| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P S Jairani, P M Aswathy, Srinivas Gopala, Joe Verghese, P S Mathuranat. Interaction with the MAPT H1H1 Genotype Increases Dementia Risk in APOE ε4 Carriers in a Population of Southern India. Dementia and geriatric cognitive disorders. vol 42. issue 5-6. 2018-01-23. PMID:27705964. |
this study delineates the role of the interaction of apolipoprotein e (apoe) and mapt alleles in contributing to disease risks of dementia in a southern indian population. |
2018-01-23 |
2023-08-13 |
Not clear |
| Florence F Roussotte, Katherine L Narr, Gary W Small, Paul M Thompso. The C677T variant in MTHFR modulates associations between blood-based and cerebrospinal fluid biomarkers of neurodegeneration. Neuroreport. vol 27. issue 12. 2018-01-11. PMID:27380243. |
in t-homozygotes who do not carry the apoe-ε4 allele, the relationship between low plasma apoe levels and an increased risk of dementia is likely obscured by the presence of elevated plasma homocysteine. |
2018-01-11 |
2023-08-13 |
human |
| Giuseppe Nicoletti, David Neil Manners, Fabiana Novellino, Claudia Testa, Monica Gagliardi, Caterina Tonon, Raffaele Lodi, Aldo Quattron. Voxel-based morphometry to detect effect of APOE on brain gray matter changes in Parkinson's Disease. Psychiatry research. Neuroimaging. vol 254. 2017-12-07. PMID:27479921. |
the goal of the study was to determine association between apoe Ɛ4 and gray matter changes in pd patients, with or without dementia. |
2017-12-07 |
2023-08-13 |
Not clear |
| Giuseppe Nicoletti, David Neil Manners, Fabiana Novellino, Claudia Testa, Monica Gagliardi, Caterina Tonon, Raffaele Lodi, Aldo Quattron. Voxel-based morphometry to detect effect of APOE on brain gray matter changes in Parkinson's Disease. Psychiatry research. Neuroimaging. vol 254. 2017-12-07. PMID:27479921. |
twenty-five pd patients with the apoe Ɛ4 (13 with dementia), 24 without Ɛ4 (12 with dementia), and 26 controls were selected. |
2017-12-07 |
2023-08-13 |
Not clear |
| Giuseppe Nicoletti, David Neil Manners, Fabiana Novellino, Claudia Testa, Monica Gagliardi, Caterina Tonon, Raffaele Lodi, Aldo Quattron. Voxel-based morphometry to detect effect of APOE on brain gray matter changes in Parkinson's Disease. Psychiatry research. Neuroimaging. vol 254. 2017-12-07. PMID:27479921. |
our results provide no evidence of an association of the apoe Ɛ4 and gray matter degenerative changes in patients with pd, either with or without dementia. |
2017-12-07 |
2023-08-13 |
Not clear |
| Donald M Lyall, Joey Ward, Stuart J Ritchie, Gail Davies, Breda Cullen, Carlos Celis, Mark E S Bailey, Jana Anderson, Jon Evans, Daniel F Mckay, Andrew M Mcintosh, Naveed Sattar, Daniel J Smith, Ian J Deary, Jill P Pel. Alzheimer disease genetic risk factor APOE e4 and cognitive abilities in 111,739 UK Biobank participants. Age and ageing. vol 45. issue 4. 2017-11-20. PMID:27103599. |
the apolipoprotein (apoe) e4 locus is a genetic risk factor for dementia. |
2017-11-20 |
2023-08-13 |
human |
| Fabricio F Oliveira, Elizabeth S Chen, Marilia C Smith, Paulo H F Bertolucc. Predictors of Cognitive and Functional Decline in Patients With Alzheimer Disease Dementia From Brazil. Alzheimer disease and associated disorders. vol 30. issue 3. 2017-11-16. PMID:26523709. |
little is known on how risk factors for alzheimer disease (ad) dementia affect disease progression, much less for populations with low mean schooling, whereas the transcription of apoe may be regulated by nongenetic factors. |
2017-11-16 |
