| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Judith K Morgan, Daniel S Shaw, Thomas M Olino, Samuel C Musselman, Nikhil T Kurapati, Erika E Forbe. History of Depression and Frontostriatal Connectivity During Reward Processing in Late Adolescent Boys. Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53. vol 45. issue 1. 2016-09-15. PMID:25915469. |
history of depression in late adolescent boys may be associated with altered coordination between the nucleus accumbens and mpfc when winning reward. |
2016-09-15 |
2023-08-13 |
human |
| Vincent Vialou, Mackenzie Thibault, Sophia Kaska, Sarah Cooper, Paula Gajewski, Andrew Eagle, Michelle Mazei-Robison, Eric J Nestler, A J Robiso. Differential induction of FosB isoforms throughout the brain by fluoxetine and chronic stress. Neuropharmacology. vol 99. 2016-08-24. PMID:26164345. |
we further uncover specific patterns of fosb gene product expression (i.e., differential expression of full-length fosb, Δfosb, and Δ2Δfosb) in brain regions associated with depression--the nucleus accumbens (nac), prefrontal cortex (pfc), and hippocampus--in response to chronic fluoxetine treatment, and contrast these patterns with differential induction of fosb isoforms in the chronic social defeat stress model of depression with and without fluoxetine treatment. |
2016-08-24 |
2023-08-13 |
mouse |
| Eric J Nestle. Role of the Brain's Reward Circuitry in Depression: Transcriptional Mechanisms. International review of neurobiology. vol 124. 2016-07-18. PMID:26472529. |
here we focus on the nucleus accumbens (nac), a critical component of the brain's reward circuitry, in depression and other stress-related disorders. |
2016-07-18 |
2023-08-13 |
Not clear |
| Yukihiko Shirayama, Tamaki Ishima, Yasunori Oda, Naoe Okamura, Masaomi Iyo, Kenji Hashimot. Opposite roles for neuropeptide S in the nucleus accumbens and bed nucleus of the stria terminalis in learned helplessness rats. Behavioural brain research. vol 291. 2016-03-28. PMID:25986404. |
we examined the antidepressant-like effects of nps infusions into the shell or core regions of the nucleus accumbens (nac) and into the bed nucleus of the stria terminalis (bnst) of learned helplessness (lh) rats (an animal model of depression). |
2016-03-28 |
2023-08-13 |
rat |
| Rosemary C Bagot, Eric M Parise, Catherine J Peña, Hong-Xing Zhang, Ian Maze, Dipesh Chaudhury, Brianna Persaud, Roger Cachope, Carlos A Bolaños-Guzmán, Joseph F Cheer, Joseph Cheer, Karl Deisseroth, Ming-Hu Han, Eric J Nestle. Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression. Nature communications. vol 6. 2016-02-29. PMID:25952660. |
ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression. |
2016-02-29 |
2023-08-13 |
mouse |
| Rosemary C Bagot, Eric M Parise, Catherine J Peña, Hong-Xing Zhang, Ian Maze, Dipesh Chaudhury, Brianna Persaud, Roger Cachope, Carlos A Bolaños-Guzmán, Joseph F Cheer, Joseph Cheer, Karl Deisseroth, Ming-Hu Han, Eric J Nestle. Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression. Nature communications. vol 6. 2016-02-29. PMID:25952660. |
enhanced glutamatergic transmission in the nucleus accumbens (nac), a region critical for reward and motivation, has been implicated in the pathophysiology of depression; however, the afferent source of this increased glutamate tone is not known. |
2016-02-29 |
2023-08-13 |
mouse |
| Scott M Thompson, Angy J Kallarackal, Mark D Kvarta, Adam M Van Dyke, Tara A LeGates, Xiang Ca. An excitatory synapse hypothesis of depression. Trends in neurosciences. vol 38. issue 5. 2016-01-19. PMID:25887240. |
