| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui-Bin Chen, Fei Li, Shuai Wu, Shu-Cheng A. [Hippocampus quinolinic acid modulates glutamate and NMDAR/mGluR1 in chronic unpredictable mild stress-induced depression]. Sheng li xue bao : [Acta physiologica Sinica]. vol 65. issue 6. 2015-05-16. PMID:24343714. |
[hippocampus quinolinic acid modulates glutamate and nmdar/mglur1 in chronic unpredictable mild stress-induced depression]. |
2015-05-16 |
2023-08-12 |
rat |
| Hui-Bin Chen, Fei Li, Shuai Wu, Shu-Cheng A. [Hippocampus quinolinic acid modulates glutamate and NMDAR/mGluR1 in chronic unpredictable mild stress-induced depression]. Sheng li xue bao : [Acta physiologica Sinica]. vol 65. issue 6. 2015-05-16. PMID:24343714. |
the present study was to investigate the role of the quinolinic acid (quin) and its relationship with n-methyl-d-aspartic acid (nmda) receptor and metabotropic glutamate receptor 1 (mglur1) in depression induced by chronic unpredictable mild stress (cums) in hippocampus. |
2015-05-16 |
2023-08-12 |
rat |
| Margarita Ivanova, Stiliana Belcheva, Iren Belcheva, Zlatislav Stoyanov, Roman Tashe. Modulatory effect of VIP injected into hippocampal CA1 area on anxiety in olfactory bulbectomized rats. Acta neurobiologiae experimentalis. vol 74. issue 3. 2015-05-15. PMID:25231851. |
despite its extensive expression in the hippocampus, amygdala and other limbic system structures, the effects of vip on anxiety and depression have not yet been fully investigated. |
2015-05-15 |
2023-08-13 |
rat |
| Margarita Ivanova, Stiliana Belcheva, Iren Belcheva, Zlatislav Stoyanov, Roman Tashe. Modulatory effect of VIP injected into hippocampal CA1 area on anxiety in olfactory bulbectomized rats. Acta neurobiologiae experimentalis. vol 74. issue 3. 2015-05-15. PMID:25231851. |
our data point to a possible involvement of hippocampal vip-ergic neurons in modulating emotional processes or adaptive responses to stressful stimuli in a rat model of depression. |
2015-05-15 |
2023-08-13 |
rat |
| Rachel A Hill, Maren Klug, Szerenke Kiss Von Soly, Michele D Binder, Anthony J Hannan, Maarten van den Buus. Sex-specific disruptions in spatial memory and anhedonia in a "two hit" rat model correspond with alterations in hippocampal brain-derived neurotrophic factor expression and signaling. Hippocampus. vol 24. issue 10. 2015-05-12. PMID:24802968. |
post-mortem studies have demonstrated reduced expression of brain-derived neurotrophic factor (bdnf) in the hippocampus of schizophrenia and major depression patients. |
2015-05-12 |
2023-08-13 |
rat |
| Yiu Chung Tse, Ixchel Montoya, Alice S Wong, Axel Mathieu, Jennifer Lissemore, Diane C Lagace, Tak Pan Won. A longitudinal study of stress-induced hippocampal volume changes in mice that are susceptible or resilient to chronic social defeat. Hippocampus. vol 24. issue 9. 2015-05-11. PMID:24753271. |
hippocampal shrinkage is a commonly found neuroanatomical change in stress-related mood disorders such as depression and post-traumatic stress disorders (ptsd). |
2015-05-11 |
2023-08-13 |
mouse |
| Yiu Chung Tse, Ixchel Montoya, Alice S Wong, Axel Mathieu, Jennifer Lissemore, Diane C Lagace, Tak Pan Won. A longitudinal study of stress-induced hippocampal volume changes in mice that are susceptible or resilient to chronic social defeat. Hippocampus. vol 24. issue 9. 2015-05-11. PMID:24753271. |
however, a smaller hippocampal volume before stress exposure has also been suggested to confer vulnerability of stressed individuals to ptsd or depression. |
2015-05-11 |
2023-08-13 |
mouse |
| Olivia F O'Leary, Daniela Felice, Stefano Galimberti, Hélène M Savignac, Javier A Bravo, Tadhg Crowley, Malika El Yacoubi, Jean-Marie Vaugeois, Martin Gassmann, Bernhard Bettler, Timothy G Dinan, John F Crya. GABAB(1) receptor subunit isoforms differentially regulate stress resilience. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 42. 2015-04-24. PMID:25288769. |
in addition, increased hippocampal expression of the gabab(1b) receptor subunit is associated with a depression-like phenotype in the helpless h/rouen genetic mouse model of depression. |
2015-04-24 |
2023-08-13 |
mouse |
| Ting Lian, Shu-Cheng A. [Antidepressant effect of microinjection of neuropeptide Y into the hippocampus is mediated by decreased expression of nitric oxide synthase]. Sheng li xue bao : [Acta physiologica Sinica]. vol 62. issue 3. 2015-04-21. PMID:20571741. |
in conclusion, reduced expression of npy and increased expression of nos in hippocampus may make significant contributions to cums-induced depression. |
2015-04-21 |
2023-08-12 |
rat |
| Matasha Dhar, Mingyan Zhu, Soren Impey, Talley J Lambert, Tyler Bland, Ilia N Karatsoreos, Takanobu Nakazawa, Suzanne M Appleyard, Gary A Wayma. Leptin induces hippocampal synaptogenesis via CREB-regulated microRNA-132 suppression of p250GAP. Molecular endocrinology (Baltimore, Md.). vol 28. issue 7. 2015-04-16. PMID:24877561. |
leptin acts in the hippocampus to enhance cognition and reduce depression and anxiety. |
2015-04-16 |
2023-08-13 |
mouse |
| Suk Yu Yau, Ang Li, Ruby L C Hoo, Yick Pang Ching, Brian R Christie, Tatia M C Lee, Aimin Xu, Kwok-Fai S. Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 44. 2015-04-14. PMID:25331877. |
