| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yilu Sun, Jia Zhao, Jianhui Ron. Dissecting the molecular mechanisms underlying the antidepressant activities of herbal medicines through the comprehensive review of the recent literatures. Frontiers in psychiatry. vol 13. 2023-01-09. PMID:36620687. |
the pathophysiology of depression is tightly regulated by the biosynthesis, transport and signaling of neurotransmitters [e.g., serotonin, norepinephrine, dopamine, or γ-aminobutyric acid (gaba)] in the central nervous system. |
2023-01-09 |
2023-08-14 |
Not clear |
| Mehjabeen Hossain, Suresh P Sulochana, Katie E Heath, Saif Mohammad Ishraq Bari, Parker Brewster, Jared Barnes, Azim Munivar, Glenn M Walker, David A Puleo, Thomas A Werfe. Interval delivery of 5HT Journal of biomedical materials research. Part A. 2023-01-06. PMID:36606344. |
interval delivery of 5ht there is an urgent unmet medical need to develop therapeutic options for the ~50% of depression patients suffering from treatment-resistant depression, which is difficult to treat with existing psycho- and pharmaco-therapeutic options. |
2023-01-06 |
2023-08-14 |
Not clear |
| Matthew Barela, Allen Wong, Rachel Chamberlai. Concussion and Psychological Effects: A Review of Recent Literature. Current sports medicine reports. vol 22. issue 1. 2023-01-06. PMID:36606633. |
primary treatment should focus on psychotherapy; however, other considerations may be warranted in certain cases, such as selective serotonin reuptake inhibitors for depression and tricyclic antidepressants and gabapentin for short-term cognitive symptom improvement. |
2023-01-06 |
2023-08-14 |
Not clear |
| Zhi-Zheng Wang, Chao Yi, Jun-Jie Huang, Teng-Fei Xu, Kang-Zhi Chen, Zu-Sheng Wang, Ya-Ping Xue, Jie-Lian Lu, Biao Nie, Ying-Jun Zhang, Chuan-Fei Jin, Ge-Fei Ha. Deciphering Nonbioavailable Substructures Improves the Bioavailability of Antidepressants by Serotonin Transporter. Journal of medicinal chemistry. 2023-01-04. PMID:36598095. |
serotonin transporter (sert) inhibitors are first-line drugs for major depression disorder, and improving their bioavailability may be able to decrease side-effects by reducing daily dose. |
2023-01-04 |
2023-08-14 |
Not clear |
| Parisa Ghanbari, Sanaz Khajehzadeh, Asieh Sayyed, Davood Raeisi, Omidreza Saleh. The effect of high intensity interval training with beetroot (Beta vulgaris) juice supplementation on serotonin and dopamine receptors expression, anxiety and depression in middle-aged diabetic rats. Avicenna journal of phytomedicine. vol 12. issue 6. 2022-12-30. PMID:36583177. |
the effect of high intensity interval training with beetroot (beta vulgaris) juice supplementation on serotonin and dopamine receptors expression, anxiety and depression in middle-aged diabetic rats. |
2022-12-30 |
2023-08-14 |
rat |
| Parisa Ghanbari, Sanaz Khajehzadeh, Asieh Sayyed, Davood Raeisi, Omidreza Saleh. The effect of high intensity interval training with beetroot (Beta vulgaris) juice supplementation on serotonin and dopamine receptors expression, anxiety and depression in middle-aged diabetic rats. Avicenna journal of phytomedicine. vol 12. issue 6. 2022-12-30. PMID:36583177. |
the aim of this study was to evaluate the effect of four weeks of high intensity interval training (hiit) with beetroot juice supplementation (bj) on serotonin and dopamine receptors in hippocampal tissue, as well as anxiety and depression in middle-aged diabetic rats. |
2022-12-30 |
2023-08-14 |
rat |
