| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arum Han, Yu-Bin Sung, Soo-Young Chung, Min-Soo Kwo. Possible additional antidepressant-like mechanism of sodium butyrate: targeting the hippocampus. Neuropharmacology. vol 81. 2014-12-15. PMID:24607816. |
however, it seems to be unsuccessful to prevent depression induction since reduction of pcreb, aceh3 and bdnf were accompanied by crs in the hippocampus. |
2014-12-15 |
2023-08-12 |
mouse |
| Huaning Wang, Ruiguo Zhang, Yuting Qiao, Fen Xue, Huang Nie, Zhangjin Zhang, Ying Wang, Zhengwu Peng, Qingrong Ta. Gastrodin ameliorates depression-like behaviors and up-regulates proliferation of hippocampal-derived neural stem cells in rats: involvement of its anti-inflammatory action. Behavioural brain research. vol 266. 2014-12-12. PMID:24613238. |
in the present study, chronic unpredictable stress (cus) was used to establish a rat depression model; the sucrose preference test, forced swim test and morris water maze test were used to assess depression-like behaviors (anhedonia, behavioral despair, motor retardation, and poor spatial memory), and the proliferation of hippocampal stem cells was tested by brdu immunohistochemistry. |
2014-12-12 |
2023-08-12 |
rat |
| Naoki Takamura, Shin Nakagawa, Takahiro Masuda, Shuken Boku, Akiko Kato, Ning Song, Yan An, Yuji Kitaichi, Takeshi Inoue, Tsukasa Koyama, Ichiro Kusum. The effect of dopamine on adult hippocampal neurogenesis. Progress in neuro-psychopharmacology & biological psychiatry. vol 50. 2014-12-11. PMID:24374069. |
cumulative studies indicated that adult hippocampal neurogenesis might be involved in the action mechanism of antidepressant drugs and/or the pathophysiology of depression. |
2014-12-11 |
2023-08-12 |
rat |
| Naoki Takamura, Shin Nakagawa, Takahiro Masuda, Shuken Boku, Akiko Kato, Ning Song, Yan An, Yuji Kitaichi, Takeshi Inoue, Tsukasa Koyama, Ichiro Kusum. The effect of dopamine on adult hippocampal neurogenesis. Progress in neuro-psychopharmacology & biological psychiatry. vol 50. 2014-12-11. PMID:24374069. |
these results suggested that da might play, at least in part, a role in adult hippocampal neurogenesis via d1-like receptor and the activation of d1-like receptor has a therapeutic potential for depression. |
2014-12-11 |
2023-08-12 |
rat |
| Gerardo Ramírez-Rodríguez, Nelly Maritza Vega-Rivera, Julián Oikawa-Sala, Ariadna Gómez-Sánchez, Leonardo Ortiz-López, Erika Estrada-Camaren. Melatonin synergizes with citalopram to induce antidepressant-like behavior and to promote hippocampal neurogenesis in adult mice. Journal of pineal research. vol 56. issue 4. 2014-12-09. PMID:24650119. |
adult hippocampal neurogenesis is affected in some neuropsychiatric disorders such as depression. |
2014-12-09 |
2023-08-12 |
mouse |
| Gerardo Ramírez-Rodríguez, Nelly Maritza Vega-Rivera, Julián Oikawa-Sala, Ariadna Gómez-Sánchez, Leonardo Ortiz-López, Erika Estrada-Camaren. Melatonin synergizes with citalopram to induce antidepressant-like behavior and to promote hippocampal neurogenesis in adult mice. Journal of pineal research. vol 56. issue 4. 2014-12-09. PMID:24650119. |
in addition, antidepressants revert alterations of hippocampal neurogenesis present in models of depression following a similar time course to the improvement of behavior. |
2014-12-09 |
2023-08-12 |
mouse |
