| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Fornaro, C I Cattaneo, D De Berardis, F V Ressico, G Martinotti, E Viet. Antidepressant discontinuation syndrome: A state-of-the-art clinical review. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 66. 2022-11-08. PMID:36345093. |
ads has been documented for most antidepressant drugs, although most literature focuses on selective serotonin reuptake inhibitors prescribed for depression. |
2022-11-08 |
2023-08-14 |
Not clear |
| Yuanbo Wang, Xia Li, Rui Jing, Wenshan Yang, Yichen Wang, Chaochen Wang, Lei Yao, Xiaoming Cui, Yuan H. KXS Balances the Tryptophan Metabolism in Mild to Moderate Depressed Patients and Chronic Restraint Stress Induced Depressive Rats. Neuropsychiatric disease and treatment. vol 18. 2022-11-08. PMID:36345420. |
kai-xin-san (kxs), a traditional chinese medicine formula, has been widely used to treat depression and modulate serotonin simultaneously, but how it regulates depressive-like behavior by shifting the balance of the tryptophan-serotonin metabolism and kynurenine pathway remains vague. |
2022-11-08 |
2023-08-14 |
rat |
| Nada Kha. The serotonin theory of depression and why we use antidepressants. The British journal of general practice : the journal of the Royal College of General Practitioners. vol 72. issue 724. 2022-10-27. PMID:36302678. |
the serotonin theory of depression and why we use antidepressants. |
2022-10-27 |
2023-08-14 |
Not clear |
| Katarzyna Stachowicz, Magdalena Sowa-Kućm. The treatment of depression - searching for new ideas. Frontiers in pharmacology. vol 13. 2022-10-24. PMID:36278184. |
selective serotonin reuptake inhibitors (ssris) and serotonin-norepinephrine reuptake inhibitors (snris) are frontline pharmacological strategies for the medical treatment of depression. |
2022-10-24 |
2023-08-14 |
Not clear |
| Sai Dheeraj Gutlapalli, Vamsi Krishna Lavu, Rana Abdelwahab Mohamed, Ruimin Huang, Shanthi Potla, Sushen Bhalla, Yousif Al Qabandi, Savitri Aninditha Nandula, Chinmayi Sree Boddepalli, Pousette Hami. The Risk of Fatal Arrhythmias in Post-Myocardial Infarction Depression in Association With Venlafaxine. Cureus. vol 14. issue 9. 2022-10-19. PMID:36258960. |
venlafaxine is a second line anti-depressant and the most commonly used in the treatment of selective serotonin reuptake inhibitor nonresponders in major depression; due to its effects on the noradrenergic and serotonergic systems as a serotonin and norepinephrine reuptake inhibitor, there has been considerable apprehension regarding its use in patients with cardiovascular diseases, particularly post-myocardial infarction depression, some of the feared adverse effects include qt prolongation, arrhythmias including torsades de pointes and sudden cardiac death. |
2022-10-19 |
2023-08-14 |
Not clear |
| Joshua S Kurtz, Neal A Patel, Julian L Gendreau, Chenyi Yang, Nolan Brown, Nick Bui, Bryce Picton, Mark Harris, Matthew Hatter, Ryan Beyer, Ronald Sahyouni, Luis Daniel Diaz-Aguilar, Joel Castellanos, Nathaniel Schuster, Mickey E Abraha. The Use of Psychedelics in the Treatment of Medical Conditions: An Analysis of Currently Registered Psychedelics Studies in the American Drug Trial Registry. Cureus. vol 14. issue 9. 2022-10-19. PMID:36259015. |
potentially, more studies could be performed to evaluate the potential of psychedelics for symptomatic treatment during opioid tapering and depression refractory to selective serotonin reuptake inhibitors. |
2022-10-19 |
2023-08-14 |
Not clear |
