| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Backe, S Bussen, T Stec. Significant decrease of maternal serum serotonin levels in singleton pregnancies complicated by the HELLP syndrome. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. vol 11. issue 6. 1998-04-07. PMID:9476090. |
we have observed a similar depression of serum serotonin concentrations both in severe preeclampsia and in the hellp syndrome, reflecting the decreased platelet content of serotonin. |
1998-04-07 |
2023-08-12 |
Not clear |
| K M Lawrence, M Kanagasundaram, S Lowther, C L Katona, M R Crompton, R W Horto. [3H] imipramine binding in brain samples from depressed suicides and controls: 5-HT uptake sites compared with sites defined by desmethylimipramine. Journal of affective disorders. vol 47. issue 1-3. 1998-04-06. PMID:9476750. |
using desmethylimipramine (dmi) defined and na+ dependent [3h]imipramine binding, we have examined both 5-ht uptake sites and sites unrelated to 5-ht uptake, in frontal cortex, putamen and substantia nigra of suicides with a firm retrospective diagnosis of depression and matched controls. |
1998-04-06 |
2023-08-12 |
Not clear |
| A Markou, T R Kosten, G F Koo. Neurobiological similarities in depression and drug dependence: a self-medication hypothesis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 18. issue 3. 1998-04-02. PMID:9471114. |
finally, the neurotransmitter systems whose function appears to be altered in depression (i.e., serotonin, norepinephrine, acetylcholine, dopamine, gamma-aminobutyric acid, corticotropin releasing factor, neuropeptide y, and somatostatin), as revealed primarily by animal studies, are discussed. |
1998-04-02 |
2023-08-12 |
Not clear |
| M Narayan, G Anderson, J Cellar, R T Mallison, L H Price, J C Nelso. Serotonin transporter-blocking properties of nefazodone assessed by measurement of platelet serotonin. Journal of clinical psychopharmacology. vol 18. issue 1. 1998-04-02. PMID:9472845. |
platelet 5-ht was measured before and during treatment with nefazodone (n = 6) or an ssri (n = 10) in patients with major depression. |
1998-04-02 |
2023-08-12 |
Not clear |
| M O'Connor, H Silve. Adding risperidone to selective serotonin reuptake inhibitor improves chronic depression. Journal of clinical psychopharmacology. vol 18. issue 1. 1998-04-02. PMID:9472852. |
adding risperidone to selective serotonin reuptake inhibitor improves chronic depression. |
1998-04-02 |
2023-08-12 |
Not clear |
| A T Hindle, P M Hopkin. 5-Hydroxytryptamine causes depression of twitch height in the partially curarized rat phrenic nerve hemidiaphragm preparation. British journal of anaesthesia. vol 80. issue 1. 1998-03-24. PMID:9505786. |
5-hydroxytryptamine causes depression of twitch height in the partially curarized rat phrenic nerve hemidiaphragm preparation. |
1998-03-24 |
2023-08-12 |
rat |
| A T Hindle, P M Hopkin. 5-Hydroxytryptamine causes depression of twitch height in the partially curarized rat phrenic nerve hemidiaphragm preparation. British journal of anaesthesia. vol 80. issue 1. 1998-03-24. PMID:9505786. |
we have shown that the addition of low concentrations of 5-ht to the indirectly stimulated partially curarized rat diaphragm preparation caused depression of twitch height. |
1998-03-24 |
2023-08-12 |
rat |
| K Bingefors, D Isacson, L von Knorrin. Antidepressant dose patterns in Swedish clinical practice. International clinical psychopharmacology. vol 12. issue 5. 1998-03-19. PMID:9466162. |
significantly higher doses were prescribed in continued treatment, as opposed to in new treatment, indicating dose titration when using tricyclic antidepressants and the most common selective serotonin reuptake inhibitors in depression. |
1998-03-19 |
2023-08-12 |
Not clear |
| A J Cleare, R M Murray, V O'Kean. Do noradrenergic reuptake inhibitors affect serotonergic function in depression? Psychopharmacology. vol 134. issue 4. 1998-03-17. PMID:9452184. |
d-fenfluramine, a specific 5-ht releasing agent without the catecholamine effects of d,l-fenfluramine, was used as a serotonergic neuroendocrine challenge in subjects with unipolar major depression. |
1998-03-17 |
2023-08-12 |
human |
| H F Chi. Antidepressants in the elderly. International journal of clinical practice. vol 51. issue 6. 1998-03-16. PMID:9489065. |
the newer antidepressants including the selective serotonin reuptake inhibitors are useful alternatives in the treatment of depression in the elderly. |
1998-03-16 |
2023-08-12 |
Not clear |
