| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S M Holliday, G L Ploske. Paroxetine. A review of its pharmacology, therapeutic use in depression and therapeutic potential in diabetic neuropathy. Drugs & aging. vol 3. issue 3. 1993-08-12. PMID:8324301. |
future research should attempt to define more fully the efficacy of paroxetine as long term prophylactic therapy for recurrent depression and to assess how its overall therapeutic profile compares with other selective serotonin reuptake inhibitors in the elderly. |
1993-08-12 |
2023-08-12 |
Not clear |
| P Yavari, G W Vogel, D B Neil. Decreased raphe unit activity in a rat model of endogenous depression. Brain research. vol 611. issue 1. 1993-07-29. PMID:8390911. |
one theory about the pathogenesis of endogenous depression is that decreased serotonergic (5-ht) neurotransmission is involved in producing the disorder. |
1993-07-29 |
2023-08-12 |
human |
| P Yavari, G W Vogel, D B Neil. Decreased raphe unit activity in a rat model of endogenous depression. Brain research. vol 611. issue 1. 1993-07-29. PMID:8390911. |
we tested the hypothesis that the discharge rate of 5-ht neurons in the drn was decreased in a new animal (rat) model of human endogenous depression. |
1993-07-29 |
2023-08-12 |
human |
| P Yavari, G W Vogel, D B Neil. Decreased raphe unit activity in a rat model of endogenous depression. Brain research. vol 611. issue 1. 1993-07-29. PMID:8390911. |
this correlation is consistent with the theory that 5-ht neurotransmission is diminished in endogenous depression. |
1993-07-29 |
2023-08-12 |
human |
| P E Stoke. Fluoxetine: a five-year review. Clinical therapeutics. vol 15. issue 2. 1993-07-26. PMID:8519034. |
the introduction in 1988 of fluoxetine hydrochloride, the first selective serotonin uptake inhibitor (ssui) or selective serotonin reuptake inhibitor (ssri) available in the united states, represented a major advance in the pharmacologic management of depression. |
1993-07-26 |
2023-08-12 |
Not clear |
| C D Wang, T K Gallaher, J C Shi. Site-directed mutagenesis of the serotonin 5-hydroxytrypamine2 receptor: identification of amino acids necessary for ligand binding and receptor activation. Molecular pharmacology. vol 43. issue 6. 1993-07-23. PMID:8316224. |
serotonin 5-hydroxytryptamine (5-ht)2 receptors are implicated in the etiology of mental disease and depression. |
1993-07-23 |
2023-08-12 |
Not clear |
| A Khan, H Mirolo, M H Mirolo, D J Dobi. Depression in the elderly: a treatable disorder. Geriatrics. vol 48 Suppl 1. 1993-07-13. PMID:8508961. |
bupropion and the new selective serotonin reuptake inhibitors are effective in treating depression and are better tolerated than the tricyclics. |
1993-07-13 |
2023-08-12 |
Not clear |
| D J Halee. Function specific supersensitivity of m-chlorophenyl piperazine-induced serotonergic neurotransmission in female compared to male rats. Life sciences. vol 52. issue 25. 1993-07-01. PMID:8388982. |
the findings along with our previous report show a functional supersensitivity of 5-ht neurotransmission involved in the regulation of hypothalamo-pituitary adrenocortical axis and appetite suppression in female sex, and suggest a possible basis for the greater occurrence of depression and anorexia in women than men. |
1993-07-01 |
2023-08-12 |
rat |
| S H Preskor. Recent pharmacologic advances in antidepressant therapy for the elderly. The American journal of medicine. vol 94. issue 5A. 1993-06-30. PMID:8503477. |
the practicing clinician now has five distinct classes of antidepressant medications that may be used for treating depression in the elderly: tricyclic antidepressants (tcas; e.g., desipramine, nortriptyline), monoamine oxidase inhibitors (maois; e.g., isocarboxazid, tranylcypromine), selective serotonin reuptake inhibitors (ssris; i.e., fluoxetine, sertraline, and paroxetine), aminoketones (i.e., bupropion), and triazolopyridines (i.e., trazodone). |
1993-06-30 |
2023-08-12 |
Not clear |
| R C Zimmermann, C J McDougle, M Schumacher, J Olcese, J W Mason, G R Heninger, L H Pric. Effects of acute tryptophan depletion on nocturnal melatonin secretion in humans. The Journal of clinical endocrinology and metabolism. vol 76. issue 5. 1993-06-23. PMID:8496306. |
however, a dysregulation in serotonin function has also been implicated in the pathophysiology of depression. |
