| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A L Peyton, R Carpenter, K Rutkowsk. The stereospecific determination of fluoxetine and norfluoxetine enantiomers in human plasma by high-pressure liquid chromatography (HPLC) with fluorescence detection. Pharmaceutical research. vol 8. issue 12. 1992-05-19. PMID:1808619. |
f is a serotonin uptake inhibitor used in the treatment of depression and is administered as a racemate. |
1992-05-19 |
2023-08-11 |
human |
| S W Burto. A review of fluvoxamine and its uses in depression. International clinical psychopharmacology. vol 6 Suppl 3. 1992-05-11. PMID:1806631. |
fluvoxamine is a potent and specific 5-ht reuptake inhibitor which has been available since 1983 and is estimated to have been given to two and a half million patients since it was first investigated in patients with depression in the late 1970s. |
1992-05-11 |
2023-08-11 |
Not clear |
| J F Deaki. Depression and 5HT. International clinical psychopharmacology. vol 6 Suppl 3. 1992-05-11. PMID:1806632. |
depression and 5ht. |
1992-05-11 |
2023-08-11 |
Not clear |
| J F Deaki. Depression and 5HT. International clinical psychopharmacology. vol 6 Suppl 3. 1992-05-11. PMID:1806632. |
5ht has been implicated in mechanisms of anxiety and depression for many years but the evidence is contradictory. |
1992-05-11 |
2023-08-11 |
Not clear |
| S M Hourani, D A Hall, C J Niema. Effects of the P2-purinoceptor antagonist, suramin, on human platelet aggregation induced by adenosine 5'-diphosphate. British journal of pharmacology. vol 105. issue 2. 1992-05-08. PMID:1559134. |
suramin (200-400 microm) also noncompetitively inhibited aggregation induced by u46619 (a thromboxane receptor agonist) or by 5-hydroxytryptamine in the presence of adrenaline (100 microm), and caused a depression of the maximal response to these agonists. |
1992-05-08 |
2023-08-11 |
human |
| A A Nierenberg, J O Cole, L Glas. Possible trazodone potentiation of fluoxetine: a case series. The Journal of clinical psychiatry. vol 53. issue 3. 1992-04-21. PMID:1548249. |
fluoxetine is an effective serotonin reuptake inhibitor antidepressant that can fail to alleviate either insomnia or major depression in a substantial minority of depressed patients. |
1992-04-21 |
2023-08-11 |
Not clear |
| C M Beasley, J H Potvin, D N Masica, D E Wheadon, B E Dornseif, L A Gendus. Fluoxetine: no association with suicidality in obsessive-compulsive disorder. Journal of affective disorders. vol 24. issue 1. 1992-04-16. PMID:1545040. |
since (a) obsessive-compulsive disorder (ocd) may involve serotonergic neural transmission abnormalities also though to be related to regulation of suicide and aggression, (b) comorbidity between ocd and depression is substantial, and (c) depression is a major risk factor for suicide, a comprehensive analysis of clinical trial data was undertaken to assess the potential association of fluoxetine, a serotonin uptake inhibitor, and suicidality (suicidal acts and ideation). |
1992-04-16 |
2023-08-11 |
Not clear |
| J L Claghor. The safety and efficacy of paroxetine compared with placebo in a double-blind trial of depressed outpatients. The Journal of clinical psychiatry. vol 53 Suppl. 1992-04-08. PMID:1531821. |
considerable research shows that serotonin dysfunction is implicated in major depression. |
1992-04-08 |
2023-08-11 |
Not clear |
| J Quintan. Platelet serotonin and plasma tryptophan decreases in endogenous depression. Clinical, therapeutic, and biological correlations. Journal of affective disorders. vol 24. issue 2. 1992-04-08. PMID:1541767. |
platelet serotonin and plasma tryptophan decreases in endogenous depression. |
1992-04-08 |
2023-08-11 |
Not clear |
| H M Pappiu. Brain injury: new insights into neurotransmitter and receptor mechanisms. Neurochemical research. vol 16. issue 9. 1992-03-19. PMID:1664496. |
cortical serotonin (5-ht) metabolism was increased throughout the lesioned hemisphere and complete inhibition of 5-ht synthesis with p-chlorophenylalanine ameliorated the decrease in cortical lcgu, interpreted as reflecting cortical functional depression. |