2023-08-13 |
human |
| Fabricio F Oliveira, Elizabeth S Chen, Marilia C Smith, Paulo H F Bertolucc. Predictors of Cognitive and Functional Decline in Patients With Alzheimer Disease Dementia From Brazil. Alzheimer disease and associated disorders. vol 30. issue 3. 2017-11-16. PMID:26523709. |
in this 44-month cohort study, 214 consecutive outpatients with late-onset ad were assessed for rates of cognitive and functional decline by way of clinical dementia rating and mini-mental state examination (mmse) scores, keeping blinded assessment of apoe haplotypes. |
2017-11-16 |
2023-08-13 |
human |
| Ziv Gan-Or, Jacques Y Montplaisir, Jay P Ross, Judes Poirier, Simon C Warby, Isabelle Arnulf, Stephanie Strong, Yves Dauvilliers, Claire S Leblond, Michele T M Hu, Birgit Högl, Ambra Stefani, Christelle Charley Monaca, Valérie Cochen De Cock, Michel Boivin, Luigi Ferini-Strambi, Giuseppe Plazzi, Elena Antelmi, Peter Young, Anna Heidbreder, Thomas R Barber, Samuel G Evetts, Michal Rolinski, Patrick A Dion, Alex Desautels, Jean-François Gagnon, Nicolas Dupré, Ronald B Postuma, Guy A Roulea. The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder. Neurobiology of aging. vol 49. 2017-11-16. PMID:27814994. |
the present study aimed to examine whether the apoe ε4 allele, associated with dementia with lewy bodies (dlb), and possibly with dementia in parkinson's disease (pd), is also associated with idiopathic rapid eye movement sleep behavior disorder (rbd). |
2017-11-16 |
2023-08-13 |
Not clear |
| M Cacciottolo, X Wang, I Driscoll, N Woodward, A Saffari, J Reyes, M L Serre, W Vizuete, C Sioutas, T E Morgan, M Gatz, H C Chui, S A Shumaker, S M Resnick, M A Espeland, C E Finch, J C Che. Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models. Translational psychiatry. vol 7. issue 1. 2017-11-16. PMID:28140404. |
residing in places with fine pm exceeding epa standards increased the risks for global cognitive decline and all-cause dementia respectively by 81 and 92%, with stronger adverse effects in apoe ɛ4/4 carriers. |
2017-11-16 |
2023-08-13 |
mouse |
| Simon R Cox, Stuart J Ritchie, David Alexander Dickie, Alison Pattie, Natalie A Royle, Janie Corley, Benjamin S Aribisala, Sarah E Harris, Maria Valdés Hernández, Alan J Gow, Susana Muñoz Maniega, John M Starr, Mark E Bastin, Joanna M Wardlaw, Ian J Dear. Interaction of APOE e4 and poor glycemic control predicts white matter hyperintensity growth from 73 to 76. Neurobiology of aging. vol 54. 2017-11-16. PMID:28324763. |
we examined whether apolipoprotein e (apoe) status interacts with vascular risk factors (vrfs) to predict the progression of white matter hyperintensities (wmhs) on brain mri scans over a specific period of life in older age when the risk of dementia increases. |
2017-11-16 |
2023-08-13 |
Not clear |
| Lan-Yan Lin, Jing Zhang, Xiao-Man Dai, Nai-An Xiao, Xi-Lin Wu, Zhen Wei, Wen-Ting Fang, Yuan-Gui Zhu, Xiao-Chun Che. Early-life stress leads to impaired spatial learning and memory in middle-aged ApoE4-TR mice. Molecular neurodegeneration. vol 11. issue 1. 2017-11-09. PMID:27406263. |
the apoe ε4 allele is associated with depression, mild cognitive impairment (mci) and dementia; however, the precise molecular mechanism through which apoe4 influences the risk of disease development remains unknown. |
2017-11-09 |
2023-08-13 |
mouse |
| Katrine Laura Rasmusse. Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: A review. Atherosclerosis. vol 255. 2017-11-06. PMID:28340945. |
plasma levels of apolipoprotein e, apoe genotype and risk of dementia and ischemic heart disease: a review. |
