| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marie-Laure Ancelin, Jacqueline Scali, Joanna Norton, Karen Ritchie, Anne-Marie Dupuy, Isabelle Chaudieu, Joanne Rya. Heterogeneity in HPA axis dysregulation and serotonergic vulnerability to depression. Psychoneuroendocrinology. vol 77. 2017-12-07. PMID:28024274. |
heterogeneity in hpa axis dysregulation and serotonergic vulnerability to depression. |
2017-12-07 |
2023-08-13 |
human |
| Chun-Hsien Hsu, Yen-Lin Chen, Dee Pei, Shu-Man Yu, I-Chao Li. Depression as the Primary Cause of Insomnia and Excessive Daytime Sleepiness in a Family with Multiple Cases of Spinocerebellar Ataxia. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine. vol 12. issue 7. 2017-12-04. PMID:27166302. |
after treatment with serotonin-norepinephrine reuptake inhibitors and noradrenergic and specific serotonergic antidepressants, symptoms of insomnia and eds, which are strongly associated with depression in sca type 2 patients, improved significantly. |
2017-12-04 |
2023-08-13 |
Not clear |
| Q-G Zhou, H-Y Wu, H Zhou, M-Y Liu, H-W Lee, X Liu, S Devkota, E J Ro, D-Y Zhu, H Su. Reactivation of Tert in the medial prefrontal cortex and hippocampus rescues aggression and depression of Tert(-/-) mice. Translational psychiatry. vol 6. issue 6. 2017-11-17. PMID:27300262. |
mechanistically, decreased serotonergic signaling and increased nitric oxide (no) transmission in the hippocampus transduced tert deficiency into depression as evidenced by our observation that the infusion of a pharmacological agonist for serotonin receptor 1a (5-htr1a) and a selective antagonist for neuronal no synthase into the hippocampus successfully normalized the depressive behavior of tert(-/-) mice. |
2017-11-17 |
2023-08-13 |
mouse |
| LeeAnn M Perry, Andrea N Goldstein-Piekarski, Leanne M William. Sex differences modulating serotonergic polymorphisms implicated in the mechanistic pathways of risk for depression and related disorders. Journal of neuroscience research. vol 95. issue 1-2. 2017-11-13. PMID:27870440. |
sex differences modulating serotonergic polymorphisms implicated in the mechanistic pathways of risk for depression and related disorders. |
2017-11-13 |
2023-08-13 |
Not clear |
| LeeAnn M Perry, Andrea N Goldstein-Piekarski, Leanne M William. Sex differences modulating serotonergic polymorphisms implicated in the mechanistic pathways of risk for depression and related disorders. Journal of neuroscience research. vol 95. issue 1-2. 2017-11-13. PMID:27870440. |
this mini-review focuses on genetic polymorphisms of the serotonergic system to illustrate how sex differences might modulate the neurobiological pathways involved in the development of depression. |
2017-11-13 |
2023-08-13 |
Not clear |
| R Hamish McAllister-Williams, Ian M Anderson, Andreas Finkelmeyer, Peter Gallagher, Heinz C R Grunze, Peter M Haddad, Tom Hughes, Adrian J Lloyd, Chrysovalanto Mamasoula, Elaine McColl, Simon Pearce, Najma Siddiqi, Baxi N P Sinha, Nick Steen, June Wainwright, Fiona H Winter, I Nicol Ferrier, Stuart Watso. Antidepressant augmentation with metyrapone for treatment-resistant depression (the ADD study): a double-blind, randomised, placebo-controlled trial. The lancet. Psychiatry. vol 3. issue 2. 2017-11-01. PMID:26727041. |
we aimed to test the proof of concept of metyrapone for the augmentation of serotonergic antidepressants in the clinically relevant population of patients with treatment-resistant depression. |
2017-11-01 |
2023-08-13 |
Not clear |
| Eyleen Corrales, Arcadi Navarro, Patricia Cuenca, Domingo Campo. Candidate gene study reveals DRD1 and DRD2 as putative interacting risk factors for youth depression. Psychiatry research. vol 244. 2017-10-31. PMID:27472173. |
we analyzed 170 single nucleotide polymorphisms (snps) in 21 candidate dopaminergic and serotonergic genes in a non-clinical sample of 410 costa rican participants of ages between 7 and 18 years, assessing the severity of depressive symptoms through the child depression inventory (cdi). |
2017-10-31 |
2023-08-13 |
human |
