| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hua Min, Farrokh Alemi, Janusz Wojtusia. Selecting Antidepressants Based on Medical History and Stress Mechanism. Cureus. vol 15. issue 4. 2023-05-11. PMID:37168173. |
conclusions many studies have raised doubt about the serotonin hypothesis as the central mechanism for depression treatment. |
2023-05-11 |
2023-08-14 |
Not clear |
| Hua Min, Farrokh Alemi, Janusz Wojtusia. Selecting Antidepressants Based on Medical History and Stress Mechanism. Cureus. vol 15. issue 4. 2023-05-11. PMID:37168173. |
the identification of a wide range of predictors for prescribing antidepressants highlights the complexity of depression treatment and the need for individualized approaches that consider patients' comorbidities and previous treatments. the significant impact of comorbidities on the response to treatment makes it improbable that the mechanism of action of antidepressants is solely based on the serotonin hypothesis. |
2023-05-11 |
2023-08-14 |
Not clear |
| Shun Hao, Wantong Shi, Weiqi Liu, Qi-Yu Chen, Min Zhu. Multiple modulatory roles of serotonin in chronic pain and injury-related anxiety. Frontiers in synaptic neuroscience. vol 15. 2023-05-05. PMID:37143481. |
serotonin (5-ht) in the central nervous system (cns) has been recognized as an important neurotransmitter and neuromodulator which regulates various physiological functions, such as pain sensation, cognition, and emotions-especially anxiety and depression. |
2023-05-05 |
2023-08-14 |
Not clear |
| Patrizia Ambrogini, Davide Lattanzi, Marica Pagliarini, Michael Di Palma, Stefano Sartini, Riccardo Cuppini, Kjell Fuxe, Dasiel Oscar Borroto-Escuel. 5HT1AR-FGFR1 Heteroreceptor Complexes Differently Modulate GIRK Currents in the Dorsal Hippocampus and the Dorsal Raphe Serotonin Nucleus of Control Rats and of a Genetic Rat Model of Depression. International journal of molecular sciences. vol 24. issue 8. 2023-04-28. PMID:37108630. |
5ht1ar-fgfr1 heteroreceptor complexes differently modulate girk currents in the dorsal hippocampus and the dorsal raphe serotonin nucleus of control rats and of a genetic rat model of depression. |
2023-04-28 |
2023-08-14 |
rat |
| Hannah P Fricke, Laura L Hernande. The Serotonergic System and Bone Metabolism During Pregnancy and Lactation and the Implications of SSRI Use on the Maternal-Offspring Dyad. Journal of mammary gland biology and neoplasia. vol 28. issue 1. 2023-04-22. PMID:37086330. |
it is estimated that postpartum depression affects 10-15% of the population, and selective serotonin reuptake inhibitors (ssri) are often used as the first-line treatment. |
2023-04-22 |
2023-08-14 |
human |
| Chungsoo Kim, Dong Yun Lee, Jimyung Park, Su-Jin Yang, Eng Hooi Tan, Daniel-Prieto Alhambra, Yo Han Lee, Sangha Lee, Seong-Ju Kim, Jeewon Lee, Rae Woong Park, Yunmi Shi. Safety Outcomes of Selective Serotonin Reuptake Inhibitors in Adolescent Attention-Deficit/Hyperactivity Disorder with Comorbid Depression: The ASSURE Study - CORRIGENDUM. Psychological medicine. 2023-04-20. PMID:37078398. |
safety outcomes of selective serotonin reuptake inhibitors in adolescent attention-deficit/hyperactivity disorder with comorbid depression: the assure study - corrigendum. |
2023-04-20 |
2023-08-14 |
Not clear |
| Han Zhao, Yue Yin, Tong Lin, Wushuang Wang, Lan Gon. Administration of serotonin and norepinephrine reuptake inhibitors tends to have less ocular surface damage in a chronic stress-induced rat model of depression than selective serotonin reuptake inhibitors. Experimental eye research. 2023-04-20. PMID:37080380. |
administration of serotonin and norepinephrine reuptake inhibitors tends to have less ocular surface damage in a chronic stress-induced rat model of depression than selective serotonin reuptake inhibitors. |
