| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Talia R Lester, Jessica E Herrmann, Yair Bannett, Rebecca M Gardner, Heidi M Feldman, Lynne C Huffma. Anxiety and Depression Treatment in Primary Care Pediatrics. Pediatrics. 2023-04-17. PMID:37066669. |
the objective of this study was to describe pcp care practices around prescription of selective serotonin reuptake inhibitors (ssri) for patients with anxiety and/or depression by using medical record review. |
2023-04-17 |
2023-08-14 |
Not clear |
| Konstantinos N Fountoulakis, Magdalini Ioannou, Mauricio Tohen, Bartholomeus C M Haarman, Carlos A Zarat. Antidepressant efficacy of cariprazine in bipolar disorder and the role of its pharmacodynamic properties: A hypothesis based on data. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 72. 2023-04-15. PMID:37060629. |
the original model suggests that a constellation of effects on different receptors is necessary and that serotonin reuptake inhibition does not appear to play a significant role in acute bipolar depression. |
2023-04-15 |
2023-08-14 |
Not clear |
| María Montserrat Somoza-Moncada, Francisco Javier Turrubiates-Hernández, José Francisco Muñoz-Valle, Jesús Alberto Gutiérrez-Brito, Saúl Alberto Díaz-Pérez, Adriana Aguayo-Arelis, Jorge Hernández-Bell. Vitamin D in Depression: A Potential Bioactive Agent to Reduce Suicide and Suicide Attempt Risk. Nutrients. vol 15. issue 7. 2023-04-13. PMID:37049606. |
among the beneficial mechanisms of vitamin d, it has been proposed that it may enhance serotonin synthesis and modulate proinflammatory cytokines since low serotonin levels and systemic inflammation have been associated with depression and suicide. |
2023-04-13 |
2023-08-14 |
Not clear |
| Qiaoyi Cui, Wei We. Comparison of the efficacy of Trazodone hydrochloride tablets alone and in combination with press-needles in the treatment of post-stroke depression. JPMA. The Journal of the Pakistan Medical Association. vol 73. issue 4. 2023-04-13. PMID:37052005. |
post treatment assessment revealed that after treatment, national institutes of health stroke scale scores, hamilton depression rating scale scores, serum 5-hydroxytryptamine and brain-derived neurotrophic factor levels of group b were lower than those of group a (all p<0.001). |
2023-04-13 |
2023-08-14 |
Not clear |
| Roland Grad, Mark H Ebel. Top 20 Research Studies of 2022 for Primary Care Physicians. American family physician. vol 107. issue 4. 2023-04-13. PMID:37054418. |
combination therapy using a selective serotonin reuptake inhibitor, serotonin-norepinephrine reuptake inhibitor, or tricyclic antidepressant with mirtazapine or trazodone is more effective than monotherapy for first-line treatment of acute severe depression and when monotherapy fails. |
2023-04-13 |
2023-08-14 |
Not clear |
| Colby E Witt, Sergio Mena, Jordan Holmes, Melinda Hersey, Anna Marie Buchanan, Brenna Parke, Rachel Saylor, Lauren E Honan, Shane N Berger, Sara Lumbreras, Frederik H Nijhout, Michael C Reed, Janet Best, James Fadel, Patrick Schloss, Thorsten Lau, Parastoo Hashem. Serotonin is a Common Thread Linking Different Classes of Antidepressants. Research square. 2023-04-10. PMID:37034599. |
our findings suggest that serotonin is a common thread that links clinically effective antidepressants, synergizing different theories of depression (synaptic plasticity, neurogenesis and the monoamine hypothesis). |
2023-04-10 |
2023-08-14 |
mouse |
| Harika Topal Önal, Derya Yetkin, Furkan Aya. Escitalopram's inflammatory effect on the mammalian macrophages and its intracellular mechanism of action. Progress in neuro-psychopharmacology & biological psychiatry. 2023-04-09. PMID:37031947. |
the majority of patients with depression are treated with antidepressant drugs that are in the serotonin reuptake inhibitor (ssri) group. |
2023-04-09 |
2023-08-14 |
Not clear |
