| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Medin, J E Rinholm, S G Owe, T Sagvolden, A Gjedde, J Storm-Mathisen, L H Bergerse. Low dopamine D5 receptor density in hippocampus in an animal model of attention-deficit/hyperactivity disorder (ADHD). Neuroscience. vol 242. 2014-05-16. PMID:23541742. |
a state of low dopaminergic activity has been implicated in attention-deficit/hyperactivity disorder (adhd). |
2014-05-16 |
2023-08-12 |
rat |
| T Medin, J E Rinholm, S G Owe, T Sagvolden, A Gjedde, J Storm-Mathisen, L H Bergerse. Low dopamine D5 receptor density in hippocampus in an animal model of attention-deficit/hyperactivity disorder (ADHD). Neuroscience. vol 242. 2014-05-16. PMID:23541742. |
the clinical symptoms of adhd include inattention, impulsivity and hyperactivity, as well as impaired learning; dopaminergic modulation of the functions in the hippocampus is important to both learning and memory. |
2014-05-16 |
2023-08-12 |
rat |
| Pablo Pandolfo, Nuno J Machado, Attila Köfalvi, Reinaldo N Takahashi, Rodrigo A Cunh. Caffeine regulates frontocorticostriatal dopamine transporter density and improves attention and cognitive deficits in an animal model of attention deficit hyperactivity disorder. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 4. 2014-01-06. PMID:22561003. |
attention deficit hyperactivity disorder (adhd) likely involves dopaminergic dysfunction in the frontal cortex and striatum, resulting in cognitive and motor abnormalities. |
2014-01-06 |
2023-08-12 |
rat |
| Pablo Pandolfo, Nuno J Machado, Attila Köfalvi, Reinaldo N Takahashi, Rodrigo A Cunh. Caffeine regulates frontocorticostriatal dopamine transporter density and improves attention and cognitive deficits in an animal model of attention deficit hyperactivity disorder. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 4. 2014-01-06. PMID:22561003. |
these findings underscore the potential for caffeine treatment to normalize frontocortical dopaminergic function and to abrogate attention and cognitive changes characteristic of adhd. |
2014-01-06 |
2023-08-12 |
rat |
| Natalia del Campo, Tim D Fryer, Young T Hong, Rob Smith, Laurent Brichard, Julio Acosta-Cabronero, Samuel R Chamberlain, Roger Tait, David Izquierdo, Ralf Regenthal, Jonathan Dowson, John Suckling, Jean-Claude Baron, Franklin I Aigbirhio, Trevor W Robbins, Barbara J Sahakian, Ulrich Mülle. A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment. Brain : a journal of neurology. vol 136. issue Pt 11. 2013-12-31. PMID:24163364. |
a positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for adhd and its treatment. |
2013-12-31 |
2023-08-12 |
human |
| Ziarih Hawi, Natasha Matthews, Edwina Barry, Aiveen Kirley, Joseph Wagner, Robyn H Wallace, Helen S Heussler, Alasdair Vance, Michael Gill, Mark A Bellgrov. A high density linkage disequilibrium mapping in 14 noradrenergic genes: evidence of association between SLC6A2, ADRA1B and ADHD. Psychopharmacology. vol 225. issue 4. 2013-10-17. PMID:23052569. |
until recently, the genes of the noradrenergic pathway were not intensively investigated in adhd compared to dopaminergic and serotonergic candidates. |
2013-10-17 |
2023-08-12 |
Not clear |
| Ayşe Nur İnci Kenar, Tuba Edgünlü, Hasan Herken, Mehmet Emin Erda. Association of synapsin III gene with adult attention deficit hyperactivity disorder. DNA and cell biology. vol 32. issue 8. 2013-09-30. PMID:23768104. |
it is supposed that synaptic protein genes together with dopaminergic genes might have roles in the etiology of adhd. |
2013-09-30 |
2023-08-12 |
Not clear |
| Glaucia Chiyoko Akutagava-Martins, Angelica Salatino-Oliveira, Christian Costa Kieling, Luis Augusto Rohde, Mara Helena Hut. Genetics of attention-deficit/hyperactivity disorder: current findings and future directions. Expert review of neurotherapeutics. vol 13. issue 4. 2013-09-20. PMID:23545057. |
the first genetic studies targeted dopaminergic genes, but the effects were small and only explained a small portion of adhd heritability. |
2013-09-20 |
2023-08-12 |
Not clear |
| Alkomiet Hasan, Marc Schneider, Thomas Schneider-Axmann, Diane Ruge, Wolfgang Retz, Michael Rösler, Peter Falkai, Thomas Wobroc. A similar but distinctive pattern of impaired cortical excitability in first-episode schizophrenia and ADHD. Neuropsychobiology. vol 67. issue 2. 2013-09-06. PMID:23295893. |
first-episode schizophrenia (fe-sz) and attention deficit hyperactivity disorder (adhd) are both neuropsychiatric disorders associated with an impaired dopaminergic transmission. |
2013-09-06 |
2023-08-12 |
human |
| Laura S Visen. [Attention deficit hyperactivity disorder (ADHD): an overview]. Vertex (Buenos Aires, Argentina). vol 23. issue 105. 2013-09-05. PMID:23269966. |
pharmacological treatment approaches for adhd as well as for some of the psychiatry comorbidities involve the dopaminergic, noradrenergic and serotoninergic systems. |
2013-09-05 |
2023-08-12 |
Not clear |
| Osman Sabuncuogl. Understanding the relationships between breastfeeding, malocclusion, ADHD, sleep-disordered breathing and traumatic dental injuries. Medical hypotheses. vol 80. issue 3. 2013-08-01. PMID:23306004. |
