| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gregor Stein, Janine S Aly, Lisa Lange, Annamaria Manzolillo, Konstantin Riege, Anna Brancato, Christian A Hübner, Gustavo Turecki, Steve Hoffmann, Olivia Engman. Npbwr1 signaling mediates fast antidepressant action. Molecular psychiatry. 2024-10-21. PMID:39433904. |
npbwr1 is increased in the nucleus accumbens of chronically stressed mice and postmortem in patients diagnosed with depression. |
2024-10-21 |
2024-10-24 |
mouse |
| Hezhi Yan, Zhaosong Chu, Zonglin Shen, Lijin Yuan, Yanru Wu, Yi Lu, Hongyan Jiang, Xiufeng X. Disrupted functional connectivity of bilateral nucleus accumbens in major depressive disorder with and without melancholic features. Neuroreport. 2024-09-18. PMID:39292961. |
our study aims to explore the differences in functional connectivity in the nucleus accumbens (nac) between patients with melancholic depression and non-melancholic depression (nmd) and their relation to melancholic depression's pathogenesis. |
2024-09-18 |
2024-09-21 |
Not clear |
| Lidia Łapińska, Aleksandra Szum-Jakubowska, Anna Krentowska, Mikołaj Pawlak, Marcin Hładuński, Napoleon Waszkiewicz, Monika Karczewska-Kupczewska, Karol Kamiński, Irina Kowalsk. The relationship between brain structure volumes, depressive symptoms and body composition in obese/overweight and normal-/underweight women. Scientific reports. vol 14. issue 1. 2024-09-09. PMID:39251805. |
beck depression inventory (bdi) score was inversely associated with nucleus accumbens volume (β = -0.217, p = 0.008) in women with bmi ≥ 25 kg/m |
2024-09-09 |
2024-09-13 |
human |
| Huizi Tian, Zhifang Wang, Yao Meng, Lu Geng, Hao Lian, Zhifei Shi, Zhidong Zhuang, Wenpeng Cai, Mengyang H. Neural mechanisms underlying cognitive impairment in depression and cognitive benefits of exercise intervention. Behavioural brain research. 2024-08-25. PMID:39182624. |
depression is associated with certain neural impairments of reward processing, especially orbitofrontal cortex, prefrontal cortex, nucleus accumbens and other striatal regions. |
2024-08-25 |
2024-08-28 |
Not clear |
| Brandon Taraku, Joana R Loureiro, Ashish K Sahib, Artemis Zavaliangos-Petropulu, Noor Al-Sharif, Amber M Leaver, Benjamin Wade, Shantanu Joshi, Roger P Woods, Randall Espinoza, Katherine L Nar. Modulation of habenular and nucleus accumbens functional connectivity by ketamine in major depression. Brain and behavior. vol 14. issue 6. 2024-06-19. PMID:38894648. |
modulation of habenular and nucleus accumbens functional connectivity by ketamine in major depression. |
2024-06-19 |
2024-06-21 |
Not clear |
| Yingying Chen, Xiaodi Xia, Zheyi Zhou, Meng Yuan, Yadong Peng, Ying Liu, Jinxiang Tang, Yixiao F. Interleukin-6 is correlated with amygdala volume and depression severity in adolescents and young adults with first-episode major depressive disorder. Brain imaging and behavior. 2024-03-12. PMID:38467915. |
in this study, we aimed to investigate the potential correlations among cytokines, depression severity, and the volumes of the amygdala, hippocampus, and nucleus accumbens in han chinese adolescents and young adults with first-episode mdd. |
2024-03-12 |
2024-03-14 |
Not clear |
| Anna C Cichocki, Richard E Zinbarg, Michelle G Craske, Iris K-Y Chat, Katherine S Young, Susan Y Bookheimer, Robin Nussloc. Transdiagnostic symptom of depression and anxiety associated with reduced gray matter volume in prefrontal cortex. Psychiatry research. Neuroimaging. vol 339. 2024-02-15. PMID:38359709. |
using structural mri, gray matter volumes were extracted for emotion generation (amygdala, nucleus accumbens) and regulation (orbitofrontal, ventrolateral, and dorsolateral prefrontal cortex) regions, often implicated in depression and anxiety. |
