| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A T Hindle, P M Hopkin. 5-Hydroxytryptamine causes depression of twitch height in the partially curarized rat phrenic nerve hemidiaphragm preparation. British journal of anaesthesia. vol 80. issue 1. 1998-03-24. PMID:9505786. |
we have shown that the addition of low concentrations of 5-ht to the indirectly stimulated partially curarized rat diaphragm preparation caused depression of twitch height. |
1998-03-24 |
2023-08-12 |
rat |
| K Bingefors, D Isacson, L von Knorrin. Antidepressant dose patterns in Swedish clinical practice. International clinical psychopharmacology. vol 12. issue 5. 1998-03-19. PMID:9466162. |
significantly higher doses were prescribed in continued treatment, as opposed to in new treatment, indicating dose titration when using tricyclic antidepressants and the most common selective serotonin reuptake inhibitors in depression. |
1998-03-19 |
2023-08-12 |
Not clear |
| A J Cleare, R M Murray, V O'Kean. Do noradrenergic reuptake inhibitors affect serotonergic function in depression? Psychopharmacology. vol 134. issue 4. 1998-03-17. PMID:9452184. |
d-fenfluramine, a specific 5-ht releasing agent without the catecholamine effects of d,l-fenfluramine, was used as a serotonergic neuroendocrine challenge in subjects with unipolar major depression. |
1998-03-17 |
2023-08-12 |
human |
| H F Chi. Antidepressants in the elderly. International journal of clinical practice. vol 51. issue 6. 1998-03-16. PMID:9489065. |
the newer antidepressants including the selective serotonin reuptake inhibitors are useful alternatives in the treatment of depression in the elderly. |
1998-03-16 |
2023-08-12 |
Not clear |
| P Mourilhe, P E Stoke. Risks and benefits of selective serotonin reuptake inhibitors in the treatment of depression. Drug safety. vol 18. issue 1. 1998-03-11. PMID:9466088. |
risks and benefits of selective serotonin reuptake inhibitors in the treatment of depression. |
1998-03-11 |
2023-08-12 |
Not clear |
| T C Pellegrino, B M Baye. Modulation of immune cell function following fluoxetine administration in rats. Pharmacology, biochemistry, and behavior. vol 59. issue 1. 1998-03-09. PMID:9443550. |
fluoxetine (flx) and other specific serotonin uptake inhibitors (ssris) have become the drugs of choice for treating depression. |
1998-03-09 |
2023-08-12 |
rat |
| T D Geracioti, P T Loosen, N N Ekhator, D Schmidt, B Chambliss, D G Baker, J W Kasckow, N M Richtand, P E Keck, M H Eber. Uncoupling of serotonergic and noradrenergic systems in depression: preliminary evidence from continuous cerebrospinal fluid sampling. Depression and anxiety. vol 6. issue 3. 1998-02-24. PMID:9442982. |
we used the technique of continuous cerebrospinal fluid (csf) sampling to test the following hypotheses regarding cns monoaminergic systems in depression: (1) absolute concentrations of the informational substances tryptophan and 5-hydroxyindoleacetic acid (5-hiaa) are altered in the cns of depressed patients (2) abnormal rhythms of tryptophan and/or 5-hiaa, or defective conversion of tryptophan to serotonin (5ht), exist in the cns of depressed patients, and (3) the relationship between the cns 5ht and norepinephrine (ne) systems is disrupted in depressed patients. |
1998-02-24 |
2023-08-12 |
human |
| F Biver, D Wikler, F Lotstra, P Damhaut, S Goldman, J Mendlewic. Serotonin 5-HT2 receptor imaging in major depression: focal changes in orbito-insular cortex. The British journal of psychiatry : the journal of mental science. vol 171. 1998-02-23. PMID:9463603. |
serotonin 5-ht2 receptor imaging in major depression: focal changes in orbito-insular cortex. |
1998-02-23 |
2023-08-12 |
Not clear |
| F Biver, D Wikler, F Lotstra, P Damhaut, S Goldman, J Mendlewic. Serotonin 5-HT2 receptor imaging in major depression: focal changes in orbito-insular cortex. The British journal of psychiatry : the journal of mental science. vol 171. 1998-02-23. PMID:9463603. |
we studied type-2 serotonin (5-ht2) receptors in the brain of patients with major depression. |
1998-02-23 |
2023-08-12 |
Not clear |
| M R Briejer, C Mathis, J A Schuurke. 5-HT receptor types in the rat ileum longitudinal muscle: focus on 5-HT2 receptors mediating contraction. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 9. issue 4. 1998-02-04. PMID:9430791. |
using (if possible) 5-ht2a receptor-selective concentrations, ketanserin, ritanserin, metergoline, spiperone, mianserin, methiothepin, mesulergine, methysergide and cisapride all inhibited the contractions to 5-ht, causing a depression of the curve to 5-ht (i.e. |
1998-02-04 |
2023-08-12 |
rat |
| A L Weiner, F F Tilden, C A McKa. Serotonin syndrome: case report and review of the literature. Connecticut medicine. vol 61. issue 11. 1998-01-30. PMID:9419960. |
