| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Javid Ghazizadeh, Sanaz Hamedeyazdan, Mohammadali Torbati, Fereshteh Farajdokht, Ali Fakhari, Javad Mahmoudi, Mostafa Araj-Khodaei, Saeed Sadigh-Etegha. Melissa officinalis L. hydro-alcoholic extract inhibits anxiety and depression through prevention of central oxidative stress and apoptosis. Experimental physiology. vol 105. issue 4. 2021-08-19. PMID:32003913. |
melissa officinalis l. hydro-alcoholic extract inhibits anxiety and depression through prevention of central oxidative stress and apoptosis. |
2021-08-19 |
2023-08-13 |
mouse |
| He Yu, Zhong-Mei He, Kun Shi, Yan Zhao, Ying Zong, Jian-Ming Li, Wei-Jia Chen, Rui D. [Study on antidepressant effect of total alkaloids of Fibraurea recisa]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 14. 2021-08-18. PMID:34402292. |
this study aimed to investigate the antidepressant effects of total alkaloids of fibraurea recisa in ht22 cells damaged by corticosterone (cort) in vitro and in a mouse model of chronic unpredictable mild stress (cums) as well as the underlying mechanisms.in cellular experiments,the viability of cort-damaged ht22 cells was detected using cell counting kit-8 (cck-8),and the cell apoptosis was detected by hoechst 33258 staining.in animal experiments,c57bl/6n mice were randomly divided into the control group,model group,low (100 mg·kg~(-1)),medium (200 mg·kg~(-1)) and high (400 mg·kg~(-1))-dose of total alkaloids of f.recisa groups,and positive control group.after 21 days of cums exposure,their depressive behaviors were observed in behavioral and morris water maze tests.the serum levels of 5-hydroxytryptamine (5-ht),dopamine (da),and norepinephrine (ne) were assessed by elisa.the expression levels of apoptosis-related proteins bcl-2,bax and cleaved caspase-3 in ht22 cells and mouse hippocampus were detected by western blot.the results suggested that total alkaloids of f.recisa alleviated the damage of ht22 cells induced by cort in a dose-dependent manner.the hoechst 33258 staining uncovered that total alkaloids of f.recisa better reduced the blue spots and inhibited cell apoptosis.the results of animal experiments showed that total alkaloids of f.recisa significantly improved the depression-like behaviors of mice and increased the serum levels of 5-ht,da and ne as compared with those in the model group.the western blot assays revealed a significant up-regulation of bcl-2 protein expression,but an obvious reduction in bax and cleaved caspase-3protein expression in the total alkaloids of f.recisa group.in conclusion,total alkaloids of f.recisa inhibited depression possibly by regulating the apoptosis-related protein expression or elevating the monoamine neurotransmitter levels in the brain. |
2021-08-18 |
2023-08-13 |
mouse |
| Arshad Ghaffari-Nasab, Reza Badalzadeh, Gisou Mohaddes, Mohammad Reza Alipou. Young plasma administration mitigates depression-like behaviours in chronic mild stress-exposed aged rats by attenuating apoptosis in prefrontal cortex. Experimental physiology. vol 106. issue 7. 2021-07-01. PMID:34018261. |
following chronic transfusion of young plasma, depressive behaviour was improved in the depression model of aged rats, which was associated with reduced apoptosis process in the prefrontal cortex. |
2021-07-01 |
2023-08-13 |
rat |
| Qinghua Li, Qingxia Luan, Hailing Zhu, Yuehua Zhao, Jiafen Ji, Fan Wu, Jingfen Ya. Circular RNA circ_0005774 contributes to proliferation and suppresses apoptosis of acute myeloid leukemia cells via circ_0005774/miR-192-5p/ULK1 ceRNA pathway. Biochemical and biophysical research communications. vol 551. 2021-06-30. PMID:33735626. |
accordingly, blocking circ_0005774 and/or overexpressing mir-192-5p could enhance apoptosis rate of hl-60 and nb4 cells, but suppress cell viability and cell cycle entrance, accompanied with depression of proliferation markers including proliferating cell nuclear antigen (pcna), cyclind1 and b cell lymphoma 2 (bcl-2). |
2021-06-30 |
2023-08-13 |
