| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H H Hansen, C Sánchez, E Meie. Neonatal administration of the selective serotonin reuptake inhibitor Lu 10-134-C increases forced swimming-induced immobility in adult rats: a putative animal model of depression? The Journal of pharmacology and experimental therapeutics. vol 283. issue 3. 1998-01-15. PMID:9400008. |
neonatal administration of the selective serotonin reuptake inhibitor lu 10-134-c increases forced swimming-induced immobility in adult rats: a putative animal model of depression? |
1998-01-15 |
2023-08-12 |
human |
| J D Favre, C Guelfi-Sozzi, B Delalleau, H Lô. Tianeptine and alcohol dependence. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 7 Suppl 3. 1998-01-15. PMID:9405962. |
several arguments are in favour of the use of antidepressant drugs in alcohol-dependent patients, especially those acting on the serotoninergic system: (1) neurochemical data indicate the interaction between alcohol and 5-ht metabolism, (2) pharmacological studies show an improvement in the behaviour of alcoholized animals treated with antidepressants, (3) depression is a frequent disease in alcoholic patients. |
1998-01-15 |
2023-08-12 |
Not clear |
| H O Kalkma. Hypersensitivity to meta-chlorophenylpiperazine (mCPP) in migraine and drug withdrawal. International journal of clinical pharmacology research. vol 17. issue 2-3. 1998-01-07. PMID:9403358. |
rats exposed to chronic mild stress (which is also a key factor in the precipitation of human depression) were hypersensitive to mcpp, whilst chronic treatment with antidepressant serotonin re-uptake inhibitors suppressed the responsiveness to mcpp. |
1998-01-07 |
2023-08-12 |
human |
| R B Lydiard, S M Stahl, M Hertzman, W M Harriso. A double-blind, placebo-controlled study comparing the effects of sertraline versus amitriptyline in the treatment of major depression. The Journal of clinical psychiatry. vol 58. issue 11. 1998-01-06. PMID:9413414. |
this study was designed to compare the efficacy, safety, tolerability profiles, and effects on quality of life of the serotonin selective reuptake inhibitor antidepressant sertraline versus the nonselective tricyclic antidepressant amitriptyline and placebo in patients with major depression. |
1998-01-06 |
2023-08-12 |
Not clear |
| P E Stokes, A Holt. Fluoxetine tenth anniversary update: the progress continues. Clinical therapeutics. vol 19. issue 5. 1997-12-30. PMID:9385500. |
rapid discontinuation or missed doses of short-half-life selective serotonin reuptake inhibitors, tcas, and heterocyclic antidepressants are associated with withdrawal symptoms of a somatic and psychological nature, which cannot only be disruptive, but can also be suggestive of relapse or recurrence of depression. |
1997-12-30 |
2023-08-12 |
Not clear |
| L A Piazza, J C Markowitz, J H Kocsis, A C Leon, L Portera, N L Miller, D Adle. Sexual functioning in chronically depressed patients treated with SSRI antidepressants: a pilot study. The American journal of psychiatry. vol 154. issue 12. 1997-12-22. PMID:9396959. |
this prospective study assessed changes in depression and sexual functioning in chronically depressed men and women during treatment with selective serotonin reuptake inhibitors (ssris). |
1997-12-22 |
2023-08-12 |
Not clear |
| A Zangen, D H Overstreet, G Yadi. High serotonin and 5-hydroxyindoleacetic acid levels in limbic brain regions in a rat model of depression: normalization by chronic antidepressant treatment. Journal of neurochemistry. vol 69. issue 6. 1997-12-12. PMID:9375680. |
high serotonin and 5-hydroxyindoleacetic acid levels in limbic brain regions in a rat model of depression: normalization by chronic antidepressant treatment. |
1997-12-12 |
2023-08-12 |
rat |
| A Zangen, D H Overstreet, G Yadi. High serotonin and 5-hydroxyindoleacetic acid levels in limbic brain regions in a rat model of depression: normalization by chronic antidepressant treatment. Journal of neurochemistry. vol 69. issue 6. 1997-12-12. PMID:9375680. |
in a genetic rat model of depression [flinders sensitive line (fsl) rats], deviations from normal serotonin (5-ht) levels and metabolism in specific brain regions were determined. |
1997-12-12 |
2023-08-12 |
rat |
| A Zangen, D H Overstreet, G Yadi. High serotonin and 5-hydroxyindoleacetic acid levels in limbic brain regions in a rat model of depression: normalization by chronic antidepressant treatment. Journal of neurochemistry. vol 69. issue 6. 1997-12-12. PMID:9375680. |
these results indicate that the behavioral deficits expressed in the fsl model for depression correlate with increased 5-ht levels in specific limbic sites and suggest the fsl rats as a novel model for clarification of the molecular mechanism of clinically used antidepressant drugs. |
1997-12-12 |
2023-08-12 |
rat |
