| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paul R Albert, Chawki Benkelfat, Laurent Descarrie. The neurobiology of depression--revisiting the serotonin hypothesis. I. Cellular and molecular mechanisms. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 367. issue 1601. 2012-12-06. PMID:22826338. |
the neurobiology of depression--revisiting the serotonin hypothesis. |
2012-12-06 |
2023-08-12 |
Not clear |
| Paul R Albert, Chawki Benkelfat, Laurent Descarrie. The neurobiology of depression--revisiting the serotonin hypothesis. I. Cellular and molecular mechanisms. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 367. issue 1601. 2012-12-06. PMID:22826338. |
the serotonin (5-ht) hypothesis of depression dates from the 1960s. |
2012-12-06 |
2023-08-12 |
Not clear |
| Paul R Alber. Transcriptional regulation of the 5-HT1A receptor: implications for mental illness. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 367. issue 1601. 2012-12-06. PMID:22826341. |
based on animal models, an integrated model for opposing roles of pre- and post-synaptic 5-ht(1a) receptors in anxiety and depression phenotypes and response to antidepressants is proposed. |
2012-12-06 |
2023-08-12 |
Not clear |
| Paul R Alber. Transcriptional regulation of the 5-HT1A receptor: implications for mental illness. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 367. issue 1601. 2012-12-06. PMID:22826341. |
targeted therapeutics to inhibit 5-ht(1a) autoreceptor expression and induce 5-ht(1a) heteroreceptor expression may ameliorate treatment of anxiety and major depression. |
2012-12-06 |
2023-08-12 |
Not clear |
| Jacob P R Jacobsen, Ivan O Medvedev, Marc G Caro. The 5-HT deficiency theory of depression: perspectives from a naturalistic 5-HT deficiency model, the tryptophan hydroxylase 2Arg439His knockin mouse. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 367. issue 1601. 2012-12-06. PMID:22826344. |
the 5-ht deficiency theory of depression: perspectives from a naturalistic 5-ht deficiency model, the tryptophan hydroxylase 2arg439his knockin mouse. |
2012-12-06 |
2023-08-12 |
mouse |
| Jacob P R Jacobsen, Ivan O Medvedev, Marc G Caro. The 5-HT deficiency theory of depression: perspectives from a naturalistic 5-HT deficiency model, the tryptophan hydroxylase 2Arg439His knockin mouse. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 367. issue 1601. 2012-12-06. PMID:22826344. |
a decreased level of brain 5-hydroxytryptamine (5-ht) has been theorized to be a core pathogenic factor in depression for half a century. |
2012-12-06 |
2023-08-12 |
mouse |
| Jacob P R Jacobsen, Ivan O Medvedev, Marc G Caro. The 5-HT deficiency theory of depression: perspectives from a naturalistic 5-HT deficiency model, the tryptophan hydroxylase 2Arg439His knockin mouse. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 367. issue 1601. 2012-12-06. PMID:22826344. |
still, a number of anomalies in putative biomarkers of central 5-ht function have been repeatedly reported in depression patients over the past 40 years, collectively indicating that 5-ht deficiency could be present in depression, particularly in severely ill and/or suicidal patients. |
2012-12-06 |
2023-08-12 |
mouse |
| Jacob P R Jacobsen, Ivan O Medvedev, Marc G Caro. The 5-HT deficiency theory of depression: perspectives from a naturalistic 5-HT deficiency model, the tryptophan hydroxylase 2Arg439His knockin mouse. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 367. issue 1601. 2012-12-06. PMID:22826344. |
this body of literature on putative 5-ht biomarker anomalies and depression has recently been corroborated by data demonstrating that such anomalies indeed occur consequent to severely reduced 5-ht(ext) levels in a mouse model of naturalistic 5-ht deficiency, the tryptophan hydroxylase 2 his(439) knockin (tph2ki) mouse. |
2012-12-06 |
2023-08-12 |
mouse |
| Jacob P R Jacobsen, Ivan O Medvedev, Marc G Caro. The 5-HT deficiency theory of depression: perspectives from a naturalistic 5-HT deficiency model, the tryptophan hydroxylase 2Arg439His knockin mouse. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 367. issue 1601. 2012-12-06. PMID:22826344. |
in this review, we will critically assess the evidence for 5-ht deficiency in depression and the possible role of polymorphisms in the tph2 gene as a causal factor in 5-ht deficiency, the latter investigated from a clinical as well as preclinical angle. |
2012-12-06 |
2023-08-12 |
mouse |
| Ute Renner, Andre Zeug, Andrew Woehler, Marcus Niebert, Alexander Dityatev, Galina Dityateva, Nataliya Gorinski, Daria Guseva, Dalia Abdel-Galil, Matthias Fröhlich, Frank Döring, Erhard Wischmeyer, Diethelm W Richter, Erwin Neher, Evgeni G Ponimaski. Heterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and trafficking. Journal of cell science. vol 125. issue Pt 10. 2012-12-03. PMID:22357950. |