1993-06-23 |
2023-08-12 |
human |
| A I Green, C P Austi. Psychopathology of pancreatic cancer. A psychobiologic probe. Psychosomatics. vol 34. issue 3. 1993-06-17. PMID:8493302. |
although confirmatory data are lacking, informed speculation centers on the potential role of adrenocorticotropic hormone, parathyroid hormone, thyrotropin-releasing hormone, glucagon, serotonin, insulin, and bicarbonate in the production of depression and/or anxiety in this disease. |
1993-06-17 |
2023-08-12 |
Not clear |
| F Song, N Freemantle, T A Sheldon, A House, P Watson, A Long, J Maso. Selective serotonin reuptake inhibitors: meta-analysis of efficacy and acceptability. BMJ (Clinical research ed.). vol 306. issue 6879. 1993-05-17. PMID:8471919. |
to examine the evidence for using selective serotonin reuptake inhibitors instead of tricyclic antidepressants in the first line treatment of depression. |
1993-05-17 |
2023-08-12 |
Not clear |
| D N Osse. A systematic approach to the classification and pharmacotherapy of nonpsychotic major depression and dysthymia. Journal of clinical psychopharmacology. vol 13. issue 2. 1993-05-06. PMID:8463446. |
after family and past history of response and cost of drug are considered, a tricyclic antidepressant is usually selected for autonomous depression patients, and mood-reactive depression patients are initially given a serotonin reuptake inhibitor. |
1993-05-06 |
2023-08-12 |
Not clear |
| D G Schlundt, K L Virts, T Sbrocco, J Pope-Cordle, J O Hil. A sequential behavioral analysis of craving sweets in obese women. Addictive behaviors. vol 18. issue 1. 1993-05-03. PMID:8465679. |
these data are not consistent with the hypothesis that sweet craver's consume high-carbohydrate, low-protein meals and snacks in order to self-medicate depression caused by serotonin depletion. |
1993-05-03 |
2023-08-12 |
human |
| Y God. [Ventilatory mechanical analysis of respiratory depression induced by serotonin]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science. vol 68. issue 1. 1993-04-02. PMID:8444402. |
[ventilatory mechanical analysis of respiratory depression induced by serotonin]. |
1993-04-02 |
2023-08-12 |
rat |
| D J Kupfe. Management of recurrent depression. The Journal of clinical psychiatry. vol 54 Suppl. 1993-04-02. PMID:8444832. |
the results of 1-year studies of maintenance therapy with serotonin selective reuptake inhibiting agents suggest that these medications will play a major role in prophylaxis for recurrent depression. |
1993-04-02 |
2023-08-12 |
Not clear |
| J P Ottervanger, P M van den Bemt, G H de Koning, B H Stricke. [Risk of hemorrhage with the use of fluoxetine (Prozac) or fluvoxamine (Fevarin)]. Nederlands tijdschrift voor geneeskunde. vol 137. issue 5. 1993-03-12. PMID:8433763. |
fluoxetine (prozac) and fluvoxamine (fevarin) are nontricyclic serotonin (5-hydroxytryptamine) reuptake inhibitors prescribed for the treatment of depression. |
1993-03-12 |
2023-08-12 |
Not clear |
| H M van Praa. About the centrality of mood lowering in mood disorders. Plenary Lecture ECNP Congress, Monte Carlo, October 1991. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 2. issue 4. 1993-03-01. PMID:1362659. |
5-ht disturbances in depression (as exemplified by lowered csf 5-hiaa) are not syndrome specific but related to components of the depressive syndrome, specifically to increased anxiety and aggression. |
1993-03-01 |
2023-08-11 |
Not clear |
| H M van Praa. About the centrality of mood lowering in mood disorders. Plenary Lecture ECNP Congress, Monte Carlo, October 1991. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 2. issue 4. 1993-03-01. PMID:1362659. |
in "5-ht related depression", the key psychopathological disturbances are dysregulation of anxiety and aggression, while mood lowering is a "by-product". |
1993-03-01 |
2023-08-11 |
Not clear |
| H M van Praa. About the centrality of mood lowering in mood disorders. Plenary Lecture ECNP Congress, Monte Carlo, October 1991. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 2. issue 4. 1993-03-01. PMID:1362659. |
based on this hypothesis it was predicted that agents which ameliorate anxiety and/or aggression via harmonization of 5-ht ergic transmission will, in addition, exert overall antidepressant effect in "5-ht related depression". |
1993-03-01 |
2023-08-11 |
Not clear |