| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Simona Scheggi, Graziano Pinna, Giulia Braccagni, Maria Graziella De Montis, Carla Gambaran. PPARα Signaling: A Candidate Target in Psychiatric Disorder Management. Biomolecules. vol 12. issue 5. 2022-05-28. PMID:35625650. |
modulation of dopamine neuronal firing in the ventral tegmental area likely contributes to pparα effects in depression, anhedonia, and autism spectrum disorder (asd). |
2022-05-28 |
2023-08-13 |
Not clear |
| Yan Li, Zhi Chen, Jianting Zhao, Heming Yu, Xiangyu Chen, Yong He, Yu Tian, Yue Wang, Chong Chen, Ke Cheng, Peng Xi. Neurotransmitter and Related Metabolic Profiling in the Nucleus Accumbens of Chronic Unpredictable Mild Stress-Induced Anhedonia-Like Rats. Frontiers in behavioral neuroscience. vol 16. 2022-05-16. PMID:35571281. |
anhedonia, as a core symptom, was closely associated with altered levels of 5-hydroxytryptamine (5-ht), dopamine (da), and diverse types of glutamate (glu) receptors in the nucleus accumbens (nac). |
2022-05-16 |
2023-08-13 |
rat |
| Steven J Lamontagne, Sarah I J Wash, Samantha H Irwin, Kate E Zucconi, Mary C Olmstea. Effects of dopamine modulation on chronic stress-induced deficits in reward learning. Cognitive, affective & behavioral neuroscience. 2022-04-09. PMID:35396630. |
anhedonia is characteristically preceded by chronic stress, likely involving downstream effects of glucocorticoid alterations on dopamine (da) function. |
2022-04-09 |
2023-08-13 |
rat |
| John Salamone, Alev Ecevitoglu, Carla Carratala-Ros, Rose Presby, Gayle Edelstein, Reileigh Fleeher, Renee Rotolo, Nicolette Meka, Sonya Srinath, Jamie C Masthay, Merce Corre. Complexities and Paradoxes in Understanding the Role of Dopamine in Incentive Motivation and Instrumental Action: Exertion of Effort vs. Anhedonia. Brain research bulletin. 2022-02-13. PMID:35151797. |
complexities and paradoxes in understanding the role of dopamine in incentive motivation and instrumental action: exertion of effort vs. anhedonia. |
2022-02-13 |
2023-08-13 |
Not clear |
| John Salamone, Alev Ecevitoglu, Carla Carratala-Ros, Rose Presby, Gayle Edelstein, Reileigh Fleeher, Renee Rotolo, Nicolette Meka, Sonya Srinath, Jamie C Masthay, Merce Corre. Complexities and Paradoxes in Understanding the Role of Dopamine in Incentive Motivation and Instrumental Action: Exertion of Effort vs. Anhedonia. Brain research bulletin. 2022-02-13. PMID:35151797. |
although impairments in mesolimbic dopamine are sometimes labeled as being due to "anhedonia", a detailed deconstruction of the findings in this area of research point to a much more complex and nuanced picture of the role that dopamine plays in regulating instrumental behavior. |
2022-02-13 |
2023-08-13 |
Not clear |
| Mandakh Bekhbat, Michael T Treadway, Jennifer C Felge. Inflammation as a Pathophysiologic Pathway to Anhedonia: Mechanisms and Therapeutic Implications. Current topics in behavioral neurosciences. 2021-12-31. PMID:34971449. |
here, we review recent evidence of relationships between inflammation and anhedonia, while highlighting translational and mechanistic work describing the impact of inflammation on synthesis, release, and reuptake of neurotransmitters like dopamine and glutamate that affects circuits to drive motivational deficits. |
2021-12-31 |
2023-08-13 |
Not clear |
| Anna-Chiara Schaub, Matthias Kirschner, Nina Schweinfurth, Laura Mählmann, Cedric Kettelhack, Etna E Engeli, Jessica P K Doll, Stefan Borgwardt, Undine E Lang, Stefan Kaiser, Marc Walter, Marcus Herdener, Johannes Wrege, André Schmid. Neural mapping of anhedonia across psychiatric diagnoses: A transdiagnostic neuroimaging analysis. NeuroImage. Clinical. vol 32. 2021-11-17. PMID:34544030. |
anhedonia has been associated with abnormal reward-related striatal dopamine functioning in patients with different psychiatric disorders. |
