| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Q-G Zhou, H-Y Wu, H Zhou, M-Y Liu, H-W Lee, X Liu, S Devkota, E J Ro, D-Y Zhu, H Su. Reactivation of Tert in the medial prefrontal cortex and hippocampus rescues aggression and depression of Tert(-/-) mice. Translational psychiatry. vol 6. issue 6. 2017-11-17. PMID:27300262. |
reactivation of tert in the medial prefrontal cortex and hippocampus rescues aggression and depression of tert(-/-) mice. |
2017-11-17 |
2023-08-13 |
mouse |
| Q-G Zhou, H-Y Wu, H Zhou, M-Y Liu, H-W Lee, X Liu, S Devkota, E J Ro, D-Y Zhu, H Su. Reactivation of Tert in the medial prefrontal cortex and hippocampus rescues aggression and depression of Tert(-/-) mice. Translational psychiatry. vol 6. issue 6. 2017-11-17. PMID:27300262. |
mechanistically, decreased serotonergic signaling and increased nitric oxide (no) transmission in the hippocampus transduced tert deficiency into depression as evidenced by our observation that the infusion of a pharmacological agonist for serotonin receptor 1a (5-htr1a) and a selective antagonist for neuronal no synthase into the hippocampus successfully normalized the depressive behavior of tert(-/-) mice. |
2017-11-17 |
2023-08-13 |
mouse |
| Judith Baka, Eszter Csakvari, Orsolya Huzian, Nikoletta Dobos, Laszlo Siklos, Csaba Leranth, Neil J MacLusky, Ronald S Duman, Tibor Hajsza. Stress induces equivalent remodeling of hippocampal spine synapses in a simulated postpartum environment and in a female rat model of major depression. Neuroscience. vol 343. 2017-11-17. PMID:28012870. |
stress induces equivalent remodeling of hippocampal spine synapses in a simulated postpartum environment and in a female rat model of major depression. |
2017-11-17 |
2023-08-13 |
rat |
| Judith Baka, Eszter Csakvari, Orsolya Huzian, Nikoletta Dobos, Laszlo Siklos, Csaba Leranth, Neil J MacLusky, Ronald S Duman, Tibor Hajsza. Stress induces equivalent remodeling of hippocampal spine synapses in a simulated postpartum environment and in a female rat model of major depression. Neuroscience. vol 343. 2017-11-17. PMID:28012870. |
although both of these factors are capable of powerfully modulating neuronal plasticity, there is no direct electron microscopic evidence of hippocampal spine synapse remodeling in postpartum depression. |
2017-11-17 |
2023-08-13 |
rat |
| Pingfu Feng, Afaf A Akladious, Yufen H. Hippocampal and motor fronto-cortical neuroligin1 is increased in an animal model of depression. Psychiatry research. vol 243. 2017-11-16. PMID:27423632. |
hippocampal and motor fronto-cortical neuroligin1 is increased in an animal model of depression. |
2017-11-16 |
2023-08-13 |
human |
| Pingfu Feng, Afaf A Akladious, Yufen H. Hippocampal and motor fronto-cortical neuroligin1 is increased in an animal model of depression. Psychiatry research. vol 243. 2017-11-16. PMID:27423632. |
we concluded that nlgn1 gene and protein expression is higher in the motor frontal cortex, hippocampus and in the prefrontal cortex in the wky rats suggesting that alterations of nlgn1 is involved in the pathology of depression but need to be further evaluated in human. |
2017-11-16 |
2023-08-13 |
human |
| Danielle Lefebvre, Lisa Marie Langevin, Natalia Jaworska, Ashley D Harris, R Marc Lebel, Yamile Jasaui, Adam Kirton, T Christopher Wilkes, Mariko Sembo, Rose Swansburg, Frank P MacMaste. A pilot study of hippocampal N-acetyl-aspartate in youth with treatment resistant major depression. Journal of affective disorders. vol 207. 2017-11-16. PMID:27721183. |
a pilot study of hippocampal n-acetyl-aspartate in youth with treatment resistant major depression. |
2017-11-16 |
2023-08-13 |
Not clear |
