| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' S Gonz\\xc3\\xa1lez, C Rangel-Barajas, M Peper, R Lorenzo, E Moreno, F Ciruela, J Borycz, J Ortiz, C Llu\\xc3\\xads, R Franco, P J McCormick, N D Volkow, M Rubinstein, B Floran, S Ferr\\xc3\\xa. Dopamine D4 receptor, but not the ADHD-associated D4.7 variant, forms functional heteromers with the dopamine D2S receptor in the brain. Molecular psychiatry. vol 17. issue 6. 2012-11-07. PMID:21844870.' |
it is therefore postulated that dysfunctional d(2s)-d(4.7) heteromers may impair presynaptic dopaminergic control of corticostriatal glutamatergic neurotransmission and explain functional deficits associated with adhd. |
2012-11-07 |
2023-08-12 |
mouse |
| Jing Wu, Haifan Xiao, Hongjuan Sun, Li Zou, Ling-Qiang Zh. Role of dopamine receptors in ADHD: a systematic meta-analysis. Molecular neurobiology. vol 45. issue 3. 2012-10-17. PMID:22610946. |
dysfunction of dopaminergic system is implicated in many neuropsychological diseases, including attention deficit hyperactivity disorder (adhd), a common mental disorder that prevalent in childhood. |
2012-10-17 |
2023-08-12 |
Not clear |
| Terje Sagvolden, Tong X. l-Amphetamine improves poor sustained attention while d-amphetamine reduces overactivity and impulsiveness as well as improves sustained attention in an animal model of Attention-Deficit/Hyperactivity Disorder (ADHD). Behavioral and brain functions : BBF. vol 4. 2012-10-02. PMID:18215285. |
there is no biological marker, but there is considerable evidence to suggest that adhd behavior is associated with poor dopaminergic and noradrenergic modulation of neuronal circuits that involve the frontal lobes. |
2012-10-02 |
2023-08-12 |
rat |
| Florence Lev. Pharmacological and therapeutic directions in ADHD: Specificity in the PFC. Behavioral and brain functions : BBF. vol 4. 2012-10-02. PMID:18304369. |
recent directions in the treatment of adhd have involved both a broadening of pharmacological perspectives to include nor-adrenergic as well as dopaminergic agents. |
2012-10-02 |
2023-08-12 |
human |
| Florence Lev. Pharmacological and therapeutic directions in ADHD: Specificity in the PFC. Behavioral and brain functions : BBF. vol 4. 2012-10-02. PMID:18304369. |
a review of animal and human studies of pharmacological and therapeutic directions in adhd suggests that the d1 receptor is a specific site for dopaminergic regulation of the pfc, but optimal levels of dopamine (da) are required for beneficial effects on working memory. |
2012-10-02 |
2023-08-12 |
human |
| R Weizman, D E Dar, S Landa, A Apter, M Gavis. "Peripheral" benzodiazepine receptor density is not altered by methylphenidate treatment in children with attention-deficit hyperactivity disorder. Journal of child and adolescent psychopharmacology. vol 3. issue 2. 2012-10-02. PMID:19630638. |
because attention-deficit hyperactivity disorder (adhd) is related to dysregulation of dopaminergic neurotransmission, and because benzodiazepines can potentially aggravate the symptoms of adhd, we have assessed the possible involvement of pbrs in the pathophysiology and pharmacotherapy of adhd. |
2012-10-02 |
2023-08-12 |
Not clear |
| Marta Ribasés, Josep Antoni Ramos-Quiroga, Amaia Hervás, Cristina Sánchez-Mora, Rosa Bosch, Anna Bielsa, Xavier Gastaminza, Klaus-Peter Lesch, Andreas Reif, Tobias J Renner, Marcel Romanos, Andreas Warnke, Susanne Walitza, Christine Freitag, Jobst Meyer, Haukur Palmason, Miquel Casas, Mònica Bayés, Bru Corman. Candidate system analysis in ADHD: evaluation of nine genes involved in dopaminergic neurotransmission identifies association with DRD1. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 13. issue 4. 2012-09-17. PMID:22404661. |
