| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shu-Yi Huang, Zong-Ying Su, Yuan-Yuan Han, Li Liu, Ying-Jie Shang, Zi-Fan Mai, Zhi-Wei Zeng, Chu-Hua L. Cordycepin improved the cognitive function through regulating adenosine A Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 110. 2023-01-12. PMID:36634379. |
cognitive dysfunction is accompanied by synaptic transmission damage in the hippocampus. |
2023-01-12 |
2023-08-14 |
Not clear |
| Huiya Ying, Zilong Zhang, Wei Wang, Zijing Yang, Cancan You, Yuanai Li, Xiaohong Cai, Xiucui L. Inhibition of Calcium-Sensing Receptor Alleviates Chronic Intermittent Hypoxia-Induced Cognitive Dysfunction via CaSR-PKC-ERK1/2 Pathway. Molecular neurobiology. 2023-01-04. PMID:36600080. |
overall, our findings revealed that casr held a critical function on cih-induced cognitive dysfunction in mice by accelerating hippocampal neuronal apoptosis and reducing synaptic plasticity via augmenting casr-pkc-erk1/2 pathway; otherwise, inhibition of casr alleviated cih-induced cognitive dysfunction. |
2023-01-04 |
2023-08-14 |
mouse |
| Lixia DU, Zhongmin Fan, Yi Li, Zongping Fang, Xijing Zhan. [Rapamycin alleviates cognitive impairment in mice with sepses-associated encephalopathy by promoting autophagy]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 12. 2022-12-30. PMID:36585229. |
conclusion rapamycin alleviated the cognitive dysfunction of sae mice by promoting autophagy in the hippocampal neurons. |
2022-12-30 |
2023-08-14 |
mouse |
| Li-Min Zhang, Zhi-You Wu, Ji-Zhen Liu, Yan Li, Jin-Meng Lv, Lu-Ying Wang, Yu-Dong Shan, Rong-Xin Song, Hui-Tao Miao, Wei Zhang, Dong-Xue Zhan. Subanesthetic dose of S-ketamine improved cognitive dysfunction via the inhibition of hippocampal astrocytosis in a mouse model of post-stroke chronic stress. Journal of psychiatric research. vol 158. 2022-12-21. PMID:36542981. |
subanesthetic dose of s-ketamine improved cognitive dysfunction via the inhibition of hippocampal astrocytosis in a mouse model of post-stroke chronic stress. |
2022-12-21 |
2023-08-14 |
mouse |
| Li-Min Zhang, Zhi-You Wu, Ji-Zhen Liu, Yan Li, Jin-Meng Lv, Lu-Ying Wang, Yu-Dong Shan, Rong-Xin Song, Hui-Tao Miao, Wei Zhang, Dong-Xue Zhan. Subanesthetic dose of S-ketamine improved cognitive dysfunction via the inhibition of hippocampal astrocytosis in a mouse model of post-stroke chronic stress. Journal of psychiatric research. vol 158. 2022-12-21. PMID:36542981. |
our current data also suggests that the subanesthetic doses of s-ketamine improved cognitive dysfunction via the inhibition of hippocampal astrocytosis in a mouse model of pscs. |
2022-12-21 |
2023-08-14 |
mouse |
| Qiong Wu, Min Yu, Zhen Wang, Xiaohong Ai, Zhenghai Liu, Jiayu Zeng, Cai Li, Lei Yuan, Jie He, Xinping Lin, Wei Wa. Alternate-day fasting for the protection of cognitive impairment in c57BL/6J mice following whole-brain radiotherapy. Neurochemistry international. 2022-12-13. PMID:36513311. |
according to our study, this is the first time we found that adf improved cognitive dysfunction induced by irradiation, and the anti-inflammatory effect of adf could be due to inhibition in nlrp3-mediated hippocampal neuronal loss by suppressing astrocyte activation. |
2022-12-13 |
2023-08-14 |
mouse |
| Zheng Xie, Xuan Wang, Xiaoxiao Luo, Jing Yan, Jie Zhang, Rao Sun, Ailin Luo, Shiyong L. Activated AMPK mitigates diabetes-related cognitive dysfunction by inhibiting hippocampal ferroptosis. Biochemical pharmacology. 2022-12-12. PMID:36502872. |
activated ampk mitigates diabetes-related cognitive dysfunction by inhibiting hippocampal ferroptosis. |
2022-12-12 |
2023-08-14 |
mouse |
