| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adnan Khan, Bushra Shal, Muhammad Naveed, Fawad Ali Shah, Ayesha Atiq, Naseem Ullah Khan, Yeong Shik Kim, Salman Kha. Matrine ameliorates anxiety and depression-like behaviour by targeting hyperammonemia-induced neuroinflammation and oxidative stress in CCl4 model of liver injury. Neurotoxicology. vol 72. 2020-01-06. PMID:30738807. |
neuroinflammation, oxidative stress, reduced neurogenesis, and apoptosis are critical factors for the development of anxiety and depression. |
2020-01-06 |
2023-08-13 |
mouse |
| Adnan Khan, Bushra Shal, Muhammad Naveed, Fawad Ali Shah, Ayesha Atiq, Naseem Ullah Khan, Yeong Shik Kim, Salman Kha. Matrine ameliorates anxiety and depression-like behaviour by targeting hyperammonemia-induced neuroinflammation and oxidative stress in CCl4 model of liver injury. Neurotoxicology. vol 72. 2020-01-06. PMID:30738807. |
the present data revealed that hyperammonemia produced due to liver injury induced oxidative stress, neuroinflammation, reduced neurogenesis and apoptosis in the hippocampus, thus, resulting in anxiety and depression. |
2020-01-06 |
2023-08-13 |
mouse |
| Huiying Li, Chengyan He, Xuekui Wang, Hai Wang, Guangxian Nan, Ling Fan. MicroRNA-183 affects the development of gastric cancer by regulating autophagy via MALAT1-miR-183-SIRT1 axis and PI3K/AKT/mTOR signals. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2019-12-24. PMID:31352788. |
our results indicate that mir-183 is under-expressed in gc cells and depression of mir-183 may enhance gc cell viability and inhibit cell apoptosis by affecting the activation of cell autophagy. |
2019-12-24 |
2023-08-13 |
Not clear |
| K M A Zinnah, Sang-Youel Par. Duloxetine Enhances TRAIL-mediated Apoptosis Anticancer research. vol 39. issue 12. 2019-12-13. PMID:31810927. |
duloxetine enhances trail-mediated apoptosis the antidepressant duloxetine is known as a serotonin-norepinephrine reuptake inhibitor, used for treating depression and anxiety. |
2019-12-13 |
2023-08-13 |
Not clear |
| Xiantao Sun, Yang Bai, Chao Yang, Shengyun Hu, Zhili Hou, Guixian Wan. Long noncoding RNA SNHG15 enhances the development of colorectal carcinoma via functioning as a ceRNA through miR-141/SIRT1/Wnt/β-catenin axis. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2019-12-02. PMID:31213086. |
depression of snhg15 depressed proliferation, enhanced apoptosis, and repressed the migration and invasion of crc cells. |
2019-12-02 |
2023-08-13 |
Not clear |
| Xiantao Sun, Yang Bai, Chao Yang, Shengyun Hu, Zhili Hou, Guixian Wan. Long noncoding RNA SNHG15 enhances the development of colorectal carcinoma via functioning as a ceRNA through miR-141/SIRT1/Wnt/β-catenin axis. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2019-12-02. PMID:31213086. |
the mrna level of snhg15 in crc tissues and cells was detected, followed by investigating the impacts of the depression of snhg15 on crc cell proliferation (viability and colony-forming), apoptosis, migration, and invasion. |
2019-12-02 |
2023-08-13 |
Not clear |
| Keiji Wakabayash. NSAIDs as Cancer Preventive Agents. Asian Pacific journal of cancer prevention : APJCP. vol 1. issue 2. 2019-11-20. PMID:12718676. |
mechanisms of action: nsaids appear to act via depression of prostaglandin synthesis through inhibiting cox-2, often overexpressed in cancers, and the resultant suppression of proliferation, possibly through enhancement of apoptosis. |
