| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huili Liu, Jun Wang, Yanrong Yuan, Jing Gu, Yongxing Ya. Hippocampal Metabolic Alterations and Cognitive Dysfunction in Varicella Zoster Virus Meningitis: A Single-Center Case Series Study. Medical science monitor : international medical journal of experimental and clinical research. vol 29. 2023-05-11. PMID:37165595. |
conclusions patients with vzv meningitis had cognitive dysfunction and altered cellular metabolism of bilateral hippocampal regions. |
2023-05-11 |
2023-08-14 |
Not clear |
| Jiang Fang, Qiang Yuan, Zhuoying Du, Quan Zhang, Lei Yang, Meihua Wang, Weijian Yang, Cong Yuan, Jian Yu, Gang Wu, Jin H. Overexpression of GPX4 attenuates cognitive dysfunction through inhibiting hippocampus ferroptosis and neuroinflammation after traumatic brain injury. Free radical biology & medicine. 2023-04-27. PMID:37105419. |
overexpression of gpx4 attenuates cognitive dysfunction through inhibiting hippocampus ferroptosis and neuroinflammation after traumatic brain injury. |
2023-04-27 |
2023-08-14 |
Not clear |
| Dylan J Dues, An Phu Tran Nguyen, Katelyn Becker, Jiyan Ma, Darren J Moor. Hippocampal subfield vulnerability to α-synuclein pathology precedes neurodegeneration and cognitive dysfunction. bioRxiv : the preprint server for biology. 2023-04-24. PMID:37090590. |
hippocampal subfield vulnerability to α-synuclein pathology precedes neurodegeneration and cognitive dysfunction. |
2023-04-24 |
2023-08-14 |
Not clear |
| Tingli Guo, Ye Yu, Wenhui Yan, Meng Zhang, Xinyao Yi, Na Liu, Xin Cui, Xiaotong Wei, Yuzhuo Sun, Zhuanzhuan Wang, Jia Shang, Wei Cui, Lina Che. Erythropoietin ameliorates cognitive dysfunction in mice with type 2 diabetes mellitus via inhibiting iron overload and ferroptosis. Experimental neurology. 2023-04-19. PMID:37075971. |
to evaluate the effects of epo on diabetes-associated cognitive dysfunction, we constructed a t2dm mouse model and found that epo not only decreased fasting blood glucose but also ameliorated hippocampal damage in the brain. |
2023-04-19 |
2023-08-14 |
mouse |
| Mingzhu Zhang, Zizheng Suo, Yinyin Qu, Yuxiang Zheng, Wenjie Xu, Bowen Zhang, Qiang Wang, Linxin Wu, Shuai Li, Yaozhong Cheng, Ting Xiao, Hui Zheng, Cheng N. Construction and analysis of circular RNA-associated competing endogenous RNA network in the hippocampus of aged mice for the occurrence of postoperative cognitive dysfunction. Frontiers in aging neuroscience. vol 15. 2023-04-13. PMID:37051377. |
construction and analysis of circular rna-associated competing endogenous rna network in the hippocampus of aged mice for the occurrence of postoperative cognitive dysfunction. |
2023-04-13 |
2023-08-14 |
mouse |
| Ji Chen, Peng Guo, Mingming Han, Kemin Chen, Jie Qin, Fengrui Yan. Cognitive protection of sinomenine in type 2 diabetes mellitus through regulating the EGF/Nrf2/HO-1 signaling, the microbiota-gut-brain axis, and hippocampal neuron ferroptosis. Phytotherapy research : PTR. 2023-04-10. PMID:37036428. |
furthermore, in vivo results confirmed that sinomenine blocked ferroptosis of hippocampal neurons and alleviated cognitive dysfunction in t2dm rats. |
2023-04-10 |
2023-08-14 |
rat |
| Junjie Liang, Shanshan Han, Chao Ye, Haimeng Zhu, Jiajun Wu, Yunjuan Nie, Gaoshang Chai, Peng Zhao, Dengxin Zhan. Minocycline Attenuates Sevoflurane-Induced Postoperative Cognitive Dysfunction in Aged Mice by Suppressing Hippocampal Apoptosis and the Notch Signaling Pathway-Mediated Neuroinflammation. Brain sciences. vol 13. issue 3. 2023-03-29. PMID:36979321. |
