| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kyosuke Uno, Hajime Miyanishi, Kengo Sodeyama, Toshiyuki Fujiwara, Toh Miyazaki, Shin-Ichi Muramatsu, Atsumi Nitt. Vulnerability to depressive behavior induced by overexpression of striatal Shati/Nat8l via the serotonergic neuronal pathway in mice. Behavioural brain research. vol 376. 2020-09-22. PMID:31520691. |
taken together, shati/nat8l in the striatum has an important role in the vulnerability to depression onsets by regulating the origin of serotonergic neuronal system via gabaergic projection neuron in the dorsal raphe from the dorsal striatum. |
2020-09-22 |
2023-08-13 |
mouse |
| Melissa J Maguire, Cerian F Jackson, Anthony G Marson, Sarah J Nevit. Treatments for the prevention of Sudden Unexpected Death in Epilepsy (SUDEP). The Cochrane database of systematic reviews. vol 4. 2020-08-31. PMID:32239759. |
preventative strategies for sudep include reducing the occurrence of gtcs by timely referral for presurgical evaluation in people with lesional epilepsy and advice on lifestyle measures; detecting cardiorespiratory distress through clinical observation and seizure, respiratory, and heart rate monitoring devices; preventing airway obstruction through nocturnal supervision and safety pillows; reducing central hypoventilation through physical stimulation and enhancing serotonergic mechanisms of respiratory regulation using selective serotonin reuptake inhibitors (ssris); and reducing adenosine and endogenous opioid-induced brain and brainstem depression. |
2020-08-31 |
2023-08-13 |
Not clear |
| Florian Javelle, Amit Lampit, Wilhelm Bloch, Peter Häussermann, Sheri L Johnson, Philipp Zimme. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis. Nutrition reviews. vol 78. issue 1. 2020-08-20. PMID:31504850. |
serotonergic dysfunction, including reduced central serotonin levels, is associated with different psychiatric syndromes, including depression. |
2020-08-20 |
2023-08-13 |
Not clear |
| Qiaohui Lu, Akihiro Mouri, Yang Yang, Kazuo Kunisawa, Tomoaki Teshigawara, Mami Hirakawa, Yuko Mori, Yasuko Yamamoto, Zou Libo, Toshitaka Nabeshima, Kuniaki Sait. Chronic unpredictable mild stress-induced behavioral changes are coupled with dopaminergic hyperfunction and serotonergic hypofunction in mouse models of depression. Behavioural brain research. vol 372. 2020-08-19. PMID:31288060. |
chronic unpredictable mild stress-induced behavioral changes are coupled with dopaminergic hyperfunction and serotonergic hypofunction in mouse models of depression. |
2020-08-19 |
2023-08-13 |
mouse |
| Eric W Prouty, Daniel J Chandler, Wen-Jun Gao, Barry D Waterhous. Selective vulnerability of dorsal raphe-medial prefrontal cortex projection neurons to corticosterone-induced hypofunction. The European journal of neuroscience. vol 50. issue 1. 2020-08-14. PMID:30687960. |
our results suggest that the serotonergic regulation of cognitive and emotional networks in the mpfc may be more sensitive to the effects of glucocorticoid excess than visual sensory circuits in the lgn and that reduced 5-ht transmission in the mpfc may underlie the association between glucocorticoid excess and depression. |
2020-08-14 |
2023-08-13 |
rat |
| Stéphane Prange, Elise Metereau, Audrey Maillet, Eugénie Lhommée, Hélène Klinger, Pierre Pelissier, Danielle Ibarrola, Rolf A Heckemann, Anna Castrioto, Léon Tremblay, Véronique Sgambato, Emmanuel Broussolle, Paul Krack, Stéphane Thoboi. Early limbic microstructural alterations in apathy and depression in de novo Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 34. issue 11. 2020-07-08. PMID:31309609. |
the objectives of this study were to investigate whether apathy and depression in de novo parkinsonian patients are related to structural alterations and how structural abnormalities relate to serotonergic or dopaminergic dysfunction. |