| P Mourilhe, P E Stoke. Risks and benefits of selective serotonin reuptake inhibitors in the treatment of depression. Drug safety. vol 18. issue 1. 1998-03-11. PMID:9466088. |
risks and benefits of selective serotonin reuptake inhibitors in the treatment of depression. |
1998-03-11 |
2023-08-12 |
Not clear |
| T C Pellegrino, B M Baye. Modulation of immune cell function following fluoxetine administration in rats. Pharmacology, biochemistry, and behavior. vol 59. issue 1. 1998-03-09. PMID:9443550. |
fluoxetine (flx) and other specific serotonin uptake inhibitors (ssris) have become the drugs of choice for treating depression. |
1998-03-09 |
2023-08-12 |
rat |
| T D Geracioti, P T Loosen, N N Ekhator, D Schmidt, B Chambliss, D G Baker, J W Kasckow, N M Richtand, P E Keck, M H Eber. Uncoupling of serotonergic and noradrenergic systems in depression: preliminary evidence from continuous cerebrospinal fluid sampling. Depression and anxiety. vol 6. issue 3. 1998-02-24. PMID:9442982. |
we used the technique of continuous cerebrospinal fluid (csf) sampling to test the following hypotheses regarding cns monoaminergic systems in depression: (1) absolute concentrations of the informational substances tryptophan and 5-hydroxyindoleacetic acid (5-hiaa) are altered in the cns of depressed patients (2) abnormal rhythms of tryptophan and/or 5-hiaa, or defective conversion of tryptophan to serotonin (5ht), exist in the cns of depressed patients, and (3) the relationship between the cns 5ht and norepinephrine (ne) systems is disrupted in depressed patients. |
1998-02-24 |
2023-08-12 |
human |
| F Biver, D Wikler, F Lotstra, P Damhaut, S Goldman, J Mendlewic. Serotonin 5-HT2 receptor imaging in major depression: focal changes in orbito-insular cortex. The British journal of psychiatry : the journal of mental science. vol 171. 1998-02-23. PMID:9463603. |
serotonin 5-ht2 receptor imaging in major depression: focal changes in orbito-insular cortex. |
1998-02-23 |
2023-08-12 |
Not clear |
| F Biver, D Wikler, F Lotstra, P Damhaut, S Goldman, J Mendlewic. Serotonin 5-HT2 receptor imaging in major depression: focal changes in orbito-insular cortex. The British journal of psychiatry : the journal of mental science. vol 171. 1998-02-23. PMID:9463603. |
we studied type-2 serotonin (5-ht2) receptors in the brain of patients with major depression. |
1998-02-23 |
2023-08-12 |
Not clear |
| M R Briejer, C Mathis, J A Schuurke. 5-HT receptor types in the rat ileum longitudinal muscle: focus on 5-HT2 receptors mediating contraction. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 9. issue 4. 1998-02-04. PMID:9430791. |
using (if possible) 5-ht2a receptor-selective concentrations, ketanserin, ritanserin, metergoline, spiperone, mianserin, methiothepin, mesulergine, methysergide and cisapride all inhibited the contractions to 5-ht, causing a depression of the curve to 5-ht (i.e. |
1998-02-04 |
2023-08-12 |
rat |
| A L Weiner, F F Tilden, C A McKa. Serotonin syndrome: case report and review of the literature. Connecticut medicine. vol 61. issue 11. 1998-01-30. PMID:9419960. |
she was already being treated for depression with paroxetine (paxil), a selective serotonin reuptake inhibitor. |
1998-01-30 |
2023-08-12 |
Not clear |
| O Bodlun. [Anxiety and depression as a hidden problem in primary health care. Only one case in four identified]. Lakartidningen. vol 94. issue 49. 1998-01-29. PMID:9445933. |
one third of the patients with a clinical diagnosis of anxiety and 47 per cent of those with diagnosed depression were offered appropriate treatment, usually medication with a selective serotonin re-uptake inhibitor (ssri) and consultation with a medical social worker. |
1998-01-29 |
2023-08-12 |
Not clear |
| P A Broderic. Alprazolam, diazepam, yohimbine, clonidine: in vivo CA1 hippocampal norepinephrine and serotonin release profiles under chloral hydrate anesthesia. Progress in neuro-psychopharmacology & biological psychiatry. vol 21. issue 7. 1998-01-28. PMID:9421826. |
indeed, 5-ht is a component of the dorsal ascending noradrenergic bundle and both neurotransmitters, ne and 5-ht, have been implicated in clinical depression. |
1998-01-28 |
2023-08-12 |
rat |
| C R Grünschlag, H L Haas, D R Steven. 5-HT inhibits lateral entorhinal cortical neurons of the rat in vitro by activation of potassium channel-coupled 5-HT1A receptors. Brain research. vol 770. issue 1-2. 1998-01-21. PMID:9372196. |
intracellular application of qx-314, a blocker of potassium conductance, significantly reduced depression of synaptic potentials by 5-ht agonists. |
1998-01-21 |
2023-08-12 |
rat |