2023-04-20 |
2023-08-14 |
human |
| Talia R Lester, Jessica E Herrmann, Yair Bannett, Rebecca M Gardner, Heidi M Feldman, Lynne C Huffma. Anxiety and Depression Treatment in Primary Care Pediatrics. Pediatrics. 2023-04-17. PMID:37066669. |
the objective of this study was to describe pcp care practices around prescription of selective serotonin reuptake inhibitors (ssri) for patients with anxiety and/or depression by using medical record review. |
2023-04-17 |
2023-08-14 |
Not clear |
| Konstantinos N Fountoulakis, Magdalini Ioannou, Mauricio Tohen, Bartholomeus C M Haarman, Carlos A Zarat. Antidepressant efficacy of cariprazine in bipolar disorder and the role of its pharmacodynamic properties: A hypothesis based on data. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 72. 2023-04-15. PMID:37060629. |
the original model suggests that a constellation of effects on different receptors is necessary and that serotonin reuptake inhibition does not appear to play a significant role in acute bipolar depression. |
2023-04-15 |
2023-08-14 |
Not clear |
| María Montserrat Somoza-Moncada, Francisco Javier Turrubiates-Hernández, José Francisco Muñoz-Valle, Jesús Alberto Gutiérrez-Brito, Saúl Alberto Díaz-Pérez, Adriana Aguayo-Arelis, Jorge Hernández-Bell. Vitamin D in Depression: A Potential Bioactive Agent to Reduce Suicide and Suicide Attempt Risk. Nutrients. vol 15. issue 7. 2023-04-13. PMID:37049606. |
among the beneficial mechanisms of vitamin d, it has been proposed that it may enhance serotonin synthesis and modulate proinflammatory cytokines since low serotonin levels and systemic inflammation have been associated with depression and suicide. |
2023-04-13 |
2023-08-14 |
Not clear |
| Qiaoyi Cui, Wei We. Comparison of the efficacy of Trazodone hydrochloride tablets alone and in combination with press-needles in the treatment of post-stroke depression. JPMA. The Journal of the Pakistan Medical Association. vol 73. issue 4. 2023-04-13. PMID:37052005. |
post treatment assessment revealed that after treatment, national institutes of health stroke scale scores, hamilton depression rating scale scores, serum 5-hydroxytryptamine and brain-derived neurotrophic factor levels of group b were lower than those of group a (all p<0.001). |
2023-04-13 |
2023-08-14 |
Not clear |
| Roland Grad, Mark H Ebel. Top 20 Research Studies of 2022 for Primary Care Physicians. American family physician. vol 107. issue 4. 2023-04-13. PMID:37054418. |
combination therapy using a selective serotonin reuptake inhibitor, serotonin-norepinephrine reuptake inhibitor, or tricyclic antidepressant with mirtazapine or trazodone is more effective than monotherapy for first-line treatment of acute severe depression and when monotherapy fails. |
2023-04-13 |
2023-08-14 |
Not clear |
| Colby E Witt, Sergio Mena, Jordan Holmes, Melinda Hersey, Anna Marie Buchanan, Brenna Parke, Rachel Saylor, Lauren E Honan, Shane N Berger, Sara Lumbreras, Frederik H Nijhout, Michael C Reed, Janet Best, James Fadel, Patrick Schloss, Thorsten Lau, Parastoo Hashem. Serotonin is a Common Thread Linking Different Classes of Antidepressants. Research square. 2023-04-10. PMID:37034599. |
our findings suggest that serotonin is a common thread that links clinically effective antidepressants, synergizing different theories of depression (synaptic plasticity, neurogenesis and the monoamine hypothesis). |
2023-04-10 |
2023-08-14 |
mouse |
| Harika Topal Önal, Derya Yetkin, Furkan Aya. Escitalopram's inflammatory effect on the mammalian macrophages and its intracellular mechanism of action. Progress in neuro-psychopharmacology & biological psychiatry. 2023-04-09. PMID:37031947. |
the majority of patients with depression are treated with antidepressant drugs that are in the serotonin reuptake inhibitor (ssri) group. |
