| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui Yu, Zhe-yu Che. The role of BDNF in depression on the basis of its location in the neural circuitry. Acta pharmacologica Sinica. vol 32. issue 1. 2011-04-25. PMID:21131999. |
here, we present an overview of the current knowledge concerning bdnf actions and associated intracellular signaling in hippocampus, prefrontal cortex, nucleus accumbens (nac) and amygdala as their relation to depression. |
2011-04-25 |
2023-08-12 |
Not clear |
| Guang Chen, Roy Twyman, Husseini K Manj. p11 and gene therapy for severe psychiatric disorders: a practical goal? Science translational medicine. vol 2. issue 54. 2011-02-01. PMID:20962329. |
in this issue of science translational medicine, alexander and colleagues describe coherent evidence drawn from humans and from modeled animals that supports a brain region-specific gene therapy for depression: adeno-associated virus (aav)-mediated transfer of the gene encoding p11 to the nucleus accumbens (nacc). |
2011-02-01 |
2023-08-12 |
mouse |
| Brian Alexander, Jennifer Warner-Schmidt, Therese Eriksson, Carol Tamminga, Margarita Arango-Lievano, Margarita Arango-Llievano, Subroto Ghose, Mary Vernov, Mihaela Stavarache, Mihaela Stavarche, Sergei Musatov, Marc Flajolet, Per Svenningsson, Paul Greengard, Michael G Kaplit. Reversal of depressed behaviors in mice by p11 gene therapy in the nucleus accumbens. Science translational medicine. vol 2. issue 54. 2011-02-01. PMID:20962330. |
these results suggest that p11 loss in rodent and human nucleus accumbens may contribute to the pathophysiology of depression. |
2011-02-01 |
2023-08-12 |
mouse |
| Yukihiko Shirayama, Shigeyuki Chak. Neurochemistry of the nucleus accumbens and its relevance to depression and antidepressant action in rodents. Current neuropharmacology. vol 4. issue 4. 2010-06-10. PMID:18654637. |
neurochemistry of the nucleus accumbens and its relevance to depression and antidepressant action in rodents. |
2010-06-10 |
2023-08-12 |
Not clear |
| Yukihiko Shirayama, Shigeyuki Chak. Neurochemistry of the nucleus accumbens and its relevance to depression and antidepressant action in rodents. Current neuropharmacology. vol 4. issue 4. 2010-06-10. PMID:18654637. |
there is accumulating evidence that the nucleus accumbens (nac) plays an important role in the pathophysiology of depression. |
2010-06-10 |
2023-08-12 |
Not clear |
| Nikolai Axmacher, Michael X Cohen, Juergen Fell, Sven Haupt, Matthias Dümpelmann, Christian E Elger, Thomas E Schlaepfer, Doris Lenartz, Volker Sturm, Charan Ranganat. Intracranial EEG correlates of expectancy and memory formation in the human hippocampus and nucleus accumbens. Neuron. vol 65. issue 4. 2010-03-25. PMID:20188658. |
we report intracranial eeg recordings from the hippocampus of epilepsy patients, and from the nucleus accumbens of depression patients. |
2010-03-25 |
2023-08-12 |
human |
| Bettina H Bewernick, René Hurlemann, Andreas Matusch, Sarah Kayser, Christiane Grubert, Barbara Hadrysiewicz, Nikolai Axmacher, Matthias Lemke, Deirdre Cooper-Mahkorn, Michael X Cohen, Holger Brockmann, Doris Lenartz, Volker Sturm, Thomas E Schlaepfe. Nucleus accumbens deep brain stimulation decreases ratings of depression and anxiety in treatment-resistant depression. Biological psychiatry. vol 67. issue 2. 2010-01-07. PMID:19914605. |
nucleus accumbens deep brain stimulation decreases ratings of depression and anxiety in treatment-resistant depression. |
2010-01-07 |
2023-08-12 |
Not clear |
| Bettina H Bewernick, René Hurlemann, Andreas Matusch, Sarah Kayser, Christiane Grubert, Barbara Hadrysiewicz, Nikolai Axmacher, Matthias Lemke, Deirdre Cooper-Mahkorn, Michael X Cohen, Holger Brockmann, Doris Lenartz, Volker Sturm, Thomas E Schlaepfe. Nucleus accumbens deep brain stimulation decreases ratings of depression and anxiety in treatment-resistant depression. Biological psychiatry. vol 67. issue 2. 2010-01-07. PMID:19914605. |
since anhedonia is a feature of depression and there is evidence of dysfunction of the reward system, dbs to the nucleus accumbens (nacc) might be promising. |
2010-01-07 |
2023-08-12 |
Not clear |
| Jennifer J Long, Jingyi Ma, L Stan Leun. Behavioral depression induced by an amygdala seizure and the opioid fentanyl was mediated through the nucleus accumbens. Epilepsia. vol 50. issue 8. 2009-08-28. PMID:19490038. |
behavioral depression induced by an amygdala seizure and the opioid fentanyl was mediated through the nucleus accumbens. |
2009-08-28 |
2023-08-12 |
Not clear |
| Jennifer J Long, Jingyi Ma, L Stan Leun. Behavioral depression induced by an amygdala seizure and the opioid fentanyl was mediated through the nucleus accumbens. Epilepsia. vol 50. issue 8. 2009-08-28. PMID:19490038. |
the hypothesis that an opioid fentanyl and an amygdala-evoked seizure induced behavioral depression through the nucleus accumbens was tested. |
2009-08-28 |
2023-08-12 |
Not clear |
| Jan Wacker, Daniel G Dillon, Diego A Pizzagall. The role of the nucleus accumbens and rostral anterior cingulate cortex in anhedonia: integration of resting EEG, fMRI, and volumetric techniques. NeuroImage. vol 46. issue 1. 2009-08-19. PMID:19457367. |
