| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junfang Wu, Zaorui Zhao, Alok Kumar, Marta M Lipinski, David J Loane, Bogdan A Stoica, Alan I Fade. Endoplasmic Reticulum Stress and Disrupted Neurogenesis in the Brain Are Associated with Cognitive Impairment and Depressive-Like Behavior after Spinal Cord Injury. Journal of neurotrauma. vol 33. issue 21. 2018-01-12. PMID:27050417. |
these findings indicate that sci causes chronic neuroinflammation that contributes to neuronal loss, impaired hippocampal neurogenesis and increased neuronal er stress in important brain regions associated with cognitive decline and physiological depression. |
2018-01-12 |
2023-08-13 |
mouse |
| Pu Hu, Yu Wang, Ji Liu, Fan-Tao Meng, Xin-Rui Qi, Lin Chen, Anne-Marie van Dam, Marian Joëls, Paul J Lucassen, Jiang-Ning Zho. Chronic retinoic acid treatment suppresses adult hippocampal neurogenesis, in close correlation with depressive-like behavior. Hippocampus. vol 26. issue 7. 2018-01-08. PMID:26860546. |
as we had shown before that chronic application of all-trans retinoic acid (ra) potently activated the hypothalamus-pituitary-adrenal (hpa) stress axis, we here questioned whether ra also induced changes in adult hippocampal neurogenesis, a form of structural plasticity sensitive to stress and implicated in aspects of depression and hippocampal function. |
2018-01-08 |
2023-08-13 |
rat |
| Maryam Ardalan, Gregers Wegener, Benedetta Polsinelli, Torsten M Madsen, Jens R Nyengaar. Neurovascular plasticity of the hippocampus one week after a single dose of ketamine in genetic rat model of depression. Hippocampus. vol 26. issue 11. 2018-01-08. PMID:27440163. |
neurovascular plasticity of the hippocampus one week after a single dose of ketamine in genetic rat model of depression. |
2018-01-08 |
2023-08-13 |
rat |
| Dávid Csabai, László Seress, Zsófia Varga, Hajnalka Ábrahám, Attila Miseta, Ove Wiborg, Boldizsár Czé. Electron Microscopic Analysis of Hippocampal Axo-Somatic Synapses in a Chronic Stress Model for Depression. Hippocampus. vol 27. issue 1. 2018-01-08. PMID:27571571. |
electron microscopic analysis of hippocampal axo-somatic synapses in a chronic stress model for depression. |
2018-01-08 |
2023-08-13 |
rat |
| Amanda J Sales, Vinícius A Hiroaki-Sato, Sâmia R L Joc. Participation of hippocampal nitric oxide synthase and soluble guanylate cyclase in the modulation of behavioral responses elicited by the rat forced swimming test. Behavioural pharmacology. vol 28. issue 1. 2018-01-08. PMID:27779493. |
systemic or hippocampal administration of nitric oxide (no) synthase inhibitors induces antidepressant-like effects in animals, implicating increased hippocampal levels of no in the neurobiology of depression. |
2018-01-08 |
2023-08-13 |
rat |
| Yongjun Xu, Hui Sheng, Qingyue Bao, Yujun Wang, Jianqiang Lu, Xin N. NLRP3 inflammasome activation mediates estrogen deficiency-induced depression- and anxiety-like behavior and hippocampal inflammation in mice. Brain, behavior, and immunity. vol 56. 2018-01-04. PMID:26928197. |
our study suggests that estrogen deficiency results in nlrp3 inflammasome activation, thereby leading to neuroinflammation in hippocampus and depression and anxiety. |
2018-01-04 |
2023-08-13 |
mouse |
| Kymberly D Young, Wayne C Drevets, Robert Dantzer, T Kent Teague, Jerzy Bodurka, Jonathan Savit. Kynurenine pathway metabolites are associated with hippocampal activity during autobiographical memory recall in patients with depression. Brain, behavior, and immunity. vol 56. 2018-01-04. PMID:27091600. |