| Gerardo Ramírez-Rodríguez, Nelly Maritza Vega-Rivera, Julián Oikawa-Sala, Ariadna Gómez-Sánchez, Leonardo Ortiz-López, Erika Estrada-Camaren. Melatonin synergizes with citalopram to induce antidepressant-like behavior and to promote hippocampal neurogenesis in adult mice. Journal of pineal research. vol 56. issue 4. 2014-12-09. PMID:24650119. |
this outcome opens the opportunity of using melatonin to promote behavioral benefits and hippocampal neurogenesis in depression and also supports the use of the mltcital combination as an alternative to treat depression. |
2014-12-09 |
2023-08-12 |
mouse |
| Hui Kong, Xiao-Ning Zeng, Yi Fan, Song-Tao Yuan, Song Ge, Wei-Ping Xie, Hong Wang, Gang H. Aquaporin-4 knockout exacerbates corticosterone-induced depression by inhibiting astrocyte function and hippocampal neurogenesis. CNS neuroscience & therapeutics. vol 20. issue 5. 2014-12-08. PMID:24422972. |
aquaporin-4 knockout exacerbates corticosterone-induced depression by inhibiting astrocyte function and hippocampal neurogenesis. |
2014-12-08 |
2023-08-12 |
Not clear |
| Junsi Zhang, Yanna Li, Jing Xu, Zhou Yan. The role of N-methyl-D-aspartate receptor in Alzheimer's disease. Journal of the neurological sciences. vol 339. issue 1-2. 2014-12-08. PMID:24548486. |
the synaptic plasticity was measured by recording long-term potentiation (ltp) and depression (ltd) in the perforant path (pp) to dentate gyrus (dg) of hippocampus. |
2014-12-08 |
2023-08-12 |
rat |
| Pei Jiang, Rui-Li Dang, Huan-De Li, Li-Hong Zhang, Wen-Ye Zhu, Ying Xue, Mi-Mi Tan. The impacts of swimming exercise on hippocampal expression of neurotrophic factors in rats exposed to chronic unpredictable mild stress. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-12-05. PMID:25477997. |
depression is associated with stress-induced neural atrophy in limbic brain regions, whereas exercise has antidepressant effects as well as increasing hippocampal synaptic plasticity by strengthening neurogenesis, metabolism, and vascular function. |
2014-12-05 |
2023-08-13 |
rat |
| Zeinab Mohamed Kamel Ismail, Mary Attia Morcos, Mohammad Deiaa Eldin Mohammad, Alshaymaa Gamal Aboulkhai. Enhancement of Neural Stem Cells after Induction of Depression in Male Albino Rats (A histological & Immunohistochemical Study). International journal of stem cells. vol 7. issue 2. 2014-12-04. PMID:25473444. |
endogenous neural stem cells (nscs) could replace damaged hippocampal neurons in depression. |
2014-12-04 |
2023-08-13 |
rat |
| Mi Kyoung Seo, Chan Hong Lee, Hye Yeon Cho, Jung Goo Lee, Bong Ju Lee, Ji Eun Kim, Wongi Seol, Young Hoon Kim, Sung Woo Par. Effects of antidepressant drugs on synaptic protein levels and dendritic outgrowth in hippocampal neuronal cultures. Neuropharmacology. vol 79. 2014-12-03. PMID:24296153. |
the alteration of hippocampal plasticity has been proposed to play a critical role in both the pathophysiology and treatment of depression. |
2014-12-03 |
2023-08-12 |
rat |
| Katarzyna Młyniec, Urszula Doboszewska, Bernadeta Szewczyk, Magdalena Sowa-Kućma, Paulina Misztak, Wojciech Piekoszewski, Franciszek Trela, Beata Ostachowicz, Gabriel Nowa. The involvement of the GPR39-Zn(2+)-sensing receptor in the pathophysiology of depression. Studies in rodent models and suicide victims. Neuropharmacology. vol 79. 2014-12-03. PMID:24333148. |
down-regulation of creb, bdnf, trkb and gpr39 receptor found under zinc-deficient conditions in the hippocampus, may play an important role in the pathophysiology of mood disorders, since most of patients suffering from depression show lower serum zinc. |
2014-12-03 |
2023-08-12 |
mouse |