candidate system analysis in adhd: evaluation of nine genes involved in dopaminergic neurotransmission identifies association with drd1. |
2012-09-17 |
2023-08-12 |
Not clear |
| Marta Ribasés, Josep Antoni Ramos-Quiroga, Amaia Hervás, Cristina Sánchez-Mora, Rosa Bosch, Anna Bielsa, Xavier Gastaminza, Klaus-Peter Lesch, Andreas Reif, Tobias J Renner, Marcel Romanos, Andreas Warnke, Susanne Walitza, Christine Freitag, Jobst Meyer, Haukur Palmason, Miquel Casas, Mònica Bayés, Bru Corman. Candidate system analysis in ADHD: evaluation of nine genes involved in dopaminergic neurotransmission identifies association with DRD1. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. vol 13. issue 4. 2012-09-17. PMID:22404661. |
based on this information we evaluated the contribution to adhd of nine genes involved in dopaminergic neurotransmission (drd1, drd2, drd3, drd4, drd5, dat1, th, dbh and comt). |
2012-09-17 |
2023-08-12 |
Not clear |
| Zeynep Yilmaz, Allan S Kaplan, Robert D Levitan, Clement C Zai, James L Kenned. Possible association of the DRD4 gene with a history of attention-deficit/hyperactivity disorder in women with bulimia nervosa. The International journal of eating disorders. vol 45. issue 4. 2012-08-10. PMID:22271608. |
up to one-third of patients with bulimia nervosa (bn) report a history of attention-deficit/hyperactivity disorder (adhd) symptoms, and the dopaminergic genes, especially the dopamine receptor d4 (drd4), have been associated independently with both binge eating and adhd. |
2012-08-10 |
2023-08-12 |
Not clear |
| Jeffery R Wickens, Brian I Hyland, Gail Trip. Animal models to guide clinical drug development in ADHD: lost in translation? British journal of pharmacology. vol 164. issue 4. 2012-03-25. PMID:21480864. |
the involvement of dopaminergic and noradrenergic systems in the pathophysiology of adhd is probable. |
2012-03-25 |
2023-08-12 |
human |
| Cristina Sánchez-Mora, Marta Ribasés, Miquel Casas, Mònica Bayés, Rosa Bosch, Noelia Fernàndez-Castillo, Lucas Brunso, Kaya K Jacobsen, Elisabeth T Landaas, Astri J Lundervold, Silke Gross-Lesch, Susanne Kreiker, Christian P Jacob, Klaus-Peter Lesch, Jan K Buitelaar, Martine Hoogman, Lambertus A L M Kiemeney, J J Sandra Kooij, Eric Mick, Phil Asherson, Stephen V Faraone, Barbara Franke, Andreas Reif, Stefan Johansson, Jan Haavik, Josep Antoni Ramos-Quiroga, Bru Corman. Exploring DRD4 and its interaction with SLC6A3 as possible risk factors for adult ADHD: a meta-analysis in four European populations. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 156B. issue 5. 2011-12-05. PMID:21595008. |
pharmacological, animal and molecular genetic studies support a role for genes of the dopaminergic system in adhd due to its essential role in motor control, cognition, emotion, and reward. |
2011-12-05 |
2023-08-12 |
Not clear |
| Zsofia Nemoda, Anna Szekely, Maria Sasvari-Szekel. Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood. Neuroscience and biobehavioral reviews. vol 35. issue 8. 2011-12-01. PMID:21527290. |
the aim of this review is to survey the most important findings concerning dopaminergic gene polymorphisms in attention deficit hyperactivity disorder (adhd), tourette syndrome (ts), obsessive compulsive disorder, and substance abuse. |
2011-12-01 |
2023-08-12 |
Not clear |
| Susanne Steinlechner, Norbert Brüggemann, Vera Sobottka, Alexander Benthien, Birte Behn, Christine Klein, Gabriele Schmid, Rebekka Lence. Restless legs syndrome as a possible predictor for psychiatric disorders in parents of children with ADHD. European archives of psychiatry and clinical neuroscience. vol 261. issue 4. 2011-10-14. PMID:20820796. |
synaptic dysfunction affecting dopaminergic transmission among other transmitter systems may be a common final pathway related to the phenotypic spectrum of adhd. |