minocycline attenuates sevoflurane-induced postoperative cognitive dysfunction in aged mice by suppressing hippocampal apoptosis and the notch signaling pathway-mediated neuroinflammation. |
2023-03-29 |
2023-08-14 |
mouse |
| Allison E Tipton, Yasmin Cruz Del Angel, Kathryn Hixson, Jessica Carlsen, Dana Strode, Nicolas Busquet, Michael H Mesches, Marco I Gonzalez, Eleonora Napoli, Shelley J Russek, Amy R Brooks-Kaya. Selective neuronal knockout of STAT3 function inhibits epilepsy progression, improves cognition, and restores dysregulated gene networks in a temporal lobe epilepsy model. Annals of neurology. 2023-03-19. PMID:36935347. |
temporal lobe epilepsy (tle) is a progressive disorder mediated by pathological changes in molecular cascades and hippocampal neural circuit remodeling that results in spontaneous seizures and cognitive dysfunction. |
2023-03-19 |
2023-08-14 |
Not clear |
| Sohir M Zohny, Mohamed Z Habib, Magda I Mohamad, Wael M Elayat, Reham M Elhossiny, Mohamed F Abd El-Salam, Ghada A M Hassan, Sawsan Aboul-Fotou. Memantine/Aripiprazole Combination Alleviates Cognitive Dysfunction in Valproic Acid Rat Model of Autism: Hippocampal CREB/BDNF Signaling and Glutamate Homeostasis. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2023-03-15. PMID:36918475. |
memantine/aripiprazole combination alleviates cognitive dysfunction in valproic acid rat model of autism: hippocampal creb/bdnf signaling and glutamate homeostasis. |
2023-03-15 |
2023-08-14 |
human |
| Masanori A Murayam. The past and present of therapeutic strategy for Alzheimer's diseases-potential for stem cell therapy. Experimental animals. 2023-03-06. PMID:36878603. |
adult neurogenesis, which governs cognitive and emotional behaviors, occurs in the hippocampus, and some research groups have reported that neural cell transplantation into the hippocampus improves cognitive dysfunction in ad model mice. |
2023-03-06 |
2023-08-14 |
mouse |
| Yunfang Su, Ningning Liu, Ruiqin Sun, Jinlian Ma, Zhonghua Li, Pan Wang, Huifen Ma, Yiran Sun, Junying Song, Zhenqiang Zhan. Radix Rehmanniae Praeparata (Shu Dihuang) exerts neuroprotective effects on ICV-STZ-induced Alzheimer's disease mice through modulation of INSR/IRS-1/AKT/GSK-3β signaling pathway and intestinal microbiota. Frontiers in pharmacology. vol 14. 2023-02-27. PMID:36843923. |
the results showed that rrp ameliorated cognitive dysfunction and neuronal pathological changes of brain tissue in icv-stz mice, reduced tau protein hyperphosphorylation, insr, irs-1, pser473-akt/akt, and pser9-gsk-3β/gsk-3β levels in hippocampal and cortical tissues. |
2023-02-27 |
2023-08-14 |
mouse |
| Hiromitsu Tanaka, Hiroaki Matsushita, Keizo Tokuhiro, Atsushi Fukunari, Yukio And. Ingestion of Soybean Sprouts Containing a HASPIN Inhibitor Improves Condition in a Mouse Model of Alzheimer's Disease. Biology. vol 12. issue 2. 2023-02-25. PMID:36829593. |
the results showed that haspin was expressed in the hippocampus and phosphorylated tau protein, while the ingestion of soybean sprouts containing coumestrol suppressed the development of spatial cognitive dysfunction in 5xfad. |
2023-02-25 |
2023-08-14 |
mouse |
| Liang Li, Fanqing Meng, Dongliang L. Downregulation of Nrf2 in the Hippocampus Contributes to Postoperative Cognitive Dysfunction in Aged Rats by Sensitizing Oxidative Stress and Neuroinflammation. Oxidative medicine and cellular longevity. vol 2023. 2023-02-23. PMID:36819786. |
downregulation of nrf2 in the hippocampus contributes to postoperative cognitive dysfunction in aged rats by sensitizing oxidative stress and neuroinflammation. |
