| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ahmed Karam Farag, Eun Joo Ro. Death-associated protein kinase (DAPK) family modulators: Current and future therapeutic outcomes. Medicinal research reviews. vol 39. issue 1. 2019-02-18. PMID:29949198. |
dapk1 regulates apoptosis, autophagy, contributes to the pathogenesis of alzheimer's disease, acts as a tumor suppressor, inhibits metastasis, mediates the body responses to viral infections, and regulates the synaptic plasticity and depression. |
2019-02-18 |
2023-08-13 |
Not clear |
| Chen-Yi-Yu Zhang, Min-Jie Zeng, Li-Ping Zhou, Ya-Qin Li, Fan Zhao, Zhi-Yuan Shang, Xue-Yang Deng, Zhan-Qiang Ma, Qiang Fu, Shi-Ping Ma, Rong Q. Baicalin exerts neuroprotective effects via inhibiting activation of GSK3β/NF-κB/NLRP3 signal pathway in a rat model of depression. International immunopharmacology. vol 64. 2019-02-15. PMID:30195108. |
but the effects of ba on neuroprotection, apoptosis, and neuroinflammation and the potential mechanisms in depression are unclear. |
2019-02-15 |
2023-08-13 |
rat |
| Ali Jahanbazi Jahan-Abad, Leila Alizadeh, Sajad Sahab Negah, Parastoo Barati, Maryam Khaleghi Ghadiri, Sven G Meuth, Stjepana Kovac, Ali Gorj. Apoptosis Following Cortical Spreading Depression in Juvenile Rats. Molecular neurobiology. vol 55. issue 5. 2019-02-08. PMID:28612259. |
apoptosis following cortical spreading depression in juvenile rats. |
2019-02-08 |
2023-08-13 |
rat |
| Xianyuan Zhao, Hong Qi, Jiamin Zhou, Shuqi Xu, Yuan Ga. P27 Protects Cardiomyocytes from Sepsis via Activation of Autophagy and Inhibition of Apoptosis. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2019-02-01. PMID:30478251. |
conclusions the study data demonstrated that the overexpression of p27 protects cardiomyocytes from sepsis-induced cardiac depression via the activation of autophagy and inhibition of apoptosis. |
2019-02-01 |
2023-08-13 |
rat |
| Min Chen, Guoping He, Qiang L. Maternal deprivation promotes hippocampal neuronal apoptosis via ERK1/2 signaling. Frontiers in bioscience (Landmark edition). vol 23. 2019-01-24. PMID:29772537. |
in conclusion, md-induced depression is associated with hippocampal neuronal apoptosis, which may be mediated by the erk1/2 signaling pathway. |
2019-01-24 |
2023-08-13 |
rat |
| Miroslav Adzic, Milos Mitic, Marija Radojci. Mitochondrial estrogen receptors as a vulnerability factor of chronic stress and mediator of fluoxetine treatment in female and male rat hippocampus. Brain research. vol 1671. 2018-05-17. PMID:28716632. |
depression is a disease of an abnormal brain energy metabolism also marked with increased apoptosis in specific brain regions. |
2018-05-17 |
2023-08-13 |
rat |
| Keng-Fan Liu, Yingxiao Li, Kai Chun Cheng, Chao Chin Hsu, Juei-Tang Cheng, Wen-Huang Pen. Changes in PPARδ expression in a rat model of stress-induced depression. Clinical and experimental pharmacology & physiology. vol 44. issue 6. 2018-01-01. PMID:28267873. |
taken together, we found that pparδ plays an important role in the regulation of serotonin transporter expression and that chronic stress may lower pparδ expression in the brain via apoptosis and may attenuate serotonin transporter expression, thus inducing depression in rats. |
2018-01-01 |
2023-08-13 |
rat |
| K E Boschen, A Y Klintsov. Neurotrophins in the Brain: Interaction With Alcohol Exposure During Development. Vitamins and hormones. vol 104. 2017-11-02. PMID:28215296. |
these areas of overlap include formation of long-term potentiation, oxidative stress processes, neuroinflammation, apoptosis and cell loss, hippocampal adult neurogenesis, dendritic morphology and spine density, vasculogenesis and angiogenesis, and behaviors related to spatial memory, anxiety, and depression. |
