| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Romy Weiland, Michael Macht, Heiner Ellgring, Silke Gross-Lesch, Klaus-Peter Lesch, Paul Paul. Olfactory and gustatory sensitivity in adults with attention-deficit/hyperactivity disorder. Attention deficit and hyperactivity disorders. vol 3. issue 1. 2011-07-26. PMID:21432618. |
increased odor sensitivity was found in medication-naïve children with adhd, but not in adult adhd, which might be due to a dopaminergic dysregulation presumed to underlie this disorder. |
2011-07-26 |
2023-08-12 |
Not clear |
| Raul R Gainetdino. Strengths and limitations of genetic models of ADHD. Attention deficit and hyperactivity disorders. vol 2. issue 1. 2011-07-18. PMID:21432587. |
mice lacking the dopamine transporter have elevated dopaminergic tone and represent a genetic animal model in which certain endophenotypes of adhd can be recapitulated. |
2011-07-18 |
2023-08-12 |
mouse |
| Soo-Churl Cho, Hyo-Won Kim, Boong-Nyun Kim, Jae-Won Kim, Min-Sup Shin, Seockhoon Chung, Dae-Yeon Cho, Sun-Woo Jung, Hee Jeong Yoo, In-Won Chung, Un-Sun Chung, Jung-Woo So. Gender-specific association of the brain-derived neurotrophic factor gene with attention-deficit/hyperactivity disorder. Psychiatry investigation. vol 7. issue 4. 2011-07-14. PMID:21253413. |
brain-derived neurotrophic factor (bdnf), which participates in the differentiation and survival of dopaminergic and noradrenergic neurons, could play a role in adhd development. |
2011-07-14 |
2023-08-12 |
Not clear |
| Jean-Martin Beaulieu, Raul R Gainetdino. The physiology, signaling, and pharmacology of dopamine receptors. Pharmacological reviews. vol 63. issue 1. 2011-06-01. PMID:21303898. |
pharmacological agents targeting dopaminergic neurotransmission have been clinically used in the management of several neurological and psychiatric disorders, including parkinson's disease, schizophrenia, bipolar disorder, huntington's disease, attention deficit hyperactivity disorder (adhd(1)), and tourette's syndrome. |
2011-06-01 |
2023-08-12 |
human |
| R Stark, E Bauer, C J Merz, M Zimmermann, M Reuter, M M Plichta, P Kirsch, K P Lesch, A J Fallgatter, D Vaitl, M J Herrman. ADHD related behaviors are associated with brain activation in the reward system. Neuropsychologia. vol 49. issue 3. 2011-05-27. PMID:21163276. |
in conclusion, our results from a non-clinical sample are in accordance with reported deficits in the reward system in adhd patients: the higher the number and severity of adhd related behaviors, the lower the neural responses in the dopaminergic driven reward anticipation task. |
2011-05-27 |
2023-08-12 |
human |
| Rajasree Nair, Shannon B Mos. Management of attention-deficit hyperactivity disorder in adults: focus on methylphenidate hydrochloride. Neuropsychiatric disease and treatment. vol 5. 2011-04-26. PMID:19721722. |
methylphenidate hydrochloride, a stimulant that acts through the dopaminergic and adrenergic pathways, has shown more than 75% efficacy in controlling the symptoms of adult adhd. |
2011-04-26 |
2023-08-12 |
Not clear |
| Kenneth Blum, Amanda Lih-Chuan Chen, Eric R Braverman, David E Comings, Thomas J H Chen, Vanessa Arcuri, Seth H Blum, Bernard W Downs, Roger L Waite, Alison Notaro, Joel Lubar, Lonna Williams, Thomas J Prihoda, Tomas Palomo, Marlene Oscar-Berma. Attention-deficit-hyperactivity disorder and reward deficiency syndrome. Neuropsychiatric disease and treatment. vol 4. issue 5. 2011-04-21. PMID:19183781. |
it has been proposed that genetic variants of dopaminergic genes and other "reward genes" are important common determinants of reward deficiency syndrome (rds), which we hypothesize includes adhd as a behavioral subtype. |
