| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Roy A Wis. Dopamine and reward: the anhedonia hypothesis 30 years on. Neurotoxicity research. vol 14. issue 2-3. 2009-03-31. PMID:19073424. |
dopamine and reward: the anhedonia hypothesis 30 years on. |
2009-03-31 |
2023-08-12 |
Not clear |
| Roy A Wis. Dopamine and reward: the anhedonia hypothesis 30 years on. Neurotoxicity research. vol 14. issue 2-3. 2009-03-31. PMID:19073424. |
the anhedonia hypothesis--that brain dopamine plays a critical role in the subjective pleasure associated with positive rewards--was intended to draw the attention of psychiatrists to the growing evidence that dopamine plays a critical role in the objective reinforcement and incentive motivation associated with food and water, brain stimulation reward, and psychomotor stimulant and opiate reward. |
2009-03-31 |
2023-08-12 |
Not clear |
| Philip Gorwoo. Neurobiological mechanisms of anhedonia. Dialogues in clinical neuroscience. vol 10. issue 3. 2008-12-23. PMID:18979942. |
the analyses of anhedonic non-clinical subjects, nonanhedonic depressed patients, and depressed patients with various levels ofanhedonia seem to favor the hypothesis that the severity of anhedonia is associated with a deficit of activity of the ventral striatum (including the nucleus accumbens) and an excess of activity of ventral region of the prefrontal cortex (including the ventromedial prefrontal cortex and the orbitofrontal cortex), with a pivotal, but not exclusive, role of dopamine. |
2008-12-23 |
2023-08-12 |
human |
| Alexandra Soliman, Gillian A O'Driscoll, Jens Pruessner, Anne-Lise V Holahan, Isabelle Boileau, Danny Gagnon, Alain Daghe. Stress-induced dopamine release in humans at risk of psychosis: a [11C]raclopride PET study. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 8. 2008-09-02. PMID:17957215. |
using positron emission tomography and [(11)c]raclopride, we measured changes in synaptic dopamine concentrations in 10 controls and 16 psychometric schizotypes; 9 with perceptual aberrations (perab, ie positive schizotypy) and 7 with physical anhedonia (physan, ie negative schizotypy). |
2008-09-02 |
2023-08-12 |
Not clear |
| Florian Schlagenhauf, Georg Juckel, Michael Koslowski, Thorsten Kahnt, Brian Knutson, Theresa Dembler, Thorsten Kienast, Jürgen Gallinat, Jana Wrase, Andreas Hein. Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapine. Psychopharmacology. vol 196. issue 4. 2008-08-14. PMID:18097655. |
high blockade of dopamine d2 receptors in the ventral striatum including the nucleus accumbens may interfere with reward anticipation and cause secondary negative symptoms such as apathy or anhedonia. |
2008-08-14 |
2023-08-12 |
Not clear |
| A Bergström, M N Jayatissa, A Mørk, O Wibor. Stress sensitivity and resilience in the chronic mild stress rat model of depression; an in situ hybridization study. Brain research. vol 1196. 2008-05-30. PMID:18234161. |
cms induced anhedonia was not related to mrna expression differences of the dopamine receptors d(1) and d(2), enkephalin, dynorphin, the nmda receptor subtype nr2b in the ventral striatum, bdnf expression in the dentate gyrus, nor corticotrophin releasing hormone (crh) and arginine vasopressin (avp) in the paraventricular nucleus of the hypothalamus. |
2008-05-30 |
2023-08-12 |
rat |
| Fleur Zijlstra, Jan Booij, Wim van den Brink, Ingmar H A Franke. Striatal dopamine D2 receptor binding and dopamine release during cue-elicited craving in recently abstinent opiate-dependent males. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 18. issue 4. 2008-04-23. PMID:18077142. |
chronic craving and anhedonia have been associated with low availability of dopamine d2 receptors (d2rs) and cue-elicited craving has been linked with endogenous dopamine release. |
2008-04-23 |
2023-08-12 |
human |
| Neil E Paterson, David J Balfour, Athina Marko. Chronic bupropion attenuated the anhedonic component of nicotine withdrawal in rats via inhibition of dopamine reuptake in the nucleus accumbens shell. The European journal of neuroscience. vol 25. issue 10. 2007-08-17. PMID:17561823. |
in conclusion, the bupropion-induced increase in extracellular dopamine in the nucleus accumbens shell may ameliorate the anhedonia associated with nicotine withdrawal, which in turn may facilitate smoking cessation. |
2007-08-17 |
2023-08-12 |
human |
| M Flavia Barbano, Martine Cado. Opioids for hedonic experience and dopamine to get ready for it. Psychopharmacology. vol 191. issue 3. 2007-06-12. PMID:17031710. |
more than two decades ago, wise proposed his "anhedonia hypothesis" to explain the role of dopamine in motivated behaviors. |
2007-06-12 |
2023-08-12 |
Not clear |
| Matthias R Lemke, H Michael Brecht, Juergen Koester, Heinz Reichman. Effects of the dopamine agonist pramipexole on depression, anhedonia and motor functioning in Parkinson's disease. Journal of the neurological sciences. vol 248. issue 1-2. 2007-01-23. PMID:16814808. |
