| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z Bhagwagar, E A Rabiner, P A Sargent, P M Grasby, P J Cowe. Persistent reduction in brain serotonin1A receptor binding in recovered depressed men measured by positron emission tomography with [11C]WAY-100635. Molecular psychiatry. vol 9. issue 4. 2004-12-22. PMID:15042104. |
positron emission tomography (pet) studies with the selective 5-ht(1a) receptor ligand, [(11)c]way-100635, have indicated that the binding potential (bp) of brain 5-ht(1a) receptors is lowered in unmedicated subjects with acute major depression. |
2004-12-22 |
2023-08-12 |
human |
| Z Bhagwagar, E A Rabiner, P A Sargent, P M Grasby, P J Cowe. Persistent reduction in brain serotonin1A receptor binding in recovered depressed men measured by positron emission tomography with [11C]WAY-100635. Molecular psychiatry. vol 9. issue 4. 2004-12-22. PMID:15042104. |
to resolve this issue, we used [(11)c]way-100635 in conjunction with pet imaging to compare 5-ht(1a) bp in 18 healthy controls and 14 male subjects with recurrent major depression who were clinically recovered and free of antidepressant medication. |
2004-12-22 |
2023-08-12 |
human |
| Z Bhagwagar, E A Rabiner, P A Sargent, P M Grasby, P J Cowe. Persistent reduction in brain serotonin1A receptor binding in recovered depressed men measured by positron emission tomography with [11C]WAY-100635. Molecular psychiatry. vol 9. issue 4. 2004-12-22. PMID:15042104. |
lowered 5-ht(1a) receptor binding availability could represent a trait abnormality that confers vulnerability to recurrent major depression. |
2004-12-22 |
2023-08-12 |
human |
| Janna L Morrison, K Wayne Riggs, Caly Chien, Nancy Gruber, I Caroline McMillen, Dan W Rura. Chronic maternal fluoxetine infusion in pregnant sheep: effects on the maternal and fetal hypothalamic-pituitary-adrenal axes. Pediatric research. vol 56. issue 1. 2004-12-22. PMID:15128928. |
depression during pregnancy is frequently treated with the selective serotonin reuptake inhibitor, fluoxetine (fx). |
2004-12-22 |
2023-08-12 |
Not clear |
| Spilios V Argyropoulos, Sean D Hood, Mariona Adrover, Caroline J Bell, Ann S Rich, Jon R Nash, Neil C Rich, Harry J Witchel, David J Nut. Tryptophan depletion reverses the therapeutic effect of selective serotonin reuptake inhibitors in social anxiety disorder. Biological psychiatry. vol 56. issue 7. 2004-12-21. PMID:15450786. |
tryptophan depletion studies have suggested that central serotonin (5-hydroxytryptamine, 5-ht) function mediates the therapeutic effect of selective serotonin reuptake inhibitors (ssris) in depression and panic disorder. |
2004-12-21 |
2023-08-12 |
Not clear |
| Guy A Farber, Joseph F Goldber. Regarding "Combining norepinephrine and serotonin reuptake inhibition mechanisms for treatment of depression: a double-blind randomized study": Optimizing initial interventions. Biological psychiatry. vol 56. issue 7. 2004-12-21. PMID:15450792. |
regarding "combining norepinephrine and serotonin reuptake inhibition mechanisms for treatment of depression: a double-blind randomized study": optimizing initial interventions. |
2004-12-21 |
2023-08-12 |
Not clear |
| Marcelo Camprubli, Marcos Suffrit. [Clinical management of patients with depression and cardiac disease]. Vertex (Buenos Aires, Argentina). vol 15. issue 57. 2004-12-21. PMID:15505684. |
treatment with selective serotonin reuptake inhibitors is effective, safe and may improve survival after myocardial infarction in patients with depression. |
2004-12-21 |
2023-08-12 |
Not clear |
| Silvia Wikinsk. [Depression and anxiety: from clinic to pharmacological treatment]. Vertex (Buenos Aires, Argentina). vol 15. issue 57. 2004-12-21. PMID:15505682. |
while the selective serotonin reuptake inhibitors seem to be indicated in depression with comorbid anxiety disorders and in anxious depression, in agitated depression may be preferable to indicate mood stabilizers or sedative antipsychotics. |
2004-12-21 |
2023-08-12 |
Not clear |
| Dorotea Muck-Seler, Nela Pivac, Maja Mustapic, Zeljka Crncevic, Miro Jakovljevic, Marina Sagu. Platelet serotonin and plasma prolactin and cortisol in healthy, depressed and schizophrenic women. Psychiatry research. vol 127. issue 3. 2004-12-14. PMID:15296821. |
our data, although obtained on peripheral biochemical markers, indicate that depression and schizophrenia are characterized by disturbed 5-ht transmission and dysregulated hpa axis activity. |
2004-12-14 |
2023-08-12 |
Not clear |
| Michelle M Haby, Bruce Tonge, Lyn Littlefield, Rob Carter, Theo Vo. Cost-effectiveness of cognitive behavioural therapy and selective serotonin reuptake inhibitors for major depression in children and adolescents. The Australian and New Zealand journal of psychiatry. vol 38. issue 8. 2004-12-14. PMID:15298580. |
cost-effectiveness of cognitive behavioural therapy and selective serotonin reuptake inhibitors for major depression in children and adolescents. |
2004-12-14 |
2023-08-12 |
Not clear |