| Man Tang, Tao He, Xiao Sun, Qing-Yan Meng, Yao Diao, Jie-Yu Lei, Xiao-Jing He, Lei Chen, Xiu-Bo Sang, Shulei Zha. Subregion-specific decreases in hippocampal serotonin transporter protein expression and function associated with endophenotypes of depression. Hippocampus. vol 24. issue 4. 2014-12-03. PMID:24436084. |
subregion-specific decreases in hippocampal serotonin transporter protein expression and function associated with endophenotypes of depression. |
2014-12-03 |
2023-08-12 |
mouse |
| Man Tang, Tao He, Xiao Sun, Qing-Yan Meng, Yao Diao, Jie-Yu Lei, Xiao-Jing He, Lei Chen, Xiu-Bo Sang, Shulei Zha. Subregion-specific decreases in hippocampal serotonin transporter protein expression and function associated with endophenotypes of depression. Hippocampus. vol 24. issue 4. 2014-12-03. PMID:24436084. |
stress influences the development of depression, and depression is associated with structural and functional changes in the hippocampus. |
2014-12-03 |
2023-08-12 |
mouse |
| Man Tang, Tao He, Xiao Sun, Qing-Yan Meng, Yao Diao, Jie-Yu Lei, Xiao-Jing He, Lei Chen, Xiu-Bo Sang, Shulei Zha. Subregion-specific decreases in hippocampal serotonin transporter protein expression and function associated with endophenotypes of depression. Hippocampus. vol 24. issue 4. 2014-12-03. PMID:24436084. |
these data indicate that subregion-specific decreases in hippocampal 5-htt protein expression and function are associated with endophenotypes of depression. |
2014-12-03 |
2023-08-12 |
mouse |
| Negar Fani, Tricia Z King, Emily Reiser, Elisabeth B Binder, Tanja Jovanovic, Bekh Bradley, Kerry J Ressle. FKBP5 genotype and structural integrity of the posterior cingulum. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 5. 2014-12-01. PMID:24253961. |
alterations in the microarchitecture of the posterior cingulum (pc), a white matter tract proximal to the hippocampus that facilitates communication between the entorhinal and cingulate cortices, have been observed in individuals with psychiatric disorders, such as depression and post-traumatic stress disorder (ptsd). |
2014-12-01 |
2023-08-12 |
Not clear |
| Lucian Hritcu, Lucian Dragos Gorga. Intranigral lipopolysaccharide induced anxiety and depression by altered BDNF mRNA expression in rat hippocampus. Progress in neuro-psychopharmacology & biological psychiatry. vol 51. 2014-11-25. PMID:24508447. |
intranigral lipopolysaccharide induced anxiety and depression by altered bdnf mrna expression in rat hippocampus. |
2014-11-25 |
2023-08-12 |
rat |
| Arnaud Tanti, Catherine Belzun. Hippocampal neurogenesis: a biomarker for depression or antidepressant effects? Methodological considerations and perspectives for future research. Cell and tissue research. vol 354. issue 1. 2014-11-24. PMID:23595256. |
hippocampal neurogenesis: a biomarker for depression or antidepressant effects? |
2014-11-24 |
2023-08-12 |
Not clear |
| Arnaud Tanti, Catherine Belzun. Hippocampal neurogenesis: a biomarker for depression or antidepressant effects? Methodological considerations and perspectives for future research. Cell and tissue research. vol 354. issue 1. 2014-11-24. PMID:23595256. |
whereas animal models of depression are associated with decreased adult hippocampal neurogenesis, antidepressant treatments, including pharmacotherapy but also electroconvulsive therapy, have the opposite action, as they stimulate cell proliferation and the survival and maturation of newborn dentate gyrus neurons. |
2014-11-24 |
2023-08-12 |
Not clear |