| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Run-Hui Tian, Yang Bai, Jing-Yang Li, Kai-Min Gu. Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression. Brain research. vol 1725. 2020-10-23. PMID:31545956. |
therefore, the present study was conducted on the effect of prlr gene on brain derived neurotrophic factor (bdnf) expression and hippocampal neuron apoptosis through the establishment of cms-induced depression mouse models, with aims of providing a new and effective therapeutic option for depression. |
2020-10-23 |
2023-08-13 |
mouse |
| Yang Yang, Zhiying Hu, Xiaoxue Du, Henry Davies, Xue Huo, Marong Fan. miR-16 and Fluoxetine Both Reverse Autophagic and Apoptotic Change in Chronic Unpredictable Mild Stress Model Rats. Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28790887. |
these findings indicate that apoptosis and autophagy related pathways could be involved in the effectiveness of antidepressants, in which mir-16 participates in the regulation of, and is likely to help integrate rapid therapeutic strategies to alleviate depression clinically. |
2020-10-01 |
2023-08-13 |
rat |
| Sang Won Jeon, Yong-Ku Ki. The role of neuroinflammation and neurovascular dysfunction in major depressive disorder. Journal of inflammation research. vol 11. 2020-10-01. PMID:29773951. |
neuroinflammation is involved in the pathophysiology of depression by increasing proinflammatory cytokines, activating the hypothalamus-pituitary-adrenal axis, increasing glucocorticoid resistance, and affecting serotonin synthesis and metabolism, neuronal apoptosis and neurogenesis, and neuroplasticity. |
2020-10-01 |
2023-08-13 |
Not clear |
| b' Dumitru A Iacobas, Sanda Iacobas, Nino Nebieridze, Libor Vel\\xc3\\xad\\xc5\\xa1ek, Jana Vel\\xc3\\xad\\xc5\\xa1kov\\xc3\\xa. Estrogen Protects Neurotransmission Transcriptome During Status Epilepticus. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:29973860.' |
se affected all major functional pathways, including apoptosis (61%), alzheimer's disease (47%), cell cycle (59%), long-term potentiation (62%), and depression (55%), as well as synaptic vesicle cycle (62%), glutamatergic (53%), gabaergic (49%), cholinergic (52%), dopaminergic (55%), and serotonergic (49%) neurotransmission. |
2020-10-01 |
2023-08-13 |
rat |
| Young-Woo Cho, Eun-Jin Kim, Marie Merci Nyiramana, Eui-Jung Shin, Hana Jin, Ji Hyeon Ryu, Kee Ryeon Kang, Gyeong-Won Lee, Hye Jung Kim, Jaehee Han, Dawon Kan. Paroxetine Induces Apoptosis of Human Breast Cancer MCF-7 Cells through Ca Cancers. vol 11. issue 1. 2020-10-01. PMID:30634506. |
paroxetine induces apoptosis of human breast cancer mcf-7 cells through ca depression is more common in women with breast cancer than the general population. |
2020-10-01 |
2023-08-13 |
human |
| Tie-Ning Zhang, Julie E Goodwin, Bing Liu, Da Li, Ri Wen, Ni Yang, Jing Xia, Han Zhou, Tao Zhang, Wen-Liang Song, Chun-Feng Li. Characterization of Long Noncoding RNA and mRNA Profiles in Sepsis-Induced Myocardial Depression. Molecular therapy. Nucleic acids. vol 17. 2020-10-01. PMID:31472370. |
gene ontology term enrichment indicated apoptosis and its related pathways showed obvious enrichment, which suggested cell apoptosis could play a critical role in the process of myocardial depression. |
2020-10-01 |
2023-08-13 |
rat |
| Tie-Ning Zhang, Julie E Goodwin, Bing Liu, Da Li, Ri Wen, Ni Yang, Jing Xia, Han Zhou, Tao Zhang, Wen-Liang Song, Chun-Feng Li. Characterization of Long Noncoding RNA and mRNA Profiles in Sepsis-Induced Myocardial Depression. Molecular therapy. Nucleic acids. vol 17. 2020-10-01. PMID:31472370. |