2011-04-21 |
2023-08-12 |
Not clear |
| Carmen López-Arvizu, Elizabeth P Sparrow, Michael J Strube, Chris Slavin, Caroline DeOleo, Justin James, Julie Hoover-Fong, Iain McIntosh, Elaine Tierne. Increased symptoms of attention deficit hyperactivity disorder and major depressive disorder symptoms in Nail-patella syndrome: potential association with LMX1B loss-of-function. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 156B. issue 1. 2011-04-04. PMID:21184584. |
analyses of lmx1b mutant mice have revealed the role of lmx1b in the development of mesencephalic dopaminergic neurons and the serotonergic system; these areas have been linked with symptoms of attention deficit hyperactivity disorder (adhd) and major depressive disorder (mdd). |
2011-04-04 |
2023-08-12 |
mouse |
| Y Simchon, A Weizman, M Rehav. The effect of chronic methylphenidate administration on presynaptic dopaminergic parameters in a rat model for ADHD. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 20. issue 10. 2010-12-22. PMID:20493667. |
the effect of chronic methylphenidate administration on presynaptic dopaminergic parameters in a rat model for adhd. |
2010-12-22 |
2023-08-12 |
rat |
| C Sánchez-Mora, M Ribasés, J A Ramos-Quiroga, M Casas, R Bosch, A Boreatti-Hümmer, M Heine, C P Jacob, K-P Lesch, O B Fasmer, P M Knappskog, J J Sandra Kooij, C Kan, J K Buitelaar, E Mick, P Asherson, S V Faraone, B Franke, S Johansson, J Haavik, A Reif, M Bayés, B Corman. Meta-analysis of brain-derived neurotrophic factor p.Val66Met in adult ADHD in four European populations. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 2. 2010-12-20. PMID:19603419. |
before the advent of the first genome-wide association studies in adhd, genetic research had mainly focused on candidate genes related to the dopaminergic and serotoninergic systems, although several other genes had also been assessed. |
2010-12-20 |
2023-08-12 |
Not clear |
| Kerstin Krauel, Hendrik C Feldhaus, Andrea Simon, Claudia Rehe, Martin Glaser, Hans-Henning Flechtner, Hans-Jochen Heinze, Ludwig Niehau. Increased echogenicity of the substantia nigra in children and adolescents with attention-deficit/hyperactivity disorder. Biological psychiatry. vol 68. issue 4. 2010-11-22. PMID:20227683. |
recent neurobiological models on attention-deficit/hyperactivity disorder (adhd) as well as findings from imaging studies suggest a crucial involvement of dopaminergic midbrain nuclei, especially the substantia nigra (sn), in the pathogenesis of adhd symptoms. |
2010-11-22 |
2023-08-12 |
Not clear |
| Fukie Niijima, Hiroko Saito, Shigeo Murai, Yuichiro Arai, Osamu Nakagawasai, Koichi Tan-No, Hiromi Watanabe, Hajime Hiraga, Takeshi Tadan. Effects of atomoxetine on levels of monoamines and related substances in discrete brain regions in mice intermittently deprived of rapid eye movement sleep. Biological & pharmaceutical bulletin. vol 33. issue 4. 2010-11-12. PMID:20410595. |
an imbalance between noradrenergic and dopaminergic systems is implicated in hyperactivity disorders, such as attention deficit/hyperactivity disorder (adhd). |
2010-11-12 |
2023-08-12 |
mouse |
| Soo-Churl Cho, Hyo-Won Kim, Boong-Nyun Kim, Jae-Won Kim, Min-Sup Shin, Dae-Yeon Cho, Seockhoon Chung, Sun-Woo Jung, Hee Jeong Yoo, In-Won Chung, Un-Sun Chung, Jung-Woo So. Neurotrophin-3 gene, intelligence, and selective attention deficit in a Korean sample with attention-deficit/hyperactivity disorder. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 6. 2010-11-02. PMID:20576502. |
