| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ernesto Solis, Keaton T Cameron-Burr, Eugene A Kiyatki. Heroin Contaminated with Fentanyl Dramatically Enhances Brain Hypoxia and Induces Brain Hypothermia. eNeuro. vol 4. issue 5. 2018-06-14. PMID:29085909. |
since respiratory depression that leads to acute hypoxia is the most dangerous complication of opioid drug use, we examined the effects of intravenous heroin and heroin contaminated with 10% fentanyl on oxygen levels in the nucleus accumbens (nac) monitored using high-speed amperometry in freely moving rats. |
2018-06-14 |
2023-08-13 |
rat |
| Idu Azogu, Helene Plamondo. Inhibition of TrkB at the nucleus accumbens, using ANA-12, regulates basal and stress-induced orexin A expression within the mesolimbic system and affects anxiety, sociability and motivation. Neuropharmacology. vol 125. 2018-06-12. PMID:28705440. |
an emerging biological substrate of depression and associated pathology is the nucleus accumbens (nac), which through interactions with limbic, cognitive and motor circuits can regulate a variety of stress responses. |
2018-06-12 |
2023-08-13 |
rat |
| Kristina E Hoque, Shannon R Blume, Stephen Sammut, Anthony R Wes. Electrical stimulation of the hippocampal fimbria facilitates neuronal nitric oxide synthase activity in the medial shell of the rat nucleus accumbens: Modulation by dopamine D1 and D2 receptor activation. Neuropharmacology. vol 126. 2018-06-12. PMID:28887183. |
the medial shell region of the nucleus accumbens (msnac) is a key center for the regulation of goal-directed behavior and is likely to be dysfunctional in neuropsychiatric disorders such as addiction, depression and schizophrenia. |
2018-06-12 |
2023-08-13 |
rat |
| Shu Liu, Tingfu Du, Zeyue Liu, Yan Shen, Jianbo Xiu, Qi X. Inverse changes in L1 retrotransposons between blood and brain in major depressive disorder. Scientific reports. vol 6. 2018-05-18. PMID:27874048. |
furthermore, l1 copy number in peripheral blood and five brain regions (prefrontal cortex, hippocampus, amygdala, nucleus accumbens and paraventricular hypothalamic nucleus) was measured in the chronic unpredictable mild stress (cums) model of depression in mice. |
2018-05-18 |
2023-08-13 |
mouse |
| Zhaoming Zhu, Guangyan Wang, Ke Ma, Shan Cui, Jin-Hui Wan. GABAergic neurons in nucleus accumbens are correlated to resilience and vulnerability to chronic stress for major depression. Oncotarget. vol 8. issue 22. 2018-03-26. PMID:28415589. |
gabaergic neurons in nucleus accumbens are correlated to resilience and vulnerability to chronic stress for major depression. |
2018-03-26 |
2023-08-13 |
Not clear |
| Chadi G Abdallah, Andrea Jackowski, Ramiro Salas, Swapnil Gupta, João R Sato, Xiangling Mao, Jeremy D Coplan, Dikoma C Shungu, Sanjay J Mathe. The Nucleus Accumbens and Ketamine Treatment in Major Depressive Disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 8. 2018-03-23. PMID:28272497. |
animal models of depression repeatedly showed stress-induced nucleus accumbens (nac) hypertrophy. |
2018-03-23 |
2023-08-13 |
human |
| Saki Minami, Hiroshi Satoyoshi, Soichiro Ide, Takeshi Inoue, Mitsuhiro Yoshioka, Masabumi Minam. Suppression of reward-induced dopamine release in the nucleus accumbens in animal models of depression: Differential responses to drug treatment. Neuroscience letters. vol 650. 2018-03-19. PMID:28432029. |
suppression of reward-induced dopamine release in the nucleus accumbens in animal models of depression: differential responses to drug treatment. |
2018-03-19 |
2023-08-13 |
Not clear |
| Saki Minami, Hiroshi Satoyoshi, Soichiro Ide, Takeshi Inoue, Mitsuhiro Yoshioka, Masabumi Minam. Suppression of reward-induced dopamine release in the nucleus accumbens in animal models of depression: Differential responses to drug treatment. Neuroscience letters. vol 650. 2018-03-19. PMID:28432029. |
we investigated reward (30% sucrose intake)-induced da release in the nucleus accumbens (nac) and the effect of chronic treatment with the antidepressant escitalopram (5mg/kg, intraperitoneally twice daily for 3 weeks) in two animal models of depression. |
2018-03-19 |
2023-08-13 |
Not clear |
| Salil Saurav Pathak, Swati Maitra, Sumana Chakravarty, Arvind Kuma. Histone Lysine Demethylases of JMJD2 or KDM4 Family are Important Epigenetic Regulators in Reward Circuitry in the Etiopathology of Depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 4. 2018-01-19. PMID:27711046. |
recent research shows dysregulation in epigenetic regulatory mechanisms, particularly the transcriptionally repressive di- and tri-methylation of histone 3 lysine 9 (h3k9me2/me3) in nucleus accumbens (nac), a critical region of the reward pathway involved in the development of anhedonia, the hallmark of depression. |
2018-01-19 |
2023-08-13 |
mouse |
| Giannina Descalzi, Vasiliki Mitsi, Immanuel Purushothaman, Sevasti Gaspari, Kleopatra Avrampou, Yong-Hwee Eddie Loh, Li Shen, Venetia Zachario. Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression. Science signaling. vol 10. issue 471. 2017-11-28. PMID:28325815. |
