| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Angela J Grippo, Elisa S Na, Ralph F Johnson, Terry G Beltz, Alan Kim Johnso. Sucrose ingestion elicits reduced Fos expression in the nucleus accumbens of anhedonic rats. Brain research. vol 1019. issue 1-2. 2004-11-04. PMID:15306261. |
chronic mild stress (cms), an animal model of depression associated with anhedonia, was used to examine nucleus accumbens (nac) activation associated with a rewarding stimulus. |
2004-11-04 |
2023-08-12 |
rat |
| Samuel B Kombian, Kethireddy V V Ananthalakshmi, Subramanian S Parvathy, Wandikayi C Matow. Dopamine and adenosine mediate substance P-induced depression of evoked IPSCs in the rat nucleus accumbens in vitro. The European journal of neuroscience. vol 18. issue 2. 2003-09-24. PMID:12887412. |
dopamine and adenosine mediate substance p-induced depression of evoked ipscs in the rat nucleus accumbens in vitro. |
2003-09-24 |
2023-08-12 |
rat |
| P Rada, S A Moreno, S Tucci, L E Gonzalez, T Harrison, D T Chau, B G Hoebel, L Hernande. Glutamate release in the nucleus accumbens is involved in behavioral depression during the PORSOLT swim test. Neuroscience. vol 119. issue 2. 2003-07-30. PMID:12770568. |
glutamate release in the nucleus accumbens is involved in behavioral depression during the porsolt swim test. |
2003-07-30 |
2023-08-12 |
rat |
| Stephen D Mague, Andrea M Pliakas, Mark S Todtenkopf, Hilarie C Tomasiewicz, Yan Zhang, William C Stevens, Robert M Jones, Philip S Portoghese, William A Carlezo. Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats. The Journal of pharmacology and experimental therapeutics. vol 305. issue 1. 2003-04-22. PMID:12649385. |
we showed previously that camp response element-binding protein (creb) within the nucleus accumbens (nac) of rats regulates immobility in the forced swim test (fst), an assay used to study depression. |
2003-04-22 |
2023-08-12 |
rat |
| Martin L Kram, Gerald L Kramer, Patrick J Ronan, Mark Steciuk, Frederick Pett. Dopamine receptors and learned helplessness in the rat: an autoradiographic study. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 4. 2003-03-12. PMID:12188094. |
(2) utilizing the learned helplessness (lh) animal model of clinical depression and quantitative autoradiography, the authors studied the densities of d1 and dopamine-2-like receptors (d2-like receptors) in medial prefrontal cortex, septum, nucleus accumbens and caudate nucleus in rats that received inescapable stress and were subsequently tested for lh behavior. |
2003-03-12 |
2023-08-12 |
rat |
| Samuel S Newton, Johannes Thome, Tanya L Wallace, Yukihikko Shirayama, Lee Schlesinger, Norio Sakai, Jingshan Chen, Rachael Neve, Eric J Nestler, Ronald S Duma. Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 24. 2003-01-23. PMID:12486182. |
together, the results demonstrate that nucleus accumbens creb-dynorphin influence behavior in the learned helplessness model and suggest that this signaling cascade may contribute to symptoms of depression. |
2003-01-23 |
2023-08-12 |
mouse |
| David Robbe, Manfred Kopf, Anne Remaury, Joel Bockaert, Olivier J Manzon. Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 12. 2002-08-02. PMID:12060781. |
endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens. |
2002-08-02 |
2023-08-12 |
mouse |
| Simon Xi-Ming Li, Kenneth W Perry, David T Won. Influence of fluoxetine on the ability of bupropion to modulate extracellular dopamine and norepinephrine concentrations in three mesocorticolimbic areas of rats. Neuropharmacology. vol 42. issue 2. 2002-04-29. PMID:11804614. |
three mesocorticolimbic areas including hypothalamus (ht), prefrontal cortex (pfc) and nucleus accumbens (acb) were selected based on their relevance to depression and antidepressant actions. |
2002-04-29 |
2023-08-12 |
rat |
| S Genedani, S Saltini, A Benelli, M Filaferro, A Bertolin. Influence of SAMe on the modifications of brain polyamine levels in an animal model of depression. Neuroreport. vol 12. issue 18. 2002-03-18. PMID:11742215. |
here we show that in a validated rat model of depression (chronic unpredictable mild stress-induced anhedonia) there is a significant reduction of putrescine, spermidine and spermine in the hippocampus, and of only putrescine in the nucleus accumbens septi. |
2002-03-18 |
2023-08-12 |
rat |
| S Genedani, S Saltini, A Benelli, M Filaferro, A Bertolin. Influence of SAMe on the modifications of brain polyamine levels in an animal model of depression. Neuroreport. vol 12. issue 18. 2002-03-18. PMID:11742215. |
these results may suggest (i) a role for brain polyamines in depression and in reward processes, and (ii) that the antidepressant effect of same may be due, at least in part, to a normalization of putrescine levels in the nucleus accumbens septi. |
2002-03-18 |
2023-08-12 |
rat |