2024-02-15 |
2024-02-18 |
Not clear |
| Yue Zhang, Jingwen Gao, Na Li, Peng Xu, Shimeng Qu, Jinqian Cheng, Mingrui Wang, Xueru Li, Yaheng Song, Fan Xiao, Xinyu Yang, Jihong Liu, Hao Hong, Ronghao Mu, Xiaotian Li, Youmei Wang, Hui Xu, Yuan Xie, Tianming Gao, Guangji Wang, Jiye A. Targeting cAMP in D1-MSNs in the nucleus accumbens, a new rapid antidepressant strategy. Acta pharmaceutica Sinica. B. vol 14. issue 2. 2024-02-07. PMID:38322327. |
studies have suggested that the nucleus accumbens (nac) is implicated in the pathophysiology of major depression; however, the regulatory strategy that targets the nac to achieve an exclusive and outstanding anti-depression benefit has not been elucidated. |
2024-02-07 |
2024-02-09 |
mouse |
| Adam Wojtas, Agnieszka Bysiek, Agnieszka Wawrzczak-Bargiela, Marzena Maćkowiak, Krystyna Gołembiowsk. Limbic System Response to Psilocybin and Ketamine Administration in Rats: A Neurochemical and Behavioral Study. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203271. |
the pathophysiology of depression is related to the reduced volume of the hippocampus and amygdala and hypertrophy of the nucleus accumbens. |
2024-01-11 |
2024-01-13 |
rat |
| Brandon Taraku, Joana R Loureiro, Ashish K Sahib, Artemis Zavaliangos-Petropulu, Noor Al-Sharif, Amber Leaver, Benjamin Wade, Shantanu Joshi, Roger P Woods, Randall Espinoza, Katherine L Nar. Ketamine treatment modulates habenular and nucleus accumbens static and dynamic functional connectivity in major depression. medRxiv : the preprint server for health sciences. 2023-12-18. PMID:38106178. |
ketamine treatment modulates habenular and nucleus accumbens static and dynamic functional connectivity in major depression. |
2023-12-18 |
2023-12-21 |
human |
| Acácio Moreira-Neto, Lucas Melo Neves, Angelo Miliatto, Valeria Juday, Raquel Marquesini, Beny Lafer, Ellison Fernando Cardoso, Carlos Ugrinowitsch, Mariana Penteado Nucci, Carla Silva-Batist. Clinical and neuroimaging correlates in a pilot randomized trial of aerobic exercise for major depression. Journal of affective disorders. vol 347. 2023-12-14. PMID:38092282. |
aerobic exercise (ae) combined with pharmacotherapy is known to reduce depressive symptoms; however, studies have not focused on long-term ae for volumetric changes of brain regions (amygdala, thalamus, and nucleus accumbens [nacc]) linked to the control of affective responses and hopelessness in individuals with major depression (md). |
2023-12-14 |
2023-12-17 |
Not clear |
| Zhaobin Chen, Yangpan Ou, Feng Liu, Huabing Li, Ping Li, Guangrong Xie, Xilong Cui, Wenbin Gu. Increased brain nucleus accumbens functional connectivity in melancholic depression. Neuropharmacology. vol 243. 2023-11-26. PMID:37995807. |
increased brain nucleus accumbens functional connectivity in melancholic depression. |
2023-11-26 |
2023-11-28 |
Not clear |
| Saba Amiri, Mohammad Arbabi, Milad Rahimi, Mansour Parvaresh-Rizi, Mehdi M Mirbagher. Effective connectivity between deep brain stimulation targets in individuals with treatment-resistant depression. Brain communications. vol 5. issue 5. 2023-10-30. PMID:37901039. |
our results showed that compared to the healthy control subjects, in the left hemisphere of treatment-resistant depression patients, the nucleus accumbens was inhibited by the inferior thalamic peduncle and excited the ventral caudate and the subcallosal cingulate gyrus, which in turn excited the lateral habenula. |
2023-10-30 |
2023-11-08 |
human |