| Ryan E Ross, Catherine J VanDerwerker, Michael E Saladin, Chris M Gregor. The role of exercise in the treatment of depression: biological underpinnings and clinical outcomes. Molecular psychiatry. 2022-10-17. PMID:36253441. |
acute bouts of exercise have been shown to transiently modulate circulating levels of serotonin and norepinephrine, brain-derived neurotrophic factor, and a variety of immuno-inflammatory mechanisms in clinical cohorts with depression. |
2022-10-17 |
2023-08-14 |
Not clear |
| Maria Becker, Karin Abaev, Elena Shmerkin, Liza Weinstein-Fudim, Albert Pinhasov, Asher Orno. Prenatal SAMe Treatment Induces Changes in Brain Monoamines and in the Expression of Genes Related to Monoamine Metabolism in a Mouse Model of Social Hierarchy and Depression, Probably via an Epigenetic Mechanism. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36233200. |
reduction in the levels of monoamines, such as serotonin and dopamine in the brain, were reported in patients and animals with depression. |
2022-10-14 |
2023-08-14 |
mouse |
| Małgorzata Gałecka, Katarzyna Bliźniewska-Kowalska, Piotr Gałecki, Janusz Szemraj, Agata Orzechowsk. Expression of p11 in Patients with Depression. Journal of clinical medicine. vol 11. issue 19. 2022-10-14. PMID:36233614. |
rt-pcr was used to evaluate gene expression at the mrna level, while enzyme-linked immunosorbent assay (elisa) was used to evaluate gene expression at the protein level; (3) results: the results indicate slightly increased s100a10 gene expression (both at the protein and mrna levels) in patients with depression, but these values do not reach statistical significance; (4) conclusions: due to the fact that the study was limited by the participation of patients already undergoing antidepressant treatment, its results may confirm that pharmacological treatment affecting serotonin neurotransmission is effective in upregulation of p11 in patients with depression. |
2022-10-14 |
2023-08-14 |
human |
| Sai Dheeraj Gutlapalli, Keerthana Prakash, Kiran Maee Swarnakari, Meena Bai, Mohana Priya Manoharan, Rabab Raja, Aneeque Jamil, Denise Csendes, Aditya Desai, Darshi M Desai, Michael Alfons. The Risk of Fatal Arrhythmias Associated With Sertraline in Patients With Post-myocardial Infarction Depression. Cureus. vol 14. issue 9. 2022-10-14. PMID:36237772. |
sertraline is a first-line antidepressant and the most commonly used in the treatment of selective serotonin reuptake inhibitor (ssri) in major depression. |
2022-10-14 |
2023-08-14 |
Not clear |
| Saara Ahmad, Arfa Azhar, Prashant Tikmani, Hamna Rafique, Asra Khan, Hanif Mesiya, Humera Saee. A randomized clinical trial to test efficacy of chamomile and saffron for neuroprotective and anti-inflammatory responses in depressive patients. Heliyon. vol 8. issue 10. 2022-10-11. PMID:36217471. |
the pathogenesis of depression initially relies on serotonin deficiency which is associated with depressive feelings. |
2022-10-11 |
2023-08-14 |
human |
| Hong Qian, Chang Shu, Ling Xiao, Gaohua Wan. Histamine and histamine receptors: Roles in major depressive disorder. Frontiers in psychiatry. vol 13. 2022-10-10. PMID:36213905. |
the monoamine hypothesis of depression suggests that 5-ht, ne, and da synergistically affect mood, which is the basis of current drug therapy for depression. |
2022-10-10 |
2023-08-14 |
Not clear |
| Hong Qian, Chang Shu, Ling Xiao, Gaohua Wan. Histamine and histamine receptors: Roles in major depressive disorder. Frontiers in psychiatry. vol 13. 2022-10-10. PMID:36213905. |
in addition, h3r can interact with other depression-related transmitters (including 5-ht, da, glu, and mch); thus, histamine may participate in the occurrence of depression through other neural circuits. |