2017-11-02 |
2023-08-13 |
Not clear |
| Fang-Bo Lin, De-Ren Hou, Qiu-Ping Tan. [Research progress of depression and the application of esketamine]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 37. issue 4. 2017-10-19. PMID:28446416. |
current evidence suggests that the occurrence of depression may be related to a reduced secretion of neurotransmitters, neuronal apoptosis, inflammation, intestinal flora and other factors. |
2017-10-19 |
2023-08-13 |
Not clear |
| Liyan Chen, Tiefeng Jin, Kun Zhu, Yingshi Piao, Taihao Quan, Chunji Quan, Zhenhua Li. PI3K/mTOR dual inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A synergistically exert anti-tumor activity in breast cancer. Oncotarget. vol 8. issue 7. 2017-09-25. PMID:28060760. |
mechanistic studies revealed that the combined therapy induced apoptosis in a caspase-dependent manner, which might be related to the further depression of the pi3k/akt/mtor signalling pathway. |
2017-09-25 |
2023-08-13 |
human |
| Dong Mei Duan, Xianzhe Dong, Ya Tu, Ping Li. A microarray study of chronic unpredictable mild stress rat blood serum with electro-acupuncture intervention. Neuroscience letters. vol 627. 2017-06-13. PMID:27264487. |
changes of mir-383-5p and mir-764-5p indicated that ea might exert its therapeutic effect on depression through promoting the neurotrophy and inhibiting the abnormal apoptosis of neurons as well as other correlative signal pathways. |
2017-06-13 |
2023-08-13 |
rat |
| Wei-Dan Jiang, Lin Feng, Biao Qu, Pei Wu, Sheng-Yao Kuang, Jun Jiang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Xiao-Qiu Zhou, Yang Li. Changes in integrity of the gill during histidine deficiency or excess due to depression of cellular anti-oxidative ability, induction of apoptosis, inflammation and impair of cell-cell tight junctions related to Nrf2, TOR and NF-κB signaling in fish. Fish & shellfish immunology. vol 56. 2017-03-06. PMID:27394967. |
changes in integrity of the gill during histidine deficiency or excess due to depression of cellular anti-oxidative ability, induction of apoptosis, inflammation and impair of cell-cell tight junctions related to nrf2, tor and nf-κb signaling in fish. |
2017-03-06 |
2023-08-13 |
cat |
| Bodo C Melni. Apoptosis May Explain the Pharmacological Mode of Action and Adverse Effects of Isotretinoin, Including Teratogenicity. Acta dermato-venereologica. vol 97. issue 2. 2017-02-28. PMID:27671426. |
furthermore, apoptosis may be the underlying and unifying mechanism of the adverse effects of isotretinoin on neural crest cells (teratogenicity), hippocampal neurones (depression), epidermal keratinocytes and mucosa cells (mucocutaneous side-effects), hair follicle cells (telogen effluvium), intestinal epithelial cells (inflammatory bowel disease), skeletal muscle cells (myalgia and release of creatine kinase), and hepatocytes (release of transaminases and very low-density lipoproteins). |
2017-02-28 |
2023-08-13 |
Not clear |
| Jing Wen, Christopher Holden Chen, Ariel Stock, Jessica Doerner, Maria Gulinello, Chaim Putterma. Intracerebroventricular administration of TNF-like weak inducer of apoptosis induces depression-like behavior and cognitive dysfunction in non-autoimmune mice. Brain, behavior, and immunity. vol 54. 2017-02-01. PMID:26721417. |
in conclusion, tweak can contribute to lupus-associated neurobehavioral deficits including depression and cognitive dysfunction by acting within the cns to enhance production of inflammatory mediators, promote disruption of the bbb, and induce apoptosis in resident brain cells. |
2017-02-01 |
2023-08-13 |
mouse |
