| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoke Di, Meiyu Wan, Ya-Nan Bai, Fengjuan Lu, Minghui Zhao, Zhifei Zhang, Yang L. Exploring the mechanism of Icariin in the treatment of depression through BDNF-TrkB pathway based on network pharmacology. Naunyn-Schmiedeberg's archives of pharmacology. 2023-07-20. PMID:37470804. |
in a cums-induced depression model, we found that icariin could effectively improve depression-like behavior of mice, increase the expression of monoamine neurotransmitters 5-hydroxytryptamine, dopamine, and norepinephrine, decrease the secretion of inflammatory factors tumor necrosis factor-α, interleukin-6, and interleukin-1β, and upregulate the relative expression levels of bdnf, p-trkb/trkb, p-akt/akt, p-creb/creb, mapk3, mapk1, bcl-2, egfr, and mtor. |
2023-07-20 |
2023-08-14 |
mouse |
| Karina Bravo, Marcelo González-Ortiz, Sebastian Beltrán-Castillo, Daniela Cáceres, Jaime Eugení. Development of the Placenta and Brain Are Affected by Selective Serotonin Reuptake Inhibitor Exposure During Critical Periods. Advances in experimental medicine and biology. vol 1428. 2023-07-19. PMID:37466774. |
selective serotonin reuptake inhibitors (ssris) are usually prescribed to treat major depression and anxiety disorders. |
2023-07-19 |
2023-08-14 |
Not clear |
| Samina Bano, Humaira Sharif, Faiza Sajid, Sumaiya Binte Hamid, Abdulla A-B Badaw. Liver tryptophan 2,3-dioxygenase: a determinant of anxiety-like behaviour - studies with chronic nicotine administration in rats. Behavioural pharmacology. 2023-07-18. PMID:37462143. |
the present study aimed to examine the relationship between behavioural measures of anxiety and depression with liver tdo activity, brain tryptophan concentration and serotonin synthesis in rats treated chronically with nicotine. |
2023-07-18 |
2023-08-14 |
mouse |
| Yéssica P López-Echeverri, Kelly J Cardona-Londoño, Jhonny F Garcia-Aguirre, Mary Orrego-Cardoz. Effects of serotonin transporter and receptor polymorphisms on depression. Revista Colombiana de psiquiatria (English ed.). 2023-07-15. PMID:37453823. |
effects of serotonin transporter and receptor polymorphisms on depression. |
2023-07-15 |
2023-08-14 |
Not clear |
| Yéssica P López-Echeverri, Kelly J Cardona-Londoño, Jhonny F Garcia-Aguirre, Mary Orrego-Cardoz. Effects of serotonin transporter and receptor polymorphisms on depression. Revista Colombiana de psiquiatria (English ed.). 2023-07-15. PMID:37453823. |
serotonin is highly implicated in the regulation of emotional state and the execution of cognitive tasks, so much so that the serotonin transporter genes (5-htt, slc6a4) and the serotonin receptor genes (htr1a, htr1b, htr2a) have become the perfect candidates when studying the effects that these genes and their polymorphic variations have on depression characteristics. |
2023-07-15 |
2023-08-14 |
Not clear |
| Dat T N Ngo, Tho H Ho, Lam K Huynh, Trang T Nguye. The interplay of membrane fluidity, acyl chain order and area per lipid on the partitioning of two antidepressants paroxetine and sertraline. Soft matter. 2023-07-12. PMID:37435937. |
selective serotonin reuptake inhibitors (ssris) are among the popular drugs for treating depression and mental disorders. |
2023-07-12 |
2023-08-14 |
Not clear |
| Carla Fonseca, Miren Ettcheto, Joana Bicker, Maria José Fernandes, Amílcar Falcão, Antoni Camins, Ana Fortun. Under the umbrella of depression and Alzheimer's disease physiopathology: can cannabinoids be a dual-pleiotropic therapy? Ageing research reviews. 2023-07-06. PMID:37414155. |
besides the well-known imbalance of neurotransmitter levels, including serotonin, noradrenaline, dopamine and glutamate, recent scientific evidence highlights aberrant spine density, neuroinflammation, dysregulation of neurotrophic factor levels and formation of amyloid beta (aβ) peptides, as the main physiopathological mechanisms compromised in depression and ad. |
2023-07-06 |
2023-08-14 |
Not clear |
| Hanga Galfalvy, Eileen Shea, Jacqueline de Vegvar, Spiro Pantazatos, Yung-Yu Huang, Ainsley K Burke, M Elizabeth Sublette, Maria A Oquendo, Francesca Zanderigo, Jeffrey M Miller, J John Man. Brain serotonin 1A receptor binding: relationship to peripheral blood DNA methylation, recent life stress and childhood adversity in unmedicated major depression. The British journal of psychiatry : the journal of mental science. 2023-07-03. PMID:37395098. |
brain serotonin 1a receptor binding: relationship to peripheral blood dna methylation, recent life stress and childhood adversity in unmedicated major depression. |
2023-07-03 |
2023-08-14 |
Not clear |
| Osvaldo P Almeid. Stroke, depression, and self-harm in later life. Current opinion in psychiatry. 2023-07-03. PMID:37395333. |
to examine recently published results of randomized placebo-controlled trials investigating the clinical effects of selective serotonin reuptake inhibitors on the prevalence of clinically significant symptoms of depression and suicidal ideation after an acute stroke. |