kynurenine pathway metabolites are associated with hippocampal activity during autobiographical memory recall in patients with depression. |
2018-01-04 |
2023-08-13 |
human |
| Kymberly D Young, Wayne C Drevets, Robert Dantzer, T Kent Teague, Jerzy Bodurka, Jonathan Savit. Kynurenine pathway metabolites are associated with hippocampal activity during autobiographical memory recall in patients with depression. Brain, behavior, and immunity. vol 56. 2018-01-04. PMID:27091600. |
we previously reported that the ratios of kynurenic acid (kyna) to the neurotoxic metabolites, 3-hydroxykynurenine (3hk) and quinolinic acid (qa), were positively correlated with hippocampal volume in depression. |
2018-01-04 |
2023-08-13 |
human |
| Kymberly D Young, Wayne C Drevets, Robert Dantzer, T Kent Teague, Jerzy Bodurka, Jonathan Savit. Kynurenine pathway metabolites are associated with hippocampal activity during autobiographical memory recall in patients with depression. Brain, behavior, and immunity. vol 56. 2018-01-04. PMID:27091600. |
conceivably, an imbalance in levels of kyna versus qa-pathway metabolites may adversely impact the function of the hippocampus and am recall, raising the possibility that kynurenine pathway may affect emotion-dependent memory within the context of depression. |
2018-01-04 |
2023-08-13 |
human |
| Burak Tan, Soner Bitiktaş, Şehrazat Kavraal, Nurcan Dursun, Hamiyet Dönmez Altuntaş, Cem Sue. Low-frequency stimulation induces a durable long-term depression in young adult hyperthyroid rats: the role of p38 mitogen-activated protein kinase and protein phosphatase 1. Neuroreport. vol 27. issue 9. 2018-01-04. PMID:27128724. |
in control rats, a standard lfs protocol induced a slight depression of the population spike (ps) amplitude during the induction phase of ltd (76±13% vs. baseline), but a small potentiation of the ps amplitude was observed in the early (107±18%) and late (111±20%) phases of ltd. interestingly, in the hyperthyroid rats, the same lfs protocol induced a reliable ltd in the dentate gyrus of the hippocampus as evidenced by a marked depression in the ps amplitude during the induction (54±6% vs. baseline) and the early phases (56±8%) of ltd. elevated mrna levels of p38-mapk and pp1 were observed in the hippocampus of the lfs-treated hyperthyroid rats compared with the hippocampus of the vehicle-treated hyperthyroid rats. |
2018-01-04 |
2023-08-13 |
rat |
| Zong-Yang Li, Qing-Zhong Li, Lei Chen, Bao-Dong Chen, Ce Zhang, Xiang Wang, Wei-Ping L. HPOB, an HDAC6 inhibitor, attenuates corticosterone-induced injury in rat adrenal pheochromocytoma PC12 cells by inhibiting mitochondrial GR translocation and the intrinsic apoptosis pathway. Neurochemistry international. vol 99. 2018-01-03. PMID:27522966. |
high levels of glucocorticoids (gcs) have been reported to damage normal hippocampal neurons, and such damage has been positively correlated with major depression (md) and chronic stress. |
2018-01-03 |
2023-08-13 |
rat |
| Keng-Fan Liu, Yingxiao Li, Kai Chun Cheng, Chao Chin Hsu, Juei-Tang Cheng, Wen-Huang Pen. Changes in PPARδ expression in a rat model of stress-induced depression. Clinical and experimental pharmacology & physiology. vol 44. issue 6. 2018-01-01. PMID:28267873. |
the present study was designed to characterize the changes in pparδ expression in the hippocampus in rats with stress-induced depression. |
2018-01-01 |
2023-08-13 |
rat |
| Keng-Fan Liu, Yingxiao Li, Kai Chun Cheng, Chao Chin Hsu, Juei-Tang Cheng, Wen-Huang Pen. Changes in PPARδ expression in a rat model of stress-induced depression. Clinical and experimental pharmacology & physiology. vol 44. issue 6. 2018-01-01. PMID:28267873. |