we found that anhedonia, but not other symptoms of depression or anxiety, was correlated with reduced nucleus accumbens (nacc) responses to rewards (gains in a monetary incentive delay task), reduced nacc volume, and increased resting delta current density (i.e., decreased resting activity) in the rostral anterior cingulate cortex (racc), an area previously implicated in positive subjective experience. |
2009-08-19 |
2023-08-12 |
Not clear |
| Michael X Cohen, Nikolai Axmacher, Doris Lenartz, Christian E Elger, Volker Sturm, Thomas E Schlaepfe. Neuroelectric signatures of reward learning and decision-making in the human nucleus accumbens. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 7. 2009-08-03. PMID:19092783. |
we recorded electrophysiological activity directly from the nucleus accumbens of five patients undergoing deep brain stimulation for treatment of refractory major depression. |
2009-08-03 |
2023-08-12 |
human |
| Matthew B Wilkinson, Guanghua Xiao, Arvind Kumar, Quincey LaPlant, William Renthal, Devanjan Sikder, Thomas J Kodadek, Eric J Nestle. Imipramine treatment and resiliency exhibit similar chromatin regulation in the mouse nucleus accumbens in depression models. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 24. 2009-07-17. PMID:19535594. |
imipramine treatment and resiliency exhibit similar chromatin regulation in the mouse nucleus accumbens in depression models. |
2009-07-17 |
2023-08-12 |
mouse |
| Matthew B Wilkinson, Guanghua Xiao, Arvind Kumar, Quincey LaPlant, William Renthal, Devanjan Sikder, Thomas J Kodadek, Eric J Nestle. Imipramine treatment and resiliency exhibit similar chromatin regulation in the mouse nucleus accumbens in depression models. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 24. 2009-07-17. PMID:19535594. |
here, we use chromatin immunoprecipitation (chip)-chip assays--chip followed by genome wide promoter array analyses--to study the effects of chronic defeat stress on chromatin regulation in the mouse nucleus accumbens (nac), a key brain reward region implicated in depression. |
2009-07-17 |
2023-08-12 |
mouse |
| O Malkesman, Y Braw, E Ram, R Maayan, A Weizman, N Kinor, G Yadid, A Welle. Dehydroepiandrosterone and monoamines in the limbic system of a genetic animal model of childhood depression. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 18. issue 4. 2008-04-23. PMID:17714920. |
monoamines and dehydroepiandrosterone (dhea) levels were measured in a genetic animal model for childhood depression in four subcortical structures: nucleus accumbens (nac), ventral tegmental area (vta), amygdala and hypothalamus. |
2008-04-23 |
2023-08-12 |
rat |
| Christopher S Monk, Rachel G Klein, Eva H Telzer, Elizabeth A Schroth, Salvatore Mannuzza, John L Moulton, Mary Guardino, Carrie L Masten, Erin B McClure-Tone, Stephen Fromm, R James Blair, Daniel S Pine, Monique Erns. Amygdala and nucleus accumbens activation to emotional facial expressions in children and adolescents at risk for major depression. The American journal of psychiatry. vol 165. issue 1. 2008-02-15. PMID:17986682. |
amygdala and nucleus accumbens activation to emotional facial expressions in children and adolescents at risk for major depression. |
2008-02-15 |
2023-08-12 |
Not clear |
| Christopher S Monk, Rachel G Klein, Eva H Telzer, Elizabeth A Schroth, Salvatore Mannuzza, John L Moulton, Mary Guardino, Carrie L Masten, Erin B McClure-Tone, Stephen Fromm, R James Blair, Daniel S Pine, Monique Erns. Amygdala and nucleus accumbens activation to emotional facial expressions in children and adolescents at risk for major depression. The American journal of psychiatry. vol 165. issue 1. 2008-02-15. PMID:17986682. |
this study compares amygdala and nucleus accumbens activation in children and adolescents at high and low risk for major depression under varying attentional and emotional conditions. |
2008-02-15 |
2023-08-12 |
Not clear |
| Thomas E Schlaepfer, Michael X Cohen, Caroline Frick, Markus Kosel, Daniela Brodesser, Nikolai Axmacher, Alexius Young Joe, Martina Kreft, Doris Lenartz, Volker Stur. Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 2. 2008-02-06. PMID:17429407. |
because a prominent clinical feature of depression is anhedonia--the inability to experience pleasure from previously pleasurable activities--and because there is clear evidence of dysfunctions of the reward system in depression, dbs to the nucleus accumbens might offer a new possibility to target depressive symptomatology in otherwise treatment-resistant depression. |
2008-02-06 |
2023-08-12 |
Not clear |
| Thomas E Schlaepfer, Michael X Cohen, Caroline Frick, Markus Kosel, Daniela Brodesser, Nikolai Axmacher, Alexius Young Joe, Martina Kreft, Doris Lenartz, Volker Stur. Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 2. 2008-02-06. PMID:17429407. |
dysfunctions of the reward system--in which the nucleus accumbens is a key structure--are implicated in the neurobiology of major depression and might be responsible for impaired reward processing, as evidenced by the symptom of anhedonia. |
2008-02-06 |
2023-08-12 |
Not clear |
| Thomas E Schlaepfer, Michael X Cohen, Caroline Frick, Markus Kosel, Daniela Brodesser, Nikolai Axmacher, Alexius Young Joe, Martina Kreft, Doris Lenartz, Volker Stur. Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 2. 2008-02-06. PMID:17429407. |
these preliminary findings suggest that dbs to the nucleus accumbens might be a hypothesis-guided approach for refractory major depression. |
2008-02-06 |
2023-08-12 |
Not clear |