2019-11-20 |
2023-08-12 |
human |
| Yuxiu Sun, Baoli Qi. Long noncoding RNA MALAT1 regulates HDAC4-mediated proliferation and apoptosis via decoying of miR-140-5p in osteosarcoma cells. Cancer medicine. vol 7. issue 9. 2019-11-14. PMID:30094957. |
meanwhile, we demonstrated that a depression of malat1 suppressed proliferation and promoted apoptosis in os cell line hos and 143b. |
2019-11-14 |
2023-08-13 |
Not clear |
| Amal Ahmed Abd El-Fattah, Atef Tadros Fahim, Nermin Abdel Hamid Sadik, Bassam Mohamed Al. Resveratrol and dimethyl fumarate ameliorate depression-like behaviour in a rat model of chronic unpredictable mild stress. Brain research. vol 1701. 2019-11-04. PMID:30244113. |
emerging evidence shows that oxidative stress, inflammation and apoptosis are main contributing pathophysiologic mechanisms of depression. |
2019-11-04 |
2023-08-13 |
rat |
| Zhuo Liu, Jian Liu, Jia Ling, Qin Yang, Hui Yang, Pan Meng, Qing DU, Hong-Qing Zhao, Yu-Hong Wan. [Effects of ELK-1/JNK/c-Fos on apoptosis of rat hippocampal neurons cultured in vitro with Zuogui Jiangtang Jieyu Formula in simulated diabetes mellitus complicated with depression]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 35. issue 1. 2019-09-05. PMID:31245952. |
[effects of elk-1/jnk/c-fos on apoptosis of rat hippocampal neurons cultured in vitro with zuogui jiangtang jieyu formula in simulated diabetes mellitus complicated with depression]. |
2019-09-05 |
2023-08-13 |
rat |
| Zhuo Liu, Jian Liu, Jia Ling, Qin Yang, Hui Yang, Pan Meng, Qing DU, Hong-Qing Zhao, Yu-Hong Wan. [Effects of ELK-1/JNK/c-Fos on apoptosis of rat hippocampal neurons cultured in vitro with Zuogui Jiangtang Jieyu Formula in simulated diabetes mellitus complicated with depression]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 35. issue 1. 2019-09-05. PMID:31245952. |
to study the effects of zuogui jiangtang jieyu formula (zgjtjyf, the chinese medicine) on hippocampal neuron apoptosis in diabetes mellitus complicated with depression (dd). |
2019-09-05 |
2023-08-13 |
rat |
| Ling-Heng Kong, Feng-Mei Xiong, Xing-Li Su, Na Sun, Jing-Jun Zhou, Jun Y. CaMKII mediates myocardial ischemia/reperfusion injury‑induced contracture in isolated rat heart. Molecular medicine reports. 2019-08-21. PMID:31432114. |
compared with control hearts, both the ir and cap groups exhibited an increase in necrosis and apoptosis, and a marked depression in contractile function. |
2019-08-21 |
2023-08-13 |
rat |
| Shiyu Gao, Jianwei Lin, Tianqi Wang, Yan Shen, Yan Li, Wenyu Yang, Kailiang Zhou, Haiyan H. Qingxin kaiqiao fang ameliorates memory impairment and inhibits apoptosis in APP/PS1 double transgenic mice through the MAPK pathway. Drug design, development and therapy. vol 13. 2019-08-09. PMID:30774310. |
this study aimed to investigate whether qkf-induced apoptosis depression is achieved through mapk pathway. |
2019-08-09 |
2023-08-13 |
mouse |
| Yang Sun, Ya Tu, Yu Guo, Hui-Li Jiang, Ya-Huan Li, Yu Wang, Bing-Cong Zhao, Xing-Zhou Gao, Xiang Li, Shi-Xing Feng, Yu-Fei L. [Acupuncture improved depressive behavior by regulating expression of hippocampal apoptosis-related factors in psychological stress-induced depression rats]. Zhen ci yan jiu = Acupuncture research. vol 44. issue 6. 2019-08-07. PMID:31368263. |