2021-11-17 |
2023-08-13 |
human |
| Everett Altherr, Aundrea Rainwater, Darian Kaviani, Qijun Tang, Ali D Güle. Long-term high fat diet consumption reversibly alters feeding behavior via a dopamine-associated mechanism in mice. Behavioural brain research. vol 414. 2021-11-04. PMID:34280463. |
our findings suggest that prolonged hfd consumption leads to anhedonia and altered feeding choices, and this is associated with changes in mesolimbic dopamine signaling. |
2021-11-04 |
2023-08-13 |
mouse |
| Hiroki Moriya, Mikael Tiger, Amane Tateno, Takeshi Sakayori, Takahiro Masuoka, WooChan Kim, Ryosuke Arakawa, Yoshiro Okub. Low dopamine transporter binding in the nucleus accumbens in geriatric patients with severe depression. Psychiatry and clinical neurosciences. vol 74. issue 8. 2021-06-09. PMID:32363761. |
especially, mdd in geriatric patients is characterized by anhedonia, which is assumed to be associated with reduced dopamine neurotransmission in the reward system. |
2021-06-09 |
2023-08-13 |
Not clear |
| Kenneth Blum, Joseph Morgan, Jean Lud Cadet, David Baron, Paul R Carney, Jag Khalsa, Rajendra D Badgaiyan, Mark S Gol. Psychoactive Drugs Like Cannabis -Induce Hypodopaminergic Anhedonia and Neuropsychological Dysfunction in Humans: Putative Induction of Dopamine Homeostasis via Coupling of Genetic Addiction Risk Severity (GARS) testing and Precision Pro-dopamine Regulation (KB220). Neurology (E-Cronicon). vol 13. issue 4. 2021-06-06. PMID:34085060. |
psychoactive drugs like cannabis -induce hypodopaminergic anhedonia and neuropsychological dysfunction in humans: putative induction of dopamine homeostasis via coupling of genetic addiction risk severity (gars) testing and precision pro-dopamine regulation (kb220). |
2021-06-06 |
2023-08-13 |
Not clear |
| Millie Rincón-Cortés, Anthony A Grac. Antidepressant effects of ketamine on depression-related phenotypes and dopamine dysfunction in rodent models of stress. Behavioural brain research. vol 379. 2021-05-03. PMID:31739001. |
in both humans and rodents, anhedonia is associated with dysfunction of the dopamine (da) system. |
2021-05-03 |
2023-08-13 |
Not clear |
| Mandakh Bekhbat, Michael T Treadway, David R Goldsmith, Bobbi J Woolwine, Ebrahim Haroon, Andrew H Miller, Jennifer C Felge. Gene signatures in peripheral blood immune cells related to insulin resistance and low tyrosine metabolism define a sub-type of depression with high CRP and anhedonia. Brain, behavior, and immunity. vol 88. 2021-04-27. PMID:32198016. |
together these data suggest that anhedonia in mdd with high crp involves both immunometabolic shifts and reduced dopamine precursor availability. |
2021-04-27 |
2023-08-13 |
Not clear |
| Kenneth Blum, Jag Khalsa, Jean Lud Cadet, David Baron, Abdalla Bowirrat, Brent Boyett, Lisa Lott, Raymond Brewer, Marjorie Gondré-Lewis, Gregory Bunt, Shan Kazmi, Mark S Gol. Cannabis-Induced Hypodopaminergic Anhedonia and Cognitive Decline in Humans: Embracing Putative Induction of Dopamine Homeostasis. Frontiers in psychiatry. vol 12. 2021-04-21. PMID:33868044. |
cannabis-induced hypodopaminergic anhedonia and cognitive decline in humans: embracing putative induction of dopamine homeostasis. |
2021-04-21 |
2023-08-13 |
Not clear |
| Kenneth Blum, Jag Khalsa, Jean Lud Cadet, David Baron, Abdalla Bowirrat, Brent Boyett, Lisa Lott, Raymond Brewer, Marjorie Gondré-Lewis, Gregory Bunt, Shan Kazmi, Mark S Gol. Cannabis-Induced Hypodopaminergic Anhedonia and Cognitive Decline in Humans: Embracing Putative Induction of Dopamine Homeostasis. Frontiers in psychiatry. vol 12. 2021-04-21. PMID:33868044. |
research shows that exposure to cannabis is associated with hypodopaminergic anhedonia (depression), cognitive decline, poor memory, inattention, impaired learning performance, reduced dopamine brain response-associated emotionality, and increased addiction severity in young adults. |