1992-03-19 |
2023-08-11 |
rat |
| P L Delgado, L H Price, H L Miller, R M Salomon, J Licinio, J H Krystal, G R Heninger, D S Charne. Rapid serotonin depletion as a provocative challenge test for patients with major depression: relevance to antidepressant action and the neurobiology of depression. Psychopharmacology bulletin. vol 27. issue 3. 1992-03-02. PMID:1775606. |
rapid serotonin depletion as a provocative challenge test for patients with major depression: relevance to antidepressant action and the neurobiology of depression. |
1992-03-02 |
2023-08-11 |
Not clear |
| b' D M\\xc3\\xbcck-Seler, M Jakovljevi\\xc4\\x87, Z Deanovi\\xc4\\x8. Effect of antidepressant treatment on platelet 5-HT content and relation to therapeutic outcome in unipolar depressive patients. Journal of affective disorders. vol 23. issue 3. 1992-02-28. PMID:1774431.' |
platelet 5-ht levels and scores on the 17-item hamilton rating scale for depression (hrs) were studied in patients with unipolar depression before and after antidepressant treatment. |
1992-02-28 |
2023-08-11 |
Not clear |
| M J Sarrias, E Martínez, P Celada, C Udina, E Alvarez, F Artiga. Plasma free 5HT and platelet 5HT in depression: case-control studies and the effect of antidepressant therapy. Advances in experimental medicine and biology. vol 294. 1992-02-25. PMID:1722955. |
plasma free 5ht and platelet 5ht in depression: case-control studies and the effect of antidepressant therapy. |
1992-02-25 |
2023-08-11 |
Not clear |
| H Nagayama, K Tsuchiyama, K Yamada, J Akiyosh. Animal study on the role of serotonin in depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 15. issue 6. 1992-02-13. PMID:1763191. |
animal study on the role of serotonin in depression. |
1992-02-13 |
2023-08-11 |
human |
| H Nagayama, K Tsuchiyama, K Yamada, J Akiyosh. Animal study on the role of serotonin in depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 15. issue 6. 1992-02-13. PMID:1763191. |
in our series of experiments the role of serotonin in human depression was studied by using animal models of depression. |
1992-02-13 |
2023-08-11 |
human |
| H Nagayama, K Tsuchiyama, K Yamada, J Akiyosh. Animal study on the role of serotonin in depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 15. issue 6. 1992-02-13. PMID:1763191. |
the results of these studies support the hypothesis that some types of human depression may be primarily due to an excessive transmission of serotonin at the synapse. |
1992-02-13 |
2023-08-11 |
human |
| P A Broderick, M F Pierce. 5-HT1A agonists uncouple noradrenergic somatodendritic impulse flow and terminal release. Brain research bulletin. vol 27. issue 5. 1992-02-06. PMID:1684526. |
in ca1 region of hippocampus, both buspirone and ipsapirone significantly depressed ne release with potencies greater than those required for the significant depression of 5-ht release. |
1992-02-06 |
2023-08-11 |
Not clear |
| I N Ferrie. Chronic depression: future prospects from recent research. International clinical psychopharmacology. vol 6 Suppl 1. 1992-02-06. PMID:1684591. |
the central role of 5ht in depression is emphasized and it seems likely that the maintenance of adequate 5ht neurotransmission is required for the treatment of chronic depression. |
1992-02-06 |
2023-08-11 |
Not clear |
| L A Hilakivi-Clark. Effects of tryptophan on depression and aggression in STZ-D mice. Diabetes. vol 40. issue 12. 1992-02-03. PMID:1756900. |
streptozocin-induced diabetic (stz-d) mice have reduced brain concentrations of tryptophan, a precursor substance for 5-hydroxytryptamine, and show lengthened immobility in porsolt's swim test, a putative animal model of depression. |
1992-02-03 |
2023-08-11 |
mouse |
| L Hernandez, M Parada, T Baptista, D Schwartz, H L West, G P Mark, B G Hoebe. Hypothalamic serotonin in treatments for feeding disorders and depression as studied by brain microdialysis. The Journal of clinical psychiatry. vol 52 Suppl. 1992-01-30. PMID:1752857. |
hypothalamic serotonin in treatments for feeding disorders and depression as studied by brain microdialysis. |
1992-01-30 |
2023-08-11 |
rat |