these data suggest that adiponectin may play a significant role in mediating the effects of exercise on hippocampal neurogenesis and depression, possibly by activation of the adnr1/ampk signaling pathways, and also raise the possibility that adiponectin and its agonists may represent a promising therapeutic treatment for depression. |
2015-04-14 |
2023-08-13 |
mouse |
| Gang Li, Ting Liu, Xiangqian Kong, Lei Wang, Xing Ji. Hippocampal glycogen synthase kinase 3β is critical for the antidepressant effect of cyclin-dependent kinase 5 inhibitor in rats. Journal of molecular neuroscience : MN. vol 54. issue 1. 2015-04-01. PMID:24563226. |
evidence of previous study showed that chronic inhibition of cdk5 in hippocampal dentate gyrus (dg) blocked the development of depressive-like symptoms, suggesting that cdk5 plays a role in development of depression. |
2015-04-01 |
2023-08-12 |
rat |
| J Macoveanu, U Knorr, A Skimminge, M G Søndergaard, A Jørgensen, M Fauerholdt-Jepsen, O B Paulson, G M Knudsen, H R Siebner, L V Kessin. Altered reward processing in the orbitofrontal cortex and hippocampus in healthy first-degree relatives of patients with depression. Psychological medicine. vol 44. issue 6. 2015-03-31. PMID:23866315. |
altered reward processing in the orbitofrontal cortex and hippocampus in healthy first-degree relatives of patients with depression. |
2015-03-31 |
2023-08-12 |
Not clear |
| Paul Willner, Jørgen Scheel-Krüger, Catherine Belzun. Resistance to antidepressant drugs: the case for a more predisposition-based and less hippocampocentric research paradigm. Behavioural pharmacology. vol 25. issue 5-6. 2015-03-31. PMID:25083567. |
the first half of this paper briefly reviews the evidence that (i) stress precipitates depression by damaging the hippocampus, leading to changes in the activity of a distributed neural system involving, inter alia, the amygdala, the ventromedial and dorsolateral prefrontal cortex, the lateral habenula and ascending monoamine pathways, and (ii) antidepressants work by repairing the damaged hippocampus, thus restoring the normal balance of activity within that circuitry. |
2015-03-31 |
2023-08-13 |
Not clear |
| Ying Xin Wang, Xiang Rong Zhang, Zhi Jun Zhang, Lei Li, Guang Jun Xi, Di Wu, Yan Juan Wan. Protein kinase Mζ is involved in the modulatory effect of fluoxetine on hippocampal neurogenesis in vitro. The international journal of neuropsychopharmacology. vol 17. issue 9. 2015-03-30. PMID:24679950. |
the efficacy of chronic selective serotonin reuptake inhibitors (ssris) on depression is paralleled by the recovery of deficits in hippocampal neurogenesis related to sustained stress and elevated glucocorticoids. |
2015-03-30 |
2023-08-12 |
rat |
| Daniel H O'Donovan, Carolina Muguruza, Luis F Callado, Isabel Roza. Guanidine-based α2-adrenoceptor ligands: Towards selective antagonist activity. European journal of medicinal chemistry. vol 82. 2015-03-30. PMID:24908653. |
depression has been linked to a selective increase in the high affinity conformation of the α2-adrenergic autoreceptors (α2-ars) in the human brain as well as to an overexpression of α2-ars in the hippocampus and cerebral cortex. |
2015-03-30 |
2023-08-13 |
human |
| Amy L Byers, Kristine Yaff. Depression and dementias among military veterans. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 3 Suppl. 2015-03-30. PMID:24924668. |
the most likely biologic mechanisms that may link depression and dementia among military veterans include vascular disease, changes in glucocorticoid steroids and hippocampal atrophy, deposition of β-amyloid plaques, inflammatory changes, and alterations of nerve growth factors. |
2015-03-30 |
2023-08-13 |
Not clear |
| Wei Deng, Fred H Gag. The effect of immature adult-born dentate granule cells on hyponeophagial behavior is related to their roles in learning and memory. Frontiers in systems neuroscience. vol 9. 2015-03-23. PMID:25798094. |
the neurogenesis hypothesis of depression is based on the correlation between the rate of adult hippocampal neurogenesis and the affective status of rodents. |
2015-03-23 |
2023-08-13 |
Not clear |
| Vernon R J Clarke, Svetlana M Molchanova, Teemu Hirvonen, Tomi Taira, Sari E Laur. Activity-dependent upregulation of presynaptic kainate receptors at immature CA3-CA1 synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 50. 2015-03-20. PMID:25505341. |
here we show that long-term depression (ltd) in the area ca1 of neonatal rodent hippocampus is associated with an upregulation of tonic inhibitory kar activity, which contributes to synaptic depression and causes a pronounced increase in short-term facilitation of transmission. |
2015-03-20 |
2023-08-13 |
Not clear |
| Suk Yu Yau, Ang Li, Aimin Xu, Kwok-Fai S. Fat cell-secreted adiponectin mediates physical exercise-induced hippocampal neurogenesis: an alternative anti-depressive treatment? Neural regeneration research. vol 10. issue 1. 2015-03-19. PMID:25788905. |
several recent publications have suggested the potential role of adiponectin, a protein hormone secreted by peripheral mature adipocytes, in mediating physical exercise-triggered enhancement of hippocampal neurogenesis and alleviation of depression. |
2015-03-19 |
2023-08-13 |
Not clear |