| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Reimold, A Batra, A Knobel, M N Smolka, A Zimmer, K Mann, C Solbach, G Reischl, F Schwärzler, G Gründer, H-J Machulla, R Bares, A Hein. Anxiety is associated with reduced central serotonin transporter availability in unmedicated patients with unipolar major depression: a [11C]DASB PET study. Molecular psychiatry. vol 13. issue 6. 2008-08-06. PMID:18268503. |
in the thalamus, a low serotonin reuptake capacity may interfere with thalamic control of cortical excitability and contribute to anxiety rather than depression per se in major depression. |
2008-08-06 |
2023-08-12 |
human |
| David Devos, Kathy Dujardin, Isabelle Poirot, Caroline Moreau, Olivier Cottencin, Pierre Thomas, Alain Destée, Regis Bordet, Luc Defebvr. Comparison of desipramine and citalopram treatments for depression in Parkinson's disease: a double-blind, randomized, placebo-controlled study. Movement disorders : official journal of the Movement Disorder Society. vol 23. issue 6. 2008-08-06. PMID:18311826. |
we sought to establish whether antidepressants provide real benefits and whether tricyclic and selective serotonin reuptake inhibitor (ssri) antidepressants differ in their short-term efficacy, because the time to onset of therapeutic benefit remains an important criterion in depression. |
2008-08-06 |
2023-08-12 |
Not clear |
| S Landy, J McGinnis, D Curlin, S C Laizur. Selective serotonin reuptake inhibitors for migraine prophylaxis. Headache. vol 39. issue 1. 2008-08-01. PMID:15613191. |
the authors believe that the selective serotonin reuptake inhibitors are not as effective as conventional migraine prophylaxis medications such as beta-blockers, tricyclic antidepressants, or divalproex sodium, but that in patients with comorbid depression who have failed conventional therapy selective serotonin reuptake inhibitors may be effective. |
2008-08-01 |
2023-08-12 |
human |
| Norbert Müller, Markus J Schwar. A psychoneuroimmunological perspective to Emil Kraepelins dichotomy: schizophrenia and major depression as inflammatory CNS disorders. European archives of psychiatry and clinical neuroscience. vol 258 Suppl 2. 2008-08-01. PMID:18516521. |
these mechanisms include the immunological balance between type-1 and type-2 immune activation which influences the tryptophan-degradating enzyme indoleamine 2,3-dioxygenase (ido) in the cns in opposite ways, leading to an altered availability of tryptophan and serotonin, and a disturbance of the kynurenine metabolism with an imbalance in favor of the production of the nmda-receptor agonist quinolinic acid in depression and of the nmda-receptor antagonist kynurenic acid in schizophrenia. |
2008-08-01 |
2023-08-12 |
Not clear |
| Anita J Bechtholt, Karen Smith, Stephanie Gaughan, Irwin Luck. Sucrose intake and fasting glucose levels in 5-HT(1A) and 5-HT(1B) receptor mutant mice. Physiology & behavior. vol 93. issue 4-5. 2008-07-31. PMID:18155098. |
serotonin (5-ht)(1a) and 5-ht(1b) receptors have been implicated in the incidence and treatment of depression in part through the examination of animals lacking these receptors. |
2008-07-31 |
2023-08-12 |
mouse |
| Andrea M Allan, Xiaomin Liang, Yuping Luo, Changhui Pak, Xuekun Li, Keith E Szulwach, Dahua Chen, Peng Jin, Xinyu Zha. The loss of methyl-CpG binding protein 1 leads to autism-like behavioral deficits. Human molecular genetics. vol 17. issue 13. 2008-07-23. PMID:18385101. |
here we show that mbd1 mutant (mbd1(-/-)) mice exhibit several core deficits frequently associated with autism, including reduced social interaction, learning deficits, anxiety, defective sensory motor gating, depression and abnormal brain serotonin activity. |
2008-07-23 |
2023-08-12 |
mouse |
| Masaki Kato, Masataka Wakeno, Gaku Okugawa, Tsuyoshi Fukuda, Yoshiteru Takekita, Yuka Hosoi, Junichi Azuma, Toshihiko Kinoshita, Alessandro Serrett. Antidepressant response and intolerance to SSRI is not influenced by G-protein beta3 subunit gene C825T polymorphism in Japanese major depressive patients. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 4. 2008-07-22. PMID:18325652. |
the aim of the present study is to test a possible effect of the c825t polymorphism on the antidepressant response and intolerance to selective serotonin reuptake inhibitors (ssris) in 146 japanese samples with major depression treated with paroxetine or fluvoxamine for 6 weeks. |
2008-07-22 |
2023-08-12 |
human |
| J D A Olivier, M G C Van Der Hart, R P L Van Swelm, P J Dederen, J R Homberg, T Cremers, P M T Deen, E Cuppen, A R Cools, B A Ellenbroe. A study in male and female 5-HT transporter knockout rats: an animal model for anxiety and depression disorders. Neuroscience. vol 152. issue 3. 2008-07-21. PMID:18295409. |
a study in male and female 5-ht transporter knockout rats: an animal model for anxiety and depression disorders. |
2008-07-21 |
2023-08-12 |
human |
| J D A Olivier, M G C Van Der Hart, R P L Van Swelm, P J Dederen, J R Homberg, T Cremers, P M T Deen, E Cuppen, A R Cools, B A Ellenbroe. A study in male and female 5-HT transporter knockout rats: an animal model for anxiety and depression disorders. Neuroscience. vol 152. issue 3. 2008-07-21. PMID:18295409. |