| A M Low, L Sormaz, C Y Kwan, E E Danie. Actions of 4-chloro-3-ethyl phenol on internal Ca2+ stores in vascular smooth muscle and endothelial cells. British journal of pharmacology. vol 122. issue 3. 1997-12-08. PMID:9351507. |
in all cases, cep caused a concentration-dependent depression of the maximum response to pe (84.8, 43.4 and 11.6% of control), 5-ht (65.4, 25.7 and 6.9% of control) and k+ (77.6, 41.1 and 10.8% of control). |
1997-12-08 |
2023-08-12 |
dog |
| M Maes, H Westenberg, E Vandoolaeghe, P Demedts, A Wauters, H Neels, H Y Meltze. Effects of trazodone and fluoxetine in the treatment of major depression: therapeutic pharmacokinetic and pharmacodynamic interactions through formation of meta-chlorophenylpiperazine. Journal of clinical psychopharmacology. vol 17. issue 5. 1997-11-21. PMID:9315986. |
it has been suggested that (1) the clinical efficacy of the heterocyclic antidepressant trazodone in depression may, in part, be attributed to its metabolite meta-chlorophenylpiperazine (mcpp); and (2) the enhancement of the efficacy of trazodone by the addition of fluoxetine, a selective serotonin reuptake inhibitor, may, in part, be ascribed to fluoxetine-induced plasma concentrations of trazodone. |
1997-11-21 |
2023-08-12 |
Not clear |
| [Panic and depression: early diagnosis of patients at risk, early treatment with an SSRI (Selective Serotonin Reuptake Inhibitor)]. Psychiatrische Praxis. vol 24. issue 5 Suppl. 1997-11-18. PMID:9361703. |
[panic and depression: early diagnosis of patients at risk, early treatment with an ssri (selective serotonin reuptake inhibitor)]. |
1997-11-18 |
2023-08-12 |
Not clear |
| H A Walsh, S Day. Inhibition of hepatic tryptophan-2,3-dioxygenase: superior potency of melatonin over serotonin. Journal of pineal research. vol 23. issue 1. 1997-11-07. PMID:9379342. |
in view of the biogenic amine deficiency hypothesis of depression and the contentious claim that hepatic tryptophan-2,3-dioxygenase (tdo) is the major peripheral determinant of brain tryptophan, brain serotonin (5-ht), and ultimately melatonin, the regulation of tdo by melatonin and 5-ht is investigated and discussed. |
1997-11-07 |
2023-08-12 |
Not clear |
| B J Wingate, J Hansen-Flasche. Anxiety and depression in advanced lung disease. Clinics in chest medicine. vol 18. issue 3. 1997-11-05. PMID:9329872. |
serotonin selective reuptake inhibitors are particularly useful in the treatment of depression and panic, and may be helpful in controlling other forms of anxiety, as well. |
1997-11-05 |
2023-08-12 |
Not clear |
| M Hotopf, G Lewis, C Norman. Putting trials on trial--the costs and consequences of small trials in depression: a systematic review of methodology. Journal of epidemiology and community health. vol 51. issue 4. 1997-10-29. PMID:9328538. |
to determine why, despite 122 randomised controlled trials, there is no consensus about whether the selective serotonin reuptake inhibitors or tricyclic and related antidepressants should be used as first line treatment of depression. |
1997-10-29 |
2023-08-12 |
Not clear |
| B E Murph. Antiglucocorticoid therapies in major depression: a review. Psychoneuroendocrinology. vol 22 Suppl 1. 1997-10-27. PMID:9264159. |
two patients with obsessive compulsive disorder associated with depression showed striking improvement on aminoglutethimide combined with a serotonin re-uptake inhibitor. |
1997-10-27 |
2023-08-12 |
Not clear |
| W E Schutzer, C L Bethe. Lack of ovarian steroid hormone regulation of norepinephrine transporter mRNA expression in the non-human primate locus coeruleus. Psychoneuroendocrinology. vol 22. issue 5. 1997-10-23. PMID:9279938. |
decreases in ovarian steroids can negatively affect mood, and drugs which block the norepinephrine transporter (net) or the serotonin transporter (sert) alleviate depression. |
1997-10-23 |
2023-08-12 |
monkey |
| E M Blain. Acute severe depression following peri-operative ondansetron. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. vol 87. issue 8. 1997-10-23. PMID:9323412. |
she had developed a severe acute major depression disorder almost immediately thereafter, possibly related to the use of a serotonin antagonist. |
1997-10-23 |
2023-08-12 |
Not clear |
| E M Blain. Acute severe depression following peri-operative ondansetron. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. vol 87. issue 8. 1997-10-23. PMID:9323412. |
anaesthesia with a propofol infusion and avoidance of serotonin antagonists provided a nausea-free postoperative course without exacerbation of the depression disorder. |
1997-10-23 |
2023-08-12 |
Not clear |
| [Panic and depression: early diagnosis of risk patients, early therapy with SSRI (Selective Serotonin Reabsorption Inhibition)]. Fortschritte der Neurologie-Psychiatrie. vol 65. issue 8 Suppl. 1997-10-23. PMID:9330650. |
[panic and depression: early diagnosis of risk patients, early therapy with ssri (selective serotonin reabsorption inhibition)]. |
1997-10-23 |
2023-08-12 |
Not clear |