| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Veysel Baskin, Ezgi Eroglu, Nusin Harmanci, Kevser Ero. Antinociceptive, anxiolytic and depression like effects of hydrogen sulfide, nitric oxide and carbon monoxide in rats and the role of opioidergic and serotonergic systems in antinociceptive activity. Fundamental & clinical pharmacology. 2022-01-28. PMID:35090186. |
antinociceptive, anxiolytic and depression like effects of hydrogen sulfide, nitric oxide and carbon monoxide in rats and the role of opioidergic and serotonergic systems in antinociceptive activity. |
2022-01-28 |
2023-08-13 |
rat |
| A Ghaderi, E C Brown, D L Clark, R Ramasubbu, Z H T Kiss, A B Protzne. Role of the serotonergic system in subcallosal DBS for treatment-resistant depression. Brain stimulation. 2021-12-30. PMID:34968745. |
role of the serotonergic system in subcallosal dbs for treatment-resistant depression. |
2021-12-30 |
2023-08-13 |
Not clear |
| Munazzah Tasleem, Abdulwahed Alrehaily, Tahani M Almeleebia, Mohammad Y Alshahrani, Irfan Ahmad, Mohammed Asiri, Nadiyah M Alabdallah, Mohd Saee. Investigation of Antidepressant Properties of Yohimbine by Employing Structure-Based Computational Assessments. Current issues in molecular biology. vol 43. issue 3. 2021-12-10. PMID:34889886. |
serotonergic neurotransmission plays a crucial role in the pathogenesis of depression; thus, serotonergic receptor agonist/antagonistic drugs are promising anti-depressants. |
2021-12-10 |
2023-08-13 |
Not clear |
| Antonio Flores-Burgess, Carmelo Millón, Belen Gago, Laura García-Durán, Noelia Cantero-García, Araceli Puigcerver, José Angel Narváez, Kjell Fuxe, Luis Santín, Zaida Díaz-Cabial. GALANIN (1-15) ENHANCES THE BEHAVIORAL EFFECTS OF FLUOXETINE IN THE OLFACTORY BULBECTOMY RAT SUGGESTING A NEW AUGMENTATION STRATEGY IN DEPRESSION. The international journal of neuropsychopharmacology. 2021-12-10. PMID:34891163. |
selective serotonergic reuptake inhibitors, including fluoxetine (flx), are the most commonly used for the treatment of major depression. |
2021-12-10 |
2023-08-13 |
rat |
| Daniel Burmester, Carl Michael von Buchwald, Poul Videbec. [Dopaminergic drugs in the treatment of depression]. Ugeskrift for laeger. vol 183. issue 47. 2021-12-08. PMID:34851261. |
a significant proportion of patients with depression do not respond to classic antidepressants addressing serotonergic or noradrenergic neurotransmission. |
2021-12-08 |
2023-08-13 |
Not clear |
| Stefania Della Vecchia, Maria Marchese, Filippo Maria Santorelli, Federico Sicc. Kir4.1 Dysfunction in the Pathophysiology of Depression: A Systematic Review. Cells. vol 10. issue 10. 2021-11-25. PMID:34685608. |
however, other dysfunctional pathomechanisms are likely involved in the disorder, and this may in part explain why some individuals with depression are resistant to serotonergic therapies. |
2021-11-25 |
2023-08-13 |
Not clear |
| Noreen Samad, Saima Khaliq, Mehtab Alam, Farzana Yasmin, Saara Ahmad, Sana Mustafa, - Azizuddin, Uzma Raz. Tryptophan lessens reserpine induced anxiety, depression and memory impairment by modulating oxidative stress and serotonergic activity. Pakistan journal of pharmaceutical sciences. vol 34. issue 4(Supplementary). 2021-11-22. PMID:34799325. |
tryptophan lessens reserpine induced anxiety, depression and memory impairment by modulating oxidative stress and serotonergic activity. |
2021-11-22 |
2023-08-13 |
rat |
| D Schneider-Matyka, E Grochans, A Lubkowska, M Panczyk, M Szku. The effect of tryptophan and serotonin levels on the severity of depressive and climacteric symptoms in perimenopausal women. European review for medical and pharmacological sciences. vol 25. issue 9. 2021-11-11. PMID:34002815. |
the dysfunctional serotonergic system is a factor contributing to the development of depression. |
2021-11-11 |
2023-08-13 |
Not clear |
| Lisa R Starr, Catherine B Stroud, Zoey A Shaw, Suzanne Vrshek-Schallhor. Stress sensitization to depression following childhood adversity: Moderation by HPA axis and serotonergic multilocus profile scores. Development and psychopathology. vol 33. issue 4. 2021-11-04. PMID:32684200. |
stress sensitization to depression following childhood adversity: moderation by hpa axis and serotonergic multilocus profile scores. |
2021-11-04 |
2023-08-13 |
Not clear |
| Lisa R Starr, Catherine B Stroud, Zoey A Shaw, Suzanne Vrshek-Schallhor. Stress sensitization to depression following childhood adversity: Moderation by HPA axis and serotonergic multilocus profile scores. Development and psychopathology. vol 33. issue 4. 2021-11-04. PMID:32684200. |
results showed significant mgps × childhood adversity × recent life stress interactions predicting depression for both hpa axis and serotonergic mgpss, with both risk scores predicting stronger childhood adversity × recent stress interactions. |
2021-11-04 |
2023-08-13 |
Not clear |