| Simona Leserri, Alba Segura-Amil, Andreas Nowacki, Ines Debove, Katrin Petermann, Lea Schäppi, Maria Giulia Preti, Dimitri Van De Ville, Claudio Pollo, Sebastian Walther, T A Khoa Nguye. Linking connectivity of deep brain stimulation of nucleus accumbens area with clinical depression improvements: a retrospective longitudinal case series. European archives of psychiatry and clinical neuroscience. 2023-09-05. PMID:37668723. |
linking connectivity of deep brain stimulation of nucleus accumbens area with clinical depression improvements: a retrospective longitudinal case series. |
2023-09-05 |
2023-09-07 |
Not clear |
| Simona Leserri, Alba Segura-Amil, Andreas Nowacki, Ines Debove, Katrin Petermann, Lea Schäppi, Maria Giulia Preti, Dimitri Van De Ville, Claudio Pollo, Sebastian Walther, T A Khoa Nguye. Linking connectivity of deep brain stimulation of nucleus accumbens area with clinical depression improvements: a retrospective longitudinal case series. European archives of psychiatry and clinical neuroscience. 2023-09-05. PMID:37668723. |
in this longitudinal, retrospective study, four female patients with treatment-resistant depression were implanted for stimulation in the nucleus accumbens area at our center. |
2023-09-05 |
2023-09-07 |
Not clear |
| Ssu-Ju Li, Yu-Chun Lo, Hsin-Yi Tseng, Sheng-Huang Lin, Chao-Hung Kuo, Ting-Chieh Chen, Ching-Wen Chang, Yao-Wen Liang, Yi-Chen Lin, Chih-Yu Wang, Tsai-Yu Cho, Mu-Hua Wang, Ching-Te Chen, You-Yin Che. Nucleus accumbens deep brain stimulation improves depressive-like behaviors through BDNF-mediated alterations in brain functional connectivity of dopaminergic pathway. Neurobiology of stress. vol 26. 2023-09-04. PMID:37664874. |
since anhedonia is a feature of depression and there is evidence of leading to metabolic disorder, deep brain stimulation (dbs) to the nucleus accumbens (nac) might be promising in modulating the dopaminergic pathway. |
2023-09-04 |
2023-09-07 |
mouse |
| Mohammad Akhoondian, Samira Rashtiani, Behrooz Khakpour Taleghani, Mohammad Rostampour, Adele Jafari, Kambiz Rohampou. Lateral habenula deep brain stimulation alleviates depression-like behaviors and reverses the oscillatory pattern in the nucleus accumbens in an animal model of depression. Brain research bulletin. 2023-08-20. PMID:37598800. |
lateral habenula deep brain stimulation alleviates depression-like behaviors and reverses the oscillatory pattern in the nucleus accumbens in an animal model of depression. |
2023-08-20 |
2023-09-07 |
rat |
| Federica Lucantonio, Shuwen Li, Jaden Lu, Jacob Roeglin, Leonardo Bontempi, Brenda C Shields, Carlos A Zarate, Michael R Tadross, Marco Pignatell. Ketamine rescues anhedonia by cell-type and input specific adaptations in the Nucleus Accumbens. bioRxiv : the preprint server for biology. 2023-06-19. PMID:37333325. |
here, we show that the nucleus accumbens (nac), a major hub of the reward circuitry, is essential for ketamine's effect in rescuing anhedonia in mice subjected to chronic stress, a critical risk factor in the genesis of depression in humans. |
2023-06-19 |
2023-08-14 |
mouse |
| Zhaosong Chu, Lijin Yuan, Mengxin He, Yuqi Cheng, Yi Lu, Xiufeng Xu, Zonglin She. Atrophy of bilateral nucleus accumbens in melancholic depression. Neuroreport. vol 34. issue 10. 2023-06-04. PMID:37270840. |
atrophy of bilateral nucleus accumbens in melancholic depression. |
2023-06-04 |
2023-08-14 |
human |
| Kevin M Manz, José C Zepeda, Zack Zurawski, Heidi E Hamm, Brad A Gruete. SNAP25 differentially contributes to G Frontiers in cellular neuroscience. vol 17. 2023-05-19. PMID:37206665. |
snap25 differentially contributes to g the nucleus accumbens (nac) guides reward-related motivated behavior implicated in pathological behavioral states, including addiction and depression. |
2023-05-19 |
2023-08-14 |
Not clear |