| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dennis J Selkoe, John Hard. The amyloid hypothesis of Alzheimer's disease at 25 years. EMBO molecular medicine. vol 8. issue 6. 2017-09-27. PMID:27025652. |
soluble oligomers of aβ42 isolated from ad patients' brains can decrease synapse number, inhibit long-term potentiation, and enhance long-term synaptic depression in rodent hippocampus, and injecting them into healthy rats impairs memory. |
2017-09-27 |
2023-08-13 |
mouse |
| Lin Chen, Xin Wang, Zi-Xuan Lin, Jian-Guo Dai, Yu-Fang Huang, Yu-Nan Zha. Preventive Effects of Ginseng Total Saponins on Chronic Corticosterone-Induced Impairment in Astrocyte Structural Plasticity and Hippocampal Atrophy. Phytotherapy research : PTR. vol 31. issue 9. 2017-09-25. PMID:28656606. |
to further explore the underlying antidepressant mechanism of ginseng total saponins (gts), this study observed the effects on hippocampal astrocyte structural plasticity and hippocampal volume in the corticosterone-induced mouse depression model. |
2017-09-25 |
2023-08-13 |
mouse |
| Jing-Ran Lin, Shun-Chang Fang, Su-Su Tang, Mei Hu, Yan Long, Arijit Ghosh, Hong-Bin Sun, Ling-Yi Kong, Hao Hon. Hippocampal CysLT Acta pharmacologica Sinica. vol 38. issue 4. 2017-09-22. PMID:28112182. |
hippocampal cyslt evidence suggests that neuroinflammation is involved in depression and that the cysteinyl leukotriene receptor 1 (cyslt |
2017-09-22 |
2023-08-13 |
Not clear |
| Jovana Joksimovic, Dragica Selakovic, Milovan Matovic, Ivan Zaletel, Nela Puskas, Gvozden Rosi. The role of neuropeptide-Y in nandrolone decanoate-induced attenuation of antidepressant effect of exercise. PloS one. vol 12. issue 6. 2017-09-19. PMID:28582442. |
furthermore, the behavioral indicators of depression showed strong correlations with the serum levels and the hippocampal content of npy. |
2017-09-19 |
2023-08-13 |
rat |
| Ya-Tin Lin, Tzu-Yu Liu, Ching-Yao Yang, Yu-Lian Yu, Ting-Chun Chen, Yuan-Ji Day, Che-Chien Chang, Guo-Jen Huang, Jin-Chung Che. Chronic activation of NPFFR2 stimulates the stress-related depressive behaviors through HPA axis modulation. Psychoneuroendocrinology. vol 71. 2017-09-18. PMID:27243477. |
in addition, transgenic (tg) mice over-expressing npffr2 displayed clear depression and anxiety-like behaviors with hyperactivity in the hypothalamic-pituitary-adrenal (hpa) axis, reduced expression of glucocorticoid receptor (gr) and neurogenesis in the hippocampus. |
2017-09-18 |
2023-08-13 |
mouse |
| Ya-Tin Lin, Tzu-Yu Liu, Ching-Yao Yang, Yu-Lian Yu, Ting-Chun Chen, Yuan-Ji Day, Che-Chien Chang, Guo-Jen Huang, Jin-Chung Che. Chronic activation of NPFFR2 stimulates the stress-related depressive behaviors through HPA axis modulation. Psychoneuroendocrinology. vol 71. 2017-09-18. PMID:27243477. |
this novel role of npffr2 in regulating the hpa axis and hippocampal function provides a new avenue for combating depression and anxiety-like disorder. |
2017-09-18 |
2023-08-13 |
mouse |
| Beata Fuchsova, Anabel Alvarez Juliá, Hooriyah S Rizavi, Alberto Carlos Frasch, Ghanshyam N Pande. Expression of p21-activated kinases 1 and 3 is altered in the brain of subjects with depression. Neuroscience. vol 333. 2017-09-06. PMID:27474226. |
using quantitative polymerase chain reaction (qpcr), mrna levels and coexpression of the group i paks: pak1, pak2, and pak3 as well as of their activators: rac1, cdc42 and arhgef7 were examined in postmortem samples from the pfc (n=25) and the hippocampus (n=23) of subjects with depression and compared to control subjects (pfc n=24; hippocampus n=21). |