| Amy M Inkster, Chaini Konwar, Maria S Peñaherrera, Ursula Brain, Almas Khan, E Magda Price, Johanna M Schuetz, Élodie Portales-Casamar, Amber Burt, Carmen J Marsit, Cathy Vaillancourt, Tim F Oberlander, Wendy P Robinso. Profiling placental DNA methylation associated with maternal SSRI treatment during pregnancy. Scientific reports. vol 12. issue 1. 2022-12-30. PMID:36585414. |
selective serotonin reuptake inhibitors (ssris) for treatment of prenatal maternal depression have been associated with neonatal neurobehavioral disturbances, though the molecular mechanisms remain poorly understood. |
2022-12-30 |
2023-08-14 |
human |
| Hoda Mojiri-Forushani, Elham Khajehali, Maryam Adelipour, Asma Mohammad. Inhibitory effects of fluoxetine on the secretion of inflammatory mediators and JAK/STAT3 and JNK/TLR4 gene expression. Molecular biology reports. 2022-12-26. PMID:36571654. |
selective serotonin reuptake inhibitors (ssris) are the most common class of medicines used for the treatment of major depression. |
2022-12-26 |
2023-08-14 |
Not clear |
| Anna Portugalov, Hiba Zaidan, Inna Gaisler-Salomon, Cecilia J Hillard, Irit Akira. FAAH Inhibition Restores Early Life Stress-Induced Alterations in PFC microRNAs Associated with Depressive-Like Behavior in Male and Female Rats. International journal of molecular sciences. vol 23. issue 24. 2022-12-23. PMID:36555739. |
we compared the effects of treatment with the fatty acid amide hydrolase (faah) inhibitor urb597, and the selective serotonin reuptake inhibitor paroxetine, on els-induced depressive-like behavior and the expression of micrornas (mirs) associated with depression in the medial prefrontal cortex (mpfc), hippocampal ca1 area, lateral habenula and dorsal raphe in rats. |
2022-12-23 |
2023-08-14 |
rat |
| The people behind the papers - Carla Argañaraz, Tamara Adjimann and Mariano Soiza-Reilly. Development (Cambridge, England). vol 149. issue 24. 2022-12-23. PMID:36562284. |
serotonin neurons have been implicated in maladaptive neural mechanisms that could contribute to mental disorders such as depression and anxiety. |
2022-12-23 |
2023-08-14 |
Not clear |
| Debora Cutuli, Giacomo Giacovazzo, Davide Decandia, Roberto Coccurell. Alzheimer's disease and depression in the elderly: A trajectory linking gut microbiota and serotonin signaling. Frontiers in psychiatry. vol 13. 2022-12-19. PMID:36532180. |
alzheimer's disease and depression in the elderly: a trajectory linking gut microbiota and serotonin signaling. |
2022-12-19 |
2023-08-14 |
Not clear |
| Debora Cutuli, Giacomo Giacovazzo, Davide Decandia, Roberto Coccurell. Alzheimer's disease and depression in the elderly: A trajectory linking gut microbiota and serotonin signaling. Frontiers in psychiatry. vol 13. 2022-12-19. PMID:36532180. |
antidepressants (i.e., serotonin reuptake inhibitors) or tryptophan dietary supplementation have been shown to reduce amyloid β-loading, reinstate microbial diversity and reduce the abundance of bacterial taxa dominant in depression and alzheimer's disease. |
2022-12-19 |
2023-08-14 |
Not clear |
| Yang He, Bas Brouwers, Hesong Liu, Hailan Liu, Katherine Lawler, Edson Mendes de Oliveira, Dong-Kee Lee, Yongjie Yang, Aaron R Cox, Julia M Keogh, Elana Henning, Rebecca Bounds, Aliki Perdikari, Vikram Ayinampudi, Chunmei Wang, Meng Yu, Longlong Tu, Nan Zhang, Na Yin, Junying Han, Nikolas A Scarcelli, Zili Yan, Kristine M Conde, Camille Potts, Jonathan C Bean, Mengjie Wang, Sean M Hartig, Lan Liao, Jianming Xu, Inês Barroso, Jacek Mokrosinski, Yong Xu, I Sadaf Farooq. Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior. Nature medicine. 2022-12-19. PMID:36536256. |
serotonin reuptake inhibitors and receptor agonists are used to treat obesity, anxiety and depression. |