serotonin receptors 5-ht(1a) and 5-ht(7) are highly coexpressed in brain regions implicated in depression. |
2012-12-03 |
2023-08-12 |
Not clear |
| Santiago Perez-Lloret, Olivier Rasco. Parkinson disease: Serotonin reuptake inhibitors for depression in PD. Nature reviews. Neurology. vol 8. issue 7. 2012-12-03. PMID:22664785. |
parkinson disease: serotonin reuptake inhibitors for depression in pd. |
2012-12-03 |
2023-08-12 |
Not clear |
| Alison Wood, Ross Runciman, Kevan R Wylie, Ross McManu. An update on female sexual function and dysfunction in old age and its relevance to old age psychiatry. Aging and disease. vol 3. issue 5. 2012-11-28. PMID:23185718. |
yet, how many old age psychiatrists commonly check with older women about whether the depression they are treating, or the ssris (selective serotonin re-uptake inhibitors) they have prescribed, have adversely affected their patient's sexual lives? |
2012-11-28 |
2023-08-12 |
Not clear |
| Enza Lacivita, Pantaleo Di Pilato, Paola De Giorgio, Nicola A Colabufo, Francesco Berardi, Roberto Perrone, Marcello Leopold. The therapeutic potential of 5-HT1A receptors: a patent review. Expert opinion on therapeutic patents. vol 22. issue 8. 2012-11-27. PMID:22788968. |
the 5-ht(1a) receptors are implicated in mood disorders (anxiety, depression), in cognition, and in modulation of pain. |
2012-11-27 |
2023-08-12 |
Not clear |
| Konstantinos N Fountoulakis, John R Kelsoe, Hagop Akiska. Receptor targets for antidepressant therapy in bipolar disorder: an overview. Journal of affective disorders. vol 138. issue 3. 2012-11-20. PMID:21601292. |
serotonin reuptake which constitutes the cornerstone in unipolar depression treatment does not seem to play a significant role for bipolar depression. |
2012-11-20 |
2023-08-12 |
Not clear |
| Masatoshi Inden, Mari Abe, Hideaki Minamino, Kazuyuki Takata, Kanji Yoshimoto, Ikuo Tooyama, Yoshihisa Kitamur. Effect of selective serotonin reuptake inhibitors via 5-HT1A receptors on L-DOPA-induced rotational behavior in a hemiparkinsonian rat model. Journal of pharmacological sciences. vol 119. issue 1. 2012-11-20. PMID:22510520. |
on the other hand, selective serotonin reuptake inhibitors (ssris) including fluoxetine have gained tremendous popularity in the treatment of depression in pd. |
2012-11-20 |
2023-08-12 |
rat |
| Lawrence P Reagan, Leah R Reznikov, Ashlie N Evans, Cecilia Gabriel, Elisabeth Mocaër, Jim R Fade. The antidepressant agomelatine inhibits stress-mediated changes in amino acid efflux in the rat hippocampus and amygdala. Brain research. vol 1466. 2012-11-20. PMID:22647752. |
agomelatine is a potent melatonergic (mt1 and mt2) receptor agonist and 5ht(2c) antagonist that is an effective antidepressant in animal models of depression and in patients suffering from depression. |
2012-11-20 |
2023-08-12 |
rat |
| K L Eskow Jaunarajs, J A George, C Bisho. L-DOPA-induced dysregulation of extrastriatal dopamine and serotonin and affective symptoms in a bilateral rat model of Parkinson's disease. Neuroscience. vol 218. 2012-11-16. PMID:22659568. |
while aspects of such neuroplasticity may be beneficial, chronic l-dopa may also modify native 5-ht function, precipitating the appearance prevalent non-motor pd symptoms such as anxiety and depression. |
2012-11-16 |
2023-08-12 |
rat |
| J P R Jacobsen, W B Siesser, B D Sachs, S Peterson, M J Cools, V Setola, J H A Folgering, G Flik, M G Caro. Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice. Molecular psychiatry. vol 17. issue 7. 2012-11-13. PMID:21537332. |
probably the foremost hypothesis of depression is the 5-hydroxytryptamine (5-ht, serotonin) deficiency hypothesis. |
2012-11-13 |
2023-08-12 |
mouse |
| J P R Jacobsen, W B Siesser, B D Sachs, S Peterson, M J Cools, V Setola, J H A Folgering, G Flik, M G Caro. Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice. Molecular psychiatry. vol 17. issue 7. 2012-11-13. PMID:21537332. |
accordingly, anomalies in putative 5-ht biomarkers have repeatedly been reported in depression patients. |
2012-11-13 |
2023-08-12 |
mouse |
| Nina Alexander, Tim Klucken, Georgia Koppe, Roman Osinsky, Bertram Walter, Dieter Vaitl, Gebhard Sammer, Rudolf Stark, Juergen Henni. Interaction of the serotonin transporter-linked polymorphic region and environmental adversity: increased amygdala-hypothalamus connectivity as a potential mechanism linking neural and endocrine hyperreactivity. Biological psychiatry. vol 72. issue 1. 2012-11-13. PMID:22418015. |
gene by environment (g×e) interaction between genetic variation in the promoter region of the serotonin transporter gene (serotonin transporter-linked polymorphic region [5-httlpr]) and stressful life events (sles) has been extensively studied in the context of depression. |
2012-11-13 |
2023-08-12 |
Not clear |