| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patrick M Fisher, Klaus K Holst, Brenda Mc Mahon, Mette E Haahr, Karine Madsen, Nic Gillings, William F Baaré, Peter S Jensen, Gitte M Knudse. 5-HTTLPR status predictive of neocortical 5-HT4 binding assessed with [(11)C]SB207145 PET in humans. NeuroImage. vol 62. issue 1. 2012-11-13. PMID:22584237. |
serotonin (5-ht) is a neuromodulator affecting myriad aspects of personality and behavior and has been implicated in the pathophysiology of affective disorders including depression and anxiety. |
2012-11-13 |
2023-08-12 |
Not clear |
| George Anderson, Michael Maes, Michael Ber. Inflammation-related disorders in the tryptophan catabolite pathway in depression and somatization. Advances in protein chemistry and structural biology. vol 88. 2012-11-13. PMID:22814705. |
these alterations in the trycat pathway in somatization and depression may interface with the role of the mu-opioid, serotonin, and oxytocin systems in the regulation of stress reactions and early attachment. |
2012-11-13 |
2023-08-12 |
Not clear |
| Chad M VanDenBer. The transdermal delivery system of monoamine oxidase inhibitors. The Journal of clinical psychiatry. vol 73 Suppl 1. 2012-11-13. PMID:22951239. |
monoamine oxidase (mao) is an enzyme that metabolizes serotonin, norepinephrine, and dopamine, the neurotransmitters that are most associated with depression; inhibiting mao, therefore, makes more of these neurotransmitters available for synaptic action. |
2012-11-13 |
2023-08-12 |
Not clear |
| Sergio Domínguez-López, Rebecca Howell, Gabriella Gobb. Characterization of serotonin neurotransmission in knockout mice: implications for major depression. Reviews in the neurosciences. vol 23. issue 4. 2012-11-13. PMID:23089640. |
characterization of serotonin neurotransmission in knockout mice: implications for major depression. |
2012-11-13 |
2023-08-12 |
mouse |
| Sergio Domínguez-López, Rebecca Howell, Gabriella Gobb. Characterization of serotonin neurotransmission in knockout mice: implications for major depression. Reviews in the neurosciences. vol 23. issue 4. 2012-11-13. PMID:23089640. |
preclinical and clinical studies have established that a dysfunction of serotonin (5-ht) neurotransmission is a common hallmark in major depression and drugs acting on the 5-ht system have antidepressant properties. |
2012-11-13 |
2023-08-12 |
mouse |
| Agnes J Jasinska, Christopher A Lowry, Margit Burmeiste. Serotonin transporter gene, stress and raphe-raphe interactions: a molecular mechanism of depression. Trends in neurosciences. vol 35. issue 7. 2012-11-12. PMID:22301434. |
serotonin transporter gene, stress and raphe-raphe interactions: a molecular mechanism of depression. |
2012-11-12 |
2023-08-12 |
Not clear |
| Agnes J Jasinska, Christopher A Lowry, Margit Burmeiste. Serotonin transporter gene, stress and raphe-raphe interactions: a molecular mechanism of depression. Trends in neurosciences. vol 35. issue 7. 2012-11-12. PMID:22301434. |
reports of gene-environment interactions (gxe) between the serotonin transporter gene and stress on risk of depression have generated both excitement and controversy. |
2012-11-12 |
2023-08-12 |
Not clear |
| Agnes J Jasinska, Christopher A Lowry, Margit Burmeiste. Corrigendum: Serotonin transporter gene, stress, and raphe–raphe interactions: a molecular mechanism of depression. Trends in neurosciences. vol 35. issue 7. 2012-11-12. PMID:22919705. |
corrigendum: serotonin transporter gene, stress, and raphe–raphe interactions: a molecular mechanism of depression. |
2012-11-12 |
2023-08-12 |
Not clear |
| Yingmei Fu, Shunying Yu, Xiaoyun Guo, Xia Li, Ting Li, Huafang Li, Yi Don. Fluvoxamine increased glutamate release by activating both 5-HT(3) and sigma-1 receptors in prelimbic cortex of chronic restraint stress C57BL/6 mice. Biochimica et biophysica acta. vol 1823. issue 4. 2012-11-09. PMID:22306004. |
the mechanism underlying these effects in depression model mice was that, fluvoxamine firstly activated presynaptic 5-ht(3) receptors, which transiently increased the ca(2+) concentration. |
2012-11-09 |
2023-08-12 |
mouse |
| Ichiro Kusumi, Katsuji Suzuki, Tsukasa Koyam. [Cellular calcium signaling in bipolar disorder]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica. vol 114. issue 7. 2012-11-09. PMID:22897029. |
moreover, serotonin-induced calcium response in monopolar depression and the other psychiatric diseases is not significantly different from that in normal subjects, which suggests that the enhanced calcium response to serotonin is specific to bipolar disorder among various diseases. |
2012-11-09 |
2023-08-12 |
human |