neurotrophin-3 (ntf3), which participates in the differentiation and survival of dopaminergic and noradrenergic neurons, has been identified as a factor in the development of adhd. |
2010-11-02 |
2023-08-12 |
Not clear |
| Y Bloch, E V Harel, S Aviram, J Govezensky, G Ratzoni, Y Levkovit. Positive effects of repetitive transcranial magnetic stimulation on attention in ADHD Subjects: a randomized controlled pilot study. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 11. issue 5. 2010-10-22. PMID:20521875. |
attention deficit hyperactivity disorder (adhd) had been suggested to involve dopaminergic prefrontal abnormalities. |
2010-10-22 |
2023-08-12 |
human |
| Viktor Mózes, Melinda Bence, Mária Sasvári-Székely, Gergely Keszle. [Dopamine D4 receptor hypoxia sensitivity and child psychiatric disorders]. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 12. issue 1. 2010-08-20. PMID:20305304. |
here we review experimental results from epidemiological, tissue and animal studies that assigned a causal role to fetal hypoxia in the development of adhd and pointed out that the dopaminergic neurotransmission is sensitive to hypoxia. |
2010-08-20 |
2023-08-12 |
Not clear |
| Viktor Mózes, Melinda Bence, Mária Sasvári-Székely, Gergely Keszle. [Dopamine D4 receptor hypoxia sensitivity and child psychiatric disorders]. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 12. issue 1. 2010-08-20. PMID:20305304. |
these observations suggest that the effect of hypoxia on the dopaminergic neurotransmission might be an important factor in the pathomechanism of adhd. |
2010-08-20 |
2023-08-12 |
Not clear |
| Diane Purper-Ouakil, Aude-Marie Lepagnol-Bestel, Edith Grosbellet, Philip Gorwood, Michel Simonnea. [Neurobiology of attention deficit/hyperactivity disorder]. Medecine sciences : M/S. vol 26. issue 5. 2010-08-11. PMID:20510147. |
despite their clinical heterogeneity and frequent comorbidities, key symptoms of adhd, such as impulsivity, hyperactivity and inattention are regularly improved by dopaminergic agonists, leading to consider dopaminergic dysfunction a possibly contributing factor in adhd. |
2010-08-11 |
2023-08-12 |
Not clear |
| Antonio C Farias, Alexandre Cunha, Cássia R Benko, James T McCracken, Maria T Costa, Lucilene G Farias, Mara L Cordeir. Manganese in children with attention-deficit/hyperactivity disorder: relationship with methylphenidate exposure. Journal of child and adolescent psychopharmacology. vol 20. issue 2. 2010-07-15. PMID:20415606. |
a role for altered functioning of the dopaminergic system in the etiology of adhd has been well established through neurochemical, neurophysiological, imaging, and genetics studies. |
2010-07-15 |
2023-08-12 |
Not clear |
| Maarten Loos, Tommy Pattij, Mieke C W Janssen, Danielle S Counotte, Anton N M Schoffelmeer, August B Smit, Sabine Spijker, Marcel M van Gaale. Dopamine receptor D1/D5 gene expression in the medial prefrontal cortex predicts impulsive choice in rats. Cerebral cortex (New York, N.Y. : 1991). vol 20. issue 5. 2010-06-28. PMID:19690230. |
genetic association studies have implicated several genes involved in dopaminergic neurotransmission in adhd. |
2010-06-28 |
2023-08-12 |
rat |
| Tobias Banaschewski, Katja Becker, Susann Scherag, Barbara Franke, David Coghil. Molecular genetics of attention-deficit/hyperactivity disorder: an overview. European child & adolescent psychiatry. vol 19. issue 3. 2010-06-14. PMID:20145962. |
in recent years a large number of studies on different candidate genes for adhd have been published, most have focused on genes involved in the dopaminergic neurotransmission system, such as drd4, drd5, dat1/slc6a3, dbh, ddc. |
2010-06-14 |
2023-08-12 |
Not clear |