| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A J Clear. Reduced whole blood serotonin in major depression. Depression and anxiety. vol 5. issue 2. 1997-10-21. PMID:9262942. |
since blood serotonin is primarily produced peripherally, these results suggest that some aspect of peripheral serotonin metabolism is abnormal in major depression. |
1997-10-21 |
2023-08-12 |
human |
| J Röschke, P Kögel, R Schlösser, P Wagner, K Mann, W Rossbach, O Benker. Analysis of sleep EEG microstructure in subchronic paroxetine treatment of healthy subjects. Psychopharmacology. vol 132. issue 1. 1997-10-20. PMID:9272758. |
paroxetine is a selective and potent serotonin reuptake inhibitor and its efficacy for the treatment of depression has been proven. |
1997-10-20 |
2023-08-12 |
human |
| J P Gardner, C A Fornal, B L Jacob. Effects of sleep deprivation on serotonergic neuronal activity in the dorsal raphe nucleus of the freely moving cat. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 17. issue 2. 1997-10-17. PMID:9252982. |
since most pharmacological treatments for depression increase brain serotonin neurotransmission, the purpose of the present study was to determine whether tsd increases the activity of serotonergic neurons in the dorsal raphe nucleus (drn) in cats. |
1997-10-17 |
2023-08-12 |
cat |
| O C Meijer, R V Van Oosten, E R De Kloe. Elevated basal trough levels of corticosterone suppress hippocampal 5-hydroxytryptamine(1A) receptor expression in adrenally intact rats: implication for the pathogenesis of depression. Neuroscience. vol 80. issue 2. 1997-10-17. PMID:9284345. |
elevated basal trough levels of corticosterone suppress hippocampal 5-hydroxytryptamine(1a) receptor expression in adrenally intact rats: implication for the pathogenesis of depression. |
1997-10-17 |
2023-08-12 |
human |
| O C Meijer, R V Van Oosten, E R De Kloe. Elevated basal trough levels of corticosterone suppress hippocampal 5-hydroxytryptamine(1A) receptor expression in adrenally intact rats: implication for the pathogenesis of depression. Neuroscience. vol 80. issue 2. 1997-10-17. PMID:9284345. |
we propose therefore that this suppressive effect on 5-hydroxytryptamine(1a) receptor expression involves enhanced occupation of mineralocorticoid receptors, under a condition of elevated basal trough corticosteroid levels as is commonly observed in human depression. |
1997-10-17 |
2023-08-12 |
human |
| A Braconnier, A Jeannea. [Anxiety, aggression, agitation and depression: psychopathologic aspects]. L'Encephale. vol 23 Spec No 3. 1997-10-15. PMID:9333560. |
the fourth model is based on the existence of a specific biological constraint related to abnormalities of serotonin metabolism, to which dysregulation of anxious and aggressive-impulsive behavior patterns during depression are considered related. |
1997-10-15 |
2023-08-12 |
Not clear |
| A Braconnier, A Jeannea. [Anxiety, aggression, agitation and depression: psychopathologic aspects]. L'Encephale. vol 23 Spec No 3. 1997-10-15. PMID:9333560. |
in conclusion, it may be considered that several models, in particular that of reaction to separation, may, at least in part, account for "positive-expression" depression, but that at least two questions have still to be answered: that regarding the relationships between depression and personality, and that concerning the relationships between the psychopathological constraints related to serotonin metabolism dysfunction and the "positive" expressions. |
1997-10-15 |
2023-08-12 |
Not clear |
| A Płaźnik, M Jessa, M Naza. The behavioral effects of NMDA antagonists in serotonin depleted rats. Pharmacology, biochemistry, and behavior. vol 58. issue 1. 1997-09-30. PMID:9264085. |
on the other hand, antagonism of cgp 37849-caused motor depression can be explained by the lowering influence of 5,7-dht on serotonin content. |
1997-09-30 |
2023-08-12 |
rat |
| L Dye, J E Blundel. Menstrual cycle and appetite control: implications for weight regulation. Human reproduction (Oxford, England). vol 12. issue 6. 1997-09-24. PMID:9221991. |
the premenstrual phase can be considered as a time when women are especially vulnerable to overconsumption, food craving and depression; this is often associated with low serotonin activity. |
1997-09-24 |
2023-08-12 |
Not clear |
| E Di Pasquale, A Lindsay, J Feldman, R Monteau, G Hilair. Serotonergic inhibition of phrenic motoneuron activity: an in vitro study in neonatal rat. Neuroscience letters. vol 230. issue 1. 1997-09-24. PMID:9259456. |
results from phrenic motoneuron whole cell recordings do not reject a presynaptic location of the 5-ht receptors responsible for this depression. |
1997-09-24 |
2023-08-12 |
rat |
| J K McQueen, H Wilson, G Fin. Estradiol-17 beta increases serotonin transporter (SERT) mRNA levels and the density of SERT-binding sites in female rat brain. Brain research. Molecular brain research. vol 45. issue 1. 1997-08-27. PMID:9105666. |
together with our previous findings, they also suggest that the sex differences in depression and the apparent psychotropic effect of e2 may be due to the action of e2 on the serotonin transporter as well as 5-ht2a receptors. |