by silencing this lncrna, we demonstrated knockdown of pvt1 expression could induce cell apoptosis in lipopolysaccharide-induced heart cells, through increasing the expression of c-myc, bid, bax, and caspase-3 and decreasing the expression of myd88 and bcl-2, thereby proving its functional role in myocardial depression. |
2020-10-01 |
2023-08-13 |
rat |
| Peng Xiao, Xiaoming Zhang, Yanfei Li, Zhongyi Ma, Shuping Si, Xinxue Ga. miR-9 inhibition of neuronal apoptosis and expression levels of apoptosis genes Bcl-2 and Bax in depression model rats through Notch pathway. Experimental and therapeutic medicine. vol 19. issue 1. 2020-10-01. PMID:31853322. |
in conclusion, mir-9 inhibitor can promote the neurological function recovery and inhibit the neuronal apoptosis of depression model rats through activating the notch signaling pathway, suggesting that mir-9 can be an important therapeutic target for depression. |
2020-10-01 |
2023-08-13 |
rat |
| Peng Xiao, Xiaoming Zhang, Yanfei Li, Zhongyi Ma, Shuping Si, Xinxue Ga. miR-9 inhibition of neuronal apoptosis and expression levels of apoptosis genes Bcl-2 and Bax in depression model rats through Notch pathway. Experimental and therapeutic medicine. vol 19. issue 1. 2020-10-01. PMID:31853322. |
mir-9 inhibition of neuronal apoptosis and expression levels of apoptosis genes bcl-2 and bax in depression model rats through notch pathway. |
2020-10-01 |
2023-08-13 |
rat |
| Peng Xiao, Xiaoming Zhang, Yanfei Li, Zhongyi Ma, Shuping Si, Xinxue Ga. miR-9 inhibition of neuronal apoptosis and expression levels of apoptosis genes Bcl-2 and Bax in depression model rats through Notch pathway. Experimental and therapeutic medicine. vol 19. issue 1. 2020-10-01. PMID:31853322. |
effects of micro ribonucleic acid (mir)-9 on neuronal apoptosis and expression levels of apoptosis genes b-cell lymphoma-2 (bcl-2) and bcl-2 associated x protein (bax) in depression model rats, as well as its regulatory mechanism, were investigated. |
2020-10-01 |
2023-08-13 |
rat |
| Cuiqin Fan, Qiqi Song, Peng Wang, Ye Li, Mu Yang, Shu Yan Y. Neuroprotective Effects of Curcumin on IL-1β-Induced Neuronal Apoptosis and Depression-Like Behaviors Caused by Chronic Stress in Rats. Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:30666189. |
in the present study, we examined the molecular events of curcumin as related to its capacity for neuroprotection against inflammation-induced neuronal apoptosis and depression-like behaviors in a rat model of depression. |
2020-09-30 |
2023-08-13 |
rat |
| Masanori Ohmoto, Yukina Shibuya, Shihori Taniguchi, Tomoki Nakade, Masaaki Nomura, Yuri Ikeda-Matsuo, Tohru Daikok. Protective effects of butein on corticosterone-induced cytotoxicity in Neuro2A cells. IBRO reports. vol 8. 2020-09-28. PMID:32181410. |
a functional understanding of the relationship between glucocorticoids and neuronal apoptosis induced by the production of reactive oxygen species (ros) may lead to a novel strategy for the treatment or prevention of depression. |
2020-09-28 |
2023-08-13 |
mouse |
| Alessandra Borsini, Carmine M Pariante, Patricia A Zunszain, Nilay Hepgul, Alice Russell, Zuzanna Zajkowska, Valeria Mondelli, Sandrine Thure. The role of circulatory systemic environment in predicting interferon-alpha-induced depression: The neurogenic process as a potential mechanism. Brain, behavior, and immunity. vol 81. 2020-08-04. PMID:31207337. |
results show that higher apoptosis during proliferation observed upon treatment of cells with baseline serum, and lower neuronal differentiation observed upon treatment with serum after 4 weeks of ifn-α, were predictive of later development of ifn-α-induced depression (odds ratio = 1.26, p = 0.06, and = 0.80, p = 0.01, respectively). |