| Jiwei Cao, Gang Xu, Jing Lan, Qingqing Huang, Zuxiong Tang, Liping Tia. High expression of piwi-like RNA-mediated gene silencing 1 is associated with poor prognosis via regulating transforming growth factor-β receptors and cyclin-dependent kinases in breast cancer. Molecular medicine reports. vol 13. issue 3. 2017-01-03. PMID:26847393. |
in addition, by overexpression and interference, it was demonstrated that hiwi promotes the activity of breast cancer cells while depression of hiwi may induce apoptosis of breast cancer cells. |
2017-01-03 |
2023-08-13 |
Not clear |
| Hui-Jun Xu, Wei-Dan Jiang, Lin Feng, Yang Liu, Pei Wu, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Xiao-Qiu Zho. Dietary vitamin C deficiency depresses the growth, head kidney and spleen immunity and structural integrity by regulating NF-κB, TOR, Nrf2, apoptosis and MLCK signaling in young grass carp (Ctenopharyngodon idella). Fish & shellfish immunology. vol 52. 2016-12-16. PMID:26944716. |
meanwhile, compared with optimal vitamin c supplementation, vitamin c deficiency decreased the activities and mrna levels of copper/zinc superoxide dismutase, manganese superoxide dismutase (mnsod), catalase, glutathione peroxidase, glutathione s-transferases and glutathione reductase (p < 0.05), and down-regulated zonula occludens (zo) 1, zo-2, claudin-b, -c, -3c, -7a, -7b, b-cell lymphoma-2, inhibitor of apoptosis protein, nf-e2-related factor 2 mrna levels (p < 0.05), increased reactive oxygen species (ros), malondialdehyde (mda) and protein carbonyl contents (p < 0.05), and up-regulated claudin-12, 15a, -15b, fas ligand, mitogen-activated protein kinase kinase 6, p38 mitogen-activated protein kinase, b-cell lymphoma protein 2 associated x protein, apoptotic protease activating factor-1, caspase-3, -7, -8, -9, kelch-like ech-associating protein (keap) 1a and keap 1b mrna levels (p < 0.05) in the head kidney and spleen under injection fish of a. hydrophila, suggesting that vitamin c deficiency could decrease fish head kidney and spleen structural integrity through depression of antioxidative ability, induction of apoptosis and disruption of tight junctional complexes. |
2016-12-16 |
2023-08-13 |
Not clear |
| D-D Qiao, G-L Mi, M-Q Tan. Tricyclic Neovibsanin Scaffold (TCNS) as an Effective Antidepressant Agent. Drug research. vol 66. issue 2. 2016-12-13. PMID:25823508. |
therefore the relief in depression by tcns may be due to suppression of mao-a expression and the apoptosis cascade by increased expression of hsp70. |
2016-12-13 |
2023-08-13 |
rat |
| Hai-Yang Yu, Zhu-Jun Yin, Shui-Jin Yang, Shi-Ping Ma, Rong Q. Baicalin Reverses Depressive-Like Behaviours and Regulates Apoptotic Signalling Induced by Olfactory Bulbectomy. Phytotherapy research : PTR. vol 30. issue 3. 2016-10-21. PMID:26681067. |
apoptosis is thought to be involved in neurological disorders including major depression. |
2016-10-21 |
2023-08-13 |
rat |
| Hai-Yang Yu, Zhu-Jun Yin, Shui-Jin Yang, Shi-Ping Ma, Rong Q. Baicalin Reverses Depressive-Like Behaviours and Regulates Apoptotic Signalling Induced by Olfactory Bulbectomy. Phytotherapy research : PTR. vol 30. issue 3. 2016-10-21. PMID:26681067. |
in this study, we examined whether the polyphenolic compound baicalin could decrease apoptosis in the olfactory bulbectomy (obx) depression rat model. |
2016-10-21 |
2023-08-13 |
rat |
| Xinrong Li, Zhifen Liu, Wei Li, Ning Sun, Yong Xu, Zhongchen Xie, Kerang Zhan. PTPRR regulates ERK dephosphorylation in depression mice model. Journal of affective disorders. vol 193. 2016-10-06. PMID:26773914. |
the protein tyrosine phosphatase receptor type r (ptprr), which regulates the dephosphorylation of the downstream mitogen-activated protein kinase (mapk) steering cell proliferation, apoptosis and synaptic plasticity, may be involved in the pathogenesis of depression. |
2016-10-06 |
2023-08-13 |
mouse |