| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thomas J Feuerstei. Presynaptic receptors for dopamine, histamine, and serotonin. Handbook of experimental pharmacology. issue 184. 2008-02-20. PMID:18064418. |
upregulation of presynaptic serotonin autoreceptors is probably involved in the pathogenesis of major depression. |
2008-02-20 |
2023-08-12 |
Not clear |
| H Silva, P Iturra, A Solari, J Villarroel, S Jerez, W Vielma, C Montes, L Pumarino, N Ro. Serotonin transporter polymorphism and fluoxetine effect on impulsiveness and aggression in borderline personality disorder. Actas espanolas de psiquiatria. vol 35. issue 6. 2008-02-19. PMID:17597424. |
the short allele (s) in depression is associated to a worse response to selective serotonin reuptake inhibitors (ssri). |
2008-02-19 |
2023-08-12 |
Not clear |
| Xenia Borue, John Chen, Barry G Condro. Developmental effects of SSRIs: lessons learned from animal studies. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 25. issue 6. 2008-02-19. PMID:17706396. |
selective serotonin reuptake inhibitors (ssris) are utilized in the treatment of depression in pregnant and lactating women. |
2008-02-19 |
2023-08-12 |
Not clear |
| Henrik Dam, Erling T Mellerup, Per Plenge, Rosa Winther, Gitta Wörtwei. The serotonin transporter and 5HT2A receptor in rat brain after localized lesions. Neurological research. vol 29. issue 7. 2008-02-19. PMID:17711618. |
the development of depression may include the serotonergic system because selective serotonin reuptake inhibitors (ssris) can be used to treat the depression. |
2008-02-19 |
2023-08-12 |
rat |
| Cullen L Schmid, Kirsten M Raehal, Laura M Boh. Agonist-directed signaling of the serotonin 2A receptor depends on beta-arrestin-2 interactions in vivo. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 3. 2008-02-12. PMID:18195357. |
our study suggests that the 5-ht2ar-beta-arrestin interaction may be particularly important in receptor function in response to endogenous serotonin levels, which could have major implications in drug development for treating neuropsychiatric disorders such as depression and schizophrenia. |
2008-02-12 |
2023-08-12 |
mouse |
| Johan Lundberg, Jacqueline Borg, Christer Halldin, Lars Fard. A PET study on regional coexpression of 5-HT1A receptors and 5-HTT in the human brain. Psychopharmacology. vol 195. issue 3. 2008-02-08. PMID:17874074. |
several lines of evidence suggest inter-dependency between the serotonin transporter (5-htt) and the 5ht1a receptor, two recognised targets for the treatment of anxiety and depression. |
2008-02-08 |
2023-08-12 |
human |
| Alessandro Serretti, Masaki Kat. The serotonin transporter gene and effectiveness of SSRIs. Expert review of neurotherapeutics. vol 8. issue 1. 2008-02-08. PMID:18088204. |
among these, gene variants in sequences of serotonin pathway proteins were candidates, both for the well-known evidence of its involvement in the development of depressive symptoms and for the worldwide use of selective serotonin reuptake inhibitors as first-choice treatment of depression. |
2008-02-08 |
2023-08-12 |
Not clear |
| Giorgio Racagni, Marco A Riva, Maurizio Popol. The interaction between the internal clock and antidepressant efficacy. International clinical psychopharmacology. vol 22 Suppl 2. 2008-02-07. PMID:17917564. |
in animals, agomelatine was shown to increase noradrenaline and dopamine (but not serotonin) in the frontal cortex, to resynchronize the sleep-wake cycle in models with disrupted circadian rhythms, and to exhibit a clear antidepressant effect in various animal models of depression. |
2008-02-07 |
2023-08-12 |
Not clear |
| Udo Dannlowski, Patricia Ohrmann, Jochen Bauer, Jürgen Deckert, Christa Hohoff, Harald Kugel, Volker Arolt, Walter Heindel, Anette Kersting, Bernhard T Baune, Thomas Suslo. 5-HTTLPR biases amygdala activity in response to masked facial expressions in major depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 2. 2008-02-06. PMID:17406646. |
this might indicate that genetic variations of the serotonin transporter could increase the risk for depression chronification via altering limbic neural activity on a preattentive level of emotion processing. |
2008-02-06 |
2023-08-12 |
human |
| Samuel Estrada-Soto, Antonino Rodríguez-Avilez, Cindy Castañeda-Avila, Patricia Castillo-España, Gabriel Navarrete-Vázquez, Lourdes Hernández, Francisco Aguirre-Cresp. Spasmolytic action of Lepechinia caulescens is through calcium channel blockade and NO release. Journal of ethnopharmacology. vol 114. issue 3. 2008-02-05. PMID:17913415. |
tc-melc also (ic50 11.2microg/ml) induced a marked depression on cumulative concentration-response curve for carbachol (emax=2.3+/-0.3g vs. 0.66+/-0.1g) and serotonin (emax=1.1+/-0.3g vs. -0.01+/-0.09g). |