| Disha Shah, Ines Blockx, Georgios A Keliris, Firat Kara, Elisabeth Jonckers, Marleen Verhoye, Annemie Van der Linde. Cholinergic and serotonergic modulations differentially affect large-scale functional networks in the mouse brain. Brain structure & function. vol 221. issue 6. 2017-09-28. PMID:26195064. |
the cholinergic system is involved in cognitive functions and is impaired in, e.g., alzheimer's disease, while the serotonergic system is involved in emotional and introspective functions and is impaired in, e.g., alzheimer's disease, depression and autism. |
2017-09-28 |
2023-08-13 |
mouse |
| Weidong Li, Yan Zhu, Shakir M Saud, Qiujun Guo, Shengyan Xi, Baohui Jia, Shuang Jiao, Xiuyan Yang, Jun Lu, Sihong Song, Ya T. Electroacupuncture relieves depression-like symptoms in rats exposed to chronic unpredictable mild stress by activating ERK signaling pathway. Neuroscience letters. vol 642. 2017-09-08. PMID:28147225. |
while the mainstay treatment for depression are pharmacological agents that modulate serotonergic and/or noradrenergic activity of the brain, recent data suggest that, neurotrophins may play a larger role in the pathogenesis of depression and may offer better therapeutic potential in alleviating symptoms associated with depression. |
2017-09-08 |
2023-08-13 |
rat |
| Antonio Flores-Burgess, Carmelo Millón, Belén Gago, Manuel Narváez, Dasiel O Borroto-Escuela, Guadalupe Mengod, José Angel Narváez, Kjell Fuxe, Luis Santín, Zaida Díaz-Cabial. Galanin (1-15) enhancement of the behavioral effects of Fluoxetine in the forced swimming test gives a new therapeutic strategy against depression. Neuropharmacology. vol 118. 2017-09-05. PMID:28288814. |
the pharmacological treatment of major depression is mainly based on drugs elevating serotonergic (5-ht) activity. |
2017-09-05 |
2023-08-13 |
rat |
| Jonathon Sens, Eric Schneider, Joseph Mauch, Anna Schaffstein, Sara Mohamed, Kathryn Fasoli, Joseph Saurine, Aikaterini Britzolaki, Connor Thelen, Pothitos M Pitychouti. Lipopolysaccharide administration induces sex-dependent behavioural and serotonergic neurochemical signatures in mice. Pharmacology, biochemistry, and behavior. vol 153. 2017-08-25. PMID:28057525. |
we further mapped the brain's serotonergic and dopaminergic activity in five limbic brain regions implicated in the pathophysiology of major depression (i.e., prefrontal cortex, hippocampus, striatum, amygdala, and hypothalamus) at two critical time-points post-lps treatment; at 6h when depression of behavioural activity is maximal, and at 24h when depressive-like symptoms develop independently of obvious locomotor performance impairments associated with acute lps administration. |
2017-08-25 |
2023-08-13 |
mouse |
| Shogo Moriya, Tomoko Soga, Dutt Way Wong, Ishwar S Parha. Transcriptome composition of the preoptic area in mid-age and escitalopram treatment in male mice. Neuroscience letters. vol 622. 2017-07-19. PMID:27113202. |
the decrease in serotonergic neurotransmission during aging can increase the risk of neuropsychiatric diseases such as depression in elderly population and decline the reproductive system. |
2017-07-19 |
2023-08-13 |
mouse |
| Shvetank Bhatt, Radhakrishnan Mahesh, Ankur Jindal, Thangaraj Devados. Neuropharmacological and neurochemical evaluation of N-n-propyl-3-ethoxyquinoxaline-2-carboxamide (6n): a novel serotonergic 5-HT3 receptor antagonist for co-morbid antidepressant- and anxiolytic-like potential using traumatic brain injury model in rats. Journal of basic and clinical physiology and pharmacology. vol 28. issue 2. 2017-07-07. PMID:27662644. |
several preclinical studies have shown that serotonergic 5-ht3 receptor antagonists play an important role in the management of neuropsychiatric disorders, such as depression and anxiety. |
2017-07-07 |
2023-08-13 |
rat |
| Teresa Ravizza, Filiz Y Onat, Amy R Brooks-Kayal, Antoine Depaulis, Aristea S Galanopoulou, Andrey Mazarati, Adam L Numis, Raman Sankar, Alon Friedma. WONOEP appraisal: Biomarkers of epilepsy-associated comorbidities. Epilepsia. vol 58. issue 3. 2017-06-21. PMID:28035782. |
