| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C F Reynolds, E Frank, J M Perel, S Mazumdar, D J Kupfe. Maintenance therapies for late-life recurrent major depression: research and review circa 1995. International psychogeriatrics. vol 7 Suppl. 1996-03-15. PMID:8580390. |
finally, we suggest that maintenance therapy trials should be extended in several directions: (a) long-term treatment of bipolar and delusional subtypes in the elderly, as well as depression associated with progressive neurodegenerative disorders such as alzheimer's dementia; (b) assessment of the benefits and risks of long-term therapy with other than tricyclic and monoamine oxidase inhibitor antidepressant agents, such as selective serotonin reuptake inhibitors; and (c) development of models of long-term course, including the interaction of treatments with medical and psychosocial variables that can have a profound impact on illness onset and offset. |
1996-03-15 |
2023-08-12 |
Not clear |
| I C Taylor, J G McConnel. Severe hyponatraemia associated with selective serotonin reuptake inhibitors. Scottish medical journal. vol 40. issue 5. 1996-03-14. PMID:8578303. |
the introduction of selective serotonin reuptake inhibitors has been reported as a major advance in the treatment of depression in that they are less sedating, have fewer anticholinergic effects and are less toxic in overdose. |
1996-03-14 |
2023-08-12 |
Not clear |
| W W Shen, J H Hs. Female sexual side effects associated with selective serotonin reuptake inhibitors: a descriptive clinical study of 33 patients. International journal of psychiatry in medicine. vol 25. issue 3. 1996-03-05. PMID:8567191. |
after the advent of selective serotonin reuptake inhibitors on the u.s. market in 1988, american psychiatrists have been faced with more choices of antidepressants for the treatment of depression. |
1996-03-05 |
2023-08-12 |
Not clear |
| R J Leo, D G Lichter, L A Hershe. Parkinsonism associated with fluoxetine and cimetidine: a case report. Journal of geriatric psychiatry and neurology. vol 8. issue 4. 1996-03-04. PMID:8561837. |
fluoxetine and other selective serotonin reuptake inhibitors (ssris) are effective for the treatment of depression in the elderly and offer a safer side-effect profile as compared to tricyclics and monoamine oxidase inhibitors. |
1996-03-04 |
2023-08-12 |
Not clear |
| J J Mann, K M Malone, D J Diehl, J Perel, T B Cooper, M A Mintu. Demonstration in vivo of reduced serotonin responsivity in the brain of untreated depressed patients. The American journal of psychiatry. vol 153. issue 2. 1996-02-23. PMID:8561196. |
for over 25 years, it has been hypothesized that major depression is due to a deficiency of available serotonin or subsensitivity of key serotonin receptors in relevant brain regions. |
1996-02-23 |
2023-08-12 |
Not clear |
| A J Cleare, J Bearn, T Allain, A McGregor, S Wessely, R M Murray, V O'Kean. Contrasting neuroendocrine responses in depression and chronic fatigue syndrome. Journal of affective disorders. vol 34. issue 4. 1996-02-20. PMID:8550954. |
hypothalamic-pituitary-adrenal (hpa) axis and central 5-ht function were compared in chronic fatigue syndrome (cfs), depression and healthy states. |
1996-02-20 |
2023-08-12 |
Not clear |
| A J Cleare, J Bearn, T Allain, A McGregor, S Wessely, R M Murray, V O'Kean. Contrasting neuroendocrine responses in depression and chronic fatigue syndrome. Journal of affective disorders. vol 34. issue 4. 1996-02-20. PMID:8550954. |
these data confirm that depression is associated with hypercotisolaemia and reduced central 5-ht neurotransmission and suggest that cfs may be associated with hypocortisolaemia and increased 5-ht function. |
1996-02-20 |
2023-08-12 |
Not clear |
| Y Gustafson, I Nilsson, M Mattsson, M Aström, G Buch. Epidemiology and treatment of post-stroke depression. Drugs & aging. vol 7. issue 4. 1996-02-07. PMID:8535057. |
the study evaluated a selective serotonin reuptake inhibitor (citalopram) and concluded that the drug was well tolerated and effective for the treatment of post-stroke depression. |
1996-02-07 |
2023-08-12 |
Not clear |
| S L Kelich, P L Meade, D E Seyle. Developmental toxicity of amesergide administered by gavage to CD rats and New Zealand white rabbits. Fundamental and applied toxicology : official journal of the Society of Toxicology. vol 27. issue 2. 1996-02-01. PMID:8529820. |
amesergide is a selective serotonin 5-htic/2 receptor antagonist being developed for the treatment of depression. |
1996-02-01 |
2023-08-12 |
rat |
| J E Cabral-Filho, E M Trindade-Filho, R C Guede. Effect of d-fenfluramine on cortical spreading depression in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 28. issue 3. 1996-01-24. PMID:8520530. |
we investigated the effect of a single ip injection of d-fenfluramine (d-fen; 5-10 mg/kg), a serotonin reuptake blocker, on cortical spreading depression (sd) in 17 male wistar rats (300-360 g body weight). |