| A Bortolozzi, A Castañé, J Semakova, N Santana, G Alvarado, R Cortés, A Ferrés-Coy, G Fernández, M C Carmona, M Toth, J C Perales, A Montefeltro, F Artiga. Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects. Molecular psychiatry. vol 17. issue 6. 2012-11-07. PMID:21808255. |
likewise, 5-ht(1a) receptor (5-ht(1a)r) gene polymorphisms leading to high 5-ht(1a)-autoreceptor expression increase depression susceptibility and decrease treatment response. |
2012-11-07 |
2023-08-12 |
mouse |
| Anne-Grete Reikvam, Steinar Hustad, Håkon Reikvam, Torunn Oveland Apelseth, Ina Nepstad, Tor Audun Hervi. The effects of selective serotonin reuptake inhibitors on platelet function in whole blood and platelet concentrates. Platelets. vol 23. issue 4. 2012-11-07. PMID:22273511. |
several studies report that patients who are treated with selective serotonin reuptake inhibitors (ssris) for depression may have increased risk of bleeding, particularly from the gastrointestinal tract. |
2012-11-07 |
2023-08-12 |
Not clear |
| Silvia Racca, Francesca Piccione, Angela Spaccamiglio, Vitina M A Carriero, Silvia De Francia, Luigi Cangemi, Paola Esculapio, Mauro Papotti, Giuseppe Migliaretti, Paolo Portaleone, Francesco Di Carlo, Giuliana Abbadess. Effects of sub-chronic nandrolone administration on hormonal adaptive response to acute stress in rats. Psychoneuroendocrinology. vol 37. issue 8. 2012-11-05. PMID:22226432. |
it has been proposed that stress has a role in depression and that serotonin is involved in both endocrine responses to stress and depressive physiopathology. |
2012-11-05 |
2023-08-12 |
rat |
| Giovanni Scapagnini, Sergio Davinelli, Filippo Drago, Antonino De Lorenzo, Giovannangelo Orian. Antioxidants as antidepressants: fact or fiction? CNS drugs. vol 26. issue 6. 2012-10-29. PMID:22668245. |
reactive oxygen and nitrogen species have been shown to modulate levels and activity of noradrenaline (norepinephrine), serotonin, dopamine and glutamate, the principal neurotransmitters involved in the neurobiology of depression. |
2012-10-29 |
2023-08-12 |
Not clear |
| Ramez Ghanbari, Mostafa El Mansari, Pierre Blie. Electrophysiological impact of trazodone on the dopamine and norepinephrine systems in the rat brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 22. issue 7. 2012-10-26. PMID:22154666. |
the enhancement in α₂-adrenergic transmission by trazodone, and its 5-ht(2a) and 5-ht(2c) receptor antagonism may contribute to its therapeutic action in major depression. |
2012-10-26 |
2023-08-12 |
rat |
| Soheila Kashanian, Sanaz Javanmardi, Arash Chitsazan, Maliheh Paknejad, Kobra Omidfa. Fluorometric study of fluoxetine DNA binding. Journal of photochemistry and photobiology. B, Biology. vol 113. 2012-10-23. PMID:22591956. |
fluoxetine (flx), a selective serotonin reuptake inhibitor (ssri), is commonly prescribed to treat depression. |
2012-10-23 |
2023-08-12 |
Not clear |
| Sharon C Sung, Charlotte L Haley, Stephen R Wisniewski, Maurizio Fava, Andrew A Nierenberg, Diane Warden, David W Morris, Benji T Kurian, Madhukar H Trivedi, A John Rus. The impact of chronic depression on acute and long-term outcomes in a randomized trial comparing selective serotonin reuptake inhibitor monotherapy versus each of 2 different antidepressant medication combinations. The Journal of clinical psychiatry. vol 73. issue 7. 2012-10-23. PMID:22687487. |
the impact of chronic depression on acute and long-term outcomes in a randomized trial comparing selective serotonin reuptake inhibitor monotherapy versus each of 2 different antidepressant medication combinations. |
2012-10-23 |
2023-08-12 |
Not clear |
| Anthony S Zannas, Douglas R McQuoid, David C Steffens, George P Chrousos, Warren D Taylo. Stressful life events, perceived stress, and 12-month course of geriatric depression: direct effects and moderation by the 5-HTTLPR and COMT Val158Met polymorphisms. Stress (Amsterdam, Netherlands). vol 15. issue 4. 2012-10-19. PMID:22044241. |
our objectives were (1) to examine how baseline stress and change in stress is associated with course of geriatric depression and (2) to test whether polymorphisms of serotonin transporter (5-httlpr) and catechol-o-methyltransferase (comt val158met) genes moderate this relation. |
2012-10-19 |
2023-08-12 |
human |
| Hideho Arit. [The neuroscience of suicide]. Brain and nerve = Shinkei kenkyu no shinpo. vol 64. issue 8. 2012-10-18. PMID:22868884. |
these could be compensatory changes in response to 5-ht hypofunction in depression and suicide. |
2012-10-18 |
2023-08-12 |
Not clear |
| Hideho Arit. [The neuroscience of suicide]. Brain and nerve = Shinkei kenkyu no shinpo. vol 64. issue 8. 2012-10-18. PMID:22868884. |
selective serotonin reuptake inhibitors (ssris) are commonly used for the treatment of depression and suicidal ideation. |
2012-10-18 |
2023-08-12 |
Not clear |