| M M Jukić, N Opel, J Ström, T Carrillo-Roa, S Miksys, M Novalen, A Renblom, S C Sim, E M Peñas-Lledó, P Courtet, A Llerena, B T Baune, D J de Quervain, A Papassotiropoulos, R F Tyndale, E B Binder, U Dannlowski, M Ingelman-Sundber. Elevated CYP2C19 expression is associated with depressive symptoms and hippocampal homeostasis impairment. Molecular psychiatry. vol 22. issue 8. 2017-11-13. PMID:27895323. |
in humans, we found that the absence of cyp2c19 was associated with a bilateral hippocampal volume increase in two independent healthy cohorts (n=386 and 1032) and a lower prevalence of major depressive disorder and depression severity in african-americans (n=3848). |
2017-11-13 |
2023-08-13 |
mouse |
| Rand Mahmoud, Steven R Wainwright, Liisa A M Gale. Sex hormones and adult hippocampal neurogenesis: Regulation, implications, and potential mechanisms. Frontiers in neuroendocrinology. vol 41. 2017-11-09. PMID:26988999. |
the review is framed around the potential functional implications of sex hormone regulation of adult hippocampal neurogenesis, with a focus on cognitive function and mood regulation, which may be related to sex differences in incidence and severity of dementia and depression. |
2017-11-09 |
2023-08-13 |
Not clear |
| M M Darby, R H Yolken, S Sabunciya. Consistently altered expression of gene sets in postmortem brains of individuals with major psychiatric disorders. Translational psychiatry. vol 6. issue 9. 2017-11-07. PMID:27622934. |
we then identified genes and canonical pathway gene sets with significantly altered expression in schizophrenia and bipolar disorder in the hippocampus and in schizophrenia, bipolar disorder and major depression in the orbitofrontal cortex. |
2017-11-07 |
2023-08-13 |
Not clear |
| Bo Jiang, Ying-Jie Wang, Hao Wang, Lu Song, Chao Huang, Qing Zhu, Feng Wu, Wei Zhan. Antidepressant-like effects of fenofibrate in mice via the hippocampal brain-derived neurotrophic factor signalling pathway. British journal of pharmacology. vol 174. issue 2. 2017-11-06. PMID:27861729. |
depression is a neuropsychiatric disorder accompanied by a decrease in the brain-derived neurotrophic factor (bdnf) signalling cascade in the hippocampus. |
2017-11-06 |
2023-08-13 |
mouse |
| Elizabeth Kulikova, Alexander Kuliko. Striatal-enriched Tyrosine Protein Phosphatase (STEP) in the Mechanisms of Depressive Disorders. Current protein & peptide science. vol 18. issue 11. 2017-11-06. PMID:28699511. |
the deficit of bdnf results in progressive degeneration of neurons in the hippocampus and cortex and increases depression risk. |
2017-11-06 |
2023-08-13 |
mouse |
| K E Boschen, A Y Klintsov. Neurotrophins in the Brain: Interaction With Alcohol Exposure During Development. Vitamins and hormones. vol 104. 2017-11-02. PMID:28215296. |
these areas of overlap include formation of long-term potentiation, oxidative stress processes, neuroinflammation, apoptosis and cell loss, hippocampal adult neurogenesis, dendritic morphology and spine density, vasculogenesis and angiogenesis, and behaviors related to spatial memory, anxiety, and depression. |
2017-11-02 |
2023-08-13 |
Not clear |
| Sonu Singh, Akanksha Mishra, Neha Srivastava, Shubha Shukl. MK-801 (Dizocilpine) Regulates Multiple Steps of Adult Hippocampal Neurogenesis and Alters Psychological Symptoms via Wnt/β-Catenin Signaling in Parkinsonian Rats. ACS chemical neuroscience. vol 8. issue 3. 2017-10-25. PMID:27977132. |
adult hippocampal neurogenesis is directly involved in regulation of stress, anxiety, and depression that are commonly observed nonmotor symptoms in parkinson's disease (pd). |
2017-10-25 |
2023-08-13 |
rat |
| D Borsook, C Linnman, V Faria, A M Strassman, L Becerra, I Elma. Reward deficiency and anti-reward in pain chronification. Neuroscience and biobehavioral reviews. vol 68. 2017-10-23. PMID:27246519. |