1996-01-24 |
2023-08-12 |
rat |
| M B Keller, W Harrison, J A Fawcett, A Gelenberg, R M Hirschfeld, D Klein, J H Kocsis, J P McCullough, A J Rush, A Schatzber. Treatment of chronic depression with sertraline or imipramine: preliminary blinded response rates and high rates of undertreatment in the community. Psychopharmacology bulletin. vol 31. issue 2. 1996-01-04. PMID:7491369. |
in this article, we report a preliminary analysis of the first 12-week phase of a multicenter clinical trial that will eventually include approximately 635 patients in acute, continuation, crossover, and maintenance studies of sertraline, a selective serotonin reuptake inhibitor (ssri), and imipramine, a tricyclic antidepressant, for the treatment of chronic depression. |
1996-01-04 |
2023-08-12 |
Not clear |
| S Hyni. [5-hydroxytryptamine (serotonin) receptors--nomenclature and classification of types and subtypes]. Ceskoslovenska fysiologie. vol 44. issue 3. 1995-12-26. PMID:7586016. |
5-ht plays an important role in depression; to cure this disease, drugs which increase levels of this neurotransmitter are used. |
1995-12-26 |
2023-08-12 |
Not clear |
| P J McGrath, F M Quitkin, D F Klei. Bromocriptine treatment of relapses seen during selective serotonin re-uptake inhibitor treatment of depression. Journal of clinical psychopharmacology. vol 15. issue 4. 1995-12-19. PMID:7593717. |
bromocriptine treatment of relapses seen during selective serotonin re-uptake inhibitor treatment of depression. |
1995-12-19 |
2023-08-12 |
Not clear |
| E A Ottevange. Fluvoxamine and clomipramine in depressed hospitalised patients: results from a randomised, double-blind study. L'Encephale. vol 21. issue 4. 1995-12-18. PMID:7588171. |
the efficacy of the selective serotonin reuptake inhibitors (ssris) and the tricyclic antidepressants is well established, although data on the efficacy of ssris in severe depression is limited. |
1995-12-18 |
2023-08-12 |
Not clear |
| D J Haleem, A Yasmeen, M A Haleem, A Zafa. 24h withdrawal following repeated administration of caffeine attenuates brain serotonin but not tryptophan in rat brain: implications for caffeine-induced depression. Life sciences. vol 57. issue 19. 1995-12-15. PMID:7475912. |
24h withdrawal following repeated administration of caffeine attenuates brain serotonin but not tryptophan in rat brain: implications for caffeine-induced depression. |
1995-12-15 |
2023-08-12 |
rat |
| D J Haleem, A Yasmeen, M A Haleem, A Zafa. 24h withdrawal following repeated administration of caffeine attenuates brain serotonin but not tryptophan in rat brain: implications for caffeine-induced depression. Life sciences. vol 57. issue 19. 1995-12-15. PMID:7475912. |
in view of a possible role of 5-ht in caffeine-induced depression the effects of repeated administration of high doses of caffeine on brain 5-ht metabolism are investigated in rats. |
1995-12-15 |
2023-08-12 |
rat |
| D J Haleem, A Yasmeen, M A Haleem, A Zafa. 24h withdrawal following repeated administration of caffeine attenuates brain serotonin but not tryptophan in rat brain: implications for caffeine-induced depression. Life sciences. vol 57. issue 19. 1995-12-15. PMID:7475912. |
the findings are discussed as repeated caffeine administration producing adaptive changes in the serotonergic neurons to decrease the conversion of tryptophan to 5-ht and this may precipitate depression particularly in conditions of caffeine withdrawal. |
1995-12-15 |
2023-08-12 |
rat |
| V M Storozhuk, V V Sachenko, J A Kruchenk. Dependence of sensorimotor cortex neuron activity on noradrenergic and serotoninergic transmission in unspecific thalamic nuclei. Neuroscience. vol 68. issue 2. 1995-12-12. PMID:7477943. |
background and evoked impulse activity greatly increased by application of 5-hydroxytryptamine after preliminary lisergamide-induced depression of the impulse activity. |
1995-12-12 |
2023-08-12 |
Not clear |
| M J Villa. [New concepts relating to histochemistry of the serotonergic neural systems of the raphe nucleus]. Acta psiquiatrica y psicologica de America latina. vol 40. issue 4. 1995-12-07. PMID:7484182. |
all these results have expanded our knowledge on the raphe nuclei and suggest that many other substances, apart from serotonin, could be involved in the regulation of processes such as sleep, anxiety and depression. |
1995-12-07 |
2023-08-12 |
Not clear |
| L Staner, M Kerkhofs, D Detroux, S Leyman, P Linkowski, J Mendlewic. Acute, subchronic and withdrawal sleep EEG changes during treatment with paroxetine and amitriptyline: a double-blind randomized trial in major depression. Sleep. vol 18. issue 6. 1995-11-30. PMID:7481419. |
paroxetine (30 mg), a selective serotonin (5-ht) reuptake inhibitor, was compared in a double-blind trial to amitriptyline (150 mg) in a sample of 40 inpatients aged 18-65 years who fulfilled research diagnostic criteria for major depression. |
1995-11-30 |
2023-08-12 |
Not clear |