-hydroxyindoleacetic acid levels in limbic brain regions in a rat model of depression: normalization by chronic antidepressant treatment. Journal of neurochemistry. vol 69. issue 6. 1997-12-12. PMID:9375680. |
high serotonin and 5-hydroxyindoleacetic acid levels in limbic brain regions in a rat model of depression: normalization by chronic antidepressant treatment. |
1997-12-12 |
2023-08-12 |
rat |
| A Zangen, D H Overstreet, G Yadi. High serotonin and 5-hydroxyindoleacetic acid levels in limbic brain regions in a rat model of depression: normalization by chronic antidepressant treatment. Journal of neurochemistry. vol 69. issue 6. 1997-12-12. PMID:9375680. |
in a genetic rat model of depression [flinders sensitive line (fsl) rats], deviations from normal serotonin (5-ht) levels and metabolism in specific brain regions were determined. |
1997-12-12 |
2023-08-12 |
rat |
| A Zangen, D H Overstreet, G Yadi. High serotonin and 5-hydroxyindoleacetic acid levels in limbic brain regions in a rat model of depression: normalization by chronic antidepressant treatment. Journal of neurochemistry. vol 69. issue 6. 1997-12-12. PMID:9375680. |
these results indicate that the behavioral deficits expressed in the fsl model for depression correlate with increased 5-ht levels in specific limbic sites and suggest the fsl rats as a novel model for clarification of the molecular mechanism of clinically used antidepressant drugs. |
1997-12-12 |
2023-08-12 |
rat |
| A M Low, L Sormaz, C Y Kwan, E E Danie. Actions of 4-chloro-3-ethyl phenol on internal Ca2+ stores in vascular smooth muscle and endothelial cells. British journal of pharmacology. vol 122. issue 3. 1997-12-08. PMID:9351507. |
in all cases, cep caused a concentration-dependent depression of the maximum response to pe (84.8, 43.4 and 11.6% of control), 5-ht (65.4, 25.7 and 6.9% of control) and k+ (77.6, 41.1 and 10.8% of control). |
1997-12-08 |
2023-08-12 |
dog |
| M Maes, H Westenberg, E Vandoolaeghe, P Demedts, A Wauters, H Neels, H Y Meltze. Effects of trazodone and fluoxetine in the treatment of major depression: therapeutic pharmacokinetic and pharmacodynamic interactions through formation of meta-chlorophenylpiperazine. Journal of clinical psychopharmacology. vol 17. issue 5. 1997-11-21. PMID:9315986. |
it has been suggested that (1) the clinical efficacy of the heterocyclic antidepressant trazodone in depression may, in part, be attributed to its metabolite meta-chlorophenylpiperazine (mcpp); and (2) the enhancement of the efficacy of trazodone by the addition of fluoxetine, a selective serotonin reuptake inhibitor, may, in part, be ascribed to fluoxetine-induced plasma concentrations of trazodone. |
1997-11-21 |
2023-08-12 |
Not clear |
| [Panic and depression: early diagnosis of patients at risk, early treatment with an SSRI (Selective Serotonin Reuptake Inhibitor)]. Psychiatrische Praxis. vol 24. issue 5 Suppl. 1997-11-18. PMID:9361703. |
[panic and depression: early diagnosis of patients at risk, early treatment with an ssri (selective serotonin reuptake inhibitor)]. |
1997-11-18 |
2023-08-12 |
Not clear |
| H A Walsh, S Day. Inhibition of hepatic tryptophan-2,3-dioxygenase: superior potency of melatonin over serotonin. Journal of pineal research. vol 23. issue 1. 1997-11-07. PMID:9379342. |
in view of the biogenic amine deficiency hypothesis of depression and the contentious claim that hepatic tryptophan-2,3-dioxygenase (tdo) is the major peripheral determinant of brain tryptophan, brain serotonin (5-ht), and ultimately melatonin, the regulation of tdo by melatonin and 5-ht is investigated and discussed. |
1997-11-07 |
2023-08-12 |
Not clear |