| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Asia Afzal, Saara Ahmad, Faiza Agha, Zehra Batool, Saiqa Tabassum, Laraib Liaquat, Sadia Sadir, Amber Nawaz, Saida Haide. Administration of 5-HT-1B agonist ameliorates pseudodementia induced by depression in rats. Pakistan journal of pharmaceutical sciences. vol 31. issue 5(Supplementary). 2019-08-16. PMID:30393230. |
however, in present study this drug was tested as a potential treatment for depression and associated memory loss by altering the serotonergic function at receptor level. |
2019-08-16 |
2023-08-13 |
rat |
| Mohsen Naji, Maxim Komarov, Giri P Krishnan, Atul Malhotra, Frank L Powell, Irma Rukhadze, Victor B Fenik, Maxim Bazheno. Computational model of brain-stem circuit for state-dependent control of hypoglossal motoneurons. Journal of neurophysiology. vol 120. issue 1. 2019-07-16. PMID:29617218. |
experimental studies suggest that withdrawal of noradrenergic and serotonergic drives importantly contributes to depression of hypoglossal motoneurons and, therefore, may contribute to osa pathophysiology; however, specific cellular and synaptic mechanisms remain unknown. |
2019-07-16 |
2023-08-13 |
Not clear |
| Mohsen Naji, Maxim Komarov, Giri P Krishnan, Atul Malhotra, Frank L Powell, Irma Rukhadze, Victor B Fenik, Maxim Bazheno. Computational model of brain-stem circuit for state-dependent control of hypoglossal motoneurons. Journal of neurophysiology. vol 120. issue 1. 2019-07-16. PMID:29617218. |
new & noteworthy in vivo studies suggest that during rapid eye movement sleep, withdrawal of noradrenergic and serotonergic drives critically contributes to depression of hypoglossal motoneurons (hms), which innervate the tongue muscles. |
2019-07-16 |
2023-08-13 |
Not clear |
| Wen Zhang, Shi-Huan Tang, Yi Zhang, De-Feng Li, Hong-Jun Yang, Yi Zhang, Fei-Fei Gu. [Study on Yueju Wan for "different diseases with same treatment" based on integrative pharmacology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 43. issue 7. 2019-07-15. PMID:29728023. |
according to the integrative analysis, it is found that atp1a1, kras, and prkaa1 were key targets, and neuron apoptotic process, neurotrophin signaling pathway, serotonergic synapse and regulation of nitric-oxide synthase activity were key pathways which played important roles in molecular mechanism of yueju wan for depression and gastrointestinal dysfunction. |
2019-07-15 |
2023-08-13 |
human |
| Wen Zhang, Shi-Huan Tang, Yi Zhang, De-Feng Li, Hong-Jun Yang, Yi Zhang, Fei-Fei Gu. [Study on Yueju Wan for "different diseases with same treatment" based on integrative pharmacology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 43. issue 7. 2019-07-15. PMID:29728023. |
in conclusion, speculated serotonergic synapse and regulation of nitric-oxide synthase activity maybe the common process in depression and gastrointestinal dysfunction. |
2019-07-15 |
2023-08-13 |
human |
| Giulia Paroni, Francesco Panza, Salvatore De Cosmo, Antonio Greco, Davide Seripa, Gianluigi Mazzoccol. Klotho at the Edge of Alzheimer's Disease and Senile Depression. Molecular neurobiology. vol 56. issue 3. 2019-07-01. PMID:29978424. |
alterations of this protein seem to influence the development of serotonergic neurons and could play a role in major depression in the elderly. |
2019-07-01 |
2023-08-13 |
Not clear |
| Dilys Lam, Marie-Laure Ancelin, Karen Ritchie, Rosanne Freak-Poli, Richard Saffery, Joanne Rya. Genotype-dependent associations between serotonin transporter gene (SLC6A4) DNA methylation and late-life depression. BMC psychiatry. vol 18. issue 1. 2019-06-25. PMID:30180828. |
disrupted serotonergic signaling is often a feature of depression and the role of the serotonin transporter gene (slc6a4), responsible for serotonin re-uptake, has received much attention in this regard. |