2017-09-06 |
2023-08-13 |
human |
| Filip Bouckaert, Annemiek Dols, Louise Emsell, François-Laurent De Winter, Kristof Vansteelandt, Lene Claes, Stefan Sunaert, Max Stek, Pascal Sienaert, Mathieu Vandenbulck. Relationship Between Hippocampal Volume, Serum BDNF, and Depression Severity Following Electroconvulsive Therapy in Late-Life Depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 11. 2017-08-31. PMID:27272769. |
relationship between hippocampal volume, serum bdnf, and depression severity following electroconvulsive therapy in late-life depression. |
2017-08-31 |
2023-08-13 |
Not clear |
| Masaaki Iwata, Hisahito Ishida, Koichi Kaneko, Yukihiko Shirayam. Learned helplessness activates hippocampal microglia in rats: A potential target for the antidepressant imipramine. Pharmacology, biochemistry, and behavior. vol 150-151. 2017-08-31. PMID:27769904. |
microglia, the resident macrophages in the brain, play a central role in the innate immune system and express inflammasomes; thus, we hypothesized that hippocampal microglia would be key mediators in the development of depression via stress-induced inflammation. |
2017-08-31 |
2023-08-13 |
rat |
| Ruyan Wu, Hailou Zhang, Wenda Xue, Zhilu Zou, Cai Lu, Baomei Xia, Wei Wang, Gang Che. Transgenerational impairment of hippocampal Akt-mTOR signaling and behavioral deficits in the offspring of mice that experience postpartum depression-like illness. Progress in neuro-psychopharmacology & biological psychiatry. vol 73. 2017-08-30. PMID:27693392. |
akt-mtor signaling in the hippocampus is implicated in depression but its role in the behavioral deficits in ppd offspring remains unknown. |
2017-08-30 |
2023-08-13 |
mouse |
| Wei Liu, Tongtong Ge, Yashu Leng, Zhenxiang Pan, Jie Fan, Wei Yang, Ranji Cu. The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex. Neural plasticity. vol 2017. 2017-08-29. PMID:28246558. |
the role of neural plasticity in depression: from hippocampus to prefrontal cortex. |
2017-08-29 |
2023-08-13 |
Not clear |
| K W Miskowiak, J Macoveanu, M Vinberg, E Assentoft, L Randers, C J Harmer, H Ehrenreich, O B Paulson, G M Knudsen, H R Siebner, L V Kessin. Effects of erythropoietin on memory-relevant neurocircuitry activity and recall in mood disorders. Acta psychiatrica Scandinavica. vol 134. issue 3. 2017-08-25. PMID:27259062. |
erythropoietin (epo) improves verbal memory and reverses subfield hippocampal volume loss across depression and bipolar disorder (bd). |
2017-08-25 |
2023-08-13 |
Not clear |
| Jonathon Sens, Eric Schneider, Joseph Mauch, Anna Schaffstein, Sara Mohamed, Kathryn Fasoli, Joseph Saurine, Aikaterini Britzolaki, Connor Thelen, Pothitos M Pitychouti. Lipopolysaccharide administration induces sex-dependent behavioural and serotonergic neurochemical signatures in mice. Pharmacology, biochemistry, and behavior. vol 153. 2017-08-25. PMID:28057525. |
we further mapped the brain's serotonergic and dopaminergic activity in five limbic brain regions implicated in the pathophysiology of major depression (i.e., prefrontal cortex, hippocampus, striatum, amygdala, and hypothalamus) at two critical time-points post-lps treatment; at 6h when depression of behavioural activity is maximal, and at 24h when depressive-like symptoms develop independently of obvious locomotor performance impairments associated with acute lps administration. |