1997-08-27 |
2023-08-12 |
rat |
| J L Yau, J Noble, J Widdowson, J R Seck. Impact of adrenalectomy on 5-HT6 and 5-HT7 receptor gene expression in the rat hippocampus. Brain research. Molecular brain research. vol 45. issue 1. 1997-08-27. PMID:9105690. |
both glucocorticoid excess and decreased serotonergic (5-ht) transmission may cause depression. |
1997-08-27 |
2023-08-12 |
rat |
| P J Goodnick, A Kumar, J H Henry, V M Buki, R B Goldber. Sertraline in coexisting major depression and diabetes mellitus. Psychopharmacology bulletin. vol 33. issue 2. 1997-08-20. PMID:9230640. |
results indicated (1) significant improvement in mean ham-d (22.6 +/- 3.4 to 4.9 +/- 5.9, p < .001) and in mean beck depression inventory (bdi) scores (21.9 +/- 10.5 to 12.7 +/- 8.3, p < .001); (2) fall in platelet serotonin (5-ht) content (79.7 +/- 22.5 to 13.6 +/- 12.7 ng/10(8) platelets, p < .001); (3) correlation of baseline platelet 5-ht content with response to sertraline by bdi scores (r = 0.51, p < .05); (4) improved dietary compliance for those with baseline value below 70 percent (59.7% to 69.1%, p < .005); and (5) 13 of 17 patients with baseline glycosylated hemoglobin a (hba1c) levels greater than 8.0, showed a reduction (p = .018). |
1997-08-20 |
2023-08-12 |
Not clear |
| Y De Sme. [Indications for new antidepressants with reference to ICD-10: a waggish question or the future of psychiatry?]. L'Encephale. vol 23. issue 2. 1997-08-19. PMID:9264934. |
the pharmacology of depression recently grows rich from "new" antidepressive agents, having selective monoaminergic activity: selective serotonin presynaptic reuptake inhibition ("ssris"), selective reversible inhibition of the monoamine oxidase a ("rimas"), selective dopaminergic or noradrenergic agents. |
1997-08-19 |
2023-08-12 |
Not clear |
| G G Kinney, G W Vogel, P Fen. Decreased dorsal raphe nucleus neuronal activity in adult chloral hydrate anesthetized rats following neonatal clomipramine treatment: implications for endogenous depression. Brain research. vol 756. issue 1-2. 1997-08-15. PMID:9187315. |
although the biological cause of endogenous depression is unknown, one commonly held hypothesis proposes that depression results, in part, from decreased central serotonin (5-ht) neurotransmission. |
1997-08-15 |
2023-08-12 |
human |
| G G Kinney, G W Vogel, P Fen. Decreased dorsal raphe nucleus neuronal activity in adult chloral hydrate anesthetized rats following neonatal clomipramine treatment: implications for endogenous depression. Brain research. vol 756. issue 1-2. 1997-08-15. PMID:9187315. |
the results thereby lend support to the hypothesis of a role for decreased central 5-ht as a substrate for the behavioral deficiencies observed in endogenous depression and suggest that these deficiencies may also result, in part, from a random, rather than orderly, temporal pattern of discharge in these neurons. |
1997-08-15 |
2023-08-12 |
human |
| E Schulz, C Fleischhaker, H E Remschmid. Correlated changes in symptoms and neurotransmitter indices during maintenance treatment with clozapine or conventional neuroleptics in adolescents and young adults with schizophrenia. Journal of child and adolescent psychopharmacology. vol 6. issue 2. 1997-08-15. PMID:9231304. |
higher serotonin levels were associated with significantly fewer negative symptoms, whereas higher mhpg levels were correlated with less depression. |
1997-08-15 |
2023-08-12 |
Not clear |
| E Schulz, C Fleischhaker, H E Remschmid. Correlated changes in symptoms and neurotransmitter indices during maintenance treatment with clozapine or conventional neuroleptics in adolescents and young adults with schizophrenia. Journal of child and adolescent psychopharmacology. vol 6. issue 2. 1997-08-15. PMID:9231304. |
these findings suggest involvement of norepinephrine and serotonin in the pathophysiology of schizophrenia (with depression associated with lower mhpg levels and negative symptoms associated with lower serotonin levels) and in the therapeutic actions of clozapine. |
1997-08-15 |
2023-08-12 |
Not clear |
| R L Findlin. Open-label treatment of comorbid depression and attentional disorders with co-administration of serotonin reuptake inhibitors and psychostimulants in children, adolescents, and adults: a case series. Journal of child and adolescent psychopharmacology. vol 6. issue 3. 1997-08-15. PMID:9231310. |
open-label treatment of comorbid depression and attentional disorders with co-administration of serotonin reuptake inhibitors and psychostimulants in children, adolescents, and adults: a case series. |
1997-08-15 |
2023-08-12 |
Not clear |
| P Hertel, G G Nomikos, B Schilström, L Arborelius, T H Svensso. Risperidone dose-dependently increases extracellular concentrations of serotonin in the rat frontal cortex: role of alpha 2-adrenoceptor antagonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 17. issue 1. 1997-08-13. PMID:9194049. |
the enhanced 5-ht output in the fc by risperidone may be of particular relevance for the treatment of schizophrenia when associated with depression and in schizoaffective disorder. |
1997-08-13 |
2023-08-12 |
rat |