2008-02-05 |
2023-08-12 |
rat |
| Ipek Yalcin, Fazilet Aksu, Sylvie Bodard, Sylvie Chalon, Catherine Belzun. Antidepressant-like effect of tramadol in the unpredictable chronic mild stress procedure: possible involvement of the noradrenergic system. Behavioural pharmacology. vol 18. issue 7. 2008-01-29. PMID:17912046. |
tramadol, which inhibits the reuptake of noradrenaline and serotonin, is effective in animal models of depression. |
2008-01-29 |
2023-08-12 |
mouse |
| Trevor Sharp, Laura Boothman, Josie Raley, Philip Quéré. Important messages in the 'post': recent discoveries in 5-HT neurone feedback control. Trends in pharmacological sciences. vol 28. issue 12. 2008-01-29. PMID:17996955. |
the neurotransmitter 5-hydroxytryptamine (5-ht, serotonin) mediates important brain functions and contributes to the pathophysiology and successful drug treatment of many common psychiatric disorders, especially depression. |
2008-01-29 |
2023-08-12 |
Not clear |
| Trevor Sharp, Laura Boothman, Josie Raley, Philip Quéré. Important messages in the 'post': recent discoveries in 5-HT neurone feedback control. Trends in pharmacological sciences. vol 28. issue 12. 2008-01-29. PMID:17996955. |
this article discusses current knowledge of the pharmacology and physiology of these new found 5-ht feedback mechanisms and considers their possible contribution to depression pathophysiology and utility as a resource of novel antidepressant drug strategies. |
2008-01-29 |
2023-08-12 |
Not clear |
| T Ushiroyama, A Ikeda, M Uek. Evaluation of double-blind comparison of fluvoxamine and paroxetine in the treatment of depressed outpatients in menopause transition. Journal of medicine. vol 35. issue 1-6. 2008-01-29. PMID:18084873. |
to evaluate the efficacy of the selective serotonin reuptake inhibitors (ssris) fluvoxamine and paroxetine in treating depression in the menopausal transition and to compare their efficacy, safety, side-effect profiles and drug compliance. |
2008-01-29 |
2023-08-12 |
Not clear |
| Glen I Spielman. Duloxetine does not relieve painful physical symptoms in depression: a meta-analysis. Psychotherapy and psychosomatics. vol 77. issue 1. 2008-01-29. PMID:18087203. |
duloxetine inhibits both serotonin and norepinephrine reuptake and is marketed as a treatment for both the core emotional symptoms and painful physical complaints that often accompany depression. |
2008-01-29 |
2023-08-12 |
Not clear |
| Zubin Bhagwagar, Naga Murthy, Sudhakar Selvaraj, Rainer Hinz, Matthew Taylor, Sabrina Fancy, Paul Grasby, Philip Cowe. 5-HTT binding in recovered depressed patients and healthy volunteers: a positron emission tomography study with [11C]DASB. The American journal of psychiatry. vol 164. issue 12. 2008-01-25. PMID:18056241. |
the serotonin transporter (5-htt) is a key target for selective serotonin reuptake inhibitors and may be involved in the pathophysiology of major depression. |
2008-01-25 |
2023-08-12 |
human |
| Olga A Sergeeva, Bettina T Amberger, Helmut L Haa. Editing of AMPA and serotonin 2C receptors in individual central neurons, controlling wakefulness. Cellular and molecular neurobiology. vol 27. issue 5. 2008-01-22. PMID:17554622. |
(1) pre-mrna editing of serotonin 2c (5-ht2c) and glutamate (glu) receptors (r) influences higher brain functions and pathological states such as epilepsy, amyotrophic lateral sclerosis, and depression. |
2008-01-22 |
2023-08-12 |
rat |
| Jarosław Sawiniec, Krzysztof Borkowski, Grazyna Ginalska, Hanna Lewandowska-Stane. Association between 5-hydroxytryptamine 1A receptor gene polymorphism and suicidal behavior. Przeglad lekarski. vol 64. issue 4-5. 2008-01-22. PMID:17724868. |
drugs targeting serotonin receptors like serotonin reuptake inhibitors (ssris) are useful in the present therapy of anxiety and depression. |
2008-01-22 |
2023-08-12 |
human |
| Brian A McMillen, J Elizabeth Shank, Kirstin B Jordan, Helen L Williams, A S Basil. Effect of DOV 102,677 on the volitional consumption of ethanol by Myers' high ethanol-preferring rat. Alcoholism, clinical and experimental research. vol 31. issue 11. 2008-01-22. PMID:17908267. |
however, the evidence that single (serotonin) or dual (serotonin-norepinephrine) neurotransmitter uptake inhibitors can treat ethanol abuse, either as a comorbidity with depression or as a separate entity, is inconsistent. |
2008-01-22 |
2023-08-12 |
rat |
| N Müller, M J Schwar. [Immunological aspects of depressive disorders]. Der Nervenarzt. vol 78. issue 11. 2008-01-15. PMID:17928982. |
the increased consumption of serotonin and its precursor tryptophan due to ido activation may explain the reduced availability of serotonin in depression. |
2008-01-15 |
2023-08-12 |
Not clear |