| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D F Avgustinovich, O V Alekseenko, I V Bakshtanovskaia, L A Koriakina, T V Lipina, M V Tenditnik, N P Bondar', I L Kovalenko, N N Kudriavtsev. [Dynamic changes of brain serotonergic and dopaminergic activities during development of anxious depression: experimental study]. Uspekhi fiziologicheskikh nauk. vol 35. issue 4. 2005-03-31. PMID:15573884. |
at the stage of pronounced depression (20 days of stress), there were no differences in 5-ht and 5-hiaa levels in all brain areas (excluding hypothalamus) of depressive animals. |
2005-03-31 |
2023-08-12 |
mouse |
| Wendol Williams, Matthias Reimold, Michael Kerich, Dan Hommer, Michael Bauer, Andreas Hein. Glucose utilization in the medial prefrontal cortex correlates with serotonin turnover rate and clinical depression in alcoholics. Psychiatry research. vol 132. issue 3. 2005-03-31. PMID:15664793. |
glucose utilization in the medial prefrontal cortex correlates with serotonin turnover rate and clinical depression in alcoholics. |
2005-03-31 |
2023-08-12 |
human |
| Wendol Williams, Matthias Reimold, Michael Kerich, Dan Hommer, Michael Bauer, Andreas Hein. Glucose utilization in the medial prefrontal cortex correlates with serotonin turnover rate and clinical depression in alcoholics. Psychiatry research. vol 132. issue 3. 2005-03-31. PMID:15664793. |
we measured the serotonin metabolite 5-hydroxyindoleacetic acid (5-hiaa) in cerebrospinal fluid (csf), regional cerebral glucose uptake (rcmrglc) as assessed with positron emission tomography in the medial prefrontal cortex (pfc) and severity of clinical depression (beck's depression inventory, bdi) in detoxified male alcoholics and age-matched healthy men. |
2005-03-31 |
2023-08-12 |
human |
| Eiji Suzuki, Shuji Marut. [Review of double-blind studies comparing SSRI and SNRI]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica. vol 106. issue 10. 2005-03-29. PMID:15669214. |
in japan, therapies for depression using serotonin-selective reuptake inhibitors and serotonin noradrenaline reuptake inhibitors have been established for several years. |
2005-03-29 |
2023-08-12 |
Not clear |
| Choon-Gon Jang, Moonkyu Kang, Jae-Han Cho, Sun-Bok Lee, Hyuntaek Kim, Soonkwon Park, Jinwoo Lee, Seong-Kyu Park, Moochang Hong, Min Kyu Shin, In-Sup Shim, Hyunsu Ba. Nelumbinis Semen reverses a decrease in 5-HT1A receptor binding induced by chronic mild stress, a depression-like symptom. Archives of pharmacal research. vol 27. issue 10. 2005-03-18. PMID:15554266. |
depression is associated with a dysfunctional serotonin (5-hydroxytryptamine; 5-ht) system. |
2005-03-18 |
2023-08-12 |
rat |
| Omer Bonne, Earle Bain, Alexander Neumeister, Allison C Nugent, Meena Vythilingam, Richard E Carson, David A Luckenbaugh, William Eckelman, Peter Herscovitch, Wayne C Drevets, Dennis S Charne. No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorder. The American journal of psychiatry. vol 162. issue 2. 2005-03-17. PMID:15677606. |
serotonin type 1a receptors (5ht1ars) have been shown to be affected by stress in experimental animals and related to anxiety and depression in humans. |
2005-03-17 |
2023-08-12 |
Not clear |
| I Petrakis, J Krysta. Neuroscience: implications for treatment. Alcohol health and research world. vol 21. issue 2. 2005-03-17. PMID:15704353. |
medications that affect the neurotransmitter serotonin, however, may alleviate symptoms of anxiety and depression in alcoholics without affecting the alcoholism itself. |
2005-03-17 |
2023-08-12 |
Not clear |
| H S Sun, H-W Tsai, H-C Ko, F-M Chang, T-L Ye. Association of tryptophan hydroxylase gene polymorphism with depression, anxiety and comorbid depression and anxiety in a population-based sample of postpartum Taiwanese women. Genes, brain, and behavior. vol 3. issue 6. 2005-03-15. PMID:15544576. |
serotonin is the biogenic amine neurotransmitter most commonly associated with depression and anxiety. |
2005-03-15 |
2023-08-12 |
human |
| Xiaoying Lu, Alasdair M Barr, Jefferson W Kinney, Pietro Sanna, Bruno Conti, M Margarita Behrens, Tamas Bartfa. A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 3. 2005-03-15. PMID:15647369. |
selective serotonin reuptake inhibitors, such as fluoxetine (flx), are the most commonly used drugs in the treatment of major depression. |
2005-03-15 |
2023-08-12 |
rat |
| Osvaldo P Almeida, Leon Flicker, Nicola T Lautenschlager, Peter Leedman, Samuel Vasikaran, Frank M van Bockxmee. Contribution of the MTHFR gene to the causal pathway for depression, anxiety and cognitive impairment in later life. Neurobiology of aging. vol 26. issue 2. 2005-03-14. PMID:15582752. |