anti-reward (ar) conversely pertains to a between-systems neuroadaptation involving over-recruitment of key limbic structures (e.g., the central and basolateral amygdala nuclei, the bed nucleus of the stria terminalis, the lateral tegmental noradrenergic nuclei of the brain stem, the hippocampus and the habenula) responsible for massive outpouring of stressogenic neurochemicals (e.g., norepinephrine, corticotropin releasing factor, vasopressin, hypocretin, and substance p) giving rise to such negative affective states as anxiety, fear and depression. |
2017-10-23 |
2023-08-13 |
Not clear |
| Wei Jia, Rui Liu, Jianguo Shi, Bin Wu, Wei Dang, Ying Du, Qiong Zhou, Jianhua Wang, Rui Zhan. Differential Regulation of MAPK Phosphorylation in the Dorsal Hippocampus in Response to Prolonged Morphine Withdrawal-Induced Depressive-Like Symptoms in Mice. PloS one. vol 8. issue 6. 2017-10-13. PMID:23823128. |
our findings support the association between hippocampal mapk phosphorylation and prolonged morphine withdrawal-induced depression, and emphasize the mkp-1 as an negative regulator of the erk phosphorylation that contributes to depression. |
2017-10-13 |
2023-08-12 |
mouse |
| Erin M van Buel, Hannes Sigrist, Erich Seifritz, Lianne Fikse, Fokko J Bosker, Robert A Schoevers, Hans C Klein, Christopher R Pryce, Ulrich Lm Eise. Mouse repeated electroconvulsive seizure (ECS) does not reverse social stress effects but does induce behavioral and hippocampal changes relevant to electroconvulsive therapy (ECT) side-effects in the treatment of depression. PloS one. vol 12. issue 9. 2017-10-13. PMID:28910337. |
mouse repeated electroconvulsive seizure (ecs) does not reverse social stress effects but does induce behavioral and hippocampal changes relevant to electroconvulsive therapy (ect) side-effects in the treatment of depression. |
2017-10-13 |
2023-08-13 |
mouse |
| Vyara Valkanova, Klaus P Ebmeier, Charlotte L Alla. Depression is linked to dementia in older adults. The Practitioner. vol 261. issue 1800. 2017-10-13. PMID:29023080. |
older people with depression are at raised risk of dementia and this risk is increased if they have had symptoms for a long time, if their symptoms are severe, where there are multiple (vascular) comorbidities, and where there are structural brain changes including hippocampal atrophy and white matter abnormalities. |
2017-10-13 |
2023-08-13 |
Not clear |
| Manuel Narváez, Dasiel O Borroto-Escuela, Carmelo Millón, Belén Gago, Antonio Flores-Burgess, Luis Santín, Kjell Fuxe, José Angel Narváez, Zaida Díaz-Cabial. Galanin receptor 2-neuropeptide Y Y1 receptor interactions in the dentate gyrus are related with antidepressant-like effects. Brain structure & function. vol 221. issue 8. 2017-10-10. PMID:26666529. |
these results indicate that galr2/npyy1r interactions can provide a novel integrative mechanism in dg in depression-related behavior and may give the basis for the development of drugs targeting galr2/npyy1r heteroreceptor complexes in the dg of the hippocampus for the treatment of depression. |
2017-10-10 |
2023-08-13 |
Not clear |
| Stephan Guggenhuber, Alan Alpar, Rongqing Chen, Nina Schmitz, Melanie Wickert, Tobias Mattheus, Anne E Harasta, Martin Purrio, Nadine Kaiser, Maurice R Elphick, Krisztina Monory, Werner Kilb, Heiko J Luhmann, Tibor Harkany, Beat Lutz, Matthias Klugman. Cannabinoid receptor-interacting protein Crip1a modulates CB1 receptor signaling in mouse hippocampus. Brain structure & function. vol 221. issue 4. 2017-10-03. PMID:25772509. |
crip1a overexpression extended the depression of excitatory currents by cannabinoids in pyramidal neurons of the hippocampus and diminished the severity of chemically induced acute epileptiform seizures. |
2017-10-03 |
2023-08-13 |
mouse |