| D T Chau, P Rada, R A Kosloff, J L Taylor, B G Hoebe. Nucleus accumbens muscarinic receptors in the control of behavioral depression: antidepressant-like effects of local M1 antagonist in the Porsolt swim test. Neuroscience. vol 104. issue 3. 2001-08-30. PMID:11440810. |
nucleus accumbens muscarinic receptors in the control of behavioral depression: antidepressant-like effects of local m1 antagonist in the porsolt swim test. |
2001-08-30 |
2023-08-12 |
rat |
| D T Chau, P Rada, R A Kosloff, J L Taylor, B G Hoebe. Nucleus accumbens muscarinic receptors in the control of behavioral depression: antidepressant-like effects of local M1 antagonist in the Porsolt swim test. Neuroscience. vol 104. issue 3. 2001-08-30. PMID:11440810. |
in the present experiments, muscarinic agonists and antagonists were locally injected into the nucleus accumbens of female sprague-dawley rats to test for their effects on behavioral depression in the porsolt swim test and locomotor activity. |
2001-08-30 |
2023-08-12 |
rat |
| G Di Chiara, P Loddo, G Tand. Reciprocal changes in prefrontal and limbic dopamine responsiveness to aversive and rewarding stimuli after chronic mild stress: implications for the psychobiology of depression. Biological psychiatry. vol 46. issue 12. 2000-02-08. PMID:10624543. |
to investigate the role in depression of phasic dopamine transmission in cortical and limbic areas, we studied the effect of cms on the responsiveness of dopamine (da) transmission to aversive and rewarding stimuli in rats by microdialysis of the nucleus accumbens (nac) shell and of the medial prefrontal cortex (pfcx). |
2000-02-08 |
2023-08-12 |
human |
| D Chau, P V Rada, R A Kosloff, B G Hoebe. Cholinergic, M1 receptors in the nucleus accumbens mediate behavioral depression. A possible downstream target for fluoxetine. Annals of the New York Academy of Sciences. vol 877. 1999-08-10. PMID:10415702. |
cholinergic, m1 receptors in the nucleus accumbens mediate behavioral depression. |
1999-08-10 |
2023-08-12 |
Not clear |
| X F Zhang, X T Hu, F J Whit. Whole-cell plasticity in cocaine withdrawal: reduced sodium currents in nucleus accumbens neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 1. 1998-01-16. PMID:9412525. |
because nucleus accumbens neurons are normally recruited to coordinate response patterns of movement and affect, the decreased excitability during cocaine withdrawal may be related to symptoms such as anergia, anhedonia, and depression. |
1998-01-16 |
2023-08-12 |
rat |
| T Kling-Petersen, E Ljung, N Waters, K Svensso. Effects on locomotor activity after local application of (+)-UH232 in discrete areas of the rat brain. Journal of neural transmission (Vienna, Austria : 1996). vol 103. issue 3. 1997-03-27. PMID:8739844. |
the potential problem of leao's spreading depression in micro-injection experiments were considered, however, spreading depression does not seem to influence the effects of (+)-uh232 locally applied into the nucleus accumbens. |
1997-03-27 |
2023-08-12 |
rat |
| Y Shaham, H Rajabi, J Stewar. Relapse to heroin-seeking in rats under opioid maintenance: the effects of stress, heroin priming, and withdrawal. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 5. 1997-01-03. PMID:8774462. |
naloxone given to heroin-maintained animals induced withdrawal symptoms, caused a mild depression in the levels of dopamine and its metabolites in the nucleus accumbens septi (nas), but did not reinstate drug-seeking. |
1997-01-03 |
2023-08-12 |
rat |
| L Svensson, J Zhang, K Johannessen, J A Enge. Effect of local infusion of glutamate analogues into the nucleus accumbens of rats: an electrochemical and behavioural study. Brain research. vol 643. issue 1-2. 1994-08-12. PMID:7518326. |
it is evident from this study that local infusion of nmda or ampa may induce spreading depression in rat nucleus accumbens and that this condition is associated with a vast release of da and behavioural activation. |
1994-08-12 |
2023-08-12 |
rat |
| J M Wilson, J N Nobrega, M E Carroll, H B Niznik, K Shannak, S T Lac, Z B Pristupa, L M Dixon, S J Kis. Heterogeneous subregional binding patterns of 3H-WIN 35,428 and 3H-GBR 12,935 are differentially regulated by chronic cocaine self-administration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 5 Pt 2. 1994-06-14. PMID:8182452. |
these data provide additional support to the hypothesis that some of the long-term effects of cocaine exposure (drug craving, depression) could be consequent to reduced nucleus accumbens dopamine function. |
1994-06-14 |
2023-08-12 |
rat |
| R A Barraco, K A Martens, M Parizon, H J Normil. Adenosine A2a receptors in the nucleus accumbens mediate locomotor depression. Brain research bulletin. vol 31. issue 3-4. 1993-06-11. PMID:8490738. |
adenosine a2a receptors in the nucleus accumbens mediate locomotor depression. |
1993-06-11 |
2023-08-12 |
mouse |