using two mouse models of neuropathic pain and depression [spared nerve injury (sni) and chronic unpredictable stress (cus)], we performed next-generation rna sequencing and pathway analysis to monitor changes in gene expression in the nucleus accumbens (nac), the medial prefrontal cortex (mpfc), and the periaqueductal gray (pag). |
2017-11-28 |
2023-08-13 |
mouse |
| Gemma Huguet, Elisabet Kadar, Yasin Temel, Lee Wei Li. Electrical Stimulation Normalizes c-Fos Expression in the Deep Cerebellar Nuclei of Depressive-like Rats: Implication of Antidepressant Activity. Cerebellum (London, England). vol 16. issue 2. 2017-09-22. PMID:27435250. |
here, we investigated the stimulation effects of the ventromedial prefrontal cortex (vmpfc), nucleus accumbens (nac), and lateral habenular nucleus on the c-fos neuronal activity in various deep cerebellar and vestibular nuclei using the unpredictable chronic mild stress (cms) animal model of depression. |
2017-09-22 |
2023-08-13 |
rat |
| Shuntaro Kohnomi, Katsuko Ebihara, Masayuki Kobayash. Suppressive regulation of lateral inhibition between medium spiny neurons via dopamine D Neuroscience letters. vol 636. 2017-08-24. PMID:27793700. |
suppressive regulation of lateral inhibition between medium spiny neurons via dopamine d the nucleus accumbens (nac) shell is closely associated with reward, psychiatric disorders (depression or schizophrenia), and drug abuse. |
2017-08-24 |
2023-08-13 |
Not clear |
| T Chase Francis, Mary Kay Lob. Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression. Biological psychiatry. vol 81. issue 8. 2017-08-22. PMID:27871668. |
emerging role for nucleus accumbens medium spiny neuron subtypes in depression. |
2017-08-22 |
2023-08-13 |
Not clear |
| T Chase Francis, Mary Kay Lob. Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression. Biological psychiatry. vol 81. issue 8. 2017-08-22. PMID:27871668. |
despite this interest, little work has addressed cell type-specific distinctions in medium spiny neurons (msns), the main projection neurons in the nucleus accumbens and dorsal striatum, and their function in relation to stress and depression. |
2017-08-22 |
2023-08-13 |
Not clear |
| Ramesh Chandra, T Chase Francis, Hyungwoo Nam, Lace M Riggs, Michel Engeln, Sarah Rudzinskas, Prasad Konkalmatt, Scott J Russo, Gustavo Turecki, Sergio D Iniguez, Mary Kay Lob. Reduced Slc6a15 in Nucleus Accumbens D2-Neurons Underlies Stress Susceptibility. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 27. 2017-08-18. PMID:28576941. |
however, no study examined slc6a15 in the ventral striatum [nucleus accumbens (nac)] in depression. |
2017-08-18 |
2023-08-13 |
mouse |
| Hee-Dae Kim, Jennifer Hesterman, Tanessa Call, Samantha Magazu, Elizabeth Keeley, Kristyna Armenta, Hope Kronman, Rachael L Neve, Eric J Nestler, Deveroux Ferguso. SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 32. 2017-07-14. PMID:27511015. |
in the present study, we show that chronic social defeat stress, an ethologically validated model of depression in mice, increases sirt1 levels in the nucleus accumbens (nac), a key brain reward region. |
2017-07-14 |
2023-08-13 |
mouse |
| Takahiro Kato, Soichiro Ide, Masabumi Minam. Pain relief induces dopamine release in the rat nucleus accumbens during the early but not late phase of neuropathic pain. Neuroscience letters. vol 629. 2017-06-29. PMID:27369326. |
the neuronal pathway from the ventral tegmental area to the nucleus accumbens (nac) is critical in the mesolimbic dopamine (da) reward circuit, and dysfunction of this pathway has been implicated in depression. |
2017-06-29 |
2023-08-13 |
rat |
| I Mavridi. [The role of the nucleus accumbens in psychiatric disorders]. Psychiatrike = Psychiatriki. vol 25. issue 4. 2016-12-13. PMID:26709994. |
nucleus accumbens deep brain stimulation has been also associated with antidepressant and anxiolytic effect, as well as quality of life improvement in patients suffering from severe resistant depression. |
2016-12-13 |
2023-08-13 |
human |
| Judith K Morgan, Daniel S Shaw, Thomas M Olino, Samuel C Musselman, Nikhil T Kurapati, Erika E Forbe. History of Depression and Frontostriatal Connectivity During Reward Processing in Late Adolescent Boys. Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53. vol 45. issue 1. 2016-09-15. PMID:25915469. |
the current study evaluated functional connectivity between the nucleus accumbens and mpfc in a sample of 166 ethnically diverse boys with and without a history of depression. |
2016-09-15 |
2023-08-13 |
human |
| Judith K Morgan, Daniel S Shaw, Thomas M Olino, Samuel C Musselman, Nikhil T Kurapati, Erika E Forbe. History of Depression and Frontostriatal Connectivity During Reward Processing in Late Adolescent Boys. Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53. vol 45. issue 1. 2016-09-15. PMID:25915469. |
boys with a history of depression showed heightened positive connectivity between the nucleus accumbens and the mpfc relative to boys with no psychiatric history when winning rewards relative to losing rewards. |
2016-09-15 |
2023-08-13 |
human |