2020-07-08 |
2023-08-13 |
Not clear |
| Louisa J. Steinberg, Mark D. Underwood, Mihran J. Bakalian, Suham A. Kassir, J. John Mann, Victoria Arang. 5-HT1A receptor, 5-HT2A receptor and serotonin transporter binding in the human auditory cortex in depression Journal of psychiatry & neuroscience : JPN. vol 44. issue 5. 2020-06-22. PMID:31120232. |
5-ht1a receptor, 5-ht2a receptor and serotonin transporter binding in the human auditory cortex in depression serotonergic system abnormalities are implicated in many psychiatric disorders, including major depression. |
2020-06-22 |
2023-08-13 |
human |
| Anna Sophie Thue Hvilsom, Thea P Lillethorup, Peter Iversen, Doris J Doudet, Gregers Wegener, Anne M Landa. Cortical and striatal serotonin transporter binding in a genetic rat model of depression and in response to electroconvulsive stimuli. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 29. issue 4. 2020-06-17. PMID:30826156. |
the serotonergic system plays an important role in depression and alterations in the serotonin transporter (sert) are seen both in depression and response to antidepressant pharmacotherapies. |
2020-06-17 |
2023-08-13 |
rat |
| Paul R. Albert, Brice Le François, Faranak Vahid-Ansar. Genetic, epigenetic and posttranscriptional mechanisms for treatment of major depression: the 5-HT1A receptor gene as a paradigm Journal of psychiatry & neuroscience : JPN. vol 44. issue 3. 2020-06-09. PMID:30807072. |
functional single-nucleotide polymorphisms and stress-induced dna methylation of the 5-ht1a promoter converge to differentially alter pre- and postsynaptic 5-ht1a receptor expression associated with major depression and reduced therapeutic response to serotonergic antidepressants. |
2020-06-09 |
2023-08-13 |
human |
| Andrew Del Colle, Narek Israelyan, Kara Gross Margoli. Novel aspects of enteric serotonergic signaling in health and brain-gut disease. American journal of physiology. Gastrointestinal and liver physiology. vol 318. issue 1. 2020-05-04. PMID:31682158. |
this review summarizes the current data focusing on the important roles that serotonin plays in ens development and motility, with a focus on novel aspects of serotonergic signaling in medical conditions in which cns and ens co-morbidities are common, including autism spectrum disorders and depression. |
2020-05-04 |
2023-08-13 |
Not clear |
| Dariusz Zurawek, Piotr Gruca, Lucyna Antkiewicz-Michaluk, Marta Dziedzicka-Wasylewsk. Resilient Phenotype in Chronic Mild Stress Paradigm Is Associated with Altered Expression Levels of miR-18a-5p and Serotonin 5-HT Molecular neurobiology. vol 56. issue 11. 2020-03-12. PMID:31098953. |
resilient phenotype in chronic mild stress paradigm is associated with altered expression levels of mir-18a-5p and serotonin 5-ht disturbed serotonergic signaling in the hippocampus observed in many individuals vulnerable to stress has been suggested as one of the primary factors contributing to the development of depression. |
2020-03-12 |
2023-08-13 |
human |
| Dan Liu, Xiao-Ya Hu, Hai-Jian Xia, Li-Jia Wang, Ping Shi, Xiang-Pan Chen, Qi-Xin Zho. Antidepressant effect of venlafaxine in chronic unpredictable stress: Evidence of the involvement of key enzymes responsible for monoamine neurotransmitter synthesis and metabolism. Molecular medicine reports. vol 20. issue 3. 2020-01-13. PMID:31322231. |
a number of studies have linked abnormalities in the function of the serotonergic and noradrenergic systems to the pathophysiology of depression. |
2020-01-13 |
2023-08-13 |
rat |