2021-04-21 |
2023-08-13 |
Not clear |
| Kenneth Blum, Jag Khalsa, Jean Lud Cadet, David Baron, Abdalla Bowirrat, Brent Boyett, Lisa Lott, Raymond Brewer, Marjorie Gondré-Lewis, Gregory Bunt, Shan Kazmi, Mark S Gol. Cannabis-Induced Hypodopaminergic Anhedonia and Cognitive Decline in Humans: Embracing Putative Induction of Dopamine Homeostasis. Frontiers in psychiatry. vol 12. 2021-04-21. PMID:33868044. |
preliminary research suggests that it is possible to induce 'dopamine homeostasis,' that is, restore dopamine function with dopamine upregulation with the proposed compound and normalize behavior in chronic cannabis users with cannabis-induced hypodopaminergic anhedonia (depression) and cognitive decline. |
2021-04-21 |
2023-08-13 |
Not clear |
| Stefano Cinque, Francesca Zoratto, Anna Poleggi, Damiana Leo, Luca Cerniglia, Silvia Cimino, Renata Tambelli, Enrico Alleva, Raul R Gainetdinov, Giovanni Laviola, Walter Adrian. Behavioral Phenotyping of Dopamine Transporter Knockout Rats: Compulsive Traits, Motor Stereotypies, and Anhedonia. Frontiers in psychiatry. vol 9. 2020-10-01. PMID:29520239. |
behavioral phenotyping of dopamine transporter knockout rats: compulsive traits, motor stereotypies, and anhedonia. |
2020-10-01 |
2023-08-13 |
mouse |
| Roberto Coccurell. Anhedonia in depression symptomatology: Appetite dysregulation and defective brain reward processing. Behavioural brain research. vol 372. 2020-09-10. PMID:31220485. |
the examination in particular of the role of dopamine, orexin and gabaergic neurotransmission is complemented by the exploration of the endocannabinoid signaling as homeostatic, anti-stress system and its relevance in depression pathophysiology and anhedonia symptoms. |
2020-09-10 |
2023-08-13 |
Not clear |
| Rubén García-Cabrerizo, M Julia García-Fuste. Methamphetamine binge administration dose-dependently enhanced negative affect and voluntary drug consumption in rats following prolonged withdrawal: role of hippocampal FADD. Addiction biology. vol 24. issue 2. 2020-05-08. PMID:29282816. |
in particular, rats treated repeatedly with methamphetamine (7.5 mg/kg) showed (1) enhanced negative affect-increased anhedonia associated with behavioral despair, (2) increased voluntary methamphetamine consumption, (3) enhanced neurotoxicity-decreased dopamine and metabolites in striatum and decreased serotonin in hippocampus, (4) altered neuroplasticity markers-decreased fadd protein and increased p-fadd/fadd balance selectively in hippocampus and (5) higher consumption rates of methamphetamine that were associated with lower fadd content in hippocampus. |
2020-05-08 |
2023-08-13 |
rat |
| Rao Fu, Wanhong Zuo, Nimisha Shiwalkar, Qinghua Mei, Qing Fan, Xuejun Chen, Jing Li, Alex Bekker, Jiang-Hong Y. Alcohol withdrawal drives depressive behaviors by activating neurons in the rostromedial tegmental nucleus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 8. 2020-03-31. PMID:30928995. |
finally, using a functional hemispheric disconnection procedure, we demonstrated that inhibition of unilateral rmtg, when combined with activation of d1 and d2 dopamine receptors in the contralateral (but not ipsilateral) acb, mitigated the anhedonia and depression-like behaviors in alcohol-withdrawal rats. |
2020-03-31 |
2023-08-13 |
rat |
| Murugaiah A M Subbaia. Triple Reuptake Inhibitors as Potential Therapeutics for Depression and Other Disorders: Design Paradigm and Developmental Challenges. Journal of medicinal chemistry. vol 61. issue 6. 2019-04-17. PMID:28731336. |
triple reuptake inhibitors (tris), which elevate dopamine in addition to serotonin and norepinephrine, may demonstrate greater efficacy, with the reversal of anhedonia and improved tolerability. |
2019-04-17 |
2023-08-13 |
Not clear |