we found that pparδ expression in the hippocampus was markedly reduced in rats with depression. |
2018-01-01 |
2023-08-13 |
rat |
| Keng-Fan Liu, Yingxiao Li, Kai Chun Cheng, Chao Chin Hsu, Juei-Tang Cheng, Wen-Huang Pen. Changes in PPARδ expression in a rat model of stress-induced depression. Clinical and experimental pharmacology & physiology. vol 44. issue 6. 2018-01-01. PMID:28267873. |
treatment with a pparδ agonist enhanced the expression of pparδ and the serotonin transporter in the hippocampus of rats with stress-induced depression. |
2018-01-01 |
2023-08-13 |
rat |
| Giulia Treccani, Kristian Gaarn du Jardin, Gregers Wegener, Heidi Kaastrup Mülle. Differential expression of postsynaptic NMDA and AMPA receptor subunits in the hippocampus and prefrontal cortex of the flinders sensitive line rat model of depression. Synapse (New York, N.Y.). vol 70. issue 11. 2017-12-22. PMID:27262028. |
differential expression of postsynaptic nmda and ampa receptor subunits in the hippocampus and prefrontal cortex of the flinders sensitive line rat model of depression. |
2017-12-22 |
2023-08-13 |
rat |
| Shizuka Kobayashi, Yamato Hida, Hiroyoshi Ishizaki, Eiji Inoue, Miki Tanaka-Okamoto, Miwako Yamasaki, Taisuke Miyazaki, Masahiro Fukaya, Isao Kitajima, Yoshimi Takai, Masahiko Watanabe, Toshihisa Ohtsuka, Toshiya Manab. The active zone protein CAST regulates synaptic vesicle recycling and quantal size in the mouse hippocampus. The European journal of neuroscience. vol 44. issue 5. 2017-12-22. PMID:27422015. |
in the ca1 region of hippocampal slices of the cast knockout mice, miniature excitatory synaptic responses were increased in size, and synaptic depression after prolonged synaptic activation was larger, which was attributable to selective impairment of synaptic vesicle trafficking via the endosome in the presynaptic terminal likely mediated by rab6. |
2017-12-22 |
2023-08-13 |
mouse |
| Bo Feng, Xiao-Yang Zhao, Yi-Zhou Song, Wen-Na Liang, Ji-Liang Li. Sarsasapogenin reverses depressive-like behaviors and nicotinic acetylcholine receptors induced by olfactory bulbectomy. Neuroscience letters. vol 639. 2017-12-19. PMID:27988349. |
the results indicate that abnormal cholinergic signalling in the hippocampus contributes to the development of depression in the ob rat model. |
2017-12-19 |
2023-08-13 |
rat |
| E Lui, M Salim, M Chahal, N Puri, E Marandi, J Quadrilatero, E Satva. Chronic corticosterone-induced impaired cognitive flexibility is not due to suppressed adult hippocampal neurogenesis. Behavioural brain research. vol 332. 2017-12-19. PMID:28578986. |
hippocampal neurogenesis has been implicated in the etiology of depression. |
2017-12-19 |
2023-08-13 |
rat |
| E Lui, M Salim, M Chahal, N Puri, E Marandi, J Quadrilatero, E Satva. Chronic corticosterone-induced impaired cognitive flexibility is not due to suppressed adult hippocampal neurogenesis. Behavioural brain research. vol 332. 2017-12-19. PMID:28578986. |
we hypothesized that suppressed hippocampal neurogenesis may contribute to impaired cognitive flexibility associated with depression. |
2017-12-19 |
2023-08-13 |
rat |
| E Lui, M Salim, M Chahal, N Puri, E Marandi, J Quadrilatero, E Satva. Chronic corticosterone-induced impaired cognitive flexibility is not due to suppressed adult hippocampal neurogenesis. Behavioural brain research. vol 332. 2017-12-19. PMID:28578986. |
results suggest cognitive flexibility is impaired in the cort-induced animal model of depression; an effect that is reversible and independent of suppressed hippocampal neurogenesis. |
2017-12-19 |
2023-08-13 |
rat |