Not clear |
| Josh Allen, Hector J Caruncho, Lisa E Kalynchu. Severe life stress, mitochondrial dysfunction, and depressive behavior: A pathophysiological and therapeutic perspective. Mitochondrion. vol 56. 2021-05-28. PMID:33220501. |
mitochondria are responsible for providing our cells with energy, as well as regulating oxidative stress and apoptosis, and considerable evidence demonstrates that mitochondria-related alterations are prevalent during chronic stress and depression. |
2021-05-28 |
2023-08-13 |
Not clear |
| Xiaoyun Guo, Ruizhi Mao, Lvchun Cui, Fan Wang, Rubai Zhou, Yun Wang, Jia Huang, Yuncheng Zhu, Yamin Yao, Guoqing Zhao, Zezhi Li, Jun Chen, Jinhui Wang, Yiru Fan. PAID study design on the role of PKC activation in immune/inflammation-related depression: a randomised placebo-controlled trial protocol. General psychiatry. vol 34. issue 2. 2021-04-30. PMID:33912799. |
microglia activation can lead to an increase in the levels of proinflammatory cytokines, including tnf-α, which leads to neuronal apoptosis in the specific neural circuits of some brain regions, abnormal cognition and treatment-resistant depression (trd). |
2021-04-30 |
2023-08-13 |
Not clear |
| Jian Liu, Yuan-Shan Han, Lin Liu, Lin Tang, Hui Yang, Pan Meng, Hong-Qing Zhao, Yu-Hong Wan. Abnormal Glu/mGluR Neural regeneration research. vol 16. issue 4. 2021-04-29. PMID:33063735. |
abnormal glu/mglur our previous studies have shown that glutamate and hippocampal neuron apoptosis are key signals and direct factors associated with diabetes-related depression, and structural and functional damage to the hippocampal neurovascular unit has been associated with diabetes-related depression. |
2021-04-29 |
2023-08-13 |
Not clear |
| Xiao Geng Zhu, Tie Ning Zhang, Ri Wen, Chun Feng Li. Overexpression of miR-150-5p Alleviates Apoptosis in Sepsis-Induced Myocardial Depression. BioMed research international. vol 2020. 2021-04-28. PMID:32908879. |
we also observed apoptosis in the heart tissue and in h9c2 cardiomyocytes stimulated with lipopolysaccharide, indicating that cell apoptosis may be an important mechanism in sepsis-induced myocardial depression. |
2021-04-28 |
2023-08-13 |
rat |
| Xiao Geng Zhu, Tie Ning Zhang, Ri Wen, Chun Feng Li. Overexpression of miR-150-5p Alleviates Apoptosis in Sepsis-Induced Myocardial Depression. BioMed research international. vol 2020. 2021-04-28. PMID:32908879. |
overexpression of mir-150-5p alleviates apoptosis in sepsis-induced myocardial depression. |
2021-04-28 |
2023-08-13 |
rat |
| Xiao Geng Zhu, Tie Ning Zhang, Ri Wen, Chun Feng Li. Overexpression of miR-150-5p Alleviates Apoptosis in Sepsis-Induced Myocardial Depression. BioMed research international. vol 2020. 2021-04-28. PMID:32908879. |
these findings suggest that mir-150-5p can alleviate apoptosis and may be a novel therapeutic target for sepsis-induced myocardial depression. |
2021-04-28 |
2023-08-13 |
rat |
| Chengping Luo, Huimin Fan, Shaojun Li, Yuling Zo. Therapeutic of Candesartan and Music Therapy in Diabetic Retinopathy with Depression in Rats. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-04-10. PMID:33833815. |
especially, music therapy further improved the effects of candesartan on retina cell apoptosis and neurotransmitter release in diabetic retinopathy rats with depression. |
2021-04-10 |
2023-08-13 |
rat |
| Luiz Arthur Rangel Cyrino, Daniela Delwing-de Lima, Oliver Matheus Ullmann, Thayná Patachini Mai. Concepts of Neuroinflammation and Their Relationship With Impaired Mitochondrial Functions in Bipolar Disorder. Frontiers in behavioral neuroscience. vol 15. 2021-03-20. PMID:33732117. |
bipolar disorder (bd) is a chronic psychiatric disease, characterized by frequent behavioral episodes of depression and mania, and neurologically by dysregulated neurotransmission, neuroplasticity, growth factor signaling, and metabolism, as well as oxidative stress, and neuronal apoptosis, contributing to chronic neuroinflammation. |
2021-03-20 |
2023-08-13 |
Not clear |
