| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giovanni Camardese, Luisa De Risio, Marco Di Nicola, Lorella Pucci, Fabrizio Cocciolillo, Pietro Bria, Alessandro Giordano, Luigi Janiri, Daniela Di Giud. Changes of dopamine transporter availability in depressed patients with and without anhedonia: a 123I-N-ω-fluoropropyl-carbomethoxy-3β- (4-Iodophenyl)tropane SPECT study. Neuropsychobiology. vol 70. issue 4. 2016-02-29. PMID:25613182. |
dopamine is an important neurotransmitter involved in the pathophysiology of depression and anhedonia. |
2016-02-29 |
2023-08-13 |
Not clear |
| Eline R Zaaijer, Lonneke van Dijk, Kora de Bruin, Anna E Goudriaan, Laureen A Lammers, Maarten W J Koeter, Wim van den Brink, Jan Booi. Effect of extended-release naltrexone on striatal dopamine transporter availability, depression and anhedonia in heroin-dependent patients. Psychopharmacology. vol 232. issue 14. 2016-01-19. PMID:25757673. |
effect of extended-release naltrexone on striatal dopamine transporter availability, depression and anhedonia in heroin-dependent patients. |
2016-01-19 |
2023-08-13 |
Not clear |
| Eline R Zaaijer, Lonneke van Dijk, Kora de Bruin, Anna E Goudriaan, Laureen A Lammers, Maarten W J Koeter, Wim van den Brink, Jan Booi. Effect of extended-release naltrexone on striatal dopamine transporter availability, depression and anhedonia in heroin-dependent patients. Psychopharmacology. vol 232. issue 14. 2016-01-19. PMID:25757673. |
however, naltrexone treatment of opioid-dependent patients may reduce striatal dopamine transporter (dat) availability and cause depression and anhedonia. |
2016-01-19 |
2023-08-13 |
Not clear |
| Jennifer C Felger, Carla R Hernandez, Andrew H Mille. Levodopa reverses cytokine-induced reductions in striatal dopamine release. The international journal of neuropsychopharmacology. vol 18. issue 4. 2015-11-20. PMID:25638816. |
studies using neuroimaging and in vivo microdialysis in humans and nonhuman primates indicate that inflammatory cytokines such as interferon-alpha reduce dopamine release in the ventral striatum in association with depressive symptoms including anhedonia and psychomotor slowing. |
2015-11-20 |
2023-08-13 |
Not clear |
| Daniel G Dillon, Isabelle M Rosso, Pia Pechtel, William D S Killgore, Scott L Rauch, Diego A Pizzagall. Peril and pleasure: an rdoc-inspired examination of threat responses and reward processing in anxiety and depression. Depression and anxiety. vol 31. issue 3. 2015-10-23. PMID:24151118. |
the mechanisms underlying such effects are unclear, but the fourth section reviews new optogenetic data in rodents indicating that gabaergic inhibition of midbrain dopamine neurons, driven by activation of the habenula, may play a fundamental role in stress-induced anhedonia. |
2015-10-23 |
2023-08-12 |
Not clear |
| Aloke K Dutta, Soumava Santra, Horrick Sharma, Chandrashekhar Voshavar, Liping Xu, Omar Mabrouk, Tamara Antonio, Maarten E A Reit. Pharmacological and behavioral characterization of D-473, an orally active triple reuptake inhibitor targeting dopamine, serotonin and norepinephrine transporters. PloS one. vol 9. issue 11. 2015-07-20. PMID:25427177. |
dopamine has been shown to play a significant role in depression including production of anhedonia which has been one of the untreated symptoms in mdd. |
2015-07-20 |
2023-08-13 |
human |
| Mariusz Papp, Piotr Gruca, Magdalena Lasoń-Tyburkiewicz, Nika Adham, Béla Kiss, István Gyertyá. Attenuation of anhedonia by cariprazine in the chronic mild stress model of depression. Behavioural pharmacology. vol 25. issue 5-6. 2015-03-31. PMID:25083572. |
the aim of this study was to evaluate whether chronic treatment with cariprazine, a dopamine d2 and d3 receptor partial agonist with preferential binding to d3 receptors, shows antidepressant-like effects in the chronic mild stress (cms)-induced anhedonia model. |
2015-03-31 |
2023-08-13 |
rat |
| Diego A Pizzagall. Depression, stress, and anhedonia: toward a synthesis and integrated model. Annual review of clinical psychology. vol 10. 2014-11-18. PMID:24471371. |
to this end, we review and integrate three bodies of independent literature investigating the role of (a) anhedonia, (b) dopamine, and (c) stress in depression. |
2014-11-18 |
2023-08-12 |
Not clear |
| Lun Zheng, Xigeng Zhen. Integration of animal behaviors under stresses with different time courses. Neural regeneration research. vol 9. issue 15. 2014-10-15. PMID:25317159. |
intraperitoneal injection or nucleus accumbens microinjection of the dopamine 2/3 receptor subtype agonist ropinirole reduced floating behaviors in depression-prone animals, but increased sucrose preference in rats showing anhedonia. |
2014-10-15 |
2023-08-13 |
rat |
| Lun Zheng, Xigeng Zhen. Integration of animal behaviors under stresses with different time courses. Neural regeneration research. vol 9. issue 15. 2014-10-15. PMID:25317159. |
