| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D A Sclar, L M Robison, T L Skaer, R F Legg, N L Nemec, R S Galin, T E Hughes, D P Bueschin. Antidepressant pharmacotherapy: economic outcomes in a health maintenance organization. Clinical therapeutics. vol 16. issue 4. 1995-01-03. PMID:7982260. |
recent pharmacotherapeutic advances in the treatment of depression have included the development of selective serotonin re-uptake inhibitors (ssris). |
1995-01-03 |
2023-08-12 |
Not clear |
| C V Vorhees, K D Acuff-Smith, M A Schilling, J E Fisher, M S Moran, J Buelke-Sa. A developmental neurotoxicity evaluation of the effects of prenatal exposure to fluoxetine in rats. Fundamental and applied toxicology : official journal of the Society of Toxicology. vol 23. issue 2. 1994-12-30. PMID:7982528. |
fluoxetine is a widely used serotonin reuptake inhibitor effective in the treatment of depression. |
1994-12-30 |
2023-08-12 |
rat |
| H Crick, N A Manuel, D I Walli. A novel 5-HT receptor or a combination of 5-HT receptor subtypes may mediate depression of a spinal monosynaptic reflex in vitro. Neuropharmacology. vol 33. issue 7. 1994-12-28. PMID:7969810. |
time for peak depression from start of agonist application was 3-4 min for 5-ht, 5 min for sumatriptan and 5-meot, 5-7 min for alpha-me 5-ht and 12 min for 8-oh-dpat. |
1994-12-28 |
2023-08-12 |
rat |
| H Crick, N A Manuel, D I Walli. A novel 5-HT receptor or a combination of 5-HT receptor subtypes may mediate depression of a spinal monosynaptic reflex in vitro. Neuropharmacology. vol 33. issue 7. 1994-12-28. PMID:7969810. |
the half-time for recovery from peak depression was 1.5 +/- 0.3 min for 5-ht, 2.8 +/- 0.3 min for 5-meot, 5.3 +/- 1.5 min for sumatriptan, 13 +/- 2.9 min for 8-oh-dpat and > 30 min for alpha-me 5-ht. |
1994-12-28 |
2023-08-12 |
rat |
| N H Jensen, L Lauritzen, M Lunde, J Eriksen, P Plenge, E T Melleru. Platelet paroxetine binding in depressed and nondepressed chronic pain patients. Acta psychiatrica Scandinavica. vol 90. issue 2. 1994-12-20. PMID:7976461. |
the pain patients who also suffered from depression in addition to the pain had significantly more serotonin transporters than the controls. |
1994-12-20 |
2023-08-12 |
Not clear |
| L Ballerini, R Corradetti, A Nistri, A M Pugliese, G Stocc. Electrophysiological interactions between 5-hydroxytryptamine and thyrotropin releasing hormone on rat hippocampal CA1 neurons. The European journal of neuroscience. vol 6. issue 6. 1994-12-07. PMID:7952282. |
5-ht (30 microm) elicited complex effects consisting of biphasic changes in membrane potential and a strong depression of the afterhyperpolarization (ahp) following a spike burst. |
1994-12-07 |
2023-08-12 |
rat |
| D E Case. Striking a balance between safety and efficacy: experience with the SSRI sertraline. International clinical psychopharmacology. vol 9 Suppl 3. 1994-12-07. PMID:7963450. |
sertraline's potent and highly selective inhibition of serotonin accounts both for its efficacy in a broad spectrum of depression and for its high tolerability and ease of use. |
1994-12-07 |
2023-08-12 |
Not clear |
| R Monteau, E Di Pasquale, G Hilair. Further evidence that various 5-HT receptor subtypes modulate central respiratory activity: in vitro studies with SR 46349B. European journal of pharmacology. vol 259. issue 1. 1994-12-01. PMID:7957597. |
the tonic discharge of cervical motoneurons and the depression of inspiratory hypoglossal activity elicited by serotonin (and 5-ht2 receptor agonist) were reduced in a dose-dependent manner by sr 46349b. |
1994-12-01 |
2023-08-12 |
rat |
| S Stah. 5HT1A receptors and pharmacotherapy. Is serotonin receptor down-regulation linked to the mechanism of action of antidepressant drugs? Psychopharmacology bulletin. vol 30. issue 1. 1994-12-01. PMID:7972628. |
a general hypothesis of 5-ht receptor dysregulation in depression suggests that 5-ht1a receptors may be down-regulated, whereas 5-ht2 receptors may be up-regulated and display an inadequate ability to convert receptor occupancy by 5-ht into an adequate physiological response. |
1994-12-01 |
2023-08-12 |
Not clear |
| W C Drevet. Geriatric depression: brain imaging correlates and pharmacologic considerations. The Journal of clinical psychiatry. vol 55 Suppl A. 1994-11-28. PMID:7961546. |
fortunately, the last decade of antidepressant drug development has produced several new agents (including the serotonin selective reuptake inhibitors and more recently, venlafaxine and nefazodone) with substantially reduced cns and cardiovascular toxicity that facilitate effective treatment of geriatric depression. |
1994-11-28 |
2023-08-12 |
Not clear |
| F Karege, J Widmer, P Bovier, J M Gaillar. Platelet serotonin and plasma tryptophan in depressed patients: effect of drug treatment and clinical outcome. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 10. issue 3. 1994-11-16. PMID:7916918. |