2019-06-25 |
2023-08-13 |
Not clear |
| Leslie Alejandra Ramírez, Elsy Arlene Pérez-Padilla, Francisco García-Oscos, Humberto Salgado, Marco Atzori, Juan Carlos Pined. A new theory of depression based on the serotonin/kynurenine relationship and the hypothalamicpituitary- adrenal axis Biomedica : revista del Instituto Nacional de Salud. vol 38. issue 3. 2019-04-16. PMID:30335249. |
a new theory of depression based on the serotonin/kynurenine relationship and the hypothalamicpituitary- adrenal axis the serotonergic and immunological hypothesis of depression proposes that certain types of excessive stress distort the relationship between the activities of the innate immune and central nervous systems, so that the stress caused by an infection, or excessive psychological stress, activate toll-like receptors such as the tlr-4, the transcription factor nf-kb, the inflammasome nlrp3, as well as the secretion of interleukin-1 beta (il-1β), interleukin-6 (il-6) and other factors of the innate immune response, causing first, the general symptoms of the disease which appear with any infection, but also those characteristic of depressive illness such as dysphoria and anhedonia.the evidence indicates that, if the stimulus persists or recurs within 24 hours, the indole-2, 3-dioxygenase enzyme (ido) of the kynurenine metabolic pathway, which increases the synthesis of quinolinic acid, is activated with an associated reduction of serotonin synthesis. |
2019-04-16 |
2023-08-13 |
Not clear |
| Yong-Ku Kim, Byung-Joo Ham, Kyu-Man Ha. Interactive effects of genetic polymorphisms and childhood adversity on brain morphologic changes in depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 91. 2019-04-15. PMID:29535036. |
interactions between childhood adversity and candidate genes for depression could affect brain morphology via the modulation of neurotrophic factors, serotonergic neurotransmission, or the hypothalamus-pituitary-adrenal (hpa) axis, and this pathway may explain the subsequent onset of depression. |
2019-04-15 |
2023-08-13 |
Not clear |
| D Caroline Blanchard, Ksenia Meyz. Risk assessment and serotonin: Animal models and human psychopathologies. Behavioural brain research. vol 357-358. 2019-03-29. PMID:28705471. |
this review examines the involvement of serotonergic mechanisms in both animal models of ra, and in an array of tasks focusing on affective cognitive changes in individuals with depression or anxiety. |
2019-03-29 |
2023-08-13 |
mouse |
| Youngmee Kim, Charles S Carver, Joachim F Hallmayer, Jamie M Zeitzer, Oxana Palesh, Eric Neri, Bita Nouriani, David Spiege. Serotonin transporter polymorphism, depressive symptoms, and emotional impulsivity among advanced breast cancer patients. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. vol 26. issue 4. 2019-03-04. PMID:29090386. |
this study tested a theory linking a marker of low serotonergic function to both depression and impulsivity in a sample of advanced breast cancer patients, among whom elevated depressive symptoms and difficulty regulating emotions are commonly reported. |
2019-03-04 |
2023-08-13 |
Not clear |
| Marina Izvolskaia, Viktoria Sharova, Liudmila Zakharov. Prenatal Programming of Neuroendocrine System Development by Lipopolysaccharide: Long-Term Effects. International journal of molecular sciences. vol 19. issue 11. 2019-02-21. PMID:30469423. |
the degradation of serotonergic neurons induced by lps in the fetus is attributed to the increased levels of interleukin (il)-6 and tumor necrosis factor (tnfα) as well as to anxiety and depression in children. |
2019-02-21 |
2023-08-13 |
rat |
| Hannah Weinberg-Wolf, Nicholas A Fagan, George M Anderson, Marios Tringides, Olga Dal Monte, Steve W C Chan. The effects of 5-hydroxytryptophan on attention and central serotonin neurochemistry in the rhesus macaque. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 7. 2019-02-08. PMID:29463909. |