2023-07-03 |
2023-08-14 |
Not clear |
| Alexander L W Smith, Catherine J Harmer, Philip J Cowen, Susannah E Murph. The Serotonin 1A (5-HT CNS drugs. 2023-06-29. PMID:37386328. |
the serotonin 1a (5-ht clinical depression is a common, debilitating and heterogenous disorder. |
2023-06-29 |
2023-08-14 |
Not clear |
| Yukun Chen, Qingze Fan, Yang Liu, Yue Shi, Hongli Lu. Cardiovascular toxicity induced by SSRIs: Analysis of spontaneous reports submitted to FAERS. Psychiatry research. vol 326. 2023-06-26. PMID:37364503. |
depression diagnoses have surged recently, and selective serotonin reuptake inhibitors (ssris) are the go-to treatment. |
2023-06-26 |
2023-08-14 |
Not clear |
| Jacqui Wis. Review that questioned serotonin theory of depression was flawed, say researchers. BMJ (Clinical research ed.). vol 381. 2023-06-20. PMID:37339807. |
review that questioned serotonin theory of depression was flawed, say researchers. |
2023-06-20 |
2023-08-14 |
Not clear |
| Na Ji, Mengzhu Lei, Yating Chen, Shaowen Tian, Chuanyu Li, Bo Zhan. How Oxidative Stress Induces Depression? ASN neuro. vol 15. 2023-06-18. PMID:37331994. |
fully uncovering the underlying mechanisms of os-induced depression is the first step towards the avenue, thus we summarize and expound possible downstream pathways of os, including mitochondrial impairment and related atp deficiency, neuroinflammation, central glutamate excitotoxicity, brain-derived neurotrophic factor/tyrosine receptor kinase b dysfunction and serotonin deficiency, the microbiota-gut-brain axis disturbance and hypothalamic-pituitary-adrenocortical axis dysregulation. |
2023-06-18 |
2023-08-14 |
Not clear |
| F Sánchez-Sánchez, B Ponce-Buj, A L Montejo-González, Y Sipán-Sarrión, A Gimeno-Marqués, A Merino-Gáme. [Impact of vortioxetine on sexual function compared to other antidepressants]. Semergen. vol 49. issue 7. 2023-06-17. PMID:37329592. |
to analyze the impact of the antidepressant vortioxetine on sexual function, compared to selective serotonin reuptake inhibitors (ssris) and mixed selective serotonin and norepinephrine reuptake inhibitors (irsn or dual) in patients with depression. |
2023-06-17 |
2023-08-14 |
Not clear |
| Marie Spies, Matej Murgaš, Chrysoula Vraka, Cecile Philippe, Gregor Gryglewski, Lukas Nics, Theresa Balber, Pia Baldinger-Melich, Annette M Hartmann, Dan Rujescu, Marcus Hacker, Edda Winkler-Pjrek, Dietmar Winkler, Rupert Lanzenberge. Impact of genetic variants within serotonin turnover enzymes on human cerebral monoamine oxidase A in vivo. Translational psychiatry. vol 13. issue 1. 2023-06-15. PMID:37322010. |
variants within the monoamine oxidase a (mao-a, maoa) and tryptophan hydroxylase 2 (tph2) genes, the main enzymes in cerebral serotonin (5-ht) turnover, affect risk for depression. |
2023-06-15 |
2023-08-14 |
human |
| Rif S El-Mallakh, Masoud Doroodgar, Omar H Elsayed, Neil Kidamb. The serotonin theory of depression. Molecular psychiatry. 2023-06-15. PMID:37322061. |
the serotonin theory of depression. |
2023-06-15 |
2023-08-14 |
Not clear |
| Lucie Bartova, Rupert Lanzenberger, Dan Rujescu, Siegfried Kaspe. Reply to: "The serotonin theory of depression: a systematic umbrella review of the evidence" published by Moncrieff J, Cooper RE, Stockmann T, Amendola S, Hengartner MP, Horowitz MA in Molecular Psychiatry (2022 Jul 20. doi: 10.1038/s41380-022-01661-0). Molecular psychiatry. 2023-06-15. PMID:37322062. |
reply to: "the serotonin theory of depression: a systematic umbrella review of the evidence" published by moncrieff j, cooper re, stockmann t, amendola s, hengartner mp, horowitz ma in molecular psychiatry (2022 jul 20. doi: 10.1038/s41380-022-01661-0). |
2023-06-15 |
2023-08-14 |
Not clear |
| Joanna Moncrieff, Ruth E Cooper, Tom Stockmann, Simone Amendola, Michael P Hengartner, Martin Plöderl, Mark A Horowit. The serotonin hypothesis of depression: both long discarded and still supported? Molecular psychiatry. 2023-06-15. PMID:37322064. |
the serotonin hypothesis of depression: both long discarded and still supported? |
2023-06-15 |
2023-08-14 |
Not clear |
| Shuchang Zhao, Kiryl D Piatkevic. Techniques for in vivo serotonin detection in the brain: State of the art. Journal of neurochemistry. 2023-06-09. PMID:37293767. |
disruptions in serotonin signaling underlie neuropsychiatric conditions such as depression and anxiety. |
2023-06-09 |
2023-08-14 |
Not clear |
| Carla S S Ferreira, Sandra C Soares, Peter Kille, Miguel Oliveir. Identifying knowledge gaps in understanding the effects of selective serotonin reuptake inhibitors (SSRIs) on fish behaviour. Chemosphere. 2023-06-07. PMID:37285976. |
selective serotonin reuptake inhibitors (ssris) are a class of antidepressants increasingly prescribed to treat patients with clinical depression. |
2023-06-07 |
2023-08-14 |
Not clear |