| Yaru Liu, Zhenyang Yan, Yafei Ren, Woyu Wang, Yinze Ke, Yifan Wang, Rongming Q. Electroacupuncture inhibits hippocampal neuronal apoptosis and improves cognitive dysfunction in mice with vascular dementia via the JNK signaling pathway. Acupuncture in medicine : journal of the British Medical Acupuncture Society. 2022-12-09. PMID:36482691. |
electroacupuncture inhibits hippocampal neuronal apoptosis and improves cognitive dysfunction in mice with vascular dementia via the jnk signaling pathway. |
2022-12-09 |
2023-08-14 |
mouse |
| Titikorn Chunchai, Hiranya Pintana, Apiwan Arinno, Benjamin Ongnok, Patcharapong Pantiya, Thawatchai Khuanjing, Nanthip Prathumsap, Chayodom Maneechote, Nipon Chattipakorn, Siriporn C Chattipakor. Melatonin and Metformin Counteract Cognitive Dysfunction Equally in Male Rats with Doxorubicin-induced Chemobrain. Neurotoxicology. 2022-12-04. PMID:36463981. |
we aimed to investigate whether mel and met provide neuroprotective effects on glial dysmorphologies, brain inflammation, oxidative stress, brain mitochondrial dysfunction, apoptosis, necroptosis, neurogenesis, hippocampal dysplasticity, and cognitive dysfunction in rats with dox-induced chemobrain. |
2022-12-04 |
2023-08-14 |
rat |
| Xiaoxuan Yang, Chen Chen, Dongmei Qu, Yanping Liu, Ning Wang, Haibi Wang, Youjia Fan, Yushan Zhou, Buwei Yu, Qingsheng Xue, Yuqing Wu, Han L. Aberrant expression of FBXO22 is associated with propofol-induced synaptic plasticity and cognitive dysfunction in adult mice. Frontiers in aging neuroscience. vol 14. 2022-11-25. PMID:36425318. |
knockdown experiments showed the downregulation of fbxo22 restored the changes by propofol treatment on hippocampal primary neurons and attenuated propofol-induced hippocampal dependent cognitive dysfunction. |
2022-11-25 |
2023-08-14 |
mouse |
| Yunping Lu, Qian Pang, Qianqian Wu, Bin Luo, Xiaofei Tang, Qingsong Jian. Molar loss further exacerbates 2-VO-induced cognitive impairment associated with the activation of p38MAPK/NFκB pathway. Frontiers in aging neuroscience. vol 14. 2022-11-21. PMID:36408103. |
our previous study found that the molar loss affected cognitive dysfunction, and the astrocytes in the hippocampus of chronic cerebral ischemia rats were affected, but the underlying mechanism is unclear. |
2022-11-21 |
2023-08-14 |
rat |
| Shahab Ghaderi, Alireza Komaki, Iraj Salehi, Zahra Basir, Masome Rashn. Possible mechanisms involved in the protective effects of chrysin against lead-induced cognitive decline: An in vivo study in a rat model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 157. 2022-11-19. PMID:36402029. |
however, chrysin treatment improved cognitive dysfunction, ameliorated hippocampal ltp impairment, modulated inflammatory status, reduced pb concentration, and prevented neuronal loss in the pb-exposed rats. |
2022-11-19 |
2023-08-14 |
rat |
| Xinyu Nan, Qi Sun, Xiaoyu Xu, Ying Yang, Yanfeng Zhen, Yameng Zhang, Haixia Zhou, Hui Fan. Forsythoside B ameliorates diabetic cognitive dysfunction by inhibiting hippocampal neuroinflammation and reducing synaptic dysfunction in ovariectomized mice. Frontiers in aging neuroscience. vol 14. 2022-11-17. PMID:36389075. |
forsythoside b ameliorates diabetic cognitive dysfunction by inhibiting hippocampal neuroinflammation and reducing synaptic dysfunction in ovariectomized mice. |
2022-11-17 |
2023-08-14 |
mouse |
| Cheng-Long Ge, Wei Chen, Li-Na Zhang, Yu-Hang Ai, Yu Zou, Qian-Yi Pen. Hippocampus-prefrontal cortex inputs modulate spatial learning and memory in a mouse model of sepsis induced by cecal ligation puncture. CNS neuroscience & therapeutics. 2022-11-15. PMID:36377471. |