| Eva O Melin, Jonatan Dereke, Magnus Hillma. Low levels of soluble TWEAK, indicating on-going inflammation, were associated with depression in type 1 diabetes: a cross-sectional study. BMC psychiatry. vol 20. issue 1. 2021-02-22. PMID:33261587. |
low levels of the soluble tumour necrosis factor-like weak inducer of apoptosis (stweak) and depression are linked to cardiovascular disease. |
2021-02-22 |
2023-08-13 |
Not clear |
| Wenfei Zhang, Qian Sun, Lingling Jia, Ming L. Ketamine exerts a protective role in a cell-based model of major depressive disorder via the inhibition of apoptosis and inflammation and activation of the Krebs cycle. Bosnian journal of basic medical sciences. vol 20. issue 1. 2020-12-18. PMID:31215856. |
in this study, we established a model of depression in pc12 cells using corticosterone to investigate the effect of ketamine and nuclear factor-κb (nf-κb) on the cell viability, apoptosis, levels of pro-inflammatory cytokines, apoptosis-related molecules, and enzymes of the krebs cycle. |
2020-12-18 |
2023-08-13 |
Not clear |
| Anwen Shao, Danfeng Lin, Lingling Wang, Sheng Tu, Cameron Lenahan, Jianmin Zhan. Oxidative Stress at the Crossroads of Aging, Stroke and Depression. Aging and disease. vol 11. issue 6. 2020-12-07. PMID:33269106. |
this review summarizes the mechanisms of os and os-mediated pathological processes, such as inflammation, apoptosis, and the microbial-gut-brain axis in stroke and depression. |
2020-12-07 |
2023-08-13 |
Not clear |
| Zhilan Peng, Cai Zhang, Ling Yan, Yongping Zhang, Zhiyou Yang, Jiajia Wang, Cai Son. EPA is More Effective than DHA to Improve Depression-Like Behavior, Glia Cell Dysfunction and Hippcampal Apoptosis Signaling in a Chronic Stress-Induced Rat Model of Depression. International journal of molecular sciences. vol 21. issue 5. 2020-12-01. PMID:32150824. |
epa is more effective than dha to improve depression-like behavior, glia cell dysfunction and hippcampal apoptosis signaling in a chronic stress-induced rat model of depression. |
2020-12-01 |
2023-08-13 |
rat |
| Yuan Hu, Xianzhe Dong, Tianyi Zhang, Hongming Ma, Wenshan Yang, Yichen Wang, Ping Liu, Yibang Che. Kai‑Xin‑San suppresses matrix metalloproteinases and myocardial apoptosis in rats with myocardial infarction and depression. Molecular medicine reports. vol 21. issue 1. 2020-10-26. PMID:31746394. |
these results indicated that mi comorbid with depression may damage the mmp balance in the central and peripheral system, and kxs may have a direct anti‑depressive and cardio‑protective effect by regulating the level of mmps and associated myocardial apoptosis. |
2020-10-26 |
2023-08-13 |
rat |
| Yuan Hu, Xianzhe Dong, Tianyi Zhang, Hongming Ma, Wenshan Yang, Yichen Wang, Ping Liu, Yibang Che. Kai‑Xin‑San suppresses matrix metalloproteinases and myocardial apoptosis in rats with myocardial infarction and depression. Molecular medicine reports. vol 21. issue 1. 2020-10-26. PMID:31746394. |
kai‑xin‑san suppresses matrix metalloproteinases and myocardial apoptosis in rats with myocardial infarction and depression. |
2020-10-26 |
2023-08-13 |
rat |
| Run-Hui Tian, Yang Bai, Jing-Yang Li, Kai-Min Gu. Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression. Brain research. vol 1725. 2020-10-23. PMID:31545956. |
reducing prlr expression and jak2 activity results in an increase in bdnf expression and inhibits the apoptosis of ca3 hippocampal neurons in a chronic mild stress model of depression. |
2020-10-23 |
2023-08-13 |
mouse |
| Run-Hui Tian, Yang Bai, Jing-Yang Li, Kai-Min Gu. Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression. Brain research. vol 1725. 2020-10-23. PMID:31545956. |
from the aforementioned findings, we concluded that prlr gene silencing results in the inhibition of hippocampal neuron apoptosis and alleviation of cms-induced depression by inactivating the jak2-stat5 signaling pathway and elevating bdnf expression, providing a new insight for the treatment of depression. |
2020-10-23 |
2023-08-13 |
mouse |