| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bekhbat Mandakh, Li Zhihao, Boadie W Dunlop, Michael T Treadway, Neeti D Mehta, Kate P Revill, Michael J Lucido, Hong Changdo, Ashchi Andrea, Evanthia C Wommack, David R Goldsmith, Haroon Ebrahim, Andrew H Miller, Jennifer C Felge. Sustained effects of repeated levodopa (L-DOPA) administration on reward circuitry, effort-based motivation, and anhedonia in depressed patients with higher inflammation. Brain, behavior, and immunity. 2024-12-18. PMID:39694342. |
evidence linking these relationships to the effects of inflammation on dopamine is consistent with our recent findings that acute levodopa (l-dopa) increased vs-vmpfc fc in association with deceased anhedonia in depressed patients with higher but not lower crp (>2 versus ≤ 2 mg/l). |
2024-12-18 |
2024-12-21 |
Not clear |
| E J Hird, A Slanina-Davies, G Lewis, M Hamer, J P Roise. From movement to motivation: a proposed framework to understand the antidepressant effect of exercise. Translational psychiatry. vol 14. issue 1. 2024-07-03. PMID:38961071. |
drawing on a broad range of research in humans and animals, we propose that by reducing inflammation and boosting dopamine transmission, with consequent effects on effort-based decision making for reward, exercise initially specifically improves 'interest-activity' symptoms of depression-namely anhedonia, fatigue and subjective cognitive impairment - by increasing propensity to exert effort. |
2024-07-03 |
2024-07-08 |
Not clear |
| Filippo Queirazza, Jonathan Cavanagh, Marios G Philiastides, Rajeev Krishnada. Mild exogenous inflammation blunts neural signatures of bounded evidence accumulation and reward prediction error processing in healthy male participants. Brain, behavior, and immunity. 2024-03-31. PMID:38555987. |
so far, it has been reported that blunted mesolimbic dopamine reward signals are associated with inflammation-induced anhedonia and apathy. |
2024-03-31 |
2024-04-03 |
human |
| Ling Wang, Sutong Wang, Weiyi Mo, Yaqing Li, Qing Yang, Yutao Tian, Chenguang Zheng, Jiajia Yang, Dong Min. Ultrasound stimulation attenuates CRS-induced depressive behavior by modulating dopamine release in the prefrontal cortex. IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society. vol PP. 2024-03-19. PMID:38498742. |
using an in vivo photometry approach, we analyzed the dopamine signal of mpfc and revealed a significant increase following the fus, positively associated with the improvement of anhedonia behavior. |
2024-03-19 |
2024-03-21 |
human |
| Tina Gupta, Kristen L Eckstrand, Erika E Forbe. Annual Research Review: Puberty and the development of anhedonia - considering childhood adversity and inflammation. Journal of child psychology and psychiatry, and allied disciplines. 2024-02-23. PMID:38391011. |
as the mechanisms of anhedonia are postulated to include the frontostriatal circuitry and the dopamine neuromodulatory system, the development and plasticity of these systems during the vulnerable period of adolescence, as well as their sensitivity to pubertal hormones, suggest that pubertal maturation could play a role in the development of anhedonia. |
2024-02-23 |
2024-02-25 |
Not clear |
| Marie-Eve Di Raddo, Marija Milenkovic, Meenalochani Sivasubramanian, Ahmed Hasbi, Jack Bergman, Sarah Withey, Bertha K Madras, Susan R Georg. Δ9-Tetrahydrocannabinol does not upregulate an aversive dopamine receptor mechanism in adolescent brain unlike in adults. Current research in neurobiology. vol 5. 2023-12-01. PMID:38020805. |
as dopamine d1-d2 receptor heteromer activation causes anxiety and anhedonia, this signaling complex was postulated to contribute to thc-induced affective symptoms. |