| Yusuf Oloruntoyin Ayipo, Iqrar Ahmad, Chien Fung Chong, Nurul Amira Zainurin, Sani Yahaya Najib, Harun Patel, Mohd Nizam Mord. Carbazole derivatives as promising competitive and allosteric inhibitors of human serotonin transporter: computational pharmacology. Journal of biomolecular structure & dynamics. 2023-04-06. PMID:37021485. |
the human serotonin transporters (hserts) are neurotransmitter sodium symporters of the aminergic g protein-coupled receptors, regulating the synaptic serotonin and neuropharmacological processes related to neuropsychiatric disorders, notably, depression. |
2023-04-06 |
2023-08-14 |
human |
| Jiayue-Clara Jiang, Chenwen Hu, Andrew M McIntosh, Sonia Sha. Investigating the potential anti-depressive mechanisms of statins: a transcriptomic and Mendelian randomization analysis. Translational psychiatry. vol 13. issue 1. 2023-04-04. PMID:37015906. |
however, genetically proxied hmgcr inhibition was strongly associated with alterations in platelets (a prominent serotonin reservoir) and monocyte percentage, which have previously been implicated in depression. |
2023-04-04 |
2023-08-14 |
human |
| Xuelian Cui, Yongjuan Xu, Haiyan Zhu, Li Wang, Jun Zho. Long noncoding RNA NONHSAG045500 regulates serotonin transporter to ameliorate depressive-like behavior via the cAMP-PKA-CREB signaling pathway in a model of perinatal depression. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. vol 36. issue 1. 2023-03-30. PMID:36997170. |
long noncoding rna nonhsag045500 regulates serotonin transporter to ameliorate depressive-like behavior via the camp-pka-creb signaling pathway in a model of perinatal depression. |
2023-03-30 |
2023-08-14 |
Not clear |
| Jan Lazur, Kamil Hnatyk, Katarzyna Kała, Katarzyna Sułkowska-Ziaja, Bożena Muszyńsk. Discovering the Potential Mechanisms of Medicinal Mushrooms Antidepressant Activity: A Review. Antioxidants (Basel, Switzerland). vol 12. issue 3. 2023-03-29. PMID:36978872. |
currently, psychopharmacotherapy is based mainly on the monoamine theory, which states that depression is caused by an insufficient level of monoamines such as serotonin, norepinephrine, and/or dopamine. |
2023-03-29 |
2023-08-14 |
Not clear |
| Ayala Gover, Kareen Endrawes, Michal Molad, Karen Lavie-Nevo, Arieh Riski. The Effect of SSRI Exposure in Pregnancy on Early Respiratory and Metabolic Adaptation in Infants Born Preterm. Children (Basel, Switzerland). vol 10. issue 3. 2023-03-29. PMID:36980066. |
selective serotonin reuptake inhibitors (ssris) are increasingly used for maternal depression during pregnancy; however, their use has been linked to adverse effects in newborns. |
2023-03-29 |
2023-08-14 |
Not clear |
| Tomasz Pawlowski, Krzysztof Malyszczak, Dariusz Pawlak, Małgorzata Inglot, Małgorzata Zalewska, Anna Grzywacz, Marek Radkowski, Tomasz Laskus, Justyna Janocha-Litwin, Dorota Frydeck. HTR1A, TPH2, and 5-HTTLPR Polymorphisms and Their Impact on the Severity of Depressive Symptoms and on the Concentration of Tryptophan Catabolites during Hepatitis C Treatment with Pegylated Interferon-α2a and Oral Ribavirin (PEG-IFN-α2a/RBV). Cells. vol 12. issue 6. 2023-03-29. PMID:36980311. |
seeing that there are no data about associations between serotonin gene polymorphism and tryptophan catabolite concentration during peg-ifn-α2a treatment, the aim of the current study is to examine (a) the associations between polymorphisms within the htr1a, tph2, and 5-htt genes and the severity of depression symptoms and (b) the relationships among rs6295, rs4570625, and 5-httlpr rs25531polymorphisms and indoleamine 2,3-dioxygenase (ido) activity, as well as kynurenine (kyn), tryptophan (trp), kynurenic acid (ka), and anthranilic acid (aa) concentrations. |
2023-03-29 |
2023-08-14 |
Not clear |
| Soner Gök, Berfin Can Gök, Erkan Alataş, Hande Senol, Osman Zülkif Topa. Effects of Selective Serotonin Reuptake Inhibitor Treatment on Ovarian Reserves in Patients with Depression. Medicina (Kaunas, Lithuania). vol 59. issue 3. 2023-03-29. PMID:36984518. |
effects of selective serotonin reuptake inhibitor treatment on ovarian reserves in patients with depression. |