2017-11-06 |
2023-08-13 |
Not clear |
| Katrine Laura Rasmusse. Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: A review. Atherosclerosis. vol 255. 2017-11-06. PMID:28340945. |
apolipoprotein e (apoe) plays a pivotal role in lipoprotein metabolism in the brain and in the periphery, and is implicated in both dementia and ischemic heart disease. |
2017-11-06 |
2023-08-13 |
Not clear |
| Katrine Laura Rasmusse. Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: A review. Atherosclerosis. vol 255. 2017-11-06. PMID:28340945. |
whether plasma levels of apoe are associated with increased risk of dementia and ischemic heart disease, and whether these associations are independent of the apoe polymorphism and of lipids and lipoproteins has only recently been established. |
2017-11-06 |
2023-08-13 |
Not clear |
| Katrine Laura Rasmusse. Plasma levels of apolipoprotein E, APOE genotype and risk of dementia and ischemic heart disease: A review. Atherosclerosis. vol 255. 2017-11-06. PMID:28340945. |
the aim of this review is to summarize and discuss the current epidemiological and biological evidence for an association of plasma levels of apoe with risk of dementia and ischemic heart disease. |
2017-11-06 |
2023-08-13 |
Not clear |
| Kimberly C Paul, Rebecca Rausch, Michelle M Creek, Janet S Sinsheimer, Jeff M Bronstein, Yvette Bordelon, Beate Rit. APOE, MAPT, and COMT and Parkinson's Disease Susceptibility and Cognitive Symptom Progression. Journal of Parkinson's disease. vol 6. issue 2. 2017-10-30. PMID:27061069. |
apolipoprotein e (apoe), catechol-o-methyl transferase (comt), and microtubule-associated protein tau (mapt) are of interest related to their contributions to cognitive decline or dementia in pd. |
2017-10-30 |
2023-08-13 |
Not clear |
| Simon Evans, Nicholas G Dowell, Naji Tabet, Sarah L King, Samuel B Hutton, Jennifer M Ruste. Disrupted neural activity patterns to novelty and effort in young adult Brain and behavior. vol 7. issue 2. 2017-10-30. PMID:28239522. |
disrupted neural activity patterns to novelty and effort in young adult the apoe e4 allele has been linked to poorer cognitive aging and enhanced dementia risk. |
2017-10-30 |
2023-08-13 |
Not clear |
| Faye McKenna, Bang-Bon Koo, Ronald Killian. Comparison of ApoE-related brain connectivity differences in early MCI and normal aging populations: an fMRI study. Brain imaging and behavior. vol 10. issue 4. 2017-10-16. PMID:26409470. |
notably, we show that (1) emci disrupts functional connectivity strength in many important functionally-linked areas; (2) apoe e4 disrupts functional connectivity strength in similar areas to emci; and (3) the differences in functional connectivity between groups shows a multifactor contribution to functional network dysfunction along the trajectory leading to dementia. |
2017-10-16 |
2023-08-13 |
human |
| Fabricio Ferreira de Oliveira, Elizabeth Suchi Chen, Marilia Cardoso Smith, Paulo Henrique Ferreira Bertolucc. Longitudinal lipid profile variations and clinical change in Alzheimer's disease dementia. Neuroscience letters. vol 646. 2017-10-10. PMID:28274859. |
in this longitudinal study, 192 consecutive outpatients with late-onset alzheimer's disease dementia were stratified according to apoe haplotypes, and followed for one year to investigate associations of lipid profile variations and lipophilic statin therapy with changes in cognition, caregiver burden, basic and instrumental functionality. |
2017-10-10 |
2023-08-13 |
Not clear |