2023-12-01 |
2023-12-07 |
monkey |
| Marie-Eve Di Raddo, Marija Milenkovic, Meenalochani Sivasubramanian, Ahmed Hasbi, Jack Bergman, Sarah Withey, Bertha K Madras, Susan R Georg. Δ9-Tetrahydrocannabinol does not upregulate an aversive dopamine receptor mechanism in adolescent brain unlike in adults. Current research in neurobiology. vol 5. 2023-12-01. PMID:38020805. |
as dopamine d1-d2 receptor heteromer activation causes anxiety and anhedonia, this signaling complex was postulated to contribute to thc-induced affective symptoms. |
2023-11-29 |
2023-12-07 |
monkey |
| Hao Guo, Jintao Guo, Zihang Gao, Fei Luo, Enming Zhan. The role of amygdala-ventral pallidum pathway in depression-like behaviors in male mice. Journal of neuroscience research. 2023-10-10. PMID:37814992. |
depressive symptoms, such as anhedonia are largely caused by dysfunction in the brain's reward system, in which the ventral pallidum (vp) participates in by controlling dopamine release. |
2023-10-10 |
2023-10-15 |
mouse |
| Rachel D Phillips, Erin C Walsh, Nicole R Zürcher, David S Lalush, Jessica L Kinard, Chieh-En Tseng, Paul M Cernasov, Delia Kan, Kaitlin Cummings, Lisalynn Kelley, David Campbell, Daniel G Dillon, Diego A Pizzagalli, David Izquierdo-Garcia, Jacob M Hooker, Moria J Smoski, Gabriel S Dichte. Striatal dopamine in anhedonia: A simultaneous [ Psychiatry research. Neuroimaging. vol 333. 2023-06-10. PMID:37301129. |
striatal dopamine in anhedonia: a simultaneous [ anhedonia is hypothesized to be associated with blunted mesocorticolimbic dopamine (da) functioning in samples with major depressive disorder. |
2023-06-10 |
2023-08-14 |
Not clear |
| Harry Costello, Yumeya Yamamori, Suzanne Reeves, Anette-Eleonore Schrag, Robert Howard, Jonathan P Roise. Longitudinal decline in striatal dopamine transporter binding in Parkinson's disease: associations with apathy and anhedonia. Journal of neurology, neurosurgery, and psychiatry. 2023-05-23. PMID:37221053. |
longitudinal decline in striatal dopamine transporter binding in parkinson's disease: associations with apathy and anhedonia. |
2023-05-23 |
2023-08-14 |
Not clear |
| L C Dormegny-Jeanjean, O A E Mainberger, C de Crespin de Billy, A Obrecht, V Danila, A Erb, H M Arcay, S Weibel, F Blanc, G Meyer, M Tomsa, G Bertschy, F Duval, J R Fouche. Safety and tolerance of combination of monoamine oxidase inhibitors and direct dopamine agonists in adults and older adults with highly resistant depression. L'Encephale. 2023-04-02. PMID:37005193. |
dopamine (da) is likely to be involved in some depressive dimensions, such as anhedonia and amotivation, which account for a part of treatment-resistant forms. |
2023-04-02 |
2023-08-14 |
Not clear |
| Xiao-Na Zhu, Jie Li, Gao-Lin Qiu, Lin Wang, Chen Lu, Yi-Ge Guo, Ke-Xin Yang, Fang Cai, Tao Xu, Ti-Fei Yuan, Ji H. Propofol exerts anti-anhedonia effects via inhibiting the dopamine transporter. Neuron. 2023-03-14. PMID:36917979. |
here, we report that propofol actively and directly binds to the dopamine transporter (dat), but not the serotonin transporter (sert), which contributes to the rapid relief of anhedonia. |
2023-03-14 |
2023-08-14 |
mouse |
| Max Berg, Marcel Riehle, Winfried Rief, Tania Lincol. Does partial blockade of dopamine D2 receptors with Amisulpride cause anhedonia? An experimental study in healthy volunteers. Journal of psychiatric research. vol 158. 2023-01-21. PMID:36680855. |
does partial blockade of dopamine d2 receptors with amisulpride cause anhedonia? |
2023-01-21 |
2023-08-14 |
human |
| Erin P Harris, Francisca Villalobos-Manriquez, Thieza G Melo, Gerard Clarke, Olivia F O'Lear. Stress during puberty exerts sex-specific effects on depressive-like behavior and monoamine neurotransmitters in adolescence and adulthood. Neurobiology of stress. vol 21. 2022-12-19. PMID:36532376. |