here, we propose an excitatory synapse hypothesis of depression in which chronic stress and genetic susceptibility cause changes in the strength of subsets of glutamatergic synapses at multiple locations, including the prefrontal cortex (pfc), hippocampus, and nucleus accumbens (nac), leading to a dysfunction of corticomesolimbic reward circuitry that underlies many of the symptoms of depression. |
2016-01-19 |
2023-08-13 |
Not clear |
| Rosemary C Bagot, Eric M Parise, Catherine J Peña, Hong-Xing Zhang, Ian Maze, Dipesh Chaudhury, Brianna Persaud, Roger Cachope, Carlos A Bolaños-Guzmán, Joseph F Cheer, Karl Deisseroth, Ming-Hu Han, Eric J Nestle. Corrigendum: Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression. Nature communications. vol 6. 2015-11-24. PMID:26080619. |
corrigendum: ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression. |
2015-11-24 |
2023-08-13 |
Not clear |
| Shuntaro Kohnomi, Shiro Konish. Multiple actions of a D₃ dopamine receptor agonist, PD128907, on GABAergic inhibitory transmission between medium spiny neurons in mouse nucleus accumbens shell. Neuroscience letters. vol 600. 2015-10-19. PMID:26033184. |
the nucleus accumbens (nac) plays a crucial role in pathophysiological responses, such as reward-related behaviors, addiction, depression and schizophrenia, through activation of dopaminergic system in the midbrain area. |
2015-10-19 |
2023-08-13 |
mouse |
| Jun Gao, Ning Zhu, Min Feng, Xiaolu Meng, Nan Su. Intra-nucleus-accumbens SKF38393 improved the impaired acquisition of morphine-conditioned place preference in depression-like rats. PsyCh journal. vol 1. issue 1. 2015-08-15. PMID:26272664. |
dopaminergic activity in the nucleus accumbens (nac) and the globus pallidus (gp) is important for the interaction between depression and addiction, with d1- and d2-like receptors playing different roles. |
2015-08-15 |
2023-08-13 |
rat |
| Clement Hamani, Beatriz O Amorim, Anne L Wheeler, Mustansir Diwan, Klaus Driesslein, Luciene Covolan, Christopher R Butson, José N Nobreg. Deep brain stimulation in rats: different targets induce similar antidepressant-like effects but influence different circuits. Neurobiology of disease. vol 71. 2015-06-02. PMID:25131446. |
recent studies in patients with treatment-resistant depression have shown similar results with the use of deep brain stimulation (dbs) in the subcallosal cingulate gyrus (scg), ventral capsule/ventral striatum (vc/vs) and nucleus accumbens (acb). |
2015-06-02 |
2023-08-13 |
rat |
| I G Sil'ki. [The mechanisms of interdependent influence of prefrontal cortex, hippocampus and amygdala on the basal ganglia functioning and selection of behaviour]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 64. issue 1. 2015-03-17. PMID:25710067. |
such suppression can be a consequence of heterosynaptic depression which is based on potentiation of efficacy of excitatory inputs from the different structures converging on inhibitory interneurons in the nucleus accumbens and basolateral amygdala. |
2015-03-17 |
2023-08-13 |
Not clear |
| Arnold E Egger. Treatment of depression with deep brain stimulation works by altering in specific ways the conscious perception of the core symptoms of sadness or anhedonia, not by modulating network circuitry. Medical hypotheses. vol 83. issue 1. 2015-01-05. PMID:24767178. |
an important advance in the management of treatment-resistant depression has recently been reported: deep brain stimulation (dbs) of the subgenual cingulate (brodmann area 25 or cg 25) or the nucleus accumbens (nacc). |
2015-01-05 |
2023-08-13 |
Not clear |