2020-08-04 |
2023-08-13 |
human |
| Gaoyou Pei, Liguo Xu, Wenhao Huang, Jianjun Yi. The protective role of microRNA-133b in restricting hippocampal neurons apoptosis and inflammatory injury in rats with depression by suppressing CTGF. International immunopharmacology. vol 78. 2020-07-13. PMID:31830619. |
the protective role of microrna-133b in restricting hippocampal neurons apoptosis and inflammatory injury in rats with depression by suppressing ctgf. |
2020-07-13 |
2023-08-13 |
human |
| Qiqi Song, Ya-Bo Feng, Liyan Wang, Jie Shen, Ye Li, Cuiqin Fan, Peng Wang, Shu Yan Y. COX-2 inhibition rescues depression-like behaviors via suppressing glial activation, oxidative stress and neuronal apoptosis in rats. Neuropharmacology. vol 160. 2020-07-08. PMID:31539536. |
inhibition of cox-2 exerts neuroprotective actions in dg regions, including suppressing neuroinflammatory response, against oxidative stress and neuronal apoptosis, which are the critical risk factors for neuronal injury and pathophysiology of depression. |
2020-07-08 |
2023-08-13 |
rat |
| Deepika Patel, Martien J Kas, Sumantra Chattarji, Bauke Buwald. Rodent models of social stress and neuronal plasticity: Relevance to depressive-like disorders. Behavioural brain research. vol 369. 2020-06-23. PMID:31022420. |
in neuropsychiatric disorders like depression structural remodeling involves apoptosis, reduced neurogenesis, and structural remodeling of neuronal dendrites which most likely reflects the latter. |
2020-06-23 |
2023-08-13 |
Not clear |
| Lanying Yu, Tiantian Liu, Shuang Fu, Li Li, Xiaoping Meng, Xin Su, Zhanfeng Xie, Jiayan Ren, Yan Meng, Xuejiao Lv, Yanwei D. Physiological functions of urea transporter B. Pflugers Archiv : European journal of physiology. vol 471. issue 11-12. 2020-05-14. PMID:31734718. |
actually, ut-b deficiency increases the sensitivity of bladder epithelial cells to apoptosis triggers in mice and ut-b-null mice develop ii-iii atrioventricular block and depression. |
2020-05-14 |
2023-08-13 |
mouse |
| Haiyang Zhang, Mian Wei, Xiangyu Lu, Qinghong Sun, Chuqiao Wang, Jiuyan Zhang, Honggang Fa. Aluminum trichloride caused hippocampal neural cells death and subsequent depression-like behavior in rats via the activation of IL-1β/JNK signaling pathway. The Science of the total environment. vol 715. 2020-04-03. PMID:32007895. |
aluminum (al) is an inorganic pollutant that induces nerve cells apoptosis and necroptosis, thereby causing depression and neurodegenerative diseases. |
2020-04-03 |
2023-08-13 |
rat |
| Lixing Xu, Jing Su, Liting Guo, Siqi Wang, Xueyang Deng, Shiping M. Modulation of LPA1 receptor-mediated neuronal apoptosis by Saikosaponin-d: A target involved in depression. Neuropharmacology. vol 155. 2020-02-28. PMID:31145906. |
modulation of lpa1 receptor-mediated neuronal apoptosis by saikosaponin-d: a target involved in depression. |
2020-02-28 |
2023-08-13 |
mouse |
| Mu Wang, Jian Guo, Li-Na Dong, Jun-Ping Wan. Cerebellar Fastigial Nucleus Stimulation in a Chronic Unpredictable Mild Stress Rat Model Reduces Post-Stroke Depression by Suppressing Brain Inflammation via the microRNA-29c/TNFRSF1A Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-02-14. PMID:31352465. |
results cerebellar fastigial nucleus stimulation reduced behaviors associated with depression in the rat model, upregulated the expression of mir-29c, and reduced the expression of tnfrsf1a and inflammatory cytokines, and mildly reduced neuronal apoptosis. |
2020-02-14 |
2023-08-13 |
human |