to investigate the effect of acupuncture on behavior changes and the expression of reactive oxygen species (ros), cytochrome c, cysteine-containing aspartate-specific proteases-3 (caspase-3), apoptosis inducing factor (aif) in the hippocampus of rats exposed to chronic restraint stress (crs), so as to provide experimental evidence for the prevention and treatment of depression. |
2019-08-07 |
2023-08-13 |
rat |
| Wen-Tao Fan, Qian Wan. [Mechanism of Acori Tatarinowii Rhizoma-Curcumae Radix treating depression based on network pharmacology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 43. issue 12. 2019-07-18. PMID:29950083. |
the possible mechanism for treating depression is the adjustment of wrong folding protein, sex hormone secretion and apoptosis of hippocampal neurons. |
2019-07-18 |
2023-08-13 |
Not clear |
| Bushra Shal, Adnan Khan, Muhammad Naveed, Naseem Ullah Khan, Ihsan-Ul-Haq, Shakir D AlSharari, Yeong Shik Kim, Salman Kha. Effect of 25-methoxy hispidol A isolated from Poncirus trifoliate against bacteria-induced anxiety and depression by targeting neuroinflammation, oxidative stress and apoptosis in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 111. 2019-06-13. PMID:30583228. |
effect of 25-methoxy hispidol a isolated from poncirus trifoliate against bacteria-induced anxiety and depression by targeting neuroinflammation, oxidative stress and apoptosis in mice. |
2019-06-13 |
2023-08-13 |
mouse |
| Bushra Shal, Adnan Khan, Muhammad Naveed, Naseem Ullah Khan, Ihsan-Ul-Haq, Shakir D AlSharari, Yeong Shik Kim, Salman Kha. Effect of 25-methoxy hispidol A isolated from Poncirus trifoliate against bacteria-induced anxiety and depression by targeting neuroinflammation, oxidative stress and apoptosis in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 111. 2019-06-13. PMID:30583228. |
neuroinflammation, oxidative stress and apoptosis are implicated in the pathogenesis of neuropsychiatric diseases like anxiety and depression. |
2019-06-13 |
2023-08-13 |
mouse |
| Jun Shen, Chujie Qu, Linling Xu, Huimin Sun, Junjian Zhan. Resveratrol exerts a protective effect in chronic unpredictable mild stress-induced depressive-like behavior: involvement of the AKT/GSK3β signaling pathway in hippocampus. Psychopharmacology. vol 236. issue 2. 2019-05-07. PMID:30374891. |
chronic unpredictable mild stress (cums) is an important contributing factor for depression with inflammatory response alteration, neuron apoptosis, and decreased neurogenesis. |
2019-05-07 |
2023-08-13 |
Not clear |
| Jun Shen, Chujie Qu, Linling Xu, Huimin Sun, Junjian Zhan. Resveratrol exerts a protective effect in chronic unpredictable mild stress-induced depressive-like behavior: involvement of the AKT/GSK3β signaling pathway in hippocampus. Psychopharmacology. vol 236. issue 2. 2019-05-07. PMID:30374891. |
previous study reported that the administration of resveratrol alleviated depression by normalizing the increased proinflammatory cytokine levels and inhibiting apoptosis in the hippocampus. |
2019-05-07 |
2023-08-13 |
Not clear |
| Lin Zhao, Huicong Ren, Shina Gu, Xiaodan Li, Cuihong Jiang, Juan Li, Mengmeng Zhang, Junlin Mu, Wenqiang Li, Wensheng Wang, Zhaohui Zhang, Jinggui Son. rTMS ameliorated depressive-like behaviors by restoring HPA axis balance and prohibiting hippocampal neuron apoptosis in a rat model of depression. Psychiatry research. vol 269. 2019-03-11. PMID:30145293. |
rtms ameliorated depressive-like behaviors by restoring hpa axis balance and prohibiting hippocampal neuron apoptosis in a rat model of depression. |
2019-03-11 |
2023-08-13 |
rat |