pubertal stress induced anhedonia in the saccharin preference test in adult males but not females, an effect paralleled by a male-specific decrease in striatal dopamine turnover. |
2022-12-19 |
2023-08-14 |
rat |
| Astrid M Cardona-Acosta, Carlos A Bolaños-Guzmá. Role of the mesolimbic dopamine pathway in the antidepressant effects of ketamine. Neuropharmacology. 2022-12-14. PMID:36516891. |
exposure to negative stress dysregulates dopamine neuronal activity disrupting reward and motivational processes resulting in anhedonia (lack of pleasure), a hallmark symptom of depression. |
2022-12-14 |
2023-08-14 |
Not clear |
| Zoltan Rihmer, Péter Döme, Cornelius Katon. Serotonin and depression - a riposte to Moncrieff et al. (2022). Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 24. issue 3. 2022-11-10. PMID:36356194. |
by contrast, depression cases with reduced positive affects (characterized by anhedonia, anergia, inhibition and reduced cognitive functions) are mainly caused by a disturbance in the metabolism of dopamine and/or noradrenaline. |
2022-11-10 |
2023-08-14 |
human |
| Laurel S Morris, Marishka Mehta, Christopher Ahn, Morgan Corniquel, Gaurav Verma, Bradley Delman, Patrick R Hof, Yael Jacob, Priti Balchandani, James W Murroug. Ventral tegmental area integrity measured with high-resolution 7-Tesla MRI relates to motivation across depression and anxiety diagnoses. NeuroImage. vol 264. 2022-11-09. PMID:36349598. |
the ventral tegmental area (vta) is one of the major sources of dopamine in the brain and has been associated with reward prediction, error-based reward learning, volitional drive and anhedonia. |
2022-11-09 |
2023-08-14 |
Not clear |
| Mandakh Bekhbat, Zhihao Li, Namrataa D Mehta, Michael T Treadway, Michael J Lucido, Bobbi J Woolwine, Ebrahim Haroon, Andrew H Miller, Jennifer C Felge. Correction to: Functional connectivity in reward circuitry and symptoms of anhedonia as therapeutic targets in depression with high inflammation: evidence from a dopamine challenge study. Molecular psychiatry. 2022-09-06. PMID:36065017. |
correction to: functional connectivity in reward circuitry and symptoms of anhedonia as therapeutic targets in depression with high inflammation: evidence from a dopamine challenge study. |
2022-09-06 |
2023-08-14 |
Not clear |
| Mandakh Bekhbat, Zhihao Li, Namrataa D Mehta, Michael T Treadway, Michael J Lucido, Bobbi J Woolwine, Ebrahim Haroon, Andrew H Miller, Jennifer C Felge. Functional connectivity in reward circuitry and symptoms of anhedonia as therapeutic targets in depression with high inflammation: evidence from a dopamine challenge study. Molecular psychiatry. 2022-08-04. PMID:35927580. |
functional connectivity in reward circuitry and symptoms of anhedonia as therapeutic targets in depression with high inflammation: evidence from a dopamine challenge study. |
2022-08-04 |
2023-08-14 |
Not clear |
| Mandakh Bekhbat, Zhihao Li, Namrataa D Mehta, Michael T Treadway, Michael J Lucido, Bobbi J Woolwine, Ebrahim Haroon, Andrew H Miller, Jennifer C Felge. Functional connectivity in reward circuitry and symptoms of anhedonia as therapeutic targets in depression with high inflammation: evidence from a dopamine challenge study. Molecular psychiatry. 2022-08-04. PMID:35927580. |
increased inflammation in major depressive disorder (mdd) has been associated with low functional connectivity (fc) in corticostriatal reward circuits and symptoms of anhedonia, relationships which may involve the impact of inflammation on synthesis and release of dopamine. |
2022-08-04 |
2023-08-14 |
Not clear |