2022-10-10 |
2023-08-14 |
Not clear |
| Barbara Polityńska, Olga Pokorska, Anna M Wojtukiewicz, Magdalena Sawicka, Marta Myśliwiec, Kenneth V Honn, Stephanie C Tucker, Marek Z Wojtukiewic. Is depression the missing link between inflammatory mediators and cancer? Pharmacology & therapeutics. 2022-10-10. PMID:36216210. |
activation of the kynurenine pathway, involving cytokines, increased tryptophan catabolism, resulting in diminished levels of serotonin, which is widely acknowledged as being the hallmark of depression. |
2022-10-10 |
2023-08-14 |
Not clear |
| b' H Sahlman, A Itkonen, M Lehtonen, L Keski-Nisula, J Rys\\xc3\\xa. Altered activities of CYP1A1 and CYP19A1 enzymes in women using SSRI medication during pregnancy. Placenta. vol 129. 2022-10-05. PMID:36198245.' |
selective serotonin reuptake inhibitors (ssris) are commonly used medication for the treatment of depression during pregnancy. |
2022-10-05 |
2023-08-14 |
Not clear |
| b' Iva Luki\\xc4\\x87, Sanja Ivkovi\\xc4\\x87, Milo\\xc5\\xa1 Miti\\xc4\\x87, Miroslav Ad\\xc5\\xbei\\xc4\\x8. Tryptophan metabolites in depression: Modulation by gut microbiota. Frontiers in behavioral neuroscience. vol 16. 2022-09-29. PMID:36172468.' |
the alterations in tryptophan metabolism such as changes in the levels of serotonin, kynurenine, and kynurenine acid have been implicated in the etiology of depression for more than 50 years. |
2022-09-29 |
2023-08-14 |
Not clear |
| Vera Dobrodeeva, Aiperi Abdyrahmanova, Darya Astafeva, Daria Smirnova, Paul Cumming, Avinash De Sousa, Igor Davydkin, Anna Yashikhina, Natalia Shnayder, Regina Nasyrov. Pharmacogenetic Aspects of COVID-19 Management and Post-COVID-19 Depression Treatment with Fluvoxamine. Psychiatria Danubina. vol 34. issue Suppl 8. 2022-09-28. PMID:36170697. |
the serotonin selective reuptake inhibitor fluvoxamine has been considered as a prophylaxis against depression in early covid-19 patients, with additional benefits apparently arising from its antiviral activity. |
2022-09-28 |
2023-08-14 |
Not clear |
| Sravanthi Penubarthi, Shabeeba Z Kailash, Kailash Sureshkumar, Aarya Krishnan Rajalakshm. Sexual Dysfunction in Remitted Female Patients with Depression on SSRIs: Associated Factors and Relation to Marital Satisfaction and Quality of Life. Indian journal of psychological medicine. vol 44. issue 5. 2022-09-26. PMID:36157018. |
sexual dysfunction, a potential side effect of selective serotonin reuptake inhibitors (ssris), can lead to marital dissatisfaction in remitted depression patients, affecting their quality of life (qol), and all of these are risk factors for treatment noncompliance. |
2022-09-26 |
2023-08-14 |
Not clear |
| Haseeb Ahsan, Mahnoor Ayub, Hafiz Muhammad Irfan, Muhammad Saleem, Irfan Anjum, Ihtisham Haider, Awais Asif, Syed Qamar Abbas, Syed Shams Ul Hulassa. Tumor necrosis factor-alpha, prostaglandin-E2 and interleukin-1β targeted anti-arthritic potential of fluvoxamine: drug repurposing. Environmental science and pollution research international. 2022-09-24. PMID:36152089. |
fluvoxamine, a selective serotonin re uptake inhibitor, is used to treat depression. |
2022-09-24 |
2023-08-14 |
human |
| Yi-Xin Xu, Shu-Hui Zhang, Jia-Lu Luan, Zhen-Hua Fu, Ming-Zhu Sun, Xin Zhao, Xi-Zeng Fen. The food preservative sodium propionate induces hyperglycaemic state and neurological disorder in zebrafish. Neurotoxicology and teratology. 2022-09-23. PMID:36150581. |
new tank test results showed depression in zebrafish reduced 5-hydroxytryptamine levels in the brain and damaged the dopamine system. |
2022-09-23 |
2023-08-14 |
zebrafish |