low ferritin levels caused by insufficient breastfeeding may contribute to adhd susceptibility because of the role of iron in dopaminergic activity. |
2013-08-01 |
2023-08-12 |
Not clear |
| Marjelo A Mines, Eleonore Beurel, Richard S Jop. Examination of methylphenidate-mediated behavior regulation by glycogen synthase kinase-3 in mice. European journal of pharmacology. vol 698. issue 1-3. 2013-06-10. PMID:23099259. |
abnormalities in dopaminergic activity have been implicated in psychiatric diseases, such as attention deficit hyperactivity disorder (adhd), and are treated with therapeutic stimulants, commonly methylphenidate or amphetamine. |
2013-06-10 |
2023-08-12 |
mouse |
| Seyed Khosrow Tayebati, Daniele Tomassoni, Francesco Ament. Spontaneously hypertensive rat as a model of vascular brain disorder: microanatomy, neurochemistry and behavior. Journal of the neurological sciences. vol 322. issue 1-2. 2013-04-11. PMID:22726353. |
shr are also characterized by a dopaminergic hypofunction and noradrenergic hyperactivity similarly as occurs in attention-deficit with hyperactivity disorder (adhd). |
2013-04-11 |
2023-08-12 |
human |
| Emrah Cayla. Biochemical and genetic analyses of childhood attention deficit/hyperactivity disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 159B. issue 6. 2013-04-09. PMID:22825876. |
to date, these studies have reported substantial evidence implicating several genes (dopaminergic: drd4, dat1, drd5, comt; noradrenergic: dbh, adra2a; serotonergic: 5-htt, htr1b, htr2a; cholinergic: chrna4, and central nervous system development pathway: snap25, bdnf) in the etiology of adhd. |
2013-04-09 |
2023-08-12 |
Not clear |
| Adel E El-Tarras, Adnan A Alsulaimani, Nabil S Awad, Nahla Mitwaly, Manal M Said, Ayman M Sabr. Association study between the dopamine-related candidate gene polymorphisms and ADHD among Saudi Arabia population via PCR technique. Molecular biology reports. vol 39. issue 12. 2013-04-04. PMID:23076524. |
there are several evidences for involvement of dopaminergic, serotonergic and noradrenergic neurotransmitter systems in the pathogenesis of adhd. |
2013-04-04 |
2023-08-12 |
human |
| Marten P Smidt, Lars von Oerthel, Elisa J Hoekstra, Raymond D Schellevis, Marco F M Hoekma. Spatial and temporal lineage analysis of a Pitx3-driven Cre-recombinase knock-in mouse model. PloS one. vol 7. issue 8. 2013-02-19. PMID:22870339. |
development and function of mesodiencephalic dopaminergic (mdda) neurons has received a lot of scientific interest since these neurons are critically involved in neurological diseases as parkinson and psychiatric diseases as schizophrenia, depression and attention deficit hyperactivity disorder (adhd). |
2013-02-19 |
2023-08-12 |
mouse |
| Samuele Cortes. The neurobiology and genetics of Attention-Deficit/Hyperactivity Disorder (ADHD): what every clinician should know. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. vol 16. issue 5. 2013-02-04. PMID:22306277. |
at a molecular level, alterations in any single neurotransmitter system are unlikely to explain the complexity of adhd; rather, the disorder has been linked to dysfunctions in several systems, including the dopaminergic, adrenergic, serotoninergic and cholinergic pathways. |
2013-02-04 |
2023-08-12 |
Not clear |
| Darko Turic, James Swanson, Edmund Sonuga-Bark. DRD4 and DAT1 in ADHD: Functional neurobiology to pharmacogenetics. Pharmacogenomics and personalized medicine. vol 3. 2012-12-12. PMID:23226043. |
the initial molecular genetic studies where candidates were selected because of the efficacy of dopaminergic compounds in the treatment of adhd were remarkably successful and provided strong evidence for the role of drd4 and dat1 variants in the pathogenesis of adhd. |
2012-12-12 |
2023-08-12 |
Not clear |
| Yannis Paloyelis, Mitul A Mehta, Stephen V Faraone, Philip Asherson, Jonna Kunts. Striatal sensitivity during reward processing in attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry. vol 51. issue 7. 2012-12-04. PMID:22721595. |
attention-deficit/hyperactivity disorder (adhd) has been linked to deficits in the dopaminergic reward-processing circuitry; yet, existing evidence is limited, and the influence of genetic variation affecting dopamine signaling remains unknown. |
2012-12-04 |
2023-08-12 |
Not clear |
| Oliver Kratz, Petra Studer, Jeska Baack, Susanne Malcherek, Karlheinz Erbe, Gunther H Moll, Hartmut Heinric. Differential effects of methylphenidate and atomoxetine on attentional processes in children with ADHD: an event-related potential study using the Attention Network Test. Progress in neuro-psychopharmacology & biological psychiatry. vol 37. issue 1. 2012-11-08. PMID:22227291. |
the differential pattern of mph vs. atx effects on attentional functions in children with adhd may be explained by the dopaminergic effects of mph within the cortico-striato-thalamo-cortical circuit. |
2012-11-08 |
2023-08-12 |
Not clear |