the concentrations of platelet 5-ht level did not correlate with either plasma trp or with clinical variables, that is, amdp depression and amdp anxiety scores. |
1994-11-16 |
2023-08-12 |
human |
| P L Delgado, L H Price, H L Miller, R M Salomon, G K Aghajanian, G R Heninger, D S Charne. Serotonin and the neurobiology of depression. Effects of tryptophan depletion in drug-free depressed patients. Archives of general psychiatry. vol 51. issue 11. 1994-11-16. PMID:7944875. |
serotonin and the neurobiology of depression. |
1994-11-16 |
2023-08-12 |
Not clear |
| P L Delgado, L H Price, H L Miller, R M Salomon, G K Aghajanian, G R Heninger, D S Charne. Serotonin and the neurobiology of depression. Effects of tryptophan depletion in drug-free depressed patients. Archives of general psychiatry. vol 51. issue 11. 1994-11-16. PMID:7944875. |
rapid dietary depletion of the precursor of serotonin synthesis, tryptophan, causes a transient return of depression in 67% of patients who have had a therapeutic antidepressant response. |
1994-11-16 |
2023-08-12 |
Not clear |
| C B Nemeroff, D L Knight, J Franks, W E Craighead, K R Krishna. Further studies on platelet serotonin transporter binding in depression. The American journal of psychiatry. vol 151. issue 11. 1994-11-15. PMID:7943450. |
further studies on platelet serotonin transporter binding in depression. |
1994-11-15 |
2023-08-12 |
human |
| A Lucchelli, M G Santagostino-Barbone, A Barbieri, M Tonin. A pharmacological analysis of receptors mediating the excitatory response to 5-hydroxytryptamine in the guinea-pig isolated trachea. British journal of pharmacology. vol 112. issue 3. 1994-11-09. PMID:7921600. |
the 5-ht2a receptor antagonist, ketanserin (0.01, 0.1 microm) markedly depressed the first phase and shifted the second phase to the right in a parallel manner, with some depression of the 5-ht response maximum. |
1994-11-09 |
2023-08-12 |
Not clear |
| C de Montign. Lithium addition in treatment-resistant depression. International clinical psychopharmacology. vol 9 Suppl 2. 1994-11-08. PMID:7930494. |
lithium administration increases the function of 5-ht neurones and thus might lead to amelioration of the non-responding depression. |
1994-11-08 |
2023-08-12 |
Not clear |
| F Petty, G Kramer, M Moelle. Does learned helplessness induction by haloperidol involve serotonin mediation? Pharmacology, biochemistry, and behavior. vol 48. issue 3. 1994-11-04. PMID:7938121. |
also, this suggests that increased da activity in mpc leads to increased 5-ht release in mpc and to subsequent behavioral depression. |
1994-11-04 |
2023-08-12 |
rat |
| L Kubin, C Reignier, H Tojima, O Taguchi, A I Pack, R O Davie. Changes in serotonin level in the hypoglossal nucleus region during carbachol-induced atonia. Brain research. vol 645. issue 1-2. 1994-09-21. PMID:7520343. |
the levels of 5ht and its metabolite, 5-hydroxyindoleacetic acid (5hiaa), were determined using hplc and electrochemical detection in dialysate samples collected over successive 20 min periods under four successive experimental conditions: control (at least 2 h after probe insertion); during the postural atonia and respiratory depression produced by pontine microinjection of carbachol; recovery from the effects of carbachol produced by pontine microinjection of atropine; and, to verify that the presence of 5ht in the dialysate was related to the activity of serotonergic cells of the brainstem, following administration of 8-oh-dpat, a 5ht 1a receptor agonist known to suppress activity in the serotonergic cells of the raphe system. |
1994-09-21 |
2023-08-12 |
Not clear |
| E K Syvälaht. Biological aspects of depression. Acta psychiatrica Scandinavica. Supplementum. vol 377. 1994-09-06. PMID:7914394. |
studies related to monoamine (noradrenaline, serotonin or 5-ht, dopamine) metabolism have assumed a major role in biochemical research into depression; this research now also includes studies on other central neurotransmitters such as gaba and glutamic acid, and neuropeptides like somatostatin and corticotropin-releasing factor (crf). |
1994-09-06 |
2023-08-12 |
Not clear |
| E H Cook, D A Charak, J Arida, J A Spohn, N J Roizen, B L Leventha. Depressive and obsessive-compulsive symptoms in hyperserotonemic parents of children with autistic disorder. Psychiatry research. vol 52. issue 1. 1994-08-30. PMID:8047619. |
parents with normal whole blood serotonin levels who had children with autistic disorder and parents of children with down's syndrome had significantly lower ces-d depression scores than parents with elevated whole blood serotonin levels who had children with autistic disorder. |
1994-08-30 |
2023-08-12 |
Not clear |