2022-12-19 |
2023-08-14 |
human |
| Veronica A Fabrizio, Christina V Lindsay, Maya Wilcox, Suyeon Hong, Tatyana Lynn, Errol R Norwitz, Kimberly A Yonkers, Vikki M Abraham. The serotonin reuptake inhibitor fluoxetine induces human fetal membrane sterile inflammation through p38 MAPK activation. Journal of reproductive immunology. vol 155. 2022-12-18. PMID:36528909. |
serotonin reuptake inhibitors (sris) are often used as first line therapy for depression and other psychiatric disorders. |
2022-12-18 |
2023-08-14 |
human |
| Djawad Radjabzadeh, Jos A Bosch, André G Uitterlinden, Aeilko H Zwinderman, M Arfan Ikram, Joyce B J van Meurs, Annemarie I Luik, Max Nieuwdorp, Anja Lok, Cornelia M van Duijn, Robert Kraaij, Najaf Ami. Gut microbiome-wide association study of depressive symptoms. Nature communications. vol 13. issue 1. 2022-12-06. PMID:36473852. |
these bacteria are known to be involved in the synthesis of glutamate, butyrate, serotonin and gamma amino butyric acid (gaba), which are key neurotransmitters for depression. |
2022-12-06 |
2023-08-14 |
human |
| Carla V Argañaraz, Tamara S Adjimann, Paula P Perissinotti, Mariano Soiza-Reill. Selective refinement of glutamate and GABA synapses on dorsal raphe 5-HT neurons during postnatal life. Development (Cambridge, England). 2022-12-02. PMID:36458556. |
serotonin (5-hydroxytryptamine, 5-ht) neurons are implicated in the etiology and therapeutics of anxiety and depression. |
2022-12-02 |
2023-08-14 |
mouse |
| Mark A Boyce, Emily L Durham, Sharon Kuo, Jane M Taylor, Rajiv Kishinchand, Amanda C LaRue, James J Cra. In utero Exposure to Selective Serotonin Re-uptake Inhibitor Affects Murine Mandibular Development. Orthodontics & craniofacial research. 2022-12-02. PMID:36458927. |
antidepressants, specifically selective serotonin re-uptake inhibitors (ssris), that alter serotonin metabolism are currently the most commonly prescribed drugs for the treatment of depression. |
2022-12-02 |
2023-08-14 |
Not clear |
| Jimin Lee, Sung Man Chan. Confounding by Indication in Studies of Selective Serotonin Reuptake Inhibitors. Psychiatry investigation. vol 19. issue 11. 2022-11-29. PMID:36444151. |
selective serotonin reuptake inhibitors (ssris) are used worldwide as the first-line pharmacological treatment for depression. |
2022-11-29 |
2023-08-14 |
Not clear |
| Sophia Keins, Jessica R Abramson, Akashleena Mallick, Juan Pablo Castello, Axana Rodriguez-Torres, Dominique Popescu, Danielle Hoffman, Christina Kourkoulis, M Edip Gurol, Steven M Greenberg, Christopher D Anderson, Anand Viswanathan, Jonathan Rosand, Alessandro Biff. Association of Depression Onset and Treatment With Blood Pressure Control After Intracerebral Hemorrhage. Stroke. 2022-11-29. PMID:36444719. |
we also investigated whether associations between depression after ich and bp measurements were mediated by treatment with selective serotonin reuptake inhibitors or norepinephrine-serotonin reuptake inhibitors antidepressants. |
2022-11-29 |
2023-08-14 |
Not clear |
| Duncan James McLauchlan, Thomas Lancaster, David Craufurd, David E J Linden, Anne E Rosse. Different depression: motivational anhedonia governs antidepressant efficacy in Huntington's disease. Brain communications. vol 4. issue 6. 2022-11-28. PMID:36440100. |
antidepressant efficacy is well-established for depression within the general population: a recent meta-analysis showed serotonin norepinephrine reuptake inhibitors, tricyclic antidepressants and mirtazapine outperformed other antidepressants. |
2022-11-28 |
2023-08-14 |
human |