2023-04-09 |
2023-08-14 |
Not clear |
| Yusuf Oloruntoyin Ayipo, Iqrar Ahmad, Chien Fung Chong, Nurul Amira Zainurin, Sani Yahaya Najib, Harun Patel, Mohd Nizam Mord. Carbazole derivatives as promising competitive and allosteric inhibitors of human serotonin transporter: computational pharmacology. Journal of biomolecular structure & dynamics. 2023-04-06. PMID:37021485. |
the human serotonin transporters (hserts) are neurotransmitter sodium symporters of the aminergic g protein-coupled receptors, regulating the synaptic serotonin and neuropharmacological processes related to neuropsychiatric disorders, notably, depression. |
2023-04-06 |
2023-08-14 |
human |
| Jiayue-Clara Jiang, Chenwen Hu, Andrew M McIntosh, Sonia Sha. Investigating the potential anti-depressive mechanisms of statins: a transcriptomic and Mendelian randomization analysis. Translational psychiatry. vol 13. issue 1. 2023-04-04. PMID:37015906. |
however, genetically proxied hmgcr inhibition was strongly associated with alterations in platelets (a prominent serotonin reservoir) and monocyte percentage, which have previously been implicated in depression. |
2023-04-04 |
2023-08-14 |
human |
| Xuelian Cui, Yongjuan Xu, Haiyan Zhu, Li Wang, Jun Zho. Long noncoding RNA NONHSAG045500 regulates serotonin transporter to ameliorate depressive-like behavior via the cAMP-PKA-CREB signaling pathway in a model of perinatal depression. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. vol 36. issue 1. 2023-03-30. PMID:36997170. |
long noncoding rna nonhsag045500 regulates serotonin transporter to ameliorate depressive-like behavior via the camp-pka-creb signaling pathway in a model of perinatal depression. |
2023-03-30 |
2023-08-14 |
Not clear |
| Jan Lazur, Kamil Hnatyk, Katarzyna Kała, Katarzyna Sułkowska-Ziaja, Bożena Muszyńsk. Discovering the Potential Mechanisms of Medicinal Mushrooms Antidepressant Activity: A Review. Antioxidants (Basel, Switzerland). vol 12. issue 3. 2023-03-29. PMID:36978872. |
currently, psychopharmacotherapy is based mainly on the monoamine theory, which states that depression is caused by an insufficient level of monoamines such as serotonin, norepinephrine, and/or dopamine. |
2023-03-29 |
2023-08-14 |
Not clear |
| Ayala Gover, Kareen Endrawes, Michal Molad, Karen Lavie-Nevo, Arieh Riski. The Effect of SSRI Exposure in Pregnancy on Early Respiratory and Metabolic Adaptation in Infants Born Preterm. Children (Basel, Switzerland). vol 10. issue 3. 2023-03-29. PMID:36980066. |
selective serotonin reuptake inhibitors (ssris) are increasingly used for maternal depression during pregnancy; however, their use has been linked to adverse effects in newborns. |
2023-03-29 |
2023-08-14 |
Not clear |
| Tomasz Pawlowski, Krzysztof Malyszczak, Dariusz Pawlak, Małgorzata Inglot, Małgorzata Zalewska, Anna Grzywacz, Marek Radkowski, Tomasz Laskus, Justyna Janocha-Litwin, Dorota Frydeck. HTR1A, TPH2, and 5-HTTLPR Polymorphisms and Their Impact on the Severity of Depressive Symptoms and on the Concentration of Tryptophan Catabolites during Hepatitis C Treatment with Pegylated Interferon-α2a and Oral Ribavirin (PEG-IFN-α2a/RBV). Cells. vol 12. issue 6. 2023-03-29. PMID:36980311. |
seeing that there are no data about associations between serotonin gene polymorphism and tryptophan catabolite concentration during peg-ifn-α2a treatment, the aim of the current study is to examine (a) the associations between polymorphisms within the htr1a, tph2, and 5-htt genes and the severity of depression symptoms and (b) the relationships among rs6295, rs4570625, and 5-httlpr rs25531polymorphisms and indoleamine 2,3-dioxygenase (ido) activity, as well as kynurenine (kyn), tryptophan (trp), kynurenic acid (ka), and anthranilic acid (aa) concentrations. |
2023-03-29 |
2023-08-14 |
Not clear |