human studies have shown that a reduction of 5-ht transporter (sert) increases the vulnerability for anxiety and depression. |
2008-07-21 |
2023-08-12 |
human |
| Anita Must, Szatmár Horváth, Zoltán Jank. [Affective and cognitive decision making in major depression: influence of the prefrontal cortex, serotonin transporter genotype and personality traits]. Ideggyogyaszati szemle. vol 61. issue 5-6. 2008-07-18. PMID:18567393. |
[affective and cognitive decision making in major depression: influence of the prefrontal cortex, serotonin transporter genotype and personality traits]. |
2008-07-18 |
2023-08-12 |
Not clear |
| Hiroki Sato, Ivan Skelin, Guy Debonnel, Mirko Diksi. Chronic buspirone treatment normalizes open field behavior in olfactory bulbectomized rats: assessment with a quantitative autoradiographic evaluation of the 5-HT1A binding sites. Brain research bulletin. vol 75. issue 5. 2008-07-10. PMID:18355630. |
from these observations, we conclude that the antidepressant effects of buspirone in the obx rat model of depression are likely mediated through the fine tuning of the regional imbalance of 5-ht(1a) receptors with even increases of about 20% in some limbic regions. |
2008-07-10 |
2023-08-12 |
human |
| David J Nut. Relationship of neurotransmitters to the symptoms of major depressive disorder. The Journal of clinical psychiatry. vol 69 Suppl E1. 2008-07-10. PMID:18494537. |
owing to the different methods of action of available antidepressant agents and the depression symptoms thought to be associated with dopamine, serotonin, and norepinephrine, current treatments can be targeted toward patients' specific symptoms. |
2008-07-10 |
2023-08-12 |
Not clear |
| George I Papakosta. Tolerability of modern antidepressants. The Journal of clinical psychiatry. vol 69 Suppl E1. 2008-07-10. PMID:18494538. |
this article compares the rates of common tolerability-related side effects among the newer (post-tricyclic era) antidepressants with the selective serotonin reuptake inhibitors, the most popular contemporary first-line treatment for depression. |
2008-07-10 |
2023-08-12 |
Not clear |
| Zvi Zemishlany, Abraham Weizma. The impact of mental illness on sexual dysfunction. Advances in psychosomatic medicine. vol 29. 2008-07-08. PMID:18391559. |
depression and anxiety are a cause for sexual dysfunction that may be aggravated by antidepressants, especially selective serotonin reuptake inhibitors (ssris). |
2008-07-08 |
2023-08-12 |
Not clear |
| C P Bots, A van Nieuw Amerongen, H S Bran. [Painful palate and xerostomia after using paroxetine]. Nederlands tijdschrift voor tandheelkunde. vol 115. issue 5. 2008-07-08. PMID:18543695. |
this article presents the case of a 58-year-old woman with diabetes mellitus type 2 who, for one and a half years, had been using paroxetine, a specific serotonin re-uptake inhibitor, to reduce a depression. |
2008-07-08 |
2023-08-12 |
Not clear |
| H Bach-Mizrachi, M D Underwood, A Tin, S P Ellis, J J Mann, V Arang. Elevated expression of tryptophan hydroxylase-2 mRNA at the neuronal level in the dorsal and median raphe nuclei of depressed suicides. Molecular psychiatry. vol 13. issue 5. 2008-07-03. PMID:18180753. |
deficient levels of serotonin are associated with suicide and depression. |
2008-07-03 |
2023-08-12 |
Not clear |
| Kuan-Pin S. Mind-body interface: the role of n-3 fatty acids in psychoneuroimmunology, somatic presentation, and medical illness comorbidity of depression. Asia Pacific journal of clinical nutrition. vol 17 Suppl 1. 2008-07-02. PMID:18296325. |
with the unsatisfaction of monoamine-based pharmacotherapy and the high comorbidity of other medical illness in depression, the serotonin hypothesis seems to fail in approaching the aetiology of depression. |
2008-07-02 |
2023-08-12 |
human |
| Kuan-Pin S. Mind-body interface: the role of n-3 fatty acids in psychoneuroimmunology, somatic presentation, and medical illness comorbidity of depression. Asia Pacific journal of clinical nutrition. vol 17 Suppl 1. 2008-07-02. PMID:18296325. |
dha deficit is associated with dysfunctions of neuronal membrane stability and transmission of serotonin, norepinephrine and dopamine, which might connect to the aetiology of mood and cognitive dysfunction of depression. |
2008-07-02 |
2023-08-12 |
human |
| Beverly H Brummett, Stephen H Boyle, Ilene C Siegler, Cynthia M Kuhn, Allison Ashley-Koch, Charles R Jonassaint, Stephan Züchner, Ann Collins, Redford B William. Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR). Behavior genetics. vol 38. issue 1. 2008-07-01. PMID:17955359. |
effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-httlpr). |
2008-07-01 |
2023-08-12 |
human |
| Beverly H Brummett, Stephen H Boyle, Ilene C Siegler, Cynthia M Kuhn, Allison Ashley-Koch, Charles R Jonassaint, Stephan Züchner, Ann Collins, Redford B William. Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR). Behavior genetics. vol 38. issue 1. 2008-07-01. PMID:17955359. |
the short (s) variant of the serotonin transporter (5-htt) gene linked functional polymorphic region (5-httlpr) is associated with depression. |
2008-07-01 |
2023-08-12 |
human |