| A J Robison, Vincent Vialou, Hao-Sheng Sun, Benoit Labonte, Sam A Golden, Caroline Dias, Gustavo Turecki, Carol Tamminga, Scott Russo, Michelle Mazei-Robison, Eric J Nestle. Fluoxetine epigenetically alters the CaMKIIα promoter in nucleus accumbens to regulate ΔFosB binding and antidepressant effects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 5. 2014-12-01. PMID:24240473. |
recent work in addiction models demonstrates that the transcription factor Δfosb and protein kinase calmodulin-dependent protein kinase ii (camkii) are co-regulated in nucleus accumbens (nac), a brain reward region implicated in both addiction and depression models including social defeat. |
2014-12-01 |
2023-08-12 |
mouse |
| Yafang Zhang, Elizabeth J Crofton, Dingge Li, Mary Kay Lobo, Xiuzhen Fan, Eric J Nestler, Thomas A Gree. Overexpression of DeltaFosB in nucleus accumbens mimics the protective addiction phenotype, but not the protective depression phenotype of environmental enrichment. Frontiers in behavioral neuroscience. vol 8. 2014-09-15. PMID:25221490. |
overexpression of deltafosb in nucleus accumbens mimics the protective addiction phenotype, but not the protective depression phenotype of environmental enrichment. |
2014-09-15 |
2023-08-13 |
rat |
| Neil Schwartz, Paul Temkin, Sandra Jurado, Byung Kook Lim, Boris D Heifets, Jai S Polepalli, Robert C Malenk. Chronic pain. Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens. Science (New York, N.Y.). vol 345. issue 6196. 2014-08-14. PMID:25082697. |
here, we demonstrate that the decreased motivation elicited in mice by two different models of chronic pain requires a galanin receptor 1-triggered depression of excitatory synaptic transmission in indirect pathway nucleus accumbens medium spiny neurons. |
2014-08-14 |
2023-08-13 |
mouse |
| B Goff, D G Gee, E H Telzer, K L Humphreys, L Gabard-Durnam, J Flannery, N Tottenha. Reduced nucleus accumbens reactivity and adolescent depression following early-life stress. Neuroscience. vol 249. 2014-04-11. PMID:23262241. |
reduced nucleus accumbens reactivity and adolescent depression following early-life stress. |
2014-04-11 |
2023-08-12 |
Not clear |
| B Goff, D G Gee, E H Telzer, K L Humphreys, L Gabard-Durnam, J Flannery, N Tottenha. Reduced nucleus accumbens reactivity and adolescent depression following early-life stress. Neuroscience. vol 249. 2014-04-11. PMID:23262241. |
developmentally, the nucleus accumbens (nacc), a limbic structure associated with reward learning and motivation, typically undergoes dramatic functional change during adolescence; therefore, age-related changes in nacc function may underlie increases in depression in adolescence following els. |
2014-04-11 |
2023-08-12 |
Not clear |
| Bo Jiang, Wei Wang, Fang Wang, Zhuang-Li Hu, Jun-Li Xiao, Si Yang, Jing Zhang, Xiao-Zhong Peng, Jin-Hui Wang, Jian-Guo Che. The stability of NR2B in the nucleus accumbens controls behavioral and synaptic adaptations to chronic stress. Biological psychiatry. vol 74. issue 2. 2014-01-17. PMID:23260228. |
the nucleus accumbens (nac) is closely correlated with depression. |
2014-01-17 |
2023-08-12 |
Not clear |
| Jenny Ceccarini, Marc De Hert, Ruud Van Winkel, Joseph Peuskens, Guy Bormans, Laura Kranaster, Frank Enning, Dagmar Koethe, F Markus Leweke, Koen Van Laer. Increased ventral striatal CB1 receptor binding is related to negative symptoms in drug-free patients with schizophrenia. NeuroImage. vol 79. 2014-01-06. PMID:23624489. |
furthermore, in the scz-f group only, cb1 receptor binding was negatively correlated to negative symptoms and to depression scores, especially in the nucleus accumbens. |
2014-01-06 |
2023-08-12 |
human |