| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaohua Xie, Xiaofeng Wu, Dongsheng Zhao, Ying Liu, Qiyue Du, Yitian Li, Yaping Xu, Yuhang Li, Yan Qiu, Yungang Yan. Fluvoxamine alleviates bleomycin-induced lung fibrosis via regulating the cGAS-STING pathway. Pharmacological research. 2022-11-26. PMID:36435270. |
herein, we reported that fluvoxamine, a selective serotonin reuptake inhibitor (ssri), used in depression and anxiety treatment, also exhibited therapeutic activities in ipf. |
2022-11-26 |
2023-08-14 |
mouse |
| Amber N Edinoff, Keerthiga Raveendran, Marc A Colon, Bennett H Thomas, Katie A Trettin, Grace W Hunt, Adam M Kaye, Elyse M Cornett, Alan D Kay. Selective Serotonin Reuptake Inhibitors and Associated Bleeding Risks: A Narrative and Clinical Review. Health psychology research. vol 10. issue 4. 2022-11-25. PMID:36425234. |
a leading hypothesis of the pathophysiology of mdd is the monoamine deficiency hypothesis which suggests that depression is caused by depletion of serotonin, norepinephrine, or dopamine in the central nervous system. |
2022-11-25 |
2023-08-14 |
Not clear |
| Amber N Edinoff, Keerthiga Raveendran, Marc A Colon, Bennett H Thomas, Katie A Trettin, Grace W Hunt, Adam M Kaye, Elyse M Cornett, Alan D Kay. Selective Serotonin Reuptake Inhibitors and Associated Bleeding Risks: A Narrative and Clinical Review. Health psychology research. vol 10. issue 4. 2022-11-25. PMID:36425234. |
serotonin is the most widely studied neurotransmitter in the pathophysiology of depression, with studies showing that reduced central serotonin synthesis leads to depressive symptoms in individuals at risk for depression. |
2022-11-25 |
2023-08-14 |
Not clear |
| Atul Kabra, Ruchika Garg, James Brimson, Jelena Živković, Saud Almawash, Muhammad Ayaz, Asif Nawaz, Syed Shams Ul Hassan, Simona Bunga. Mechanistic insights into the role of plant polyphenols and their nano-formulations in the management of depression. Frontiers in pharmacology. vol 13. 2022-11-24. PMID:36419621. |
selective serotonin reuptake inhibitors (ssris) monoamine oxidase (mao) inhibitors, tricyclic antidepressants (tcas), and atypical antidepressants are some of the conventional medications used to treat depression. |
2022-11-24 |
2023-08-14 |
Not clear |
| Yan Zhuang, Runying Zeng, Xiao Liu, Longhe Yang, Zhuhua Cha. Neoagaro-Oligosaccharides Ameliorate Chronic Restraint Stress-Induced Depression by Increasing 5-HT and BDNF in the Brain and Remodeling the Gut Microbiota of Mice. Marine drugs. vol 20. issue 11. 2022-11-24. PMID:36422003. |
neoagaro-oligosaccharides ameliorate chronic restraint stress-induced depression by increasing 5-ht and bdnf in the brain and remodeling the gut microbiota of mice. |
2022-11-24 |
2023-08-14 |
mouse |
| Yan Zhuang, Runying Zeng, Xiao Liu, Longhe Yang, Zhuhua Cha. Neoagaro-Oligosaccharides Ameliorate Chronic Restraint Stress-Induced Depression by Increasing 5-HT and BDNF in the Brain and Remodeling the Gut Microbiota of Mice. Marine drugs. vol 20. issue 11. 2022-11-24. PMID:36422003. |
anxiety and depression behaviors were assessed by open field tests (oft) and forced swimming tests (fst), while interleukin 18 (il-18), 5-hydroxytryptamine (5-ht) and brain-derived neurotrophic factor (bdnf) were the molecular biomarkers of depression. |
2022-11-24 |
2023-08-14 |
mouse |
| Marion Brow. The serotonin theory of depression and why we use antidepressants. The British journal of general practice : the journal of the Royal College of General Practitioners. vol 72. issue 725. 2022-11-24. PMID:36424166. |
the serotonin theory of depression and why we use antidepressants. |
2022-11-24 |
2023-08-14 |
Not clear |
| Satya Kumar Avula, Ajmal Khan, Sobia Ahsan Halim, Najeeb Ur Rehman, Nasiara Karim, Imran Khan, Rene Csuk, Biswanath Das, Ahmed Al-Harras. Synthesis and antidepressant-like effects of new 5-epi-incensole and 5-epi- incensole acetate in chronic unpredictable mild stress model of depression; behavioural and biochemical correlates. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 156. 2022-11-22. PMID:36411640. |
taken together these data revealed that compounds 3 and 5 exerted antidepressant-like effects in chronic unpredictable mild stress-induced depression paradigm and are likely mediated via modulating the central oxidative stress, mao-a activity with a consequent increase in brain na and 5-ht levels in inflammatory pathways. |
2022-11-22 |
2023-08-14 |
mouse |
| Elizabeth M Knapp, Andrea Kaiser, Rebecca C Arnold, Maureen M Sampson, Manuela Ruppert, Li Xu, Matthew I Anderson, Shivan L Bonanno, Henrike Scholz, Jeffrey M Donlea, David E Krant. Mutation of the Drosophila melanogaster serotonin transporter dSERT impacts sleep, courtship, and feeding behaviors. PLoS genetics. vol 18. issue 11. 2022-11-21. PMID:36409783. |
