| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Simon Reiche, Leo Hermle, Stefan Gutwinski, Henrik Jungaberle, Peter Gasser, Tomislav Maji\\xc4\\x8. Serotonergic hallucinogens in the treatment of anxiety and depression in patients suffering from a life-threatening disease: A systematic review. Progress in neuro-psychopharmacology & biological psychiatry. vol 81. 2018-06-27. PMID:28947181.' |
serotonergic hallucinogens in the treatment of anxiety and depression in patients suffering from a life-threatening disease: a systematic review. |
2018-06-27 |
2023-08-13 |
Not clear |
| R Slopień, A Rózycka, A Slopień, M Pawlak, A Warenik-Szymankiewicz, S Sajdak, P Jagodzińsk. The genetic background of climacteric symptoms in women during menopause. Clinical and experimental obstetrics & gynecology. vol 43. issue 4. 2018-06-20. PMID:29734534. |
among the candidate genes in the aetiology of depression the following were selected for the research: the serotonergic system receptor genes: 5htr2a, 5htr1b, 5htr2c, tph 1, tph2, and mao-a; the genes of noradrenergic and dopaminergic systems (comt, net), the genes of the gabaergic (gabrbl) system, a gene of the estrogen receptor (esr1), and the genes of the enzymes crucial in the methyl cycle (mthrf, mtr, and mthfd1). |
2018-06-20 |
2023-08-13 |
human |
| b' Ivana Peri\\xc4\\x87, Andrijana Stanisavljevi\\xc4\\x87, Peter Gass, Dragana Filipovi\\xc4\\x8. Fluoxetine reverses behavior changes in socially isolated rats: role of the hippocampal GSH-dependent defense system and proinflammatory cytokines. European archives of psychiatry and clinical neuroscience. vol 267. issue 8. 2018-06-13. PMID:28474231.' |
fluoxetine (flx) is a first-line treatment for depression; however, its downstream mechanisms of action beyond serotonergic signaling remain ill-defined. |
2018-06-13 |
2023-08-13 |
rat |
| Zafer Iscan, Gopalkumar Rakesh, Samantha Rossano, Jie Yang, Mengru Zhang, Jeffrey Miller, Gregory M Sullivan, Priya Sharma, Matthew McClure, Maria A Oquendo, J John Mann, Ramin V Parsey, Christine DeLorenz. A positron emission tomography study of the serotonergic system in relation to anxiety in depression. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 27. issue 10. 2018-05-30. PMID:28811068. |
a positron emission tomography study of the serotonergic system in relation to anxiety in depression. |
2018-05-30 |
2023-08-13 |
Not clear |
| Mohamed Elsaed Ebad. Drug repurposing may generate novel approaches to treating depression. The Journal of pharmacy and pharmacology. vol 69. issue 11. 2018-05-28. PMID:28925030. |
in addition to reduced noradrenergic and serotonergic neurotransmission in the brain, other coincidence features such as glutamate neurotoxicity, inflammation and/or cerebrovascular insufficiency are implicated in the pathogenesis of major depressive disorder and late-life depression. |
2018-05-28 |
2023-08-13 |
Not clear |
| Rubem Carlos Araújo Guedes, Maria das Graças Rodrigues de Araújo, Taciana Cristovam Verçosa, Francisca Martins Bion, Andrea Lima de Sá, Antônio Pereira, Ricardo Abadie-Guede. Evidence of an inverse correlation between serotonergic activity and spreading depression propagation in the rat cortex. Brain research. vol 1672. 2018-05-18. PMID:28751192. |
evidence of an inverse correlation between serotonergic activity and spreading depression propagation in the rat cortex. |
2018-05-18 |
2023-08-13 |
rat |
| Rubem Carlos Araújo Guedes, Maria das Graças Rodrigues de Araújo, Taciana Cristovam Verçosa, Francisca Martins Bion, Andrea Lima de Sá, Antônio Pereira, Ricardo Abadie-Guede. Evidence of an inverse correlation between serotonergic activity and spreading depression propagation in the rat cortex. Brain research. vol 1672. 2018-05-18. PMID:28751192. |
in this study, we investigated whether brain serotonergic activity influences the excitability-related phenomenon known as cortical spreading depression (csd). |
2018-05-18 |
2023-08-13 |
rat |
| Elisa M Ruohonen, Piia Astikaine. Brain responses to sound intensity changes dissociate depressed participants and healthy controls. Biological psychology. vol 127. 2018-04-23. PMID:28499838. |
whether these manifestations of sensory over-excitability in depression are directly related to the serotonergic neurotransmission requires further research. |
2018-04-23 |
2023-08-13 |
human |
| Mustapha Riad, Antonia Kobert, Laurent Descarries, Sandra Boye, Pierre-Paul Rompré, Jean-Claude Lacaill. Chronic fluoxetine rescues changes in plasma membrane density of 5-HT1A autoreceptors and serotonin transporters in the olfactory bulbectomy rodent model of depression. Neuroscience. vol 356. 2018-04-12. PMID:28528967. |
our findings support the hypothesis that changes in efficacy of serotonergic neurotransmission in this model of depression depends on both activity and density of cell surface-expressed sert and 5-ht1a auto-receptors. |
2018-04-12 |
2023-08-13 |
rat |
| b' Nevena Todorovi\\xc4\\x87, Dragana Filipovi\\xc4\\x8. Prefrontal cortical glutathione-dependent defense and proinflammatory mediators in chronically isolated rats: Modulation by fluoxetine or clozapine. Neuroscience. vol 355. 2018-03-28. PMID:28499974.' |