2017-08-25 |
2023-08-13 |
mouse |
| Yujin Guo, Hualin Cai, Lei Chen, Donglou Liang, Ranyao Yang, Ruili Dang, Pei Jian. Quantitative profiling of neurotransmitter abnormalities in the hippocampus of rats treated with lipopolysaccharide: Focusing on kynurenine pathway and implications for depression. Journal of neuroimmunology. vol 295-296. 2017-08-17. PMID:27235347. |
quantitative profiling of neurotransmitter abnormalities in the hippocampus of rats treated with lipopolysaccharide: focusing on kynurenine pathway and implications for depression. |
2017-08-17 |
2023-08-13 |
rat |
| Weiwei Yang, Shun Y. Synucleinopathies: common features and hippocampal manifestations. Cellular and molecular life sciences : CMLS. vol 74. issue 8. 2017-08-17. PMID:27826641. |
cognitive impairment and depression associated with hippocampal dysfunction are frequently observed in these disorders. |
2017-08-17 |
2023-08-13 |
Not clear |
| Xiao-Yan Zhou, Fang Zhang, Xiao-Tong Hu, Jing Chen, Ren-Xian Tang, Kui-Yang Zheng, Yuan-Jian Son. Depression can be prevented by astaxanthin through inhibition of hippocampal inflammation in diabetic mice. Brain research. vol 1657. 2017-08-07. PMID:28017669. |
depression can be prevented by astaxanthin through inhibition of hippocampal inflammation in diabetic mice. |
2017-08-07 |
2023-08-13 |
mouse |
| Xiao-Yan Zhou, Fang Zhang, Xiao-Tong Hu, Jing Chen, Ren-Xian Tang, Kui-Yang Zheng, Yuan-Jian Son. Depression can be prevented by astaxanthin through inhibition of hippocampal inflammation in diabetic mice. Brain research. vol 1657. 2017-08-07. PMID:28017669. |
the critical factor considered in a depression induced by diabetes is the inflammation eliciting hippocampal, amygdala and thalamic neuronal injury. |
2017-08-07 |
2023-08-13 |
mouse |
| Xiao-Yan Zhou, Fang Zhang, Xiao-Tong Hu, Jing Chen, Ren-Xian Tang, Kui-Yang Zheng, Yuan-Jian Son. Depression can be prevented by astaxanthin through inhibition of hippocampal inflammation in diabetic mice. Brain research. vol 1657. 2017-08-07. PMID:28017669. |
these findings suggest that the mechanism of astaxanthin in preventing depression in diabetic mice involves the inhibition of inflammation/inflammation inhibition, thereby protecting neurons in hippocampus, amygdala and hypothalamus against hyperglycemic damage. |
2017-08-07 |
2023-08-13 |
mouse |
| Mahesh Shivarama Shetty, Sreedharan Sajikuma. 'Tagging' along memories in aging: Synaptic tagging and capture mechanisms in the aged hippocampus. Ageing research reviews. vol 35. 2017-08-02. PMID:28065806. |
hippocampal synaptic plasticity, such as long-term potentiation (ltp) and depression (ltd), are candidate cellular correlates of learning and memory and alterations in these properties have been well documented in aging. |
2017-08-02 |
2023-08-13 |
Not clear |
| Magda A Eldomiaty, Shaima M Almasry, Maha K Desouky, Sami A Algaid. Voluntary running improves depressive behaviours and the structure of the hippocampus in rats: A possible impact of myokines. Brain research. vol 1657. 2017-07-31. PMID:27919728. |
after voluntary running, there was significant decrease in number degenerated neurons in hippocampal areas and significant increase in number of healthy neurons in the upper limb of the dentate gyrus, but not in its lower limb, compared to depression group. |
2017-07-31 |
2023-08-13 |
rat |