the serotonin transporter (sert) regulates extracellular serotonin levels and is the target of most current drugs used to treat depression. |
2022-11-21 |
2023-08-14 |
drosophila_melanogaster |
| Amanda J Sales, Izaque S Maciel, Carlos C Crestani, Francisco S Guimarães, Sâmia Rl Joc. S-adenosyl-l-methionine antidepressant-like effects involve activation of 5-HT Neurochemistry international. 2022-11-19. PMID:36402294. |
s-adenosyl-l-methionine antidepressant-like effects involve activation of 5-ht s-adenosyl-l-methionine (same), a methyl donor, induces antidepressant effects in preclinical and clinical studies of depression. |
2022-11-19 |
2023-08-14 |
mouse |
| Julie Yi, Justin Lu, Annie Yang, Elisabeth Breese Mars. In-hospital predictors of post-stroke depression for targeted initiation of Selective Serotonin Reuptake Inhibitors (SSRIs). BMC psychiatry. vol 22. issue 1. 2022-11-19. PMID:36402974. |
in-hospital predictors of post-stroke depression for targeted initiation of selective serotonin reuptake inhibitors (ssris). |
2022-11-19 |
2023-08-14 |
Not clear |
| Salar Vaseghi, Ali Mostafavijabbari, Mohammad-Sadegh Alizadeh, Reza Ghaffarzadegan, Gita Kholghi, Mohammad-Reza Zarrindas. Intricate role of sleep deprivation in modulating depression: focusing on BDNF, VEGF, serotonin, cortisol, and TNF-α. Metabolic brain disease. 2022-11-18. PMID:36399239. |
intricate role of sleep deprivation in modulating depression: focusing on bdnf, vegf, serotonin, cortisol, and tnf-α. |
2022-11-18 |
2023-08-14 |
Not clear |
| K Gao, C-L Chen, X-Q Ke, Y-X Yu, S Chen, G-C Liu, H-F Wang, Y-J L. Ingestion of Beneficial microbes. 2022-11-15. PMID:36377577. |
certain probiotic strains have been revealed to improve depressive behaviours and the dysregulation of 5-hydroxytryptamine (5-ht) metabolism in depression. |
2022-11-15 |
2023-08-14 |
Not clear |
| Joanna Jastrzębska, Małgorzata Frankowska, Irena Smaga, Magdalena Hubalewska-Mazgaj, Agata Suder, Renata Pieniążek, Edmund Przegaliński, Małgorzata Fili. Evaluation of the 5-HT Pharmacological reports : PR. 2022-11-14. PMID:36374478. |
evaluation of the 5-ht epidemiological data indicate a high rate of comorbidity of depression and cocaine use disorder (cud). |
2022-11-14 |
2023-08-14 |
Not clear |
| Zoltan Rihmer, Péter Döme, Cornelius Katon. Serotonin and depression - a riposte to Moncrieff et al. (2022). Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 24. issue 3. 2022-11-10. PMID:36356194. |
serotonin and depression - a riposte to moncrieff et al. |
2022-11-10 |
2023-08-14 |
human |
| Zoltan Rihmer, Péter Döme, Cornelius Katon. Serotonin and depression - a riposte to Moncrieff et al. (2022). Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 24. issue 3. 2022-11-10. PMID:36356194. |
in their recently published systematic "umbrella" review, moncrieff and colleagues conclude that there is no consistent evidence that depression is caused by decreased serotonin activity in the central nervous system (cns). |
2022-11-10 |
2023-08-14 |
human |
| Zoltan Rihmer, Péter Döme, Cornelius Katon. Serotonin and depression - a riposte to Moncrieff et al. (2022). Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 24. issue 3. 2022-11-10. PMID:36356194. |
however, this paper - which was extensively publicized and received a lot of attention on the social media - can cause misunderstandings, since the serotonin hypothesis of depression in its original form (i.e. |
2022-11-10 |
2023-08-14 |
human |
| Zoltan Rihmer, Péter Döme, Cornelius Katon. Serotonin and depression - a riposte to Moncrieff et al. (2022). Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 24. issue 3. 2022-11-10. PMID:36356194. |
reduced serotonin activity in the cns = depression) formulated more than 50 years ago has been considered outdated for several decades. |
2022-11-10 |
2023-08-14 |
human |
| Zoltan Rihmer, Péter Döme, Cornelius Katon. Serotonin and depression - a riposte to Moncrieff et al. (2022). Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 24. issue 3. 2022-11-10. PMID:36356194. |
of the role of serotonin in the pathogenesis of depression may undermine confidence in ssris in many patients. |
2022-11-10 |
2023-08-14 |
human |
| Felix P Mayer, Marco Niello, Daniela Cintulova, Spyridon Sideromenos, Julian Maier, Yang Li, Simon Bulling, Oliver Kudlacek, Klaus Schicker, Hideki Iwamoto, Fei Deng, Jinxia Wan, Marion Holy, Rania Katamish, Walter Sandtner, Yulong Li, Daniela D Pollak, Randy D Blakely, Marko D Mihovilovic, Michael H Baumann, Harald H Sitt. Serotonin-releasing agents with reduced off-target effects. Molecular psychiatry. 2022-11-09. PMID:36352123. |
increasing extracellular levels of serotonin (5-ht) in the brain ameliorates symptoms of depression and anxiety-related disorders, e.g., social phobias and post-traumatic stress disorder. |
2022-11-09 |
2023-08-14 |
Not clear |