furthermore, dysfunction in serotonergic transmission, hyperactivity of the hypothalamic-pituitary-adrenocortical axis, the role of the inflammatory cytokines, and the contributions of genetic factors have all recently been regarded as relevant for understanding epilepsy-associated depression and cognitive deficits. |
2017-06-21 |
2023-08-13 |
Not clear |
| Audrey Maillet, Paul Krack, Eugénie Lhommée, Elise Météreau, Hélène Klinger, Emilie Favre, Didier Le Bars, Emmanuelle Schmitt, Amélie Bichon, Pierre Pelissier, Valérie Fraix, Anna Castrioto, Véronique Sgambato-Faure, Emmanuel Broussolle, Léon Tremblay, Stéphane Thoboi. The prominent role of serotonergic degeneration in apathy, anxiety and depression in de novo Parkinson's disease. Brain : a journal of neurology. vol 139. issue Pt 9. 2017-06-05. PMID:27538418. |
the prominent role of serotonergic degeneration in apathy, anxiety and depression in de novo parkinson's disease. |
2017-06-05 |
2023-08-13 |
human |
| Audrey Maillet, Paul Krack, Eugénie Lhommée, Elise Météreau, Hélène Klinger, Emilie Favre, Didier Le Bars, Emmanuelle Schmitt, Amélie Bichon, Pierre Pelissier, Valérie Fraix, Anna Castrioto, Véronique Sgambato-Faure, Emmanuel Broussolle, Léon Tremblay, Stéphane Thoboi. The prominent role of serotonergic degeneration in apathy, anxiety and depression in de novo Parkinson's disease. Brain : a journal of neurology. vol 139. issue Pt 9. 2017-06-05. PMID:27538418. |
pathophysiological evidence suggests that parkinsonian apathy is primarily due to a mesolimbic dopaminergic denervation, but the role of the serotonergic alteration has never been examined, despite its well-known involvement in the pathogenesis of depression and anxiety. |
2017-06-05 |
2023-08-13 |
human |
| Audrey Maillet, Paul Krack, Eugénie Lhommée, Elise Météreau, Hélène Klinger, Emilie Favre, Didier Le Bars, Emmanuelle Schmitt, Amélie Bichon, Pierre Pelissier, Valérie Fraix, Anna Castrioto, Véronique Sgambato-Faure, Emmanuel Broussolle, Léon Tremblay, Stéphane Thoboi. The prominent role of serotonergic degeneration in apathy, anxiety and depression in de novo Parkinson's disease. Brain : a journal of neurology. vol 139. issue Pt 9. 2017-06-05. PMID:27538418. |
regression analyses also revealed that the severity of apathy was moreover mainly related to specific serotonergic lesions within the right-sided anterior caudate nucleus and the orbitofrontal cortex, while the degree of both depression and anxiety was primarily linked to serotonergic disruption within the bilateral subgenual parts and/or the right dorsal part of the anterior cingulate cortex, without prominent role of the dopaminergic degeneration in the pathogenesis of these three non-motor signs. |
2017-06-05 |
2023-08-13 |
human |
| Jesus-Servando Medel-Matus, Don Shin, Raman Sankar, Andrey Mazarat. Galanin contributes to monoaminergic dysfunction and to dependent neurobehavioral comorbidities of epilepsy. Experimental neurology. vol 289. 2017-05-15. PMID:28013000. |
these findings suggest that endogenous galanin, acting through galr1 may be involved in the pathophysiology of epilepsy-associated depression and adhd via inhibiting rn-pfc serotonergic and lc-pfc noradrenergic transmissions respectively. |
2017-05-15 |
2023-08-13 |
human |
| Yuko Yoshimura, Chihiro Ishikawa, Haruki Kasegai, Tomoyuki Masuda, Masaaki Yoshikawa, Takashi Shig. Roles of 5-HT Neuroscience research. vol 115. 2017-04-11. PMID:27702575. |
roles of 5-ht the possible interactions between serotonergic and glutamatergic systems during neural development and under the pathogenesis of depression remain unclear. |
2017-04-11 |
2023-08-13 |
Not clear |
| Frank M Schmidt, Stephanie Schindler, Melanie Adamidis, Maria Strauß, Anja Tränkner, Robert Trampel, Martin Walter, Ulrich Hegerl, Robert Turner, Stefan Geyer, Peter Schönknech. Habenula volume increases with disease severity in unmedicated major depressive disorder as revealed by 7T MRI. European archives of psychiatry and clinical neuroscience. vol 267. issue 2. 2017-03-10. PMID:26873703. |
evidence comes from its impact on the regulation of serotonergic and dopaminergic neurons, the role in emotional processing and studies on animal models of depression. |
2017-03-10 |
2023-08-13 |
Not clear |