| A Feuchtl, M Bagli, R Stephan, C Frahnert, H Kölsch, K U Kühn, M L Ra. Pharmacokinetics of m-chlorophenylpiperazine after intravenous and oral administration in healthy male volunteers: implication for the pharmacodynamic profile. Pharmacopsychiatry. vol 37. issue 4. 2004-12-14. PMID:15467976. |
serotonin plays an important role in psychiatric diseases, most notably in depression and anxiety. |
2004-12-14 |
2023-08-12 |
human |
| Alexander Neumeister, Theresa Young, Juergen Stastn. Implications of genetic research on the role of the serotonin in depression: emphasis on the serotonin type 1A receptor and the serotonin transporter. Psychopharmacology. vol 174. issue 4. 2004-12-02. PMID:15249991. |
implications of genetic research on the role of the serotonin in depression: emphasis on the serotonin type 1a receptor and the serotonin transporter. |
2004-12-02 |
2023-08-12 |
Not clear |
| Alexander Neumeister, Theresa Young, Juergen Stastn. Implications of genetic research on the role of the serotonin in depression: emphasis on the serotonin type 1A receptor and the serotonin transporter. Psychopharmacology. vol 174. issue 4. 2004-12-02. PMID:15249991. |
consequently, ongoing research determines whether serotonin related genes account for the very robust differential behavioral and neural mechanisms that discriminate patients with depression from healthy controls. |
2004-12-02 |
2023-08-12 |
Not clear |
| Alexander Neumeister, Theresa Young, Juergen Stastn. Implications of genetic research on the role of the serotonin in depression: emphasis on the serotonin type 1A receptor and the serotonin transporter. Psychopharmacology. vol 174. issue 4. 2004-12-02. PMID:15249991. |
serotonin type 1(a) receptors and the serotonin transporters are reduced in depression, and recent genetic research in animals and humans has implicated both in depression. |
2004-12-02 |
2023-08-12 |
Not clear |
| George M Anderso. Peripheral and central neurochemical effects of the selective serotonin reuptake inhibitors (SSRIs) in humans and nonhuman primates: assessing bioeffect and mechanisms of action. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 22. issue 5-6. 2004-12-02. PMID:15380838. |
in summary, the studies described have found that: human fetal exposure to ssris has substantial effects on 5-ht transport in utero; exposure to ssris through breastmilk of mothers treated for postpartum depression usually has negligible effects on 5-ht uptake; prescribed ssris appear to exert similar effects on 5-ht transporter blockade in children and adults; and rapid and sustained increases are seen in monkey cisternal csf levels of 5-ht upon initiation of ssri administration. |
2004-12-02 |
2023-08-12 |
human |
| Seema Bhatnagar, Nathan Nowak, Leslie Babich, Lauren Bo. Deletion of the 5-HT3 receptor differentially affects behavior of males and females in the Porsolt forced swim and defensive withdrawal tests. Behavioural brain research. vol 153. issue 2. 2004-11-30. PMID:15265651. |
the central serotonin (5-ht) system is important in regulating behaviors associated with anxiety and depression. |
2004-11-30 |
2023-08-12 |
mouse |
| Mark P Mattson, Stuart Maudsley, Bronwen Marti. BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends in neurosciences. vol 27. issue 10. 2004-11-30. PMID:15374669. |
impaired 5-ht and bdnf signaling is central to depression and anxiety disorders, but could also play important roles in the pathogenesis of several age-related disorders, including insulin resistance syndrome, alzheimer's disease and huntington's disease. |
2004-11-30 |
2023-08-12 |
Not clear |
| Marco Giorgetti, Laurence H Tecot. Contributions of 5-HT(2C) receptors to multiple actions of central serotonin systems. European journal of pharmacology. vol 488. issue 1-3. 2004-11-29. PMID:15044029. |
further evidence for a role of these receptors in affect regulation arises from recent findings that alterations in 5-ht(2c) mrna editing are observed in the brains of suicide victims with a history of depression and in animals exposed to antidepressant drug treatment. |
2004-11-29 |
2023-08-12 |
Not clear |
| Greer M Murphy, Steven B Hollander, Heidi E Rodrigues, Charlotte Kremer, Alan F Schatzber. Effects of the serotonin transporter gene promoter polymorphism on mirtazapine and paroxetine efficacy and adverse events in geriatric major depression. Archives of general psychiatry. vol 61. issue 11. 2004-11-24. PMID:15520364. |
effects of the serotonin transporter gene promoter polymorphism on mirtazapine and paroxetine efficacy and adverse events in geriatric major depression. |
2004-11-24 |
2023-08-12 |
Not clear |
| Thomas I F H Cremers, Marco Giorgetti, Fokko J Bosker, Sandra Hogg, Jørn Arnt, Arne Mørk, Gerard Honig, Klaus-Peter Bøgesø, Ben H C Westerink, Hans den Boer, Håkan V Wikstrom, Laurence H Tecot. Inactivation of 5-HT(2C) receptors potentiates consequences of serotonin reuptake blockade. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 10. 2004-11-22. PMID:15138437. |
these findings reveal an unanticipated pharmacological action of 5-ht(2c) receptors that warrants consideration in the development of novel strategies for the treatment of depression. |
2004-11-22 |
2023-08-12 |
mouse |