although the antidepressant fluoxetine (flx) represents the first-line treatment for depression and the atypical antipsychotic clozapine (clz) is considered as a second-line treatment for psychotic disorders, the downstream mechanisms of action of these treatments, beyond serotonergic or dopaminergic signaling, remain elusive. |
2018-03-28 |
2023-08-13 |
rat |
| Davide Zarcone, Simona Corbett. Shared mechanisms of epilepsy, migraine and affective disorders. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 38. issue Suppl 1. 2018-03-08. PMID:28527083. |
in women, hormonal fluctuations are also crucial, especially in the post-partum and late luteal phase, when the estrogenic reduction, associated with up-regulation of snps and down-regulation of serotonergic and gabaergic systems, increases the risk of migraine and depression. |
2018-03-08 |
2023-08-13 |
Not clear |
| b' Vjekoslav Peitl, Mario \\xc5\\xa0tefanovi\\xc4\\x87, Dalibor Karlovi\\xc4\\x8. Depressive symptoms in schizophrenia and dopamine and serotonin gene polymorphisms. Progress in neuro-psychopharmacology & biological psychiatry. vol 77. 2018-03-05. PMID:28416295.' |
as impaired serotonergic and dopaminergic neurotransmission is implicated in the pathogenesis of depression and schizophrenia this study sought to investigate the putative association between several functional gene polymorphisms (sert 5-httlpr, mao-a vntr, comt val158met and dat vntr) and schizophrenia. |
2018-03-05 |
2023-08-13 |
human |
| José Alfonso Ontiveros-Sánchez de la Barquer. [Response to serotonergic and noradrenergic antidepressants: a crossover study of fluoxetine and desipramine in patients with first major depression episode]. Gaceta medica de Mexico. vol 153. issue 6. 2018-03-01. PMID:29206826. |
[response to serotonergic and noradrenergic antidepressants: a crossover study of fluoxetine and desipramine in patients with first major depression episode]. |
2018-03-01 |
2023-08-13 |
Not clear |
| Robert Z Wang, Vishal Vashistha, Sukhdeep Kaur, Nathan W Houchen. Serotonin syndrome: Preventing, recognizing, and treating it. Cleveland Clinic journal of medicine. vol 83. issue 11. 2018-01-25. PMID:27824534. |
as the use of serotonergic agents to treat depression has increased, so too has the incidence of serotonin syndrome. |
2018-01-25 |
2023-08-13 |
Not clear |
| Milap A Nowrangi, Constantine G Lyketsos, Paul B Rosenber. Principles and management of neuropsychiatric symptoms in Alzheimer's dementia. Alzheimer's research & therapy. vol 7. issue 1. 2018-01-11. PMID:27391771. |
treatment strategies for dysregulated mood syndromes (depression and apathy) have primarily targeted serotonergic mechanisms with antidepressants or dopaminergic mechanisms with psychostimulants. |
2018-01-11 |
2023-08-13 |
Not clear |
| William T Donnelly, Donald Bartlett, J C Leite. Serotonin in the solitary tract nucleus shortens the laryngeal chemoreflex in anaesthetized neonatal rats. Experimental physiology. vol 101. issue 7. 2018-01-02. PMID:27121960. |
thus, endogenous 5-ht released within the nts may curtail the respiratory depression that is part of the lcr, and serotonergic shortening of the lcr may be attributed to activation of 5-ht3 receptors within the nts. |
2018-01-02 |
2023-08-13 |
rat |
| Marc Fakhour. Revisiting the Serotonin Hypothesis: Implications for Major Depressive Disorders. Molecular neurobiology. vol 53. issue 5. 2017-12-22. PMID:25823514. |
understanding the role of the serotonergic pathway will significantly help improve our knowledge of the pathophysiology of depression and may open up avenues for the development of new antidepressant drugs. |
2017-12-22 |
2023-08-13 |
mouse |
| Kristian Gaarn Du Jardin, Heidi Kaastrup Müller, Connie Sanchez, Gregers Wegener, Betina Elfvin. Gene expression related to serotonergic and glutamatergic neurotransmission is altered in the flinders sensitive line rat model of depression: Effect of ketamine. Synapse (New York, N.Y.). vol 71. issue 1. 2017-12-22. PMID:27589698. |
gene expression related to serotonergic and glutamatergic neurotransmission is altered in the flinders sensitive line rat model of depression: effect of ketamine. |
2017-12-22 |
2023-08-13 |
rat |
| Kristian Gaarn Du Jardin, Heidi Kaastrup Müller, Connie Sanchez, Gregers Wegener, Betina Elfvin. Gene expression related to serotonergic and glutamatergic neurotransmission is altered in the flinders sensitive line rat model of depression: Effect of ketamine. Synapse (New York, N.Y.). vol 71. issue 1. 2017-12-22. PMID:27589698. |
major depressive disorder (mdd) is associated with dysfunctional serotonergic and glutamatergic neurotransmission, and the genetic animal model of depression flinders sensitive line (fsl) rats display alterations in these systems relatively to their control strain flinders resistant line (frl). |
2017-12-22 |
2023-08-13 |
rat |
| Aet O'Leary, Kadri Kõiv, Karita Raudkivi, Jaanus Harr. Antidepressants differentially affect striatal amphetamine-stimulated dopamine and serotonin release in rats with high and low novelty-oriented behaviour. Pharmacological research. vol 113. issue Pt B. 2017-12-15. PMID:26920253. |
in the studies of depression pathogenesis and antidepressant action, the monoaminergic hypothesis of depression has mainly focused on the serotonergic and noradrenergic mechanisms. |
2017-12-15 |
2023-08-13 |
rat |