here, we investigated the role of hippocampus (hpc)-prefrontal cortex (pfc) in cognitive dysfunction in sepsis induced by cecal ligation puncture (clp) in mice. |
2022-11-15 |
2023-08-14 |
mouse |
| Yuki Murakami, Ryota Hosomi, Ayano Nishimoto, Toshimasa Nishiyama, Munehiro Yoshida, Kenji Fukunag. Protective Effects of Fish (Alaska Pollock) Protein Intake against Short-Term Memory Decline in Senescence-Accelerated Mice. Nutrients. vol 14. issue 21. 2022-11-14. PMID:36364879. |
these results suggest that fp intake prevents age-related cognitive dysfunction by maintaining axonal morphology in the hipp of samp10 mice. |
2022-11-14 |
2023-08-16 |
mouse |
| Andrea Flores, Paula Moyano, Emma Sola, José Manuel García, Jimena García, María José Anadon, María Teresa Frejo, Maria Victoria Naval, Maria de la Cabeza Fernadez, Javier Del Pin. Single and repeated bisphenol A treatment induces ROS, Aβ and hyperphosphorylated-tau accumulation, and insulin pathways disruption, through HDAC2 and PTP1B overexpression, leading to SN56 cholinergic apoptotic cell death. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 170. 2022-11-14. PMID:36374790. |
cortex and hippocampus neuronal networks control cognitive functions, which are innervated by basal forebrain cholinergic neurons (bfcn), and their neurodegeneration induces cognitive dysfunctions. |
2022-11-14 |
2023-08-14 |
Not clear |
| João S Gonçalves, Raquel M Seiça, João Laranjinha, Cátia F Lourenç. Impairment of neurovascular coupling in the hippocampus due to decreased nitric oxide bioavailability supports early cognitive dysfunction in type 2 diabetic rats. Free radical biology & medicine. 2022-11-13. PMID:36372286. |
impairment of neurovascular coupling in the hippocampus due to decreased nitric oxide bioavailability supports early cognitive dysfunction in type 2 diabetic rats. |
2022-11-13 |
2023-08-14 |
rat |
| Qi Zhang, Yanan Li, Xupeng Wang, Chunping Yin, Qi Zhou, Junfei Guo, Juan Zhao, Xiaohui Xian, Zhiyong Hou, Qiujun Wan. Sevoflurane exposure causes neuronal apoptosis and cognitive dysfunction by inducing ER stress Frontiers in aging neuroscience. vol 14. 2022-11-07. PMID:36337694. |
sevoflurane exposure causes neuronal apoptosis and cognitive dysfunction by inducing er stress the role of the inositol 1, 4, 5-trisphosphate receptor (ip3r) in hippocampal neuronal apoptosis and cognitive dysfunction induced by sevoflurane is currently unclear. |
2022-11-07 |
2023-08-14 |
rat |
| Salonee V Patel, Courtney M DeCarlo, Shae A Book, Ashley L Schormans, Shawn N Whitehead, Brian L Allman, Sarah H Haye. Noise exposure in early adulthood causes age-dependent and brain region-specific impairments in cognitive function. Frontiers in neuroscience. vol 16. 2022-10-31. PMID:36312027. |
interestingly, we found no significant relationships between spatial learning ability and the level of hearing loss or altered microglial density in the hippocampus following noise exposure, suggesting that other changes in the brain likely contribute to hippocampal-dependent cognitive dysfunction following noise exposure. |
2022-10-31 |
2023-08-14 |
human |
| Wen-Rui Gao, Xiao-Hong Hu, Kai-Yue Yu, Hong-Yan Cai, Zhao-Jun Wang, Lei Wang, Mei-Na W. Selective Orexin 1 Receptor Antagonist SB-334867 Aggravated Cognitive Dysfunction in 3xTg-AD Mice. Behavioural brain research. 2022-10-24. PMID:36280008. |
considering that ox1r is highly expressed in the hippocampus and plays important roles in learning and memory, the effects of ox1r in ad cognitive dysfunction and its possible mechanism should be investigated. |
2022-10-24 |
2023-08-14 |
mouse |