| Manuel A Giannoni-Guzmán, Anna Kamitakahara, Valerie Magalong, Pat Levitt, Douglas G McMaho. Circadian photoperiod alters TREK-1 channel function and expression in dorsal raphe serotonergic neurons via melatonin receptor 1 signaling. Journal of pineal research. vol 70. issue 2. 2021-11-01. PMID:33210730. |
previous work in our laboratory has shown that developmental exposure to seasonal photoperiods has enduring effects on the activity of mouse dorsal raphe serotonergic neurons, their intrinsic electrical properties, as well as on depression and anxiety-related behaviors. |
2021-11-01 |
2023-08-13 |
mouse |
| Takashi Shiroyama, Kouji Fukuyama, Motohiro Okad. Distinct Effects of Escitalopram and Vortioxetine on Astroglial L-Glutamate Release Associated with Connexin43. International journal of molecular sciences. vol 22. issue 18. 2021-11-01. PMID:34576176. |
it has been established that enhancement of serotonergic transmission contributes to improvement of major depression; however, several post-mortem studies and experimental depression rodent models suggest that functional abnormalities of astrocytes play important roles in the pathomechanisms/pathophysiology of mood disorders. |
2021-11-01 |
2023-08-13 |
rat |
| Ariel Ketcherside, Ian Matthews, Francesca Filbe. The Serotonin Link between Alcohol Use and Affective Disorders. Journal of addiction & prevention. vol 1. issue 2. 2021-10-23. PMID:34676279. |
specifically, we examine the role of serotonergic receptors, transporters, and networks in incidences of alcohol dependence that is comorbid with depression to facilitate a deeper understanding of these mechanisms necessary for the development of more effective and personalized treatments. |
2021-10-23 |
2023-08-13 |
Not clear |
| Charles S Carver, Sheri L Johnson, Jutta Joorman. Two-Mode Models of Self-Regulation as a Tool for Conceptualizing Effects of the Serotonin System in Normal Behavior and Diverse Disorders. Current directions in psychological science. vol 18. issue 4. 2021-10-20. PMID:20161026. |
one hypothesis is that low serotonergic function plus high sensitivity to incentives yields vulnerability to impulsive approach, whereas low serotonergic function plus low incentive sensitivity yields vulnerability to depression. |
2021-10-20 |
2023-08-12 |
Not clear |
| Brian E Leonar. The concept of depression as a dysfunction of the immune system. Current immunology reviews. vol 6. issue 3. 2021-10-20. PMID:21170282. |
both experimental and clinical evidence shows that a rise in the concentrations of proinflammatory cytokines and glucocorticoids, as occurs in chronically stressful situations and in depression, contribute to the behavioural changes associated with depression.a defect in serotonergic function is associated with hypercortisolaemia and the increase in proinflammatory cytokines that accompany depression. |
2021-10-20 |
2023-08-12 |
Not clear |
| Frank G Gilliam, Hrvoje Hecimovic, Matthew S Gentr. Serotonergic therapy in epilepsy. Current opinion in neurology. vol 34. issue 2. 2021-10-15. PMID:33664206. |
the serotonergic system is implicated in multiple aspects of epilepsy, including seizure susceptibility, sudden unexpected death in epilepsy (sudep), and comorbid depression. |
2021-10-15 |
2023-08-13 |
human |
| Shami Kanekar, Chandni Sheth, Hendrick Ombach, Jadeda Brown, Michael Hoffman, Robert Ettaro, Perry Rensha. Sex-based changes in rat brain serotonin and behavior in a model of altitude-related vulnerability to treatment-resistant depression. Psychopharmacology. vol 238. issue 10. 2021-10-15. PMID:34159421. |
depression and ssri resistance are linked to disrupted serotonergic function, and hypobaric hypoxia may reduce the oxygen-dependent synthesis of serotonin. |
2021-10-15 |
2023-08-13 |
rat |
| Dominika Siodłak, Gabriel Nowak, Katarzyna Mlynie. Interaction between zinc, the GPR39 zinc receptor and the serotonergic system in depression. Brain research bulletin. vol 170. 2021-10-07. PMID:33549699. |
interaction between zinc, the gpr39 zinc receptor and the serotonergic system in depression. |
2021-10-07 |
2023-08-13 |
Not clear |
| Dominika Siodłak, Gabriel Nowak, Katarzyna Mlynie. Interaction between zinc, the GPR39 zinc receptor and the serotonergic system in depression. Brain research bulletin. vol 170. 2021-10-07. PMID:33549699. |
in this review, we aim to describe interactions between the serotonergic and zincergic systems and to highlight their significance in the pathophysiology and treatment of depression. |
2021-10-07 |
2023-08-13 |
Not clear |
| Grzegorz Ślifirski, Marek Król, Jadwiga Turł. 5-HT Receptors and the Development of New Antidepressants. International journal of molecular sciences. vol 22. issue 16. 2021-09-28. PMID:34445721. |
the complex nature of the serotonergic system and interactions with other neurochemical systems indicate that the development of depression may be mediated by various pathomechanisms, the common denominator of which is undoubtedly the disturbed transmission in central 5-ht synapses. |
2021-09-28 |
2023-08-13 |
human |