psychiatric disorders, particularly depression and anxiety, are often associated with impaired serotonergic function. |
2019-02-08 |
2023-08-13 |
monkey |
| K Højgaard, S L Christiansen, E V Bouzinova, O Wibor. Disturbances of diurnal phase markers, behavior, and clock genes in a rat model of depression; modulatory effects of agomelatine treatment. Psychopharmacology. vol 235. issue 3. 2019-01-22. PMID:29151193. |
the present study focuses on circadian rhythm disturbances in the chronic mild stress (cms) animal model of depression and examined whether the atypical antidepressant, agomelatine, which is mediating its action via melatonergic and serotonergic receptors, is capable of resynchronizing the perturbed rhythm. |
2019-01-22 |
2023-08-13 |
rat |
| Kasper Petersen, Peter Hjort. [Cyclizine is sold in Denmark as an over-the-counter drug and has serious side effects when overdosed]. Ugeskrift for laeger. vol 180. issue 3. 2019-01-18. PMID:29336302. |
cyclizine is sold in denmark as an over-the-counter drug and affects not only histaminergic but also muscarinergic, serotonergic and α-adrenergic receptors, with side effects such as respiratory depression and cardiac arrhythmias, leading to fatalities. |
2019-01-18 |
2023-08-13 |
Not clear |
| Hiroyuki Muraoka, Hidehiro Oshibuchi, Masahiko Kawano, Takaaki Kawano, Takahiro Tsutsumi, Makiko Yamada, Jun Ishigooka, Katsuji Nishimura, Ken Inad. Escitalopram attenuates fear stress-induced increase in amygdalar dopamine following methamphetamine-induced sensitisation: Implications of fine-tuning action of selective serotonin reuptake inhibitors on emotional processing. European journal of pharmacology. vol 834. 2018-12-18. PMID:29981749. |
serotonin reuptake inhibitors modulate the serotonergic pathways of the nervous system and are widely used for treating psychiatric conditions such as anxiety and depression. |
2018-12-18 |
2023-08-13 |
rat |
| Yu P Sivola. [Serotonin neurotrasmission and treatment options for depression]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 117. issue 11. 2018-11-01. PMID:29265105. |
the medicines with serotonergic properties include trazodone, which is intermediate between tricyclic antidepressants with their powerful antidepressive effect and selective serotonin reuptake inhibitors, as first-line agents in the treatment of depression and anxiety disorders. |
2018-11-01 |
2023-08-13 |
Not clear |
| Elżbieta Żmudzka, Kinga Sałaciak, Jacek Sapa, Karolina Pytk. Serotonin receptors in depression and anxiety: Insights from animal studies. Life sciences. vol 210. 2018-10-15. PMID:30144453. |
thus, serotonergic system is an important target in the treatment of psychiatric disorders, such as major depression and anxiety. |
2018-10-15 |
2023-08-13 |
Not clear |
| Przemysław Paweł Taciak, Natalia Lysenko, Aleksander Paweł Mazure. Drugs which influence serotonin transporter and serotonergic receptors: Pharmacological and clinical properties in the treatment of depression. Pharmacological reports : PR. vol 70. issue 1. 2018-09-07. PMID:29309998. |
drugs which influence serotonin transporter and serotonergic receptors: pharmacological and clinical properties in the treatment of depression. |
2018-09-07 |
2023-08-13 |
Not clear |
| Kun Li, Si Shen, Yu-Tian Ji, Xu-Yun Li, Li-San Zhang, Xiao-Dong Wan. Melatonin Augments the Effects of Fluoxetine on Depression-Like Behavior and Hippocampal BDNF-TrkB Signaling. Neuroscience bulletin. vol 34. issue 2. 2018-08-28. PMID:29086908. |
recently, the melatonergic system that is closely associated with the serotonergic system has been implicated in the pathophysiology and treatment of depression. |
2018-08-28 |
2023-08-13 |
mouse |