she was already being treated for depression with paroxetine (paxil), a selective serotonin reuptake inhibitor. |
1998-01-30 |
2023-08-12 |
Not clear |
| O Bodlun. [Anxiety and depression as a hidden problem in primary health care. Only one case in four identified]. Lakartidningen. vol 94. issue 49. 1998-01-29. PMID:9445933. |
one third of the patients with a clinical diagnosis of anxiety and 47 per cent of those with diagnosed depression were offered appropriate treatment, usually medication with a selective serotonin re-uptake inhibitor (ssri) and consultation with a medical social worker. |
1998-01-29 |
2023-08-12 |
Not clear |
| P A Broderic. Alprazolam, diazepam, yohimbine, clonidine: in vivo CA1 hippocampal norepinephrine and serotonin release profiles under chloral hydrate anesthesia. Progress in neuro-psychopharmacology & biological psychiatry. vol 21. issue 7. 1998-01-28. PMID:9421826. |
indeed, 5-ht is a component of the dorsal ascending noradrenergic bundle and both neurotransmitters, ne and 5-ht, have been implicated in clinical depression. |
1998-01-28 |
2023-08-12 |
rat |
| C R Grünschlag, H L Haas, D R Steven. 5-HT inhibits lateral entorhinal cortical neurons of the rat in vitro by activation of potassium channel-coupled 5-HT1A receptors. Brain research. vol 770. issue 1-2. 1998-01-21. PMID:9372196. |
intracellular application of qx-314, a blocker of potassium conductance, significantly reduced depression of synaptic potentials by 5-ht agonists. |
1998-01-21 |
2023-08-12 |
rat |
| H H Hansen, C Sánchez, E Meie. Neonatal administration of the selective serotonin reuptake inhibitor Lu 10-134-C increases forced swimming-induced immobility in adult rats: a putative animal model of depression? The Journal of pharmacology and experimental therapeutics. vol 283. issue 3. 1998-01-15. PMID:9400008. |
neonatal administration of the selective serotonin reuptake inhibitor lu 10-134-c increases forced swimming-induced immobility in adult rats: a putative animal model of depression? |
1998-01-15 |
2023-08-12 |
human |
| J D Favre, C Guelfi-Sozzi, B Delalleau, H Lô. Tianeptine and alcohol dependence. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 7 Suppl 3. 1998-01-15. PMID:9405962. |
several arguments are in favour of the use of antidepressant drugs in alcohol-dependent patients, especially those acting on the serotoninergic system: (1) neurochemical data indicate the interaction between alcohol and 5-ht metabolism, (2) pharmacological studies show an improvement in the behaviour of alcoholized animals treated with antidepressants, (3) depression is a frequent disease in alcoholic patients. |
1998-01-15 |
2023-08-12 |
Not clear |
| H O Kalkma. Hypersensitivity to meta-chlorophenylpiperazine (mCPP) in migraine and drug withdrawal. International journal of clinical pharmacology research. vol 17. issue 2-3. 1998-01-07. PMID:9403358. |
rats exposed to chronic mild stress (which is also a key factor in the precipitation of human depression) were hypersensitive to mcpp, whilst chronic treatment with antidepressant serotonin re-uptake inhibitors suppressed the responsiveness to mcpp. |
1998-01-07 |
2023-08-12 |
human |
| R B Lydiard, S M Stahl, M Hertzman, W M Harriso. A double-blind, placebo-controlled study comparing the effects of sertraline versus amitriptyline in the treatment of major depression. The Journal of clinical psychiatry. vol 58. issue 11. 1998-01-06. PMID:9413414. |
this study was designed to compare the efficacy, safety, tolerability profiles, and effects on quality of life of the serotonin selective reuptake inhibitor antidepressant sertraline versus the nonselective tricyclic antidepressant amitriptyline and placebo in patients with major depression. |
1998-01-06 |
2023-08-12 |
Not clear |
| P E Stokes, A Holt. Fluoxetine tenth anniversary update: the progress continues. Clinical therapeutics. vol 19. issue 5. 1997-12-30. PMID:9385500. |
rapid discontinuation or missed doses of short-half-life selective serotonin reuptake inhibitors, tcas, and heterocyclic antidepressants are associated with withdrawal symptoms of a somatic and psychological nature, which cannot only be disruptive, but can also be suggestive of relapse or recurrence of depression. |
1997-12-30 |
2023-08-12 |
Not clear |
| L A Piazza, J C Markowitz, J H Kocsis, A C Leon, L Portera, N L Miller, D Adle. Sexual functioning in chronically depressed patients treated with SSRI antidepressants: a pilot study. The American journal of psychiatry. vol 154. issue 12. 1997-12-22. PMID:9396959. |
this prospective study assessed changes in depression and sexual functioning in chronically depressed men and women during treatment with selective serotonin reuptake inhibitors (ssris). |
1997-12-22 |
2023-08-12 |
Not clear |