subjects with the tt genotype have higher homocysteine levels and may be particularly prone to experiencing depression as a result of high plasma hcy and dysfunction of methylation metabolic pathways critical to the synthesis of noradrenaline and serotonin. |
2005-03-14 |
2023-08-12 |
human |
| Aminul Islam, Kevin S J Thompson, Saghir Akhtar, Sheila L Handle. Increased 5-HT2A receptor expression and function following central glucocorticoid receptor knockdown in vivo. European journal of pharmacology. vol 502. issue 3. 2005-03-08. PMID:15476747. |
the role of glucocorticoid receptors in modulating 5-ht(2a) receptor expression and function in the central nervous system (cns) is presently unclear, but 5-ht(2a) receptor function also appears altered in depression. |
2005-03-08 |
2023-08-12 |
rat |
| Xiaodong Zhang, Raul R Gainetdinov, Jean-Martin Beaulieu, Tatyana D Sotnikova, Lauranell H Burch, Redford B Williams, David A Schwartz, K Ranga R Krishnan, Marc G Caro. Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron. vol 45. issue 1. 2005-03-07. PMID:15629698. |
dysregulation of central serotonin neurotransmission has been widely suspected as an important contributor to major depression. |
2005-03-07 |
2023-08-12 |
human |
| Xiaodong Zhang, Raul R Gainetdinov, Jean-Martin Beaulieu, Tatyana D Sotnikova, Lauranell H Burch, Redford B Williams, David A Schwartz, K Ranga R Krishnan, Marc G Caro. Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron. vol 45. issue 1. 2005-03-07. PMID:15629698. |
identification of a loss-of-function mutation in htph2 suggests that defect in brain serotonin synthesis may represent an important risk factor for unipolar major depression. |
2005-03-07 |
2023-08-12 |
human |
| Trudo Lemmen. Confronting the conflict of interest crisis in medical research. Monash bioethics review. vol 23. issue 4. 2005-03-03. PMID:15688510. |
in the last couple of years, serious controversies have raised doubts over the reliability of research supporting the efficacy and safety of selective serotonin reuptake inhibitors, popular drugs used for the treatment of depression and a variety of related conditions. |
2005-03-03 |
2023-08-12 |
Not clear |
| Waguih William Ishak, Mark H Rapaport, Jennifer G Gott. The effectiveness of atypical antipsychotic medications in depressive disorders. Current psychiatry reports. vol 6. issue 6. 2005-03-02. PMID:15538989. |
this stimulated the initiation of several clinical trials that showed the efficacy of atypical antipsychotic medication augmentation of selective serotonin reuptake inhibitors for patients with treatment-resistant depression. |
2005-03-02 |
2023-08-12 |
Not clear |
| Andreas Heinz, Dieter F Braus, Michael N Smolka, Jana Wrase, Imke Puls, Derik Hermann, Sabine Klein, Sabine M Grüsser, Herta Flor, Gunter Schumann, Karl Mann, Christian Büche. Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nature neuroscience. vol 8. issue 1. 2005-03-02. PMID:15592465. |
major depression is conditionally linked to a polymorphism of the human serotonin transporter gene (slc6a4). |
2005-03-02 |
2023-08-12 |
human |
| D Gourion, E Perrin, Ph Quinti. [Fluoxetine: an update of its use in major depressive disorder in adults]. L'Encephale. vol 30. issue 4. 2005-03-01. PMID:15597466. |
the therapeutic response in major depression for ssris (ie 15-20 days) maybe due to a progressive desensitization of somatodendritic 5-ht autoreceptors in the midbrain raphe nucleus. |
2005-03-01 |
2023-08-12 |
Not clear |
| Gyöngyi Gesztely. [Primary headache and depression]. Orvosi hetilap. vol 145. issue 48. 2005-03-01. PMID:15638035. |
this theory is supported by the role of the same neurotransmitter systems (mostly serotonin and dopamine) in headaches as well as in depression. |
2005-03-01 |
2023-08-12 |
Not clear |
| Ahmad R Hariri, Emily M Drabant, Karen E Munoz, Bhaskar S Kolachana, Venkata S Mattay, Michael F Egan, Daniel R Weinberge. A susceptibility gene for affective disorders and the response of the human amygdala. Archives of general psychiatry. vol 62. issue 2. 2005-02-24. PMID:15699291. |
a common regulatory variant (5-httlpr) in the human serotonin transporter gene (slc6a4), resulting in altered transcription and transporter availability, has been associated with vulnerability for affective disorders, including anxiety and depression. |
2005-02-24 |
2023-08-12 |
human |
| Martin Reivich, Jay D Amsterdam, David J Brunswick, Chyng Yann Shiu. PET brain imaging with [11C](+)McN5652 shows increased serotonin transporter availability in major depression. Journal of affective disorders. vol 82. issue 2. 2005-02-23. PMID:15488265. |
pet brain imaging with [11c](+)mcn5652 shows increased serotonin transporter availability in major depression. |
2005-02-23 |
2023-08-12 |
Not clear |