| Naoya Nishitani, Kazuki Nagayasu, Nozomi Asaoka, Mayumi Yamashiro, Chihiro Andoh, Yuma Nagai, Haruko Kinoshita, Hiroyuki Kawai, Norihiro Shibui, Beihui Liu, James Hewinson, Hisashi Shirakawa, Takayuki Nakagawa, Hitoshi Hashimoto, Sergey Kasparov, Shuji Kanek. Manipulation of dorsal raphe serotonergic neurons modulates active coping to inescapable stress and anxiety-related behaviors in mice and rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 4. 2019-12-13. PMID:30377380. |
these findings further our understanding of the pathophysiological role of dorsal raphe serotonergic neurons in different species and the role of these neurons as therapeutic targets in major depression and anxiety disorders. |
2019-12-13 |
2023-08-13 |
mouse |
| Michael E. Newman, Baruch Shapira, Bernard Lere. Evaluation of central serotonergic function in affective and related disorders by the fenfluramine challenge test: a critical review. The international journal of neuropsychopharmacology. vol 1. issue 1. 2019-11-20. PMID:11281946. |
the blunted prolactin release is not due to a deficient secretory capacity of pituitary lactotrophs and is congruent with other evidence for reduced central serotonergic function in major depression. |
2019-11-20 |
2023-08-12 |
human |
| Michael E. Newman, Ofer Agid, Eitan Gur, Bernard Lere. Pharmacological mechanisms of T3 augmentation of antidepressant action. The international journal of neuropsychopharmacology. vol 3. issue 2. 2019-11-20. PMID:11343595. |
interactions of t3 with mechanisms involved in noradrenergic and serotonergic neurotransmission are of particular interest in that these systems have been implicated in the neurobiology of depression and in the actions of antidepressant drugs. |
2019-11-20 |
2023-08-12 |
Not clear |
| A Coppen, K M Woo. PERIPHERAL SEROTONERGIC AND ADRENERGIC RESPONSES IN DEPRESSION. Acta psychiatrica Scandinavica. vol 61. issue S280. 2019-11-20. PMID:28678355. |
peripheral serotonergic and adrenergic responses in depression. |
2019-11-20 |
2023-08-13 |
Not clear |
| J A Den Boer, H G M Westenber. Serotonergic compounds in panic disorder, obsessive-compulsive disorder and anxious depression: A concise review. Human psychopharmacology. vol 10 Suppl 3. issue S3. 2019-11-20. PMID:29569409. |
serotonergic compounds in panic disorder, obsessive-compulsive disorder and anxious depression: a concise review. |
2019-11-20 |
2023-08-13 |
Not clear |
| Sumana Gadde, Carl Brown, Amy Shah, Rif S El-Mallak. Long-term prospective mood self-rating and antidepressant treatment. Irish journal of psychological medicine. vol 28. issue 4. 2019-11-20. PMID:30200014. |
cycling and increase in depression was noted after years of continuous use of serotonergic antidepressant treatment. |
2019-11-20 |
2023-08-13 |
Not clear |
| Suzanne Vrshek-Schallhorn, Catherine B Stroud, Leah D Doane, Susan Mineka, Richard E Zinbarg, Eva E Redei, Michelle G Craske, Emma K Ada. Cortisol awakening response and additive serotonergic genetic risk interactively predict depression in two samples: The 2019 Donald F. Klein Early Career Investigator Award Paper. Depression and anxiety. vol 36. issue 6. 2019-10-28. PMID:31017373. |
cortisol awakening response and additive serotonergic genetic risk interactively predict depression in two samples: the 2019 donald f. klein early career investigator award paper. |
2019-10-28 |
2023-08-13 |
human |
| Darin J Knapp, Kathryn M Harper, Joshua Melton, George Brees. Comparative effects of stressors on behavioral and neuroimmune responses of fawn-hooded (FH/Wjd) and Wistar rats: Implications for models of depression. Journal of neuroimmunology. vol 322. 2019-10-03. PMID:30049539. |
fawn hooded (fh/wjd) rats have long been used as a model of depression based on their depressive-like behaviors, high basal corticosterone levels and altered serotonergic levels, but little is known about the neuroimmune function in this model. |
2019-10-03 |
2023-08-13 |
rat |