2011-10-14 |
2023-08-12 |
Not clear |
| Zeynep Yilmaz, Allan S Kaplan, Clement C Zai, Robert D Levitan, James L Kenned. COMT Val158Met variant and functional haplotypes associated with childhood ADHD history in women with bulimia nervosa. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 4. 2011-09-13. PMID:21300128. |
up to one third of patients with bulimia nervosa (bn) report a history of adhd symptoms, and both disorders may also be associated with dopaminergic abnormalities. |
2011-09-13 |
2023-08-12 |
Not clear |
| Sandra J England, Daniel L Picchietti, Barbara Vera Couvadelli, Barbara C Fisher, Fouzia Siddiqui, Mary L Wagner, Wayne A Hening, Daniel Lewin, Glenna Winnie, Barry Cohen, Arthur S Walter. L-Dopa improves Restless Legs Syndrome and periodic limb movements in sleep but not Attention-Deficit-Hyperactivity Disorder in a double-blind trial in children. Sleep medicine. vol 12. issue 5. 2011-09-01. PMID:21463967. |
in a previous open-label study, dopaminergic agents improved restless legs syndrome (rls) and periodic limb movements in sleep (plms), as well as attention-deficit-hyperactivity disorder (adhd) in children with both disorders. |
2011-09-01 |
2023-08-12 |
Not clear |
| b' Bogus\\xc5\\x82awa Budziszewska, Agnieszka Basta-Kaim, Marta Kubera, W\\xc5\\x82adys\\xc5\\x82aw Laso\\xc5\\x8. [Immunological and endocrinological pattern in ADHD etiopathogenesis]. Przeglad lekarski. vol 67. issue 11. 2011-08-30. PMID:21442976.' |
recently, it has been postulated that the reduced activity of the dopaminergic and noradrenergic systems play a crucial role in adhd pathogenesis. |
2011-08-30 |
2023-08-12 |
Not clear |
| b' Bogus\\xc5\\x82awa Budziszewska, Agnieszka Basta-Kaim, Marta Kubera, W\\xc5\\x82adys\\xc5\\x82aw Laso\\xc5\\x8. [Immunological and endocrinological pattern in ADHD etiopathogenesis]. Przeglad lekarski. vol 67. issue 11. 2011-08-30. PMID:21442976.' |
it is evidenced by the fact that drugs intensifying the noradrenergic and dopaminergic transmission are the most successful for adhd treatment. |
2011-08-30 |
2023-08-12 |
Not clear |
| b' Bogus\\xc5\\x82awa Budziszewska, Agnieszka Basta-Kaim, Marta Kubera, W\\xc5\\x82adys\\xc5\\x82aw Laso\\xc5\\x8. [Immunological and endocrinological pattern in ADHD etiopathogenesis]. Przeglad lekarski. vol 67. issue 11. 2011-08-30. PMID:21442976.' |
glucocorticoids are known to intensify the dopaminergic system activity, so the decrease in their expression in adhd can cause the hypofunction of this system. |
2011-08-30 |
2023-08-12 |
Not clear |
| Thomas Dresler, Ann-Christine Ehlis, Sebastian Heinzel, Tobias J Renner, Andreas Reif, Christina G Baehne, Monika Heine, Andrea Boreatti-Hümmer, Christian P Jacob, Klaus-Peter Lesch, Andreas J Fallgatte. Dopamine transporter (SLC6A3) genotype impacts neurophysiological correlates of cognitive response control in an adult sample of patients with ADHD. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 11. 2011-08-08. PMID:20631685. |
studies provide ample evidence for a dysfunction in dopaminergic neurotransmission in attention-deficit/hyperactivity disorder (adhd). |
2011-08-08 |
2023-08-12 |
Not clear |
| Terje Sagvolde. Impulsiveness, overactivity, and poorer sustained attention improve by chronic treatment with low doses of l-amphetamine in an animal model of Attention-Deficit/Hyperactivity Disorder (ADHD). Behavioral and brain functions : BBF. vol 7. 2011-08-02. PMID:21450079. |
there is no biological marker, but there is considerable evidence to suggest that adhd behavior is associated with poor dopaminergic and noradrenergic modulation of neuronal circuits that involve the frontal lobes. |
2011-08-02 |
2023-08-12 |
rat |