effects of the dopamine agonist pramipexole on depression, anhedonia and motor functioning in parkinson's disease. |
2007-01-23 |
2023-08-12 |
Not clear |
| Marco Sarchiapone, Vladimir Carli, Giovanni Camardese, Chiara Cuomo, Daniela Di Giuda, Maria-Lucia Calcagni, C Focacci, Sergio De Risi. Dopamine transporter binding in depressed patients with anhedonia. Psychiatry research. vol 147. issue 2-3. 2006-12-07. PMID:16952448. |
dopamine transporter binding in depressed patients with anhedonia. |
2006-12-07 |
2023-08-12 |
human |
| Marco Sarchiapone, Vladimir Carli, Giovanni Camardese, Chiara Cuomo, Daniela Di Giuda, Maria-Lucia Calcagni, C Focacci, Sergio De Risi. Dopamine transporter binding in depressed patients with anhedonia. Psychiatry research. vol 147. issue 2-3. 2006-12-07. PMID:16952448. |
these findings suggest an alteration in dat density in depressed patients with anhedonia that may be a primary susceptibility factor or a secondary phenomenon to reduced dopamine concentration in the synaptic cleft. |
2006-12-07 |
2023-08-12 |
human |
| Johanneke E van der Harst, Anne-Marie Baars, Berry M Spruij. Announced rewards counteract the impairment of anticipatory behaviour in socially stressed rats. Behavioural brain research. vol 161. issue 2. 2005-08-02. PMID:15922044. |
several lines of evidence exist for the role of dopamine in the mechanism of action of antidepressant treatments concerning their therapeutic effect on anhedonia. |
2005-08-02 |
2023-08-12 |
rat |
| Eliyahu Dremencov, Michael E Newman, Noa Kinor, Gitit Blatman-Jan, Cheryl J Schindler, David H Overstreet, Gal Yadi. Hyperfunctionality of serotonin-2C receptor-mediated inhibition of accumbal dopamine release in an animal model of depression is reversed by antidepressant treatment. Neuropharmacology. vol 48. issue 1. 2005-04-28. PMID:15617725. |
dopamine release in the nucleus accumbens mediates motivation and reward, making it a likely candidate to be involved in anhedonia, one of the major symptoms of depression. |
2005-04-28 |
2023-08-12 |
rat |
| David J K Balfou. Neuroplasticity within the mesoaccumbens dopamine system and its role in tobacco dependence. Current drug targets. CNS and neurological disorders. vol 1. issue 4. 2003-06-10. PMID:12769613. |
nicotine withdrawal, following a period of chronic exposure, diminishes the activity of the dopamine projections to the accumbal shell, a response that is thought to be the neural correlate of the anhedonia experienced by many abstinent smokers. |
2003-06-10 |
2023-08-12 |
Not clear |
| Andrew Chih Wei Huang, Sigmund Hsia. Haloperidol attenuates rewarding and aversively conditioned suppression of saccharin solution intake: reevaluation of the anhedonia hypothesis of dopamine blocking. Behavioral neuroscience. vol 116. issue 4. 2003-01-07. PMID:12148931. |
haloperidol attenuates rewarding and aversively conditioned suppression of saccharin solution intake: reevaluation of the anhedonia hypothesis of dopamine blocking. |
2003-01-07 |
2023-08-12 |
Not clear |
| Violetta Klimek, Jane E Schenck, Hui Han, Craig A Stockmeier, Gregory A Ordwa. Dopaminergic abnormalities in amygdaloid nuclei in major depression: a postmortem study. Biological psychiatry. vol 52. issue 7. 2002-12-20. PMID:12372665. |
a deficiency of mesolimbic dopamine (da) is a leading candidate for the etiology of certain symptoms of depression (e.g., anhedonia and loss of motivation). |
2002-12-20 |
2023-08-12 |
human |
| Everett H Ellinwood, Colin Davidson, Guo-Zhong Yu, George R King, Tong H Le. Effect of daily dosing duration of direct and indirect dopamine receptor agonists: cocaine cross-tolerance following chronic regimens. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 12. issue 5. 2002-11-22. PMID:12208558. |
however, 24-h dosing of dopamine (da) agonists may induce side effects of insomnia and psychosis, as well as anergia and anhedonia which may actually potentiate abuse. |
2002-11-22 |
2023-08-12 |
Not clear |
| Andreas Stevens, Jürgen Schwarz, Benedikt Schwarz, Ilona Ruf, Thomas Kolter, Joerg Czekall. Implicit and explicit learning in schizophrenics treated with olanzapine and with classic neuroleptics. Psychopharmacology. vol 160. issue 3. 2002-07-08. PMID:11889499. |
novel and classic neuroleptics differ in their effects on limbic striatal/nucleus accumbens (na) and prefrontal cortex (pfc) dopamine turnover, suggesting differential effects on implicit and explicit learning as well as on anhedonia. |
2002-07-08 |
2023-08-12 |
Not clear |
| E F Schmidt, M A Sutton, C A Schad, D A Karanian, E S Brodkin, D W Sel. Extinction training regulates tyrosine hydroxylase during withdrawal from cocaine self-administration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 7. 2001-06-28. PMID:11264329. |
the ability of extinction training to restore nac th levels is hypothesized to accelerate recovery from dopamine depletion and anhedonia during cocaine withdrawal. |
2001-06-28 |
2023-08-12 |
rat |