our results suggest that dopamine 2/3 receptor subtypes in the nucleus accumbens play an important role in floating behaviors and anhedonia. |
2014-10-15 |
2023-08-13 |
rat |
| Peng Zhong, Xiaojie Liu, Zhen Zhang, Ying Hu, Sarah J Liu, Martha Lezama-Ruiz, Milan Joksimovic, Qing-song Li. Cyclin-dependent kinase 5 in the ventral tegmental area regulates depression-related behaviors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 18. 2014-06-23. PMID:24790206. |
dopamine neurons in the ventral tegmental area (vta) govern reward and motivation and dysregulated dopaminergic transmission may account for anhedonia and other symptoms of depression. |
2014-06-23 |
2023-08-13 |
mouse |
| b' Francesca Zoratto, Marco Fiore, Syed F Ali, Giovanni Laviola, Simone Macr\\xc3\\xa. Neonatal tryptophan depletion and corticosterone supplementation modify emotional responses in adult male mice. Psychoneuroendocrinology. vol 38. issue 1. 2013-05-20. PMID:22613034.' |
maternal care was scored throughout treatment and adult offspring were tested for: anhedonia (progressive ratio schedule); anxiety-related behaviour (approach-avoidance conflict paradigm); bdnf, dopamine and serotonin concentrations in selected brain areas. |
2013-05-20 |
2023-08-12 |
mouse |
| Jennifer C Felger, Andrew H Mille. Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise. Frontiers in neuroendocrinology. vol 33. issue 3. 2013-04-05. PMID:23000204. |
however, chronic inflammation and exposure to inflammatory cytokines appears to lead to persisting alterations in the basal ganglia and dopamine function reflected by anhedonia, fatigue, and psychomotor slowing. |
2013-04-05 |
2023-08-12 |
Not clear |
| C Nocjar, J Zhang, P Feng, J Panksep. The social defeat animal model of depression shows diminished levels of orexin in mesocortical regions of the dopamine system, and of dynorphin and orexin in the hypothalamus. Neuroscience. vol 218. 2012-11-16. PMID:22626650. |
two brain neuropeptides that have been implicated in anhedonia symptomology in preclinical depression models are dynorphin and orexin; which are concentrated along lateral hypothalamic dopamine reward pathways. |
2012-11-16 |
2023-08-12 |
rat |
| Francesca Assogna, Luca Cravello, Carlo Caltagirone, Gianfranco Spallett. Anhedonia in Parkinson's disease: a systematic review of the literature. Movement disorders : official journal of the Movement Disorder Society. vol 26. issue 10. 2012-04-23. PMID:21661052. |
in this systematic review, we aimed to evaluate the role of anhedonia in parkinson's disease and its relationships with other clinical characteristics, dopamine dysfunction, and antiparkinsonian therapy. |
2012-04-23 |
2023-08-12 |
Not clear |
| J Liu, S M Perez, W Zhang, D J Lodge, X-Y L. Selective deletion of the leptin receptor in dopamine neurons produces anxiogenic-like behavior and increases dopaminergic activity in amygdala. Molecular psychiatry. vol 16. issue 10. 2012-02-03. PMID:21483433. |
depression-related behaviors, as assessed by chronic stress-induced anhedonia, forced swim and tail-suspension tests, were not affected by deletion of lepr in dopamine neurons. |
2012-02-03 |
2023-08-12 |
mouse |
| Victoria B Gradin, Poornima Kumar, Gordon Waiter, Trevor Ahearn, Catriona Stickle, Marteen Milders, Ian Reid, Jeremy Hall, J Douglas Steel. Expected value and prediction error abnormalities in depression and schizophrenia. Brain : a journal of neurology. vol 134. issue Pt 6. 2011-07-29. PMID:21482548. |
the dopamine system has been linked to anhedonia in depression and both the positive and negative symptoms of schizophrenia, but it remains unclear how dopamine dysfunction could mechanistically relate to observed symptoms. |
2011-07-29 |
2023-08-12 |
Not clear |
| Henry H Holcomb, Laura M Rowlan. How schizophrenia and depression disrupt reward circuitry. Current treatment options in neurology. vol 9. issue 5. 2011-07-14. PMID:17716599. |
also, dopamine loss itself does not appear to predict depression or anhedonia, the diminished capacity to experience pleasure. |
2011-07-14 |
2023-08-12 |
Not clear |
| Agnieszka Krzyzosiak, Monika Szyszka-Niagolov, Marta Wietrzych, Serge Gobaille, Shin-ichi Muramatsu, Wojciech Kreze. Retinoid x receptor gamma control of affective behaviors involves dopaminergic signaling in mice. Neuron. vol 66. issue 6. 2010-08-06. PMID:20620876. |
we show here that ablation of rxrgamma in mice leads to depressive-like behaviors including increased despair and anhedonia, which were accompanied by reduced expression of dopamine d2 receptor in the shell of nucleus accumbens (nac) and altered serotonin signaling. |
2010-08-06 |
2023-08-12 |
mouse |
| M R Lemk. [Antidepressant effects of dopamine agonists. Experimental and clinical findings]. Der Nervenarzt. vol 78. issue 1. 2009-05-29. PMID:17187269. |
controlled and open studies in depressed patients with parkinson's disease show therapeutic effects of dopamine agonists on motor deficits, anhedonia, and depression. |
2009-05-29 |
2023-08-12 |
Not clear |