2023-02-23 |
2023-08-14 |
rat |
| Liang Li, Fanqing Meng, Dongliang L. Downregulation of Nrf2 in the Hippocampus Contributes to Postoperative Cognitive Dysfunction in Aged Rats by Sensitizing Oxidative Stress and Neuroinflammation. Oxidative medicine and cellular longevity. vol 2023. 2023-02-23. PMID:36819786. |
moreover, upregulation of hippocampal nrf2 in aged rats with intracerebroventricular infusion of a nrf2 activator reduced levels of ros and proinflammatory cytokines in the hippocampus, ameliorating cognitive dysfunction after surgery. |
2023-02-23 |
2023-08-14 |
rat |
| Sitthisak Thongrong, Serm Surapinit, Tichanon Promsrisuk, Jinatta Jittiwat, Ratchaniporn Kongsu. Pinostrobin alleviates chronic restraint stress‑induced cognitive impairment by modulating oxidative stress and the function of astrocytes in the hippocampus of rats. Biomedical reports. vol 18. issue 3. 2023-02-17. PMID:36798091. |
chronic stress has been recognized to induce the alterations of neuronal and glial cells in the hippocampus, and is thus implicated in cognitive dysfunction. |
2023-02-17 |
2023-08-14 |
rat |
| Xuena Zhang, Mingying Li, Yun Yue, Ying Zhang, Anshi W. Luteoloside prevents sevoflurane-induced cognitive dysfunction in aged rats via maintaining mitochondrial function and dynamics in hippocampal neurons. Neuroscience. 2023-02-10. PMID:36764603. |
luteoloside prevents sevoflurane-induced cognitive dysfunction in aged rats via maintaining mitochondrial function and dynamics in hippocampal neurons. |
2023-02-10 |
2023-08-14 |
rat |
| Xiao-Hui Li, Hong-Can Zhu, Xue-Min Cui, Wang Wang, Lin Yang, Li-Bo Wang, Neng-Wei Hu, Dong-Xiao Dua. Death-associated protein kinase 1 is associated with cognitive dysfunction in major depressive disorder. Neural regeneration research. vol 18. issue 8. 2023-02-08. PMID:36751808. |
we previously showed that death-associated protein kinase 1 (dapk1) expression is increased in hippocampal tissue in a mouse model of major depressive disorde and is related to cognitive dysfunction in alzheimer's disease. |
2023-02-08 |
2023-08-14 |
mouse |
| Xiao-Hui Li, Hong-Can Zhu, Xue-Min Cui, Wang Wang, Lin Yang, Li-Bo Wang, Neng-Wei Hu, Dong-Xiao Dua. Death-associated protein kinase 1 is associated with cognitive dysfunction in major depressive disorder. Neural regeneration research. vol 18. issue 8. 2023-02-08. PMID:36751808. |
exercise and treatment with the antidepressant drug citalopram decreased dapk1 expression and tau protein phosphorylation in hippocampal tissue and improved both depressive symptoms and cognitive dysfunction. |
2023-02-08 |
2023-08-14 |
mouse |
| Niels Hansen, Katrin Radenbach, Kristin Rentzsch, Janosch Fox, Jens Wiltfang, Claudia Bartel. Cerebrospinal Fluid Homer-3 Autoantibodies in a Patient with Amnestic Mild Cognitive Impairment. Brain sciences. vol 13. issue 1. 2023-01-21. PMID:36672107. |
we also propose that cognitive dysfunction might result from impaired ampar signaling in the hippocampus induced by homer-3 antibodies, which will have to be verified in further research. |
2023-01-21 |
2023-08-14 |
Not clear |
| Cui-Zhu Yang, Shu-Han Wang, Run-Heng Zhang, Jia-Hong Lin, Ying-Hong Tian, Ya-Qi Yang, Jing Liu, Yu-Xin M. Neuroprotective effect of astragalin via activating PI3K/Akt-mTOR-mediated autophagy on APP/PS1 mice. Cell death discovery. vol 9. issue 1. 2023-01-21. PMID:36681681. |
in this study, we found that ast ameliorated cognitive dysfunction, reduced hippocampal neuronal damage and loss, and aβ pathology in app/ps1 mice. |
2023-01-21 |
2023-08-14 |
mouse |