2023-03-29 |
2023-08-14 |
Not clear |
| Punya Sachdeva, Seongmin Ji, Shampa Ghosh, Soumya Ghosh, Manchala Raghunath, Hyunjin Kim, Rakesh Bhaskar, Jitendra Kumar Sinha, Sung Soo Ha. Plausible Role of Stem Cell Types for Treating and Understanding the Pathophysiology of Depression. Pharmaceutics. vol 15. issue 3. 2023-03-29. PMID:36986674. |
antidepressants manage clinical depression and function by modulating the serotonin, norepinephrine, and dopamine neurotransmitter levels in the brain. |
2023-03-29 |
2023-08-14 |
Not clear |
| Bence Bruncsics, Gabor Hullam, Bence Bolgar, Peter Petschner, Andras Millinghoffer, Kinga Gecse, Nora Eszlari, Xenia Gonda, Debra J Jones, Sorrel T Burden, Peter Antal, Bill Deakin, Gyorgy Bagdy, Gabriella Juhas. Genetic risk of depression is different in subgroups of dietary ratio of tryptophan to large neutral amino acids. Scientific reports. vol 13. issue 1. 2023-03-27. PMID:36973313. |
manipulation of intake of serotonin precursor tryptophan has been exploited to rapidly induce and alleviate depression symptoms. |
2023-03-27 |
2023-08-14 |
Not clear |
| Bence Bruncsics, Gabor Hullam, Bence Bolgar, Peter Petschner, Andras Millinghoffer, Kinga Gecse, Nora Eszlari, Xenia Gonda, Debra J Jones, Sorrel T Burden, Peter Antal, Bill Deakin, Gyorgy Bagdy, Gabriella Juhas. Genetic risk of depression is different in subgroups of dietary ratio of tryptophan to large neutral amino acids. Scientific reports. vol 13. issue 1. 2023-03-27. PMID:36973313. |
our aim was to investigate the effect of habitual tryptophan intake on mood symptoms and to determine the effect of risk variants on depression in those with high and low tryptophan intake in the whole genome and specifically in serotonin and kynurenine pathways. |
2023-03-27 |
2023-08-14 |
Not clear |
| Bence Bruncsics, Gabor Hullam, Bence Bolgar, Peter Petschner, Andras Millinghoffer, Kinga Gecse, Nora Eszlari, Xenia Gonda, Debra J Jones, Sorrel T Burden, Peter Antal, Bill Deakin, Gyorgy Bagdy, Gabriella Juhas. Genetic risk of depression is different in subgroups of dietary ratio of tryptophan to large neutral amino acids. Scientific reports. vol 13. issue 1. 2023-03-27. PMID:36973313. |
npbwr1 among serotonin genes and poli in kynurenine pathway genes were significantly associated with depression in the low but not in the high tlr group. |
2023-03-27 |
2023-08-14 |
Not clear |
| Bence Bruncsics, Gabor Hullam, Bence Bolgar, Peter Petschner, Andras Millinghoffer, Kinga Gecse, Nora Eszlari, Xenia Gonda, Debra J Jones, Sorrel T Burden, Peter Antal, Bill Deakin, Gyorgy Bagdy, Gabriella Juhas. Genetic risk of depression is different in subgroups of dietary ratio of tryptophan to large neutral amino acids. Scientific reports. vol 13. issue 1. 2023-03-27. PMID:36973313. |
our findings demonstrate a markedly distinct genetic risk profile for depression in groups with low and high dietary tlr, with association with serotonin and kynurenine pathway variants only in case of habitual food intake leading to low tlr. |
2023-03-27 |
2023-08-14 |
Not clear |
| Bence Bruncsics, Gabor Hullam, Bence Bolgar, Peter Petschner, Andras Millinghoffer, Kinga Gecse, Nora Eszlari, Xenia Gonda, Debra J Jones, Sorrel T Burden, Peter Antal, Bill Deakin, Gyorgy Bagdy, Gabriella Juhas. Genetic risk of depression is different in subgroups of dietary ratio of tryptophan to large neutral amino acids. Scientific reports. vol 13. issue 1. 2023-03-27. PMID:36973313. |
our results confirm the relevance of the serotonin hypothesis in understanding the neurobiological background of depression and highlight the importance of understanding its differential role in the context of environmental variables such as complexity of diet in influencing mental health, pointing towards emerging possibilities of personalised prevention and intervention in mood disorders in those